presentation on pharmaceutical syrup
DESCRIPTION
It is a liquid dosage form existing in single phase which is made of concentrated aqueous preparations of 85% sugar or sugar substitute with or without flavoring agents and medicinal substances in a homogenous mixture.TRANSCRIPT
MOST CONVENIENT DOSAGE FORM
PHARMACEUTICALSYRUP
12203058 Mst. Annita Amin12203061 Ferdous Alam (Papry)12203082 Md.Ahsanul Haque Chowdhury12203089 Sadia Rahman12203103 Md. Mahade Hashan
GROUP MEMBERS
It is a liquid dosage form existing in single phase which is made of concentrated aqueous preparations of 85% sugar or sugar substitute with or without flavoring agents and medicinal substances in a homogenous mixture.
WHAT IS SYRUP
Aromatic Or Medicinal syrups Adjuvant syrup
Extractive drugs Chemical
TYPES OF SYRUP
Syrups contain the following components: Sweetening Agent Antimicrobial Preservatives Viscosity Modifier Flavoring Agent Colorants
OTHERS Solvents Solubilizing Agents, Thickeners or Stabilizers.
COMPONENTS OF SYRUP
Pharmaceutical syrups are produced by mixing purified water, sweeteners, active ingredients (API), aromas, flavors and other ingredients (thickeners) etc.
PREPARATION OF SYRUP
There are four methods. Based on the physical and chemical properties of the ingredients;the method is selected-
Solution with heat Agitation without heat Addition of sucrose to liquid medicament Percolation method
METHODS OF PREPARATION
Formulation
The manufacturing process must achieve the following factors: Dissolving of the sugars to form a syrup Hydration of powdered ingredients Blending ingredients of widely different
viscosity Suspension or dissolving of active ingredients The end product must be smooth, agglomerate-
free and homogeneous.
FACTORS TO BE TAKEN INTO CONSIDERATION
Using conventional mixers and agitators for this process leads to several potential problems:
Conventional agitators cannot dissolve high concentrations of sugars at ambient temperature.Heating of the mixture will be required to aid solution. This is energy inefficient.The cooling process after this further adds to costs and process time.Crystallization of the syrup can occur during heating/cooling.Active ingredients can be damaged by heat.
problems
solution
These problems can be overcome by using a Silverson High Shear mixer. It has a few advantages. They are:
A Silverson high shear mixer can produce 66% sucrose syrup at ambient temperature.
Consistent product quality and repeatability is obtained.
An agglomerate free mixture is produced
Appropriate for any patient, whatever the age is The most natural and easiest route of
administration Economical and safe to the patient No nursing is required, which means the patient
can take it with no help The liquid dosage form is expected for certain
types of products like cough medicines
ADVANTAGES OF SYRUP
Delayed onset of action because absorption takes time
Not suitable in emergency and for unconscious patients
Not convenient for a patient with a gastrointestinal disorder such as diarrhea, constipation, ulceration, and hyperacidity in stomach
Can’t avoid first pass metabolism
DISADVANTAGES OF SYRUP
Syrup, as a pharmaceutical product requires safe, secure and tamper-proof handling while packaging. Packaging of syrups needs to ensure complete protection from contamination and microbial growth. Our inevitable packaging support assures the safe and secure packaging of syrups so as to ensure their extended shelf life.
The general processes are:
Filling
Sealing
Capping
Coding & labeling
Wrapping
Packaging of Syrup
Flow chart for Oral liquid packaging
Bottle washing Filling Cap sealing Inspection Turn table
Outer labeling Inkjet print Checking Cap printing Labeling
Checking & Stacking
The ideal container should be: Strong enough to protect the contents against
crushing during handling & transport. Convenient to use in order to promote good
patient compliance (i.e. encourage the patient). Easy to open & close. Sufficiently transparent to allow for inspection of
the contents in the case of liquid preparations.
Brand Name Company Active Ingredient Therapeutic Class Use Dose and Dosages
Ambrox Square Pharmaceutical Ltd. Ambroxol Hydrochloride Cough & Cold Remedies Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid
mucus including acute and chronic bronchitis
2 -5 years old - 2.5 ml, 2-3 times a day, 5 - 10 years old - 5 ml, 2-3 times
a day, 10 years old and adults - 10 ml, 3 times a day.
Brofex Square Pharmaceutical Ltd. Dextromethorphan Cough & Cold Remedies Chronic dry cough/unproductive cough & acute dry cough which is