Produced by Huh Jae-won

구조 : 특이점은 가상의 코팅지역을 만들었다 .

분포와 삽입된 구조

LTR 을 기존의 Repbase 에 있는것보다 더 보강해서 컨센선스 서열을 만들었다 .

진화적 분석과 삽입시기

Retroelement(HERV-M) contribute to the diversification of

PPHLN1 gene during the Primate evolution

Expression Profiling of HERV-M related alternative transcript

Brain Prostate Testis Kidney Heart Liver Lung Placenta Ske-M Spleen Thymus

Uterus

Human Chimp Go Or Gi Rhesus

Hu AT Hu Bo Rhe AT Rhe Bo Cord B Rhe Hi 1 2

Million years

Human

Chimpanzee

Gorilla

Orangutan

Gibbon

Old World monkeys

New World monkeys

Prosimians

60 50 40 30 20 10

Evolution of PPHLN1 related HERV-M

Divergence : 10%(±1.5%)

HERVM

gag pol

5’ LTR

PBS

3’ LTR

LTR

INRnaseHRT

LTR

1 458 620 1338 1461 2215 2644 3050 3818 4038 1 458

1 77 3402 3626

3928 3967 4038 1 458

Splicing of HERV-M

Aligment of PPHLN1 Transcripts

1 2 3 4 5 6 7 8 9 10 11 12 13 14

HERV-MLTR5BMER58A

Alusq/x

L1ME4a

1 2 3 4 5 6 7 8 9 10

AluJo

Transcript variant 1

Human

Transcript variant 2

Transcript variant 3

Transcript variant 4

Transcript variant 5

Transcript variant 1

Mouse

Transcript variant 2

VS

Orthologous region

The Structure of PPHLN1 Gene

Evolution of PPHLN1 transcripts

Common

ancestor

Type 1 transcript

Type 2 transcript

Mu1(Duplication)

Hu1Hu2Hu3Hu4

(Retroelements : Alu, Line, HERV)

Mu2

Hu5

PPHLN1 gene

Driving Forces