principia posthuman

Melanie Swan MS Futures Group

+1-650-681-9482@LaBlogga, @DIYgenomics

[email protected]

March 31, 2012, Sunnyvale CA

Slides: http://slideshare.net/LaBlogga

Image credit: Natasha Vita-More, Primo Posthuman

Elements of a Principia Posthuman

Human Body 2.0 Redesign, Democracy, and Next-generation Intelligence

March 31, 2012Principia Posthuman 2

About Melanie Swan

Founder DIYgenomics, futurist and applied genomics expert

Current projects: MelanieSwan.com Education: MBA Finance, Wharton; BA

French/Economics, Georgetown Univ Work experience: Fidelity, JP Morgan, iPass,

RHK/Ovum, Arthur Andersen Sample publications:

Source: http://melanieswan.com/publications.htm

Swan, M. Crowdsourced Health Research Studies: An Important Emerging Complement to Clinical Trials in the Public Health Research Ecosystem. J Med Internet Res 2012, Mar;14(2):e46.

Swan, M. Scaling crowdsourced health studies: the emergence of a new form of contract research organization. Personalized Medicine 2012, Mar;9(2):223-234.

Swan, M. Steady advance of stem cell therapies. Rejuvenation Res 2011, Dec;14(6):699-704. Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for

crowdsourced preventive medicine research. J Participat Med 2010, Dec 23; 2:e20. Swan, M. Multigenic Condition Risk Assessment in Direct-to-Consumer Genomic Services. Genet Med

2010, May;12(5):279-88. Swan, M. Emerging patient-driven health care models: an examination of health social networks,

consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009, 2, 492-525.


CONTACT presentations

Data Visualization in Second Life (2008)

Future of Life Sciences: the Great Convergence of Life and Technology (2009)

Revolutionizing Biology with Personal Genomes (2010)

Principia Posthuman (2012)

Slides: http://slideshare.net/LaBloggaImage credit: Natasha Vita-More, Primo Posthuman

March 31, 2012Principia Posthuman

The future is notoriously hard to predict

4

Positional nanoassembly

Young lady’s illustrated primer


Simple models for thinking about the future

Past Present Future

Image: http://www.sydmead.com


The role of time in thinking:GPS for the Mind exercise

Plot time orientation: certainty, possibility, probability www.mindtimemaps.com/start/contact

Image: http://www.mindtime.com

Source: Fortunato, VJ and Furey, JT. The theory of MindTime: The relationships between Future, Past, and Present thinking and psychological well-being and distress. Personality and Individual Differences. January 2011, 50(1), pp. 20-4. http://www.miindtime.com

certainty possibility

probability


GPS for the Mind exercise

CONTACT GPS for the Mind exercise (4 minutes)

1. Sign up for a free account at www.mindtimemaps.com (use an anonymous name if you prefer)

2. Complete the GPS for the Mind exercise at the community site: www.mindtimemaps.com/start/contact

3. Results: return to the community site www.mindtimemaps.com/start/contact and click on the Groups icon, then CONTACT to see the results

Source: http://www.mindtimemaps.com

Image: Salvador Dali

http://www.mindtimemaps.com/

http://www.mindtimemaps.com/start/fqxi

http://www.mindtimemaps.com/start/contact


Agenda

Context for Principia Posthuman Elements of a Principia Posthuman

Quantitative: science, human body 2.0 redesign Qualitative: social constructs, democracy Concepts: philosophy, next-generation

intelligence

Conclusion



PhilosophyConcerned with: Understanding

Art, aesthetics, economics, politics, societal design

Concerned with: Experience

Concepts

Qualitative

Quantitative Science and technologyConcerned with: Characterization

Next-generation intelligence

Democracy

Human Body 2.0 Redesign

Image: http://integral-options.blogspot.com

Aspen rhizome


Agenda



intelligence

Conclusion


Miniaturization trend, next node: microdots

Computing machinery

Room(s) size Handheld Invisible Non matter-based?

2050s2000s10-100 years ago 2100+

Information storage

DNA sequencing


Information transmission eras

Painting, scrolls Press, Transistor DNA

Analog Digital Life code ?

?

