prior to the start of the program, check your syllabus to ensure you have the participant survey and...
TRANSCRIPT
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Prior to the start of the program, check your syllabus to ensure you have the participant survey and CME evaluation:
• In the front of your syllabus• Remove from your packet• Fill out the demographic information at the top• Throughout the program, please take a moment to answer
the corresponding Activity Survey questions on this form (slides will be marked as “Polling Questions” throughout the deck)
Please Help Us with the Following
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melano ma me lano ma
metasta tic metasta tic New and Emerging Therapies for
A CME-certified Oncology Exchange Activity
Jointly provided by Potomac Center for Medical Education and Rockpointe Oncology
This activity is supported by educational grants from Genentech and Novartis Pharmaceuticals Corporation
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Please note, all pertinent CME information, statements, and disclosures can be found in your program syllabus, including:
• Faculty/Steering Committee and Non-faculty Planner/Reviewer Disclosures
• Educational Objectives• Accreditation and Credit Designation Statements• Faculty/Steering Committee Bios
CME Information
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Polling Question 1Pre-activity Survey
How confident are you in your ability to adopt new and emerging therapies for the management of metastatic melanoma?
A. Not at all confident
B. Slightly confident
C. Confident
D. Very confident
E. Expert
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Educational Objectives
• Evaluate the efficacy and safety of approved and emerging therapies for metastatic melanoma
• Explain the value of a multidisciplinary approach for the treatment of melanoma to improve patient outcomes
• Recognize the importance of patients actively participating in their treatment decisions and health management
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Checkpoint Blockade for Melanoma
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Case 1: BRAF Wild-type Melanoma
• A 42-year-old woman is found to have melanoma metastatic to lung and subcutaneous sites
• Her melanoma does not have a BRAF mutation• She has a KPS of 80%• She is overweight and has type II diabetes controlled with
metformin• No other significant medical history
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Polling Question 2Case Study 1
Which of the following FDA-approved therapies is associated with the highest response rate for a patient like this?
A. Dacarbazine
B. Vemurafenib
C. High-dose interleukin-2 therapy
D. Either nivolumab or pembrolizumab
E. Ipilimumab
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Polling Question 3Case Study 1
The patient is treated with a PD-1 inhibitor and develops diarrhea up to 8 times per day. She otherwise feels well except for a mild rash and fatigue. The best recommendation for this patient is:
A. Imodium and close monitoring
B. Intensive oral hydration until diarrhea resolves
C. Urgent colonoscopy as an outpatient
D. High-dose steroids and close monitoring
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Blocking CTLA-4 and PD-1
T cellTumor cell
MHCTCR
PD-L1PD-1- - -
T cell
Dendriticcell
MHCTCR
CD28
B7 CTLA-4- - -
Activation(cytokines, lysis, proliferation,
migration to tumor)
B7+++
+++
CTLA-4 Blockade PD-1 Blockade
anti-CTLA-4 anti-PD-1
Tumor Microenvironment
+++
PD-L2PD-1
anti-PD-1
- - -
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FDA-approved Checkpoint Blocking Antibodies
Antibody Trade name Target
Ipilimumab Yervoy CTLA4
Pembrolizumab Keytruda PD1
Nivolumab Opdivo PD1
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Ipilimumab vs gp100 Vaccine vs Both: OS and ORR
Adapted from Hodi FS et al. N Engl J Med. 2010;363:711.
Ipi alone
Ipi + vaccine
Vaccine alone
11% 5.7% 1.5%
Response rates
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Dacarbazine ± Ipilimumab: OS and ORR
Adapted from Robert C et al. N Engl J Med. 2011;364:2517.
Response rates Ipi + DTIC DTIC alone
15.2% 10.3%
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Ipilimumab: Pooled OS Data from Multiple Trials
Schadendorf D et al. J Clin Oncol. 2015;33:1889-1894.
