Nama: Winna Marantika Saputri Nim: 26141345C Progdi: D III Anafarma Fakultas: Farmasi Kelompok: 3

Alkaloids Isolated from Natural Herbs as the Anticancer AgentsJin-Jian Lu,Jiao-Lin Bao,Xiu-Ping Chen,Min Huang,andYi-Tao WangState Key Laboratory of Quality Research in Chinese Medicine (University of Macau) and Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomas Pereira, Taipa 999078, Macao, ChinaReceived 11 May 2012; Revised 17 July 2012; Accepted 30 July 2012Academic Editor: Alvin J.Beitz

AbstractAlkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers bothin vitroandin vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs. This paper focuses on the naturally derived alkaloids with prospective anticancer properties, such as berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the mechanisms of action of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made.

Nama: Winna Marantika SaputriNim: 26141345C Progdi: D III Anafarma Fakultas: Farmasi Kelompok: 3

Alkaloid Terisolasi dari Herbal Alami sebagai Agen Anti KankerJin- Jian Lu, Jiao - Lin Bao, Xiu - Ping Chen, Huang Min, dan Yi - Tao WangNegara Laboratorium Kualitas Penelitian Kunci Pengobatan di Cina (University of Macau) dan Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Toma Pereira, Taipa 999.078, Makau, Cina

Diterima 11 Mei 2012 ; Revisi 17 Juli 2012 ; Diterima 30 Juli 2012

AbstrakAlkaloid adalah senyawa kimia penting yang berfungsi sebagai reservoir kaya untuk penemuan obat. Beberapa alkaloid diisolasi dari tumbuh-tumbuhan alami antiproliferasi pameran dan antimetastasis efek pada berbagai jenis kanker secara in vitro dan in vivo. Alkaloid, seperti camptothecin dan vinblastine, telah berhasil dikembangkan menjadi obat antikanker. Makalah ini berfokus pada alkaloid alami berasal dengan sifat antikanker calon, seperti berberin, Evodiamine, matrine, piperine, sanguinarine, dan tetrandrine, dan merangkum mekanisme kerja senyawa ini . Berdasarkan informasi dalam literatur yang diringkas dalam makalah ini, penggunaan alkaloid sebagai agen antikanker yang sangat menjanjikan, namun penelitian lebih lanjut dan uji klinis yang diperlukan sebelum rekomendasi akhir pada alkaloid tertentu dapat dibuat .