2000-21001455 & 1950-200017,300 years ago 2100+

(Kuhnian paradigms, Foucauldian epistemes)


Prominent artificial intelligence eras

Expert syst, CYC NLP, HTM, NCC Google, Watson

Enumeration Biomimicry Big data ?

?

2000s+1990s+1950s 2100+


Big data: personal health informatics

14Academic papers re: integrated health data streams: Auffray C, et al. Looking back at genomic medicine in 2011. Genome Med. 2012 Jan 30;4(1):9.

Chen R et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307.

DNA: SNP mutations

Microbiomics

Proteomics

RNA expression profiling

Epigenetics

Health 2.0:Personal health

informaticsDNA: Structural

variation

Metabolomics


DNA sequencing: 10x/yr improvement

15

Biology is an information technology

Image credit: http://pubs.acs.org/cen/_img/87/i50/8750cover2_law.gif

I hate you01001001001000000110100001100001011101000110010100100000011110010110111101110101

I love you 01001001001000000110110001101111011101100110010100100000011110010110111101110101


Biology is the information technology

Image credit: J. Craig Venter Institute

Image credit: Anthony Atala lab

Image credit: Thomas Matthiesen

Artificial cell booted to life

Algal biofuelImage credit: http://www.rexresearch.com

Whole organ decellularization and recellularization (heart)

Organ regeneration (urethra)

DNA nanotechnology latch box for drug delivery

Image credit: Aarhus University


Agenda



intelligence

Conclusion


Agency: collective intelligence computing

18

Crowdsourcing

Quantified self-tracking

DIYbio labs

Consumer blood tests

Citizen science

Concierge research

Consumer genomics

Health 2.0:Crowdsourced

health computing

Ambient mental performance optimization

Continuous sampling


Mobile is the platform

Explosive growth US: more cell phones (328 m) than people (315 m)1

One billion+ worldwide smartphone users by 20132

App downloads: 5 bn in 2010 versus 300 mn in 20094

Health-related apps: 7,0004

81% physicians using smartphones 20123

Studies: thousands recruited in months2

Intimate continuous interaction platform Phone loss noticed within 5 minutes vs. 1 hour for wallet loss Kids chat with Siri as virtual friend

19

1Kang C. Number of cell phones exceeds US population. Washington Post. October 11, 2011.2Dufau S. Smart phone, smart science: how the use of smartphones can revolutionize research in cognitive science. PLoS One. 2011.3Kiser K. 25 ways to use your smartphone. Physicians share their favorite uses and apps. Minn Med. 2011. 4Boulos MN. How smartphones are changing the face of mobile and participatory healthcare. Biomed Eng Online. 2011.

Image credit: http://www.psfk.com

Image credit: tehgaygeek.blogspot.com


Participatory health activity landscape

20

(Light) Level of Engagement (Intense)

Social media

Mobile health apps

PHRs (personal

health records)

Consumer genomics

Image credit: Getty Images

DIYbio (do-it-yourself

biology)


Citizen science


DIYbio (do-it-yourself

biology)

Concepts in participatory health

21


Citizen science

http://ezramagazine.cornell.edu

http://www.iab.keio.ac.jp

http://thecoolgadgets.com


Citizen science definition

Institutional science research

Citizen science health and biology

Citizen science: 200+ organizations1

1http://scienceforcitizens.net/finder

Performing scientific investigation without professional training in the field Image credit: http://www.southernfriedscience.com


Citizen science health – why now?

Tools Plummeting cost of genome sequencing Availability of consumer blood tests Online bioinformatics tools

Education and support Local DIYbio labs, online forums

23

Image credits: http://www.biocurious.orgImage credit: http://diybionyc.blogspot.com


Goal: personalized knowledge through quantified self-tracking

Format: monthly ‘show n tell’ meetups Outcome: optimality and improvement

Example: personalized interventions for depression, low energy, sleep quality

24

Image credit: http://www.nationalpost.com Image credit: Quantified Self

Source: Swan, M. Overview of Crowdsourced Health Research Studies. 2012. Forthcoming.


Quantified self study examples

Low-cost home-administered blood, urine, saliva tests

OrSense continuous non-invasive glucose monitoring

Cholestech LDX home cholesterol test

ZRT Labs dried blood spot tests

Food consumption (1 yr)1 and the Butter Mind study2

Study

1Source: http://flowingdata.com/2011/06/29/a-year-of-food-consumption-visualized2Source: http://quantifiedself.com/2011/01/results-of-the-buttermind-experiment


Health social networks and collaboration

Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.

