produced from adrenal glnad content: epinephrine (adrenaline) nor epinephrine(nor adrenaline)...
TRANSCRIPT
Catcholaminnes hormone
Produced from adrenal glnad content:
Epinephrine (adrenaline)Nor epinephrine(nor adrenaline)Dopamine
Biosynthesis of Catecholamines
Inactivation of Norepinephrine
Function of hormone
Catcholamines : help the body respond to stress or fright and fight-or-fight ,increase heart rate, blood pressure breathing muscle strength
:Adrenaline and noradrenalin: secretion when stress, emotion pain fight-fight Dopamine : affect of feeling and behaviors
Metabolism of dopamine
Major acidic metabolites:
.A3,4-dihydroxy phenylacetic acid
(DOPAC)
.BHomovallic acid (HVA)
Localization of catecholamine neurons
Immunocytochemistry (ICH): antibody against synthesis enzyme, uptake transporter and receptor
In situ hybridization (ISH): cDNA or cRNA probe synthesis enzyme, transporter and receptor
Receptor autoradiography: radiolabelled ligand ([3H] or [125I]) against receptor
Inactivation of Norepinephrine
Autoreceptor: inhibit transmitter release
:Target tissue The target tissue is brain
:Disease Parkinson disease:
Deficiency f dopamine Schizopheremia:Increase of dopamine Mental depression:
Deficiency of norepinephrine
Parkinson’s Symptoms
Metabolic causes: -Hypothyroidism
-Hypoparathyroidism-Alcohol withdrawl (pseudoparkinsonism)
-Chronic liver failure-Wilson’s disease
Symptoms of Schizophrenia
Profound disruption in cognition and emotion, affecting the most fundamental
human attributes :-Language
-Thought-Perception
-Affect-Sense of self
Physical depression symptoms which you may suffer from :include
-Over-eating -Over-drinking
-Lack of interest in sex -Poor concentration
-Violent or aggressive behavior in men -Not interested in your appearance or
hygiene -Mood swings
-Anger
serotonin
serotonin hormone
gland: produced from pineal gland
Hormone: serotonin
N
C
N
C NH2
COOH COOH
NH2
OH
N
C NH2
OH H
Tryptophan 5-Hydroxytryptophan
5-Hydroxytryptamine
N
C COOH
5-OH Indole Acetaldehyde
5-Hydroxy Indole Acetic Acid
Tryptophan hydroxylase
5-OH Tryptophan decarboxylase
MAO
Aldehyde
dehydrogenase
(Rate limiting)
In diet. ActiveCNS transport
serotonin
function of hormone:
neurotransmitter in:
modulation of anger , aggression , bodytemperature, sleep human sexualitystimulating vomiting
target tissue:
CNS (central nervous system)
disease:
a-mental depression: deficieny of serotonin
b-malignant carcinoid: increase of serotonin
malignant carcinoid symptoms include the following
1-Myopathy2-Arthritis
3-Arthralgias4-Irritability, aggression, and lack of impulse
control; these have been linked with low levels of plasma tryptophan and presumably with low brain serotonin.15