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PRODUCT CATALOGUE• Stomachhealthtests• Quicktests• Monoclonalantibodies• Acetaldehydebindingproducts• Instruments• Partneringopportunities

About Biohit 3

GastroPanel 4-6

Instruments 23-26

Contents

GastroPanel 4GastroPanel Report 6s

Quick Tests 12-17

Monoclonal Antibodies 18

Acetaldehyde binding products 19-22

References 28-29

Biohit Lactose Intorelance quick test 13Biohit Celiac quick test 14Biohit ColonView 15Biohit Helicobacter Pylori UFT300 quick test 16Biohit Helicobacter Pylori quick test 17

Acetium capsule 21Acetium lozenge 22

Photometers and washers 23Automates 24-26

Laboratory Tests 7

Biohit Calprotectin ELISA 7Biohit Active B12 (holotranscobalamin) ELISA 8Biohit Total 25OH Vitamin D ELISA kit 9GA-mapTM Dysbiosis test 10

3

BiohitinBriefBiohitOyjisagloballyoperatingFinnishbiotechnologycompanyestablishedin1988.Biohit’smissionis“InnovatingforHealth”.

Biohitshouldersitssocialresponsibilitybycreatinginnovativenewtechnologiesandservicesthathelpphysiciansandresearchinstitutionstopromotediagnosticsandresearch.Theycanalsopreventdiseasesofthegastrointestinaltract,exposuretoacetaldehyde,humansufferingandfinancialloss,therebygeneratingwellbeing.Beingasociallyresponsiblecompany,wefeelitisourdutytoraisepublicawarenessofacetaldehyde,agroup1carcinogen,andtoinnovateanddevelopthemarketingofourproductsandservices,ensuringtheirmaximumavailabilitytothepublic.BiohitisheadquarteredinHelsinkiandhassubsidiariesinItalyandtheUK.Biohit’sSeriesBshare(BIOBV)isquotedonNASDAQOMXHelsinkisince1999,Smallcap/Healthcare.

Innovations

Gastrointestinaldisordersareagrowingworldwidephenomenonthatalsoinvolvessignificantmedical,ethicalandfinancialissues.Gastrointestinaldisordersarealsothemostcommoncauseofcomplaintsregardingtreatment,orinsufficienttreatment.Suchproblemsareessentiallyrelatedtoissuesaffectingthegeneralhealthcaresectorandgrowingfinancialconstraintscausedbytheageingpopulation.

Biohit’sproductsandservicesaresafe,ethicalandcostefficientinnovationsfordiagnosingandpreventinggastrointestinaldiseasesandtheassociatedrisks.

www.biohithealthcare.com

GastroPanel®

GastroPanel innovation has been developed as a result of decades of medical research in order to reliably diagnose H. pylori infection and atrophic gastritis. Until the development of GastroPanel,

gastroscopy and pathological biopsy examination were the only reliable methods for the diagnosis of

these conditions.

Innovation in the diagnosis of atrophic gastritis from blood sample

GastroPanel®

4

StomachhealthtestfordyspepticpatientsandscreeningofasymtomaticpersonsGastroPanel® is a straightforward stomach health test fromblood sample and a reliable tool for finding out the statusand function of stomachmucosa. GastroPanel test providesdoctorswithlaboratorydatatosupporttheirclinicaldecision-making and helps to prioritize patients requiring furthergastricinvestigations.GastroPanelreporthasbeendevelopedtoassistdoctorsininterpretingthetestresults.

GastroPanel is used as a first-line investigation of patientssuffering from dyspepsia. It is a particularly useful tool forgeneralpractitionersandoccupationalhealthdoctors,astheresultscanbeusedtoassesstheneedforfurtherinvestigations.GastroPanelisapatient-friendlytestthatprovidesanoverviewoftheconditionofthegastricmucosa.Theresultsmayalsoservetomotivatethepatienttoattendfurtherinvestigations,includingagastroscopy.

GastroPanel is a simple blood test that can be used toassess theconditionof thegastricmucosaandtoconfirmthediagnosisofhypochlorhydria.GastroPanelwillnotonlyidentify anH. pylori infection butwill indicatewhether thechangesinthemucosaareduetoatrophicgastritis.

Since H. pylori andatrophicgastritisarethemostimportantrisk factors for stomach cancer, GastroPanel can also beusedforstomachcancerriskscreening.

GastroPanel®

GastroPanel biomarkers

GastroPanel can be used to:• Identifypatientswithhealthygastricmucosa• DiagnoseH. pylori• Diagnoseatrophicgastritis• Identifypatientswithalteredacidproduction• Identifypatientsrequiringgastroscopy• Screeningasymptomaticpersonsforstomach

cancerrisk

GastroPanel will highlight the following risks:• VitaminB12andothermicronutrientdeficiencies• Pepticandduodenalulcers• Gastricandesophagealcancer

GastroPanel will provide recommendations on further investigations:• Gastroscopyandbiopsy• Helicobactereradicationtreatment• Furtherinvestigationofmalabsorptionor

anaemia

Standard GastroPanel kits

Cat. No. Product Qty

601300 GastroPanelstandard 1package

601010.01 PepsinogenIELISAkit 96tests

601020.02 PepsinogenIIELISAkit 96tests

601035 Gastrin-17ELISAkit* 96tests

601040.02 Helicobacter pylori IgGELISAkit 96tests

*FDA approved in the United States

5

GastroPanelkitsarebasedontheELISA(enzyme-linkedimmunosorbentassay)principleandhencecanbeusedwithavarietyofanalysisequipment(manualorautomated).Thelatestkitsfeatureunifiedreagentsandreactionconditions,makingthemevenmoreaccessible

Unified GastroPanel kits


606400 GastroPanelunified 1package

606010 GastroPanelPepsinogenI 96tests

606020 GastroPanelPepsinogenII 96tests

606035 GastroPanelGastrin-17 96tests

606040 GastroPanelHelicobacter pylori 96tests

GastroPanel® ReportWith GastroPanel examination concentrations of fourbiomarkersinabloodsamplearedetermined.BiomarkerssecretedbythecellsingastricmucosaarepepsinogenI(PGI),pepsinogen II (PGII) and gastrin-17b (G17b). Additionally,Helicobacter pylori antibodiesaremeasured.

An overall interpretation of all four biomarker resultsprovidesamorereliableandcomprehensiveunderstandingoftheconditionandfunctioningofthegastricmucosathancouldbeachievedusingjustoneortwobiomarkers.WealsorecommendtoviewtheGastroPanelflowchart(below),whichprovidesexamplesofhowtointerpretthebiomarkerresults.However,pleasenotethattheGastroPanelreportprovidesamoreaccurateinterpretationoftheresults.

GastroPanel – interpretation guide snapshot

GastroPanel®6

GastroPanel report by the GastroSoft® helps interpret the results

GastroPanel report 2.11.2012

Patient DataName Firstname Lastname (#1)Date of birthAge 69

EradicatedUse of PPIAcidic symptomsUse of NSAIDs

Assay DataCollected 27.8.2012Analyzed 28.8.2012

reference range:Pepsinogen I (PGI) 12,8 µg/l * 30 - 160 µg/lPepsinogen II (PGII) 7,5 µg/l 3 - 15 µg/lPGI/PGII 1,7 * 3 - 20 Gastrin 17B 34,0 pmol/l * < 7 pmol/lH. pylori antibodies (HPAB) 15,0 EIU < 30 EIU

Interpretation

27.3.1943

Don't knowNo

The results indicate atrophic gastritis (loss of gastric glandural cells) in the corpus due to a past Helicobacter pylori infection. Acid secretion in the stomach is decreased.