Health collaboration communities

Health social networks

(global & local)


Agenda



intelligence

Conclusion


Professionalizing participative health: Philosophical validation

Towards an epistemology of citizen science Provide a structure and context for participant-derived health

knowledge

Q1: Are new kinds of knowledge are being formed through group collaborations such as wikipedia and health social networks?

Q2: How to characterize the knowledge generated by traditional medicine, self-experimentation, and health collaboration communities?

Image credit: http://inkingrey.com


Ontological shift

Old thinking:

My health is the responsibility of my physician

New thinking:

My health is my responsibility

… and I have the tools to make managing it easy

Image credit: http://efx3.com


Genome politics and regulation

Our world is not Gattaca Personal genomics has

destigmatized health issues

Issues: human cloning, sex selection, genetic privacy, non-discrimination UN Convention on Human Rights and

Biomedicine 1997 (Ch IV Human Genome) U.S. Genetic Information Nondiscrimination

Act (GINA) 2008

Biocitizenry, health as a human right

Image credit: http://www.sonypictures.com

Image credit: http://sciencephoto.com

30


Role of participative health: future medicine

Individual

2. Peer collaboration and health advisors

Health social networks, crowdsourced studies, health advisors, wellness coaches, preventive care plans,

boutique physicians, genetics coaches, aestheticians, medical tourism

3. Public health systemDeep expertise of traditional health system

for disease and trauma treatment

1. Continuous health information climate Automated digital health monitoring, self-tracking devices, and mobile apps providing personalized recommendations

Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.


Health self-management

Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525, Figure 1.

A new model of health and health care


Biotechnicity and computational philosophy

33

Computational tools of health-related philosophical discovery •Hardware and software devices and algorithms: quantitative health data streams, health-related smartphone applications, personal electronic health records, quantified self-tracking devices •Crowdsourced human computing networks: crowdsourced disease prediction, health social networks, quantified self n=1 health self-experimentation, crowdsourced health research studies, DIYbio labs

Epistemic advance: new knowledge generation•Content: New data streams, larger data sets, more granular data, higher order magnitude science•Process: New algorithms and new models

Metaphysical shift: new ways of being •Meaning of health and health outcomes•Sense of self and group identity, biocitizenry

Source: Swan, M. Biotechnicity 2.0: Computation-enabled Philosophical Advance in the Epistemology of Human Biology and the Ontology of Bioidentity. 2012. Submitted.

Image credit: http://stemcellresources.org

Concepts

Qualitative

Quantitative


Agenda



intelligence

Conclusion


GPS for the Mind exercise

CONTACT GPS for the Mind exercise (4 minutes)

1. Sign up for a free account at www.mindtimemaps.com (use an anonymous name if you prefer)

2. Complete the GPS for the Mind exercise at the community site: www.mindtimemaps.com/start/contact

3. Results: return to the community site www.mindtimemaps.com/start/contact and click on the Groups icon, then CONTACT to see the results



http://www.mindtimemaps.com/

http://www.mindtimemaps.com/start/fqxi

http://www.mindtimemaps.com/start/contact


GPS for the Mind results



Past, present, future Self, group, country



PhilosophyConcerned with: Understanding

Art, aesthetics, economics, politics, societal design

Concerned with: Experience

Concepts

Qualitative

Quantitative Science and technologyConcerned with: Characterization

Next-generation intelligence

Democracy

Human Body 2.0 Redesign

Image: http://integral-options.blogspot.com

Aspen rhizome

Slides: http://slideshare.net/LaBlogga

Creative Commons 3.0 license

Image: Natasha Vita-More, Primo Posthuman

Image: AmericanThinker.com

Melanie Swan MS Futures Group

+1-650-681-9482@LaBlogga, @DIYgenomics

[email protected]

Principia Posthuman

Thank you!Questions?


DIYgenomics participant-organized studies 7 studies in open enrollment (vitamin deficiency, aging, and

mental performance); 5 in design (oncology, calcinosis)

Source: Swan, M., Crowdsourced health research studies. J Med Internet Res 2012, Mar;14(2):e46