principles of immunology transplantation immunology 4/25/06
Post on 20-Dec-2015
232 views
TRANSCRIPT
Principles of Immunology
Transplantation Immunology4/25/06
Word/Terms List
Allograft Autograft GVH HLA Isograft MHC Xenograft
Transplantation Immunology
Types of transplants
Autograft Isograft Allograft Xenograft
Graft Rejection
First set
Second set
Analogous to primary and secondary antibody response
Causes of Rejection
MHC – HLA antigens in humans
Haplotypes
DTH reaction
Cell-mediated immunity
Stages of Rejection
Sensitization-
APCs from donor APCs from host
“Passenger leukocytes”
CD8 and CD4 both react
Stages of Rejection Effector stage
C mediated Ab response
ADCC
CTLs
DTH
Compatibility Tests
ABO Microcytotoxicity
Pre existing Ab C mediated
Mixed lymphocyte reaction Measures T helper activation Uses radioactive thymidine as
determinant
Clinical Types of Rejection Hyperacute
<24 hours Preexisting Ab ABO mismatch
Acute Weeks Macrophages Cytokines
Chronic Months or longer Humoral and cell-mediated
General Immunosupression
Mitotic Inhibitors Affects all rapidly dividing cells
Steroids Anti inflammatory
Cytokine inhibitors Inhibits T cell proliferation
Specific Immunosupression
Monoclonal Ab Anti CD3
Blocking co stimulation CTLA injection
Immune Tolerance
Non immunogenic tissue
Privileged sites
Induced tolerance