Ask a doctor about the possibility of undergoing gastroscopy.

Yes (over 1 y)

No

Copyright Biohit Oyj, Finland, 2012. For Research Use Only in the USA and Japan. Subject to change without prior notice. GastroSoft D version:1.50

Information on interpretation on the next page.Test and create your own GastroPanel report at

www.gastropanel.com > Healthcare professionals and laboratories

> GastroPanel report

GastroSoft® is a software application designed toassist clinicians/medical doctors in interpretingGastroPanel test results with optional anamnesticinformation.TheGastroPanelreport is intendedforhealthcare professionals only. The final diagnosismustbemadebytheclinician/medicaldoctor.

Structural and functional causes of dyspeptic symptoms diagnosed by GastroPanel test (PGI, PGII, PGI/PGII, G-17, Hp-Ab)

Gastroscopy mandatory

PGI or PGI/PGII Low;

G-17b High; Hp+ or Hp-

Atrophic gastritis in the

corpus

PGI, PGII, G-17b High;

PGI/PGII Normal, Hp-

Short (4-10-day)

pause in PPI treatment

PGI and PGII need more time than G-17b to turn normal

PGI, PGII, PGI/PGII Normal or

High; Hp-; G-17b High

Healthy stomach

mucosa, patient possibly on

PPI treatment; stomach is

hypochlorhydric

No need for gastroscopy

PGI, PGII, PGI/PGII, G-17b

Normal; Hp-

Healthy stomach mucosa

No need for gastroscopy

PGI, PGII, PGI/PGII, G-17 Normal or High; Hp+

Superficial, non-atrophic H.pylori (Hp)

gastritis

Eradicate Hp and consider gastroscopy if symptoms

PGI Low, PGII Normal or Low; PGI/PGII Low,

G-17b Low, Hp+

Atrophic pangastritis

PGI, PGI/PGII Normal; G-17b

Low; Hp+

Atrophic gastritis in the

antrum

Normal structure Referral to Specialist; gastroscopy/biopsyReferral to General Practitioner

PGI, PGII, PGI/PGII Normal,

Hp-; G-17b Low

Healthy stomach

mucosa; high acid output

is likely

No need for gastroscopy;

GERD or NERD conceivable

Biohit Calprotectin ELISA

BiohitCalprotectinELISAisaquantitativetestwhichprovidesareliabledifferentiationbetweeninflammatoryboweldiseases(IBD) and irritable bowel syndrome (IBS). IBD is commonlyassociated with conditions such as ulcerative colitis andCrohn’sdisease.PatientssufferingfromeitherIBSorIBDmayexperiencesimilarsymptomsandaclinicalexaminationalonemaynotbesufficienttogiveaspecificdiagnosis.Furthermore,these conditions may appear from early childhood to lateadulthood and the diagnosis is often delayed due to vaguesymptomsorreluctancetoperformendoscopy.WithBiohitCalprotectinELISA,thedeterminationbetweenIBSandIBDcanbemadenon-invasivelyandin-expensivelyfromastoolsample.InorganicdisorderslikeIBD,theconcentrationfecal calprotectin increases significantly, whereas withfunctionaldisorderslikeIBSthisdoesnotoccur.

Biohit Calprotectin ELISA can also be used for monitoringthemucosalhealingofapatientwith IBD.This forexamplehelpstosupportthepractitionerinmakinginformeddecisionsconcerningmedicationandtheneed formedicalproceduressuchasendoscopyorsurgery.

Applications• Differentiatesinflammatoryboweldiseases(IBD)

fromirritablebowelsyndrome(IBS)• MonitoringofmucosalhealingwithIBDpatients• Relapseprediction(clinicalremission)

Sampling made easy• Consistenceofthefecesdoesnotaffectthe

result• Onlyasmallamountofsamplerequired• Easyhandlingwithhygienicextractiontubes=

reducedprocesstime

Straightforward analysis• Wideassayrangewithonlyonedilution25–

2500mg/kginfeces• Fitsdirectlyintoautomatedsystems(e.g.Dynex

DS2)• Validatedresultsfromaprovenassay



602260 BiohitCalprotectinELISAkit 96tests

602270 Biohitextractiontubes 50pcs

Not available in the United States. In Japan for research use only.


FormonitoringtreatmentanddifferentiatingbetweenIBDandIBS

7

ThetraditionalmethodofdiagnosingvitaminB12deficiencyhasbeentomeasuretheconcentrationoftotalvitamin-B12intheserum.ThetotalvitaminB12concentrationessentiallyreflectsvitamin-B12whichisboundtoitstwocarrierproteinsforming,holohaptocorrin (holoHC) and holotranscobalamin(holoTC).Whilst holoHCaccounts for 70% - 80%of the vitaminB12in serum, only holoTC (active vitamin B12) can be used byhumancells.MeasurementoftotalvitaminB12canhencegiveerroneousresultsbecauseitmeasuresthevitaminB12whichis incirculationbutdoesnot indicate theactivevitaminB12thatisavailabletothecellsofthebody.

BiohitActiveB12(holotranscobalamin)ELISAtestprovidesasolutiontothisdiagnosticparadox:thistestdirectlymeasures(holoTC)–thebiochemicallyactiveformofvitaminB12–fromthehumanserum.ThistestiswellsuitedforthescreeningofpatientswithasuspectedvitaminB12deficiency.BiohitActiveB12testcanalsobeusedforconfirmingthevitaminB12statusinthelargenumberofpatientswhogetaninconclusiveresultfromtotalvitaminB12tests.

Biohit Active B12 (holotranscobalamin) ELISA • Measurestheconcentrationofactivevitamin

B12(holotranscobalamin)availabletothecells• ProvenELISAtechnology,supportforboth

automatedandmanualanalysismethods• UnliketotalB12kits,noissueswithIntrinsic

FactorBlockingAntibody(IFBA)interferences• Numerousclinicalstudiesprovingthe

performanceofActiveB12overtotalB12

Biohit Active B12 (holotranscobalamin) ELISA


602290 BiohitActiveB12 (holotranscobalamin) ELISAkit 96tests

In the United States and Japan for research use only.

ForaconclusivedeterminationofthevitaminB12status

Biohit Active B12 (holotranscobalamin)

Biohit Active B12 (holotranscobalamin)8

Biohit Total 250H Vitamin D ELISA kit 9

VitaminDhasmultiplerolesinthehumanbody.Inadditiontoitswellestablishedroleintheregulationofcalciumabsorptionandpromotingbonegrowth, it isrecognizedforotherhealthbenefits including reducing risk of diseases such as type 1diabetesandcommoncancers.

The best indicator of vitamin D status is the serumconcentration of 25OH vitaminD. For a correct diagnosis ofvitaminDdeficiency, theassaymust recognize twovitaminsimportantinthehumanbody,vitaminD2andD3.

TheBIOHITTotal 25OHvitaminDELISAkit is aquantitativeimmunoenzymaticassay.Whiledetectingboth25OHvitaminD2andD3,thekitprovidesclinicallyrelevantinformationonthe vitaminD status.Reliability of the results is ensuredbyvalidationagainsttheID-LC/MS-MSReferenceMeasurementProcedure(Ghentmethod)asapprovedbytheVitaminDStandardizationProgram(VDSP)withR>0.97.

Biohit Total 25OH Vitamin D ELISA kit• Detectsboth25OHvitaminD2andD3fora

clinicallymeaningfulassessmentofvitaminDstatus

• CalibratedagainsttheID-LC/MS-MSReferenceMeasurementProcedure

• User-friendlyandfullyautomatableassayprotocol

Biohit Total 250H Vitamin D ELISA kit


602 310.02 BIOHITTotal25OH 96tests VitaminDELISA

ForaconclusivedeterminationofthevitaminDstatus

Biohit Total 25OH Vitamin D ELISA kit

In the United States and Japan for research use only. Check availability for other markets.

The GA-mapTM Dysbiosis test is the first CE marked gutmicrobiota DNA analysis tool to identify and characterizedysbiosis.

Profiling gut microbiota dysbiosisenables personalized treatment Profiling dysbiosis in gut microbiota using new moleculardiagnostictechnologiesopensthewaytoanexcitingneweraofpersonalizedtreatmentofgastrointestinaldiseases.

Monitor the microbiotaTheGA-mapTMDysbiosistestcanbeusedformonitoringtheeffectonthemicrobiotaofarangeofdifferenttreatmentsinordertofindclinicallyimportantsubgroups:-Diets-Probiotics-Prebiotics-Antibiotics-Drugs,suchasTNFinhibitors-Fecalmicrobiotatransplantation-Lifestylechanges

GA-mapTM Dysbiosis testNumerousstudieshavesuggestedaroleforgutmicrobiotaingastrointestinaldiseases,andonlyrecentlyhavelinksbetweendysbiosisandIBS/IBDbeenexplored.WorkingwithleadingexpertsinScandinaviaandEurope,severalstudieshavebeenperformedinordertodocumentdysbiosistestinvariouspatientpopulations:

• 73%oftheIBSpatientshadadysbioticintestinalmicrobiota

• 27%oftheIBSpatientshadamicrobiotanotdifferentfromthemicrobiotaprofilefoundinahealthypopulation

• TheGA-mapTMDysbiosistestisthefirstCE-markedgutmicrobiotatestavailableforclinicaluse.Samplescanbesenttothecertifiedlaboratoryforanalysis.Itisalsopossibletoestablishtheprocedureatthehospitalmolecularlaboratory.

Reference: Casén C et al. Deviations in human gut microbiota: a novel diagnostics test for determining dysbiosis in patients with IBS or IBD. Aliment Pharmacol Ther 2015; 42: 71–83.

Easyaccesstopatientfecalmicrobiota

GA-mapTM Dysbiosis test

GA-mapTM Dysbiosis test


602350 GA-mapTMsampleanalysis

602360 GP-mapTMtest 75test

BiohithaspartneredwithGeneticAnalysis,aleadingmoleculardiagnosticscompanyfocusedondevelopingnovelDNAbasedtestsforgastrointestinaldiseases.TheGA-mapTMDysbiosistestisaCEmarkedtestprovidingthefirstdirectmeasurementofdysbiosisinIBSandIBDpatients,pavingthewayforpersonalizedtreatment.

GA-mapTM Dysbiosis test10

Organised population-based screening for cervical cancer, breast cancer and colorectal cancer has been conducted in Finland for several years. Cancer is suitable for population-based screening, if the disease is common, its precursors are established, and by detecting these, one can prevent cancer. Also gastric cancer meets all these requirements. In Finland, with a population of 5,4 million, 600–700 new cases of gastric can-cer are diagnosed every year. Because of a delayed diagnosis, this cancer typically has a poor prognosis, i.e., 5-year survival rate of 20 %.

The two most important risk factors of gastric cancer are Helicobacter pylori infection and atrophic gastritis (AG). Both conditions can be accurately diagnosed by a simple blood test, known as GastroPanel. The 13C urea breath test (UBT), stool antigen test and antibody tests do not detect atrophic gastritis which is caused by Helicobacter pylori infection or an autoimmune disease. The UBT and stool antigen test may give up to 50 % false negative results for Helicobacter pylori infection if the patient has a) AG, b) MALT lymphoma, c) bleeding peptic ulcer disease, or d) if the patient is currently receiving antibio-tics or PPIs.

1) Terveyskirjasto: Helikobakteeri-infektio (Helicobacter pylori infection)2) Telaranta-Keerie A et al.: Prevalence of undiagnosed advanced atrophic corpus gastritis in Finland: an observational study among 4,256 volunteers without specific complaints. Scand J Gastroenterol. 2010;45:1036-413) www.gastropanel.com > GastroPanel is a blood test for the reliable diagnosis of a Helicobacter pylori infection and an asymptomatic atrophic gastritis, the cause of anacidic stomach.4) www.biohithealthcare.com > “Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers”, Scan-dinavian Journal of Gastroenterology 2012; 47: 136-147

Prevention of gastric cancer generates significant cost savings

test indicates atrophic gastritis, the subject is at risk for developing malabsorption of vitamin B12-, iron-, calci-um- and magnesium as well as some drugs. Malab-sorption of vitamin B12 increases the risk of dementia, Alzheimer’s disease, depression and polyneuropathies, all of which would benefit from early diagnosis to enab-le effective prevention and treatment.

The GastroPanel blood test enables early detection of these risk groups and their referral for further tests and specific therapy. (3,4). At national level, the GastroPanel screening of one specific age cohort, e.g. 50-year-old people (n=68.000), for the known risk factors of gastric cancer (Helicobacter pylori and atrophic gastritis) would generate savings of tens of millions of euros in the pub-lic health sector in Finland.

Advertorial

A test for Helicobacter pylori and atrophic gastritis

It is estimated that 15–20 % of Finnish population has Helicobacter pylori infection. In most cases, this infec-tion is asymptomatic, but it can also be responsible for a variety of nonspecific abdominal symptoms (dys-pepsia).

In the stomach mucosa, Helicobacter pylori infection starts as superficial gastritis, but if not eradicated it becomes chronic and eventually develops into AG and anacidic stomach. (1)

Atrophic gastritis is the cause of anacidic stomach, which increases the risk of gastric cancer up to 90-fold, when severe and affecting the entire stomach (antrum and corpus).

Currently, some 4 % of the Finnish population is af-fected by atrophic gastritis, but of people over 70 ye-ars of age, some 8 % suffer from AG. (2)

Major cost savings for municipalities

The GastroPanel test developed by Biohit Oyj in Fin-land can help diagnose both Helicobacter pylori in-fection and AG (anacidic stomach). If the GastroPanel

Quick tests12

Biohit Quick Tests are easy-to-use tools for the rapid diagnosis of gastroenterological disorders.

The quick test product family includes biopsy based Lactose Intolerance and Helicobacter Pylori

quick tests, a point-of-care celiac quick test and an advanced FOB test, ColonView.

Biohit Quick tests

Innovation in rapid diagnostics

Quick tests


ColonViewquick test

Literature 1. Sieg, A. et al. Detection of colorectal neoplasms by the highly sensitive hemoglobin-haptoglobin complex in feces. International Journal of Colorectal Disease 1999; 14: 267-271.

2. Lüthgens K. et al. Hemoglobin-Haptoglobin Complex: A Highly Sensitive Assay for the Detection of Fecal Occult Blood. Clinical Laboratory 1998; 44: 543-551.

3. Yamamoto M. et al. Cost-effectiveness analysis of immunochemi-cal occult blood screening for colorectal cancer among three fecal sampling methods. Hepatogastroenterology 2000, 47(32): 396-399.

Test performanceCarefully shake the Sample Collection Tube. Unscrew and remove the white cap. This reveals a dropper. Drop 3 drops onto the Sample well of the Hb or Hb/Hp test strip in the cassette. The sample is absorbed in 5 to 15 minutes. Results can be read after 15 to 25 minutes.

www.biohit.de

Easy-to-use, simple quick test for detecting colonrectal cancer

Unternehmen:

Abteilung:

Name:

Telefon:

Fax:

Email:

Ich bitte um ein Angebot!

Ich wünche weitere informationen über ColonView Schnelltest

Ihre Anfrage senden Sie bitte per Fax an: 06003 8282 22

Biohit Deutchland GmbHRaiffenstraße 1a - 61191 Rosbach v. d. Höhe

Telefon: 06003 8282 0 Telefax: 06003 8282 22Email: [email protected]

RESU

LTS

IN

20 min

C T S

C

T

C

T

C

T

C

T

5-15 min

Cat. No Item

602210 10 tests/package

602230 30 tests/package

Ordering details

Biohit Lactose Intorelance Quick Test


602 010 Biohit Lactose Intorelance quick test kit 25 tests

602 012 Biohit Lactose Intorelance quick test kit 10 tests

BiohitLactoseIntolerancequicktestConfirmed results during gastroscopyTheBiohitLactoseIntolerancequicktestdetectsalltypesoflactasedeficiencyfrombiopsyspecimens.Thisgivesaddedvaluetogastroscopieswithminimumeffort.Thetestisbasedonthenormallactaseenzymereactionandisthereforeabletodetectlactasedeficiencyaswellasindicatethefunctionalityoftheenzyme.TheBiohitlactoseintolerancequicktestisnotonlyasensitivediagnostictool,butithasalsobeenfoundtobemoreaccuratethanlactosebreathtestinpredictingclinicalresponsetolactose-freediet.

Easy testing from a duodenal biopsy specimenThetestprocedureoftheBiohitLactoseIntolerancequicktestisfastandsimple.Thebiopsyspecimenisplacedinthetestplateandtestreagentsareaddedonthesample.Clearcolorchangeindicatesthetestresultwithin20minutesenablingtestingandreportingduringonevisit.

RESULTS IN

20 minFROM BIOPSY

Biohit Lactose Intolerance quick test• Resultsin20minutes• Simplecolorchartinterpretation• Allreagentsready-to-use• Sensitivity95%,specificity100%• Superiorsensitivitycomparedtolactose breath test

13

RESULTS IN

10 min

BiohitCeliacquicktestAccurate results from fingertip bloodTheBiohitCeliacquicktestenablesnon-invasiveandaccuratetestingofceliacdiseasefromonlyadropofblood.Thetestisbasedonthedetectionofthreeformsofanti-tissuetransglutaminaseantibodies(tTG);IgA,IgGandIgM.Thetestthereforedeliversasuperiorsensitivity,especiallyinpatientswithIgAdeficiency.

Easy testing at the point-of-careThebloodsamplefortheceliacquicktestistakenasafinger-pricksample.Thesampleisplacedonalateralflowtestcassettealongwithabuffersolution.Thetestresultisclearlyvisiblewithin10minutes.

Biohit Celiac quick test• Resultsin10minutes• Finger-pricksamplecollection• Easy-to-uselateralflowquicktest• Sensitivity>99%,Specificity98,9%

Quick tests14

Biohit Celiac Quick test


602070 BiohitCeliacquicktest 20test/package

Not available in the United States. In Japan for research use only.

Use an electronic Quick test reader for objective interpretation of the Celiac Quick test. Contact Biohit for more information > [email protected]

Quick test reader

Cat. No. Product

740400 QuickTestReader

BiohitColonViewquicktestDetects bleeding derived from both lower and upper GI tractTheBiohitColonViewquicktestisanimmunologicallateralflowtestwhichdetectshemoglobinandhemoglobin-haptoglobincomplex(i.e.degradedhemoglobin)fromastoolsample.ThetestcanbeusedtodetectbleedingderivedfromthecolonorupperpartsoftheGItract.ThisgivestheColonViewtestasuperiorsensitivityandspecificitytodetectbleedingcancertumorsaswellastheirprecursors(smallpolypsandadenomas).

One sample is enough for dual testingCleverdesignoftheColonViewsamplingtubeeliminatespatienterrorsandensuresthattherewillalwaysbeacorrectsampleamount.Thesamplingtubeisalsoaclosedsystemwhichmakesithygienictohandlebythepatientaswellasduringtransportationandinthelaboratory.Thesamplingtubecontainsallthenecessaryreagentsandnoadditionalaccessoriesareneededfortheanalysis.OnesampleisenoughforthetestingofbothHbandHb/Hpcomplex.

Biohit ColonView quick test• Advancedtooltodetectbleedingfromlower andupperGItract• SuperiorsensitivityandPPV• Cleverdesignofthesamplingtubeeliminates patienterrors• Closedsystemhygienicsampling, transportationandanalysis• Specificity100%

RESULTS IN

5 min - 15 min

Quick tests 15


Biohit ColonView quick test kit


602250.02 BiohitColonViewquicktestkit 30tests

Use an electronic Quick test reader for objective interpretation of the ColonView Quick test. Contact Biohit for more information > [email protected]

Quick test reader

Cat. No. Product

740400 QuickTestReader

Quick tests16

BiohitHelicobacter pylori UFT300quicktestUltra-fast H. pylori detection from a biopsyTheBiohitH. pyloriUFT300isatruequicktestforthedetectionofH. pylorifromabiopsyspecimen.ThebiopsytakenduringgastroscopycanbetestedimmediatelytodiagnoseH. pyloriinfectionortodeterminethesuccessoferadicationtherapy.Thetestresultsarereadyinonly5minutesenablingdiagnosisandreportingatthesametime.Thissavesthepatientfromanunnecessaryvisittothedoctorforhearingthetestresults.TheBiohitH. pyloriUFT300quicktesthasexcellentsensitivityandspecificitywhichmakesitahighlyreliableandaccuratetoolfordiagnostics.

Biopsy testing could not be easierTheBiohitH. pyloriUFT300quicktestiseasyandeffortlesstouse.Thebiopsyspecimenisplacedintothetesttube/welloftheplateandmixedwiththetestreagent.ClearcolorchangeindicatesthepresenceofH. pyloriinthespecimen.Theprocedureissafeandhygienicfortheuser,andtheinterpretationoftheresultdoesn’trequirespecialisttraining.


Biohit Helicobacter pylori quick test with plate


602005PLA BiohitUFT300quicktestkit 5tests

602019PLA BiohitUFT300quicktestkit 50tests

602017 Positivecontrol 1

5 minFROM BIOPSY

RESULTS IN

Biohit Helicobacter pylori UFT300 quick test• Ready-to-usetestkit• Resultsreadyin5min(bothpositiveandnegative)• Storageinroomtemperature• Sensitivity94,5%,Specificity100%• Testingandreportingduringoneappointment

Biohit Helicobacter pylori quick test with tube


602005 BiohitUFT300quicktestkit 5tests



602017 Positivecontrol 1

Plate and tube versions available!

Quick tests

Biohit Helicobacter pylori quicktestEasy testing from a biopsy specimenTheBiohitH. pyloriquicktestisaone-steptestmethodtodetectH. pyloriinfectionfromabiopsysampleduringgastroscopy.TheBiohitH. pyloriquicktestcanbeusedtodiagnoseH. pyloriinfectionortodeterminethesuccessoferadicationtherapy.ThepositiveresultsforH. pylori arereadyinafewminutes,andthefinalconfirmationofanegativetestresultisreadyinjust30minutes.

UsingtheBiohitH. pyloriquicktestisaneasyone-stepprocedure.Thebiopsyspecimenisimmersedintothegelmedium,andifH. pyloriureaseispresentinthespeci-men,aredcolordevelopsinthegel.Interpretationoftheindicatorcolorissimpleanddoesnotrequireanyspecial-isttraining.


Biohit Helicobacter pylori Quick test


602015 BiohitHelicobacter pylori QuickTestKit 50tests

2 min - 30 minFROM BIOPSY

RESULTS IN

Biohit Helicobacter pylori quick test• Testingandreportingduringgastroscopy• One-steptestprocedure• Positiveresultsin1-2min.(neg.max30min.)

17

MAbsinotherconcentrationsandindifferentbuffersystemsareavailableatrequest.*TheBiohitmonoclonalantibodiesareapplicablein:IHC=Immunohistochemistry,WB=WesternBlotting,FIA=Time-resolvedFluorescenceImmunoassay,IP=ImmunoprecipitationEIA=EnzymeImmunoassay**Reactivitywithparaffinsections

MonoclonalAntibodiesSpecificity Clone # Host Subclass Format Qty Applications* Paraffin** Ordering #

Monoclonal Antibodies to Human Gastric Biomarkers

PepsinogenI 4C6.1 mouse IgG1 purified 100μg IHC yes 610055

PepsinogenII L10CC10 mouse IgG1 purified 100μg IHC yes 610056

Monoclonal Antibodies to Phytoestrogen

Genistein L22FA2 mouse IgG1 purified 100μg EIA,FIA - 610058

Monoclonal Antibodies to Human Extracellular Matrix Components

CellularFibronectin(cFn) DH1 mouse IgG1 purified 100μg IHC,WB,EIA no 610001

Tenascin-C EB2 mouse IgG1 purified 100μg IHC,WB,EIA no 610002

Tenascin-C DB7 mouse IgG2a purified 100μg IHC,WB yes 610003

Laminin(ß1-chain) DG10 mouse IgG1 purified 100μg IHC,WB no 610004

Laminin(ɣ1-chain) BC7 mouse IgG1 purified 100μg IHC,IP no 610005

PlasmaFibronectin(pFn) BF12 mouse IgG1 purified 100μg IHC,WB no 610006

Vitronectin BE10 mouse IgG1 purified 100μg IHC,WB no 610007

Monoclonal Antibodies to Human Integrins

ß1 -Integrin DF5 mouse IgG1 purified 100μg IHC,WB yes 610008

ß1 -Integrin DF7 mouse IgG1 purified 100μg IHC,WB yes 610009

ß3-Integrin BB10 mouse IgG1 purified 100μg IHC,WB no 610010

IIb-Integrin CA3 mouse IgG1 purified 100μg IHC,WB no 610011

Monoclonal Antibodies to Human Endothelial Cell Surface Marker

PECAM-1 CE6 mouse IgG1 purified 100μg IHC,WB no 610027

Monoclonal Antibodies to Human Neurotransmitter Substances

GABA 5A9 mouse IgG1 purified 100μg IHC,EIA yes 610025

CGRP CD8 mouse IgG1 purified 100μg IHC,WB,EIA yes 610026

Monoclonal Antibodies to Human Cytoskeletal Polypeptides

-Actinin CB11 mouse IgG1 purified 100μg IHC,WB no 610012

-Fodrin AA6 mouse IgG1 purified 100μg IHC,WB no 610013

Vinculin FB11 mouse IgG1 purified 100μg IHC,WB no 610014

Cytokeratin18 4B11 mouse IgG1 purified 100μg IHC,WB,IP no 610015

Cytokeratin8,18,19 2A4 mouse IgG1 purified 100μg IHC,WB no 610016

Cytokeratin7,17,19 4F5 mouse IgG1 purified 100μg IHC,WB no 610017

Vimentin 65E mouse IgG1 purified 100μg IHC,WB no 610018

Neurofilaments150,200 13AA mouse IgG1 purified 100μg IHC,WB no 610021

Neurofilaments70,200 14BA mouse IgG1 purified 100μg IHC,WB no 610022

Monoclonal Antibodies to Human Spectrins

Erythroid -Spectrin AF10 mouse IgG1 purified 100μg IP,WB,IHC no 610023

Erythroidß-Spectrin DB2 mouse IgG1 purified 100μg IP,WB,IHC no 610024

Monoclonal Antibodies18

Acetiumreducestheriskofcancercausedbyacetaldehyde.Acetaldehydeisacarcinogenthatisparticularlydangerousif:

• you are suffering from an anacidic (low- or no-acid) stomach• you are taking antacid medication• you are suffering from a chronic Helicobacter pylori infection• you smoke

AcetiumcontainsL-cysteine,whichisanaturalaminoacid.AcetiuminnovationslowlyreleasesL-cysteinebindingcarcinogenicacetaldehydelocallyinthestomachandpreventsitsabsorptionintothebody.Inadditiontoreducingcancerrisk,eliminationofacetaldehydemaybebeneficialinthealleviationofnicotineaddiction.

TheproductrangeincludestheAcetiumcapsuleforanacidicstomachprotectionandtheAcetiumlozengeforsmokers.

ACETIUM® – Protect your stomach!

Acetaldehyde binding products 19

Acetaldehyde binding products

Where does acetaldehyde come from and where is it found?

Acetaldehydeisthemostcommoncarcinogenintheworld.Itcanbefoundinmanytypesoffoodaswellasinalcoholandtobacco.

Acetaldehydeisnaturallypresentinmanytypesoffood.Itisparticularlyabundantinfoodproducedbyfermentation,suchasalcoholicbeverages,vinegar,dairyproducts,home-brewedbeerandmead.

Duetoitspleasantapple-likesmell,acetaldehydeisalsousedasaflavoringinsomepastries,fruitjuices,softdrinks,sweetdessertsanddairyproducts.

Themostsignificantsourcesofacetaldehydeexposurearehighconsumptionofalcoholicbeveragesandsmoking.

How does acetaldehyde act in the body?

Inanormal,healthystomach,hydrochloricacid(HCI)cankilltheacetaldehyde-producingmicrobes(yeastsandbacteria)ofthedigestivetract,whicharecarriedfromthemouthtothestomachwithsaliva.Incertainconditionsthesemicrobesformacetaldehydefromalcoholbyoxidationorbyfermentationofingestedsugar.

Insomepeople,acid-producingcellsofthemucousmembraneofthestomachdisappearduetoatrophyofthemucousmembrane(aconditioncalledatrophicgastritis),andthereforemicrobesareabletomultiplyinthestomach.Peoplewhohavetakenantacidmedicinesforalongtimetotreatacidicstomachconditionsarealsoatriskofmicrobialgrowthinthestomach.Unliketheliver,themucousmembraneoftheintestinesandthemicrobesofthestomacharenotabletoprocessacetaldehydeandturnitintoaceticacidandwater.Therefore,anabundanceofacetaldehydeaccumulatesinthesaliva,anacidicstomach,andthelowerdigestivetract.

Maximum amount of acetaldehyde

Ithasbeenestimatedthatthedailyacetaldehydeintakebyapersonofaverageweight(70kg)shouldnotexceed0.4milligrams.Thismeansthattheacetaldehydecontentofa100mlservingofanyalcoholicbeverageorfoodshouldnotexceed50μmol/l.Theacetaldehydecontentofsomefoodcanbemanythousandsoftimeshigherthanthesafetylimit.

Thehighestacetaldehydecontentscanbefoundincertainalcoholicbeverages(suchascalvados,sherryandciders),fermentedproductsandsomefruitsandfruit-basedproducts.

AcetaldehydeisaGroupIhumancarcinogenthatweareexposedtoeveryday

20

Acetium®capsuleAcetiumcapsulescontainL-cysteine,whichisanaturalaminoacid.L-cysteineeffectivelybindsacetaldehydefromsalivaandformsaharmlesscompoundthatcanbeexcretedfromthebody.IfyouaretakingantacidmedicinesonaregularbasisorsufferingfromananacidicstomachorHelicobacter pyloriinfection,thebacteriaandyeastsfromthemouthcanliveinthestomach.Thesebacteriaandyeastsproducecarcinogenicacetaldehydeeverytimeyouconsumealcoholicbeveragesandfoodthatcontainsalcoholorsugar.

Acetium


620070 AcetiumFI-SWE-EN 4x15blisters

620095 AcetiumITA-GER-FRA 4x15blisters

Not available in the United States.

Acetium capsule• Protectsthestomach,especiallyifyouaresuffering

fromananacidic(low-orno-acid)stomachortakingantacidmedicines

• Effectivelyremovesacetaldehydewhentakenduringmealsandalcoholconsumption

Acetaldehyde binding products 21

Acetium®lozengeAcetiumlozengescontainL-cysteine,whichisanaturalaminoacid.L-cysteineeffectivelybindsacetaldehydefromsalivaandformsaharmlesscompoundthatcanbeexcretedfromthebody.

L-cysteineremovesover90percentoftheacetaldehydedissolvedintosalivaduringsmokingandalcoholconsumption.Therecommendeddosageis1or2lozengesduringsmoking.

*Acetiumlozengesdonotreduceotheradverseeffectsofsmoking,nordotheyremovecarcinogensotherthanacetaldehyde.Itisrecommendedtoquitsmokingduetoallitsadverseeffects.

Acetium Lozenge

Product Qty

LozengeDisplay 10x30lozenges

Not available in the United States

Acetium lozenge• Removes acetaldehyde fromsaliva during smoking

andalcoholconsumption.• Potentially alleviates acetaldehyde-enhanced nico-

tineaddictionamongsmokers• Reducestheadverseeffectsofsmokingifyouarenot

abletoquit*.• Tooth-friendly,containsxylitol.Poororalhygienein-

creaseslocalacetaldehydeformation.

Acetaldehyde binding products22

BP Microplate ReadersTheBP800MicroplateReaderhasallthefeaturesofamodernmicroplatephotometertoautomaticallyperformendpointanalysisforavarietyofELISA-basedapplications.Withthehelpofthein-buildintuitiveuserinterface,newtestprotocolscanbemadefastandeasily.Extensiveon-boarddatareductionsurpassesmanypersonalcomputersoftwarepackageswithitsextensivecurve-fitting,cut-offcalculation,datatransformationandvalidationcapabilities.TheBP800isdesignedtoserveasastand-alonesystem,oraspartofalargerlaboratorydatanetwork,sendingreceiving,andmanipulatingassaydataasneeded.Therefore,inadditiontotheprinterinterface,theinstrumenthasaserialinterfacetobecontrolledwithapersonalcomputerforfurtherprocessinganddistributionofdata.

TheBP808MicroplateReaderisan8-channelmicroplatephotometer(IU-model)withfour-zoneincubationto50°Candalinearshaking.Duetothefastreadingcapabilitytheunitisalsosuitableforkineticapplications.In-builduserinterface,datareduction,serialandparallelI/OareprovideaswiththeBP800,offeringanadvancedreaderfordifferentkindofapplication.

Thee-LisaXListhemosteasy-to-use,yetusefulsoftwareutilityforsupportingtheBiohitmicroplatereaderswithendpointtypeassayssuchastheBiohitGastroPanelassays-PepsinogenIandII,Gastrin-17andHelicobacter pyloriorotherBiohitELISAbasedtests.IthasbeendesignedtobeusedtogetherwithMicrosoftExcel™,providingnumerouspossibilitiesfordataprocessingandvalidation.Thee-LisaXLisdeliveredwithExceltemplatesforBiohitassays.

TheBiohitBP-seriesmicroplatereadersaredeliveredwiththeBiohite-LisaXLforWindows,providingimmediateeasy-to-usemeasurementswhenPCisusedtocontrolthereader.

Instruments

Cat. No. Product

740030 BP800MicroplatePhotometer

740031 BP800MicoplatePhotometer340nm(UV)

740032 BP800MicroplatePhotometer384(NB)

740040 BP808MicroplatePhotometer

740041 BP808MicroplatePhotometer(UV,I)

740050 BW50/8MicroplateStripWasher

740051 BW50/16MicroplateStripWasher384

740052 BP50/12MicroplateStripWasher

740053 BP50/8VMicroplateStripWasher

BW 50 WasherTheBW50isaself-containedandprogrammablemicroplatewashersuitableforEIA,FIA,RIA,DNAprobeandcellularassays.Itallowsfullcontrolofprecisefluidicdeliveryfromthegentledrippingofasimplesqueezebottletothefullforceofpressuredeliverysystems.TheBW50isaperfectcompanionfortheBiohit’sBP-seriesreaders.Thebuiltinuserinterfaceandtheon-boardsoftwareenablesimilarintuitiveeasyprogrammingaswiththeBP-readers.Thiscommonalityallowsthelaboratorytechniciantoeasilydevelopbothwashinganddatareductionprotocolsforthoseassaysofinterest.TheBW50canbedeliveredpreprogrammedforBiohitdiagnostickits.

Microplatephotometersandwashers

Instruments 23

Theinstrumentisfullofuniquefeaturessuchasintelligentracks,highprecisionliquidhandler,orbitalMTPshaker,build-inbarcodereader,convectionincubator,on-boardcamera.Theanalyzerprovidescomplete,walk-awayautomationofupto192patientsamples.Ithasasmallestfootprintonanycomparableinstrumentandthereforecanbeplacedonastandard60cmlabtable.CompletelyopenarchitectureallowsanyELISAprotocoltobeprogrammedandrunonuptoeightdifferentassayssimultaneously.TheCLIAoptionenablestheplatformtoprocesschemiluminescenceassaysaswell.

BiohitAutomatedImmunoassayAnalyzerprovidescompact,cost-efficientandcompletelyopensystemtoautomateGastroPaneloranyotherEIAassays.

BIOHITAutomatedImmunoassayAnalyzer

Instruments

Cat. No. Product

742000 AutomatedImmunoassayAnalyzer

742001 AutomatedImmunoassayAnalyzer(withCLIA-option)

BiohitAutomatedImmunoassayAnalyzerismanufacturedbyGoldStandardDiagnosticsInc.

Automated Immunoassay Analyzer• Fullyopensystem• ConvectionIncubator• OrbitalShaker• Built-inEIA/CLIAReader• On-BoardCamera• HighprecisionMicro-Syringe• SlidingSampleTray• IntegratedBarcodeReader• Upto8assayssimultaneously• Intelligentracksproviding192samplepositions• 16customreagentpositions• Smallestfootprint,lightestinweight• Consistent,accurateandreliableresults• Intelligent,IntuitiveandAdaptableSoftware• In-buildLIMSsupport

Instruments24

Instruments

Dynex DS2®

Designedwithfullwalkawaycapability,DS2®quicklyandeasilyprocessestwo96-wellmicroplatesandupto12differentassayssimultaneously.Thesystemalsofeaturesauser-friendlycontrolsystem,chainofcustodymanagementandon-boardinstrumentdiagnostics.

DS2®deliverssample-in/results-outautomationofmicroplateassays:•Sampledilutionanddistribution•Incubation,washingandreagentdispensing•Readingwithautomaticdatareductionandqualitycontrol•Automaticbarcodescanning

Theflexible,opensystemdesignofDS2isidealforvirtuallyanyELISAapplication,suchasGastroPanelfromBiohit.

DynexAutomatedSystems

Dynex Automated Systems• Userfriendlygraphicalsoftware• 2-positionincubator• Slide-insampleracks,max100samplesperrun• Disposabletips(max.216+20pcs)• 12x8DWpredilutionstrips• Linearshaker14-20Hz• 4-assaysperplate• 8-channelwasher• Option: integrated bar code reader, LIMS-interface

software

DS2® Automated Systems

Cat. No. Product

742300 DS2®Automated2-plateSystemwithincubators

742301 DS2®Automated2-plateSystemwithincubatorsandBar codeReader

DS2ismanufacturedbyDynexTechnologies

25

GastroPanel• AgréusL,KuipersEJ,KupcinskasL,MalfertheinerP,DiMarioF,LejaM,MahachaiV,YaronN,vanOijenM,PerezPerezG,Rugge

M,RonkainenJ,SalaspuroM,SipponenP,SuganoK,SungJ.Rationaleindiagnosisandscreeningofatrophicgastritiswithstomachspecificplasmabiomarkers.ScandJGastroenterol2012;47:136-147.

• BenberinV,BektayevaR,KarabayevaR,LebedevA,AkemeyevaK,PaloheimoL,SyrjänenK.PrevalenceofH.pyloriInfectionandAtrophicGastritisAmongSymptomaticandDyspepticAdultsinKazakhstan.AHospitalbasedScreeningStudyUsingaPanelofSerumBiomarkers.AnticancerReresearch2013;33:4595-4602.

• GermanaB,DiMarioF,CavallaroLG,MoussaAM,LecisP,LiatoupolouS,ComparatoG,CarloniC,BertiatoG,BattiestelB,PapaN,AragonaG,CavestroGM,IoriV,MerliR,BertoliniS,CaruanaP,FranzeA.ClinicalusefulnessofserumpepsinogensIandII,gastrin-17andanti-Helicobacterpyloriantibodiesinthemanagementofdyspepticpatientsinprimarycare.DigLiverDis2005;37:501–508.

• SipponenP,HärkönenM.Hypochlorhydricstomach:ariskconditionforcalciummalabsorptionandosteoporosis?ScandJGastroenterol2010;45:133-138.

• StorskrubbT,AroP,RonkainenJ,SipponenP,NyhlinH,TalleyNJ,EngstrandL,StolteM,ViethM,WalkerM,AgreusL.Serumbiomarkersprovideanaccuratemethodfordiagnosisofatrophicgastritisinageneralpopulation:TheKalixandastudy.ScandJGastroenterol2008;43:1448-1455.

• Telaranta-KeerieA,KaraR,PaloheimoL,HärkönenM,SipponenP.PrevalenceofundiagnosedadvancedatrophiccorpusgastritisinFinland:anobservationalstudyamong4256volunteerswithoutspecificcomplaints.ScandJGastroenterol2010;45:1036-104.

• VäänänenH,VauhkonenM,HelskeT,KääriäinenI,RasmussenM,Tunturi-HihnalaH,KoskenpatoJ,SotkaM,TurunenM,SandströmR,RistikankareM,JussilaA,SipponenP.Non-EndoscopicDiagnosisofAtrophicGastritiswithaBloodTest.CorrelationbetweenGastricHistologyandSerumLevelsofGastrin-17andPepsinogenI.AMulticentreStudy.EurJGastroenterolHepatol2003;15:885-891.

Biohit Calprotectin ELISA• TibbleJ,TeahonK,ThjodleifssonB,RosethA,SigthorssonG,BridgerS,FosterR,SherwoodR,FagerholM,BjarnasonI.A

simplemethodforassessingintestinalinflammationinCrohn’sdisease.Gut2000;47:506–513.• TibbleJ,SighthorssonG,FosterR,ForgacsI,BjarnasonI.UseofsurrogatemarkersofinflammationandRomecriteriato

distinguishorganicfromnonorganicintestinaldisease.Gastroenterol2002;123:450–460.• TibbleJ,SigthorssonG,FosterR,SherwoodR,FagerholM,BjarnasonI.Faecalcalprotectinandfaecaloccultbloodtestsinthe

diagnosisofcolorectalcarcinomaandadenoma.Gut2001;49:402–408.• TibbleJA,SigthorssonG,FosterR,ScottD,FagerholMK,RosethA,BjarnasonI.HighprevalenceofNSAIDenteropathyas

demonstratedbyasimplefaecaltest.Gut1999;45:362–366.• TibbleJA,BjarnasonI.Non-invasiveinvestigationofinflammatoryboweldisease.WorldJGastroenterol2001;7:460-465.• TibbleJA,SigthorssonG,BridgerS,FagerholM,BjarnasonI.Surrogatemarkersofintestinalinflammationarepredictiveof

relapseinpatientswithquiescentinflammatoryboweldisease.Gastroenterol2000;119:15-22.• TønH.Improvedassayforfecalcalprotectin.ClinicaChimicaActa2000;292:41-54

Biohit Active B12 (holotranscobalamin) ELISA• NexoE.HvasA-M.BleieØetal.Holo-transcobalaminisanearlymarkerofchangesincobalaminhomeostasis.Arandomized

placebo-controlledstudy.ClinChem2002;48(10):1768-71• ValenteE.ScottJM.UelandPMetal.Diagnosticaccuracyofholotranscobalamin.methylmalonicacid.serumcobalamin.and

otherindicatorsoftissuevitaminB12statusintheelderly.ClinChem2011;57(6):856-863• NexoE.Hoffmann-LuckeE.Holotranscobalamin.amarkerofvitaminB12status:analyticalaspectsandclinicalutility.AmJClin

Nutr2011;94(1):359S-365S• ObeidR.JoumaM.HermannW.Cobalaminstatus(holotranscobalamin.methylmalonicacid)andfolateasdeterminantsof

homocysteineconcentration.ClinChem2002;48(11):2064-5• Lloyd-WrightZ.HvasA-M.MollerJetal.HolotranscobalaminasanindicatorofdietaryvitaminB12deficiency.ClinChem

2003;49(12):2076-8.• RefsumH.SmithAD.LowVitaminB12statusinconfirmedAlzheimer’sdiseaseasrevealedbyserumholotranscobalamin.J

NeurolNeurosurgPsychiatry2003;74:959-61• ChenX.RemachaAF.SardaMPetal.Influenceofcobalamindeficiencycomparedwiththatofcobalaminabsorptiononserum

holo-transcobalaminII.AmJClinNutr2005;81:110-14 Biohit Lactose Intolerance quick test• FranzèJ,ParodiA,SavarinoE,MoranaE,BertelèA,SavarinoV,DiMarioF.Acomparisonbetweenlactosebreathtestandquick

testonduodenalbiopsiesforlactasedeficiency,inpatientswithselfreportedlactoseintolerance.Gut2009;58(SupplII):A261.• GhanghroI,BasuS,VidyarthiM,McTaggertC,HollandersD.TheIncidenceofLactoseDeficiencyinanendoscopicallyand

histologicallynormalgroupofwhiteCaucasians.GastroenterologyToday2009;19(3):76-78.• KuokkanenM,MyllyniemiM,VauhkonenM,HelskeT,KääriäinenI,KaresvuoriS,LinnalaA,HärkönenM,JärveläI,Sipponen

P.Abiopsy-basedquicktestinthediagnosisofduodenalhypolactasiainuppergastrointestinalendoscopy.Endoscopy2006;38(7):708-712.

• OjettiV,LaMuraR,ZoccoMA,CesaroP,DeMasiE,LaMazzaA,CammarotaG,GasbarriniG,GasbarriniA.Quicktest:anewtestforthediagnosisofduodenalhypolactasia.DigDisSci.2008Jun;53(6):1589-92

• OrlandiM,NetzerP,InauenW.IDENTIFYINGLACTOSEINTOLERANCEWITHANOVELBIOPSY-BASEDRAPIDLACTASETEST.Gut2006;Vol55(supplV):A98

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Laboratory1998;44:543-551.• MillerAB.AnEpidemiologicalPerspectiveonCancerScreening.ClinicalBiochemistry1995;28(1):41-48.• RansohoffDFandLangCA.ImprovingtheFecalOccult-BloodTest.TheNewEnglandJournalofMedicine1996;334(3):189-190.• ScreeningforColorectalCancer-UnitedStates1992-1993;andNewGuidelines;MobilityandMortalityWeeklyReport1995;45(5):

107-110• SiegAetal.Detectionofcolorectalneoplasmsbythehighlysensitivehemoglobin-haptoglobincomplexinfeces.International

JournalofColorectalDisease1999;14:267-271.• YamamotoM.;NakamaH.;Cost-e”ectivenessanalysisofimmunochemicaloccultbloodscreeningforcolorectalcanceramong

threefecalsamplingmethods:Hepatogastroenterology;2000Mar-Apr;47(32):396-9.• VasilyevS,SmirnovaE,PopovD,SemenovA,EklundC,HendolinP,PaloheimoL,SyrjänenK.ANew-GenerationFecal

ImmunochemicalTest(FIT)isSuperiortoQuaiac-basedTestinDetectingColorectalNeoplasiaamongColonoscopyReferralPatients.AnticancerRes2015;35:2873-2880.

Biohit Helicobacter pylori quick test• KoumiA,FilippidisT,LeontaraV,MakriL,PanosMZ.DetectionofHelicobacter pylori:Afasterureasetestcansaveresources.

WorldJGastroenterol.2011Jan21;17(3):349-53.• McNichollAG,DuconsJ,BarrioJ,BujandaL,Forné-BarderaM,AparceroR,PonceJ,RiveraR,Dedeu-CusoJM,Garcia-Inglesias

P,MontoroM,BejeranoA,Ber-NietoY,MadrigalB,ZapataE,Loras-AlastrueyC,CastroM,NevarezA,MendezI,Bory-RosF,Miquel-PlanasM,VeraJ,NyssenOP,GispertJP.AccuracyofUltra-RapidUreaseTestforthediagnosisofH. pyloriinfection.Helicobacter2010;15(4):360.

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dyspepticpatients”AlimentaryPharmacology&Therapeutics(2010)31,331–338• VairaD.et.al.“AcomparisonamongstthreerapidureaseteststodiagnoseHelicobacter pylori infectionin375consecutive

dyspeptic”InternEmergMed(2010)5:41–47• ZulloA.et.al.“RapidureasetestforH. pyloridiagnosis:prosandcons”(2010)InternEmergMed

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Chemistry(1998)273(4):2288-2295.• SárdyM.etal.“RecombinanthumantissuetransglutaminaseELISAforthediagnosisofgluten-sensitiveenteropathy”.Clinical

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TherapeuticPatents(2002)12(1):45-51.• HanssonT.etal.“Recombinanthumantissuetransglutaminasefordiagnosisandfollow-upofchildhoodcoeliacdisease”.

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Disease”.ClinicalGastroenterologyandHepatology(2004)2:480–484.• 7.JenningsJ.etal.“Newdevelopmentsinceliacdisease”.CurrentOpinioninGastroenterology(2003)19(2):118-129.• 8.GeorgeDA,etal.“Theroleofnear-patientcoeliacserologytestinginthefollow-upofpatientswithcoeliacdisease”.Frontline

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theAchlorhydricStomachWithCysteine.AlcoholClinExpRes2010;35(3):516-522.• LinderborgK,SalaspuroM,VäkeväinenS.Asinglesipofastrongalcoholicbeveragecausesexposuretocarcinogenic

concentrationsofacetaldehydeintheoralcavity.FoodChemToxicol.2011Sep;49(9):2103-6.• SalaspuroM.Interactionsofalcoholandtobaccoingastrointestinalcancer.JGastroenterolHepatol2012;27(Suppl2):135-139.• SalaspuroM.Acetaldehydeasacommondenominatorandcumulativecarcinogenindigestivetractcancers.ScandJ

Gastroenterol2009.• SalaspuroV,SalaspuroM.Synergisticeffectofalcoholdrinkingandsmokingoninvivoacetaldehydeconcentrationinsaliva.IntJ

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References 27

2 GastroPanel

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