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Key Take Away
• Ipilimumab improves overall survival compared to chemotherapy alone
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12/06 5/07
4 blinded doses ipilimumab
4 10 mg/kg doses ipilimumab
No drug
Delayed Response with Ipilimumab TreatmentPre-treatment 10/06 (Week 12)
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Ipilimumab Toxicities
Toxicity Signs/symptoms TreatmentColitis Watery diarrhea, bowel wall
edema on CTSystemic steroids
Rash/itching Rash/itching Usually antihistamines or topical steroids
Hypophysitis Headache, fatigue, enlarged pituitary on brain MRI
Systemic steroids. Usually will need chronic cortisol and thyroid hormone replacement
Hepatitis Usually asymptomatic; Elevated transaminases
Systemic steroids
Thyroiditis Fatigue Systemic steroids
Uveitis Decreased visual acuity Ophthalmology consult
Adrenalitis Fatigue Systemic steroids
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Key Take Away
• Immunotherapy requires close follow-up for immune-related adverse events
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FDA-approved Anti-PD1 Antibodies
Antibody Trade name TargetPembrolizumab Keytruda PD1
Nivolumab Opdivo PD1
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Antitumor Activity of Pembrolizumab
Hamid O et al. N Engl J Med. 2013;369:134.
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Best Overall Response to Nivolumab
Robert C et al. N Engl J Med. 2015;372:320.
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Nivolumab vs Dacarbazine: OS and PFS
Robert C et al. N Engl J Med. 2015;372:320.
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Pembrolizumab vs Ipilimumab OS and PFS
Robert C et al. N Engl J Med 2015;372:2521
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Ipilimumab vs Ipilimumab + NivolumabChange in Tumor Burden, Durability of Tumor Regressions, and Progression-free Survival
Postow MA et al. N Engl J Med. 2015;372:2006.
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Ipilimumab vs Nivolumab vs Both: PFS
Larkin J et al. N Engl J Med. 2015;373:23.
Ipi alone Ipi + Nivo Nivo alone
2.9 mos 11.5 mos 6.9 mos
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Anti-PD1 Antibody ToxicitiesSame as Ipi Except Less Common, Plus Pneumonitis
Toxicity Signs/symptoms TreatmentPneumonitis Dyspnea, cough, infiltrates Systemic steroidsColitis Watery diarrhea, bowel wall
edema on CTSystemic steroids
Rash/itching Rash/itching Usually antihistamines or topical steroids
Hypophysitis Headache, fatigue, enlarged pituitary on brain MRI
Systemic steroids. Usually will need chronic cortisol and thyroid hormone replacement
Hepatitis Usually asymptomatic. Elevated transaminases
Systemic steroids
Thyroiditis Fatigue Systemic steroidsUveitis Decreased acuity Ophthalmology consultAdrenalitis Fatigue Systemic steroids
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Key Take Away
• Anti-PD1 antibodies (pembrolizumab and nivolumab) have higher response rates and lower incidences of immune-related adverse events compared to ipilimumab
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Response of a Large Chest-wall Melanoma Metastasis to One Dose of Ipilimumab Plus Nivolumab
Chapman PB et al. N Engl J Med. 2015;372:2073.
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Larkin J et al. N Engl J Med 2015;373:23-34
Ipilimumab vs Nivolumab vs Both: Adverse Events
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FDA-approved Checkpoint Blocking Antibodies: SUMMARY
Ipilimumab Nivolumab Pembrolizumab Ipi + Nivo combination
ORR (approx.) 11-19% 40-44% 34% 58-61%
OS 11.4 mo ND ND ND
Toxicity 3+ 1+ 1+ 4+
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Key Take Away
• Combination ipilimumab + nivolumab have a higher response rate than either drug alone, but much higher incidence of adverse events
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Targeted Therapy for Melanoma
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Case 2: BRAF-Mutated Melanoma
• A 42-year-old woman is found to have melanoma metastatic to lung and subcutaneous sites
• Her melanoma is found to have a BRAF V600E mutation • She has a KPS of 80%• She is overweight and has type II diabetes controlled with
metformin• No other significant medical history
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Polling Question 4Case Study 2
Which of the following FDA-approved therapies is associated with the highest response rate for this patient?
A. Dacarbazine
B. Either vemurafenib or dabrafenib
C. Dabrafenib plus trametinib
D. Either nivolumab or pembrolizumab
E. Ipilimumab
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Polling Question 5Case Study 2
Which of the following FDA-approved therapies has been shown to improve overall survival for a patient with metastatic melanoma harboring BRAF V600E mutation:
A. Dabrafenib plus trametinib, nivolumab, IL-2
B. Vemurafenib, dabrafenib plus trametinib, nivolumab
C. Dacarbazine, vemurafenib, pembrolizumab
D. IL-2, vemurafenib, dabrafenib
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Blocking BRAF and MEK
Modified from Ribas et al. Nat Rev Clin Oncol. 2011;8:426.
BRAF Inhibitors
VemurafenibDabrafenibEncorafenib
MEK Inhibitors
TrametinibCobimetinibBinimetinib
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FDA-approved Molecularly Targeted Therapies
Drug Trade name TargetVemurafenib Zelboraf BRAFDabrafenib Tafinlar BRAFTrametinib Mekinist MEK
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Treating BRAFV600E Mutant Melanoma with a BRAF Inhibitor Leads to Rapid Response
McArthur et al. J Clin Oncol. 2012;30:1628.
Day 15
Baseline
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Vemurafenib vs Dacarbazine (DTIC):OS, PFS, and ORR
Chapman et al. N Engl J Med. 2011;364:2507.
Vemu DTIC
ORR 56.9% 8.6%mPFS 6.9 months 1.6 monthsmOS 13.6 months 9.7 months
*V600E mutation
only
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48% confirmed response rate (2 complete responses)
5% confirmed response rate (0 complete responses)
Antitumor Activity of Vemurafenib vs DTIC
Chapman et al. N Engl J Med. 2011;364:2507.
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Activity of RAF inhibitor in BRAF-mutated melanoma with brain metastases
Baseline Week 32
Courtesy of Chapman P and Memorial Sloan Kettering Cancer Center.
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• Median time 8 weeks (range 2–36)• Each dot represents weeks to development of first lesion
BRAF Inhibitor Toxicity: Cutaneous Squamous Carcinomas, Keratoacanthoma Type
Ribas et al. Proc ASCO. 2011; abstract 8509.
0 5 10 15 20 25 3530 40
Time on vemurafenib (weeks)
Median
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SCC/KAs 9% in monotherapy arm vs 2% in combination arm
Response rate 51% in monotherapy arm vs 67% in combination arm, P=0.002
Dabrafenib ± Trametinib: PFS and ORR
Long et al. N Engl J Med. 2014;371:1877.
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Dabrafenib ± Trametinib: PFS – Elevated LDH Patients
Long et al. N Engl J Med. 2014;371:1877.
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Vemurafenib ± Cobimetinib: PFS
Larkin et al. N Engl J Med. 2014;371:1867.
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Dabrafenib ± Trametinib : OS
Long et al. N Engl J Med. 2014;371:1877.
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Dabrafenib ± Trametinib: OS – Elevated LDH Patients
Long et al. N Engl J Med. 2014;371:1877.
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HR 0.69 (95% CI 0.53-0.89) P=0.005
Dabrafenib + Trametinib vs Vemurafenib: OS
Robert et al. N Engl J Med. 2015;372:30.
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Vemurafenib ± Cobimetinib : OS
Larkin et al. N Engl J Med. 2014;371:1867.
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FDA-approved Molecularly Targeted Therapies: SUMMARY
Vemurafenib Dabrafenib TrametinibDabrafenib + Trametinib
combination
ORR (approx.) 51% 53% 22% 69%
OS 17 mos median65% 1 year
19 mos median68% 1 year42% 2 years
Not reported25 mos median
74% 1 year51% 2 year
Toxicity 2+ 2+ 2+ 1+
Based on recent phase III trial data
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Key Take Away
• Dabrafenib + trametinib has a higher response rate and better overall survival than dabrafenib alone. The combination regimen also has a higher incidence of fever and fatigue.
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Questions?
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Participant Survey and CME Evaluation
• CME Evaluation
– If you’re seeking credit, ensure you’ve filled in your name and demographic information on page 1 and complete the CME Evaluation part of your form (after the In-Activity Survey)
– Your answers are important and will help us identify remaining educational gaps and shape future CME activities
– Return all forms to on-site CME staff
Thank you for joining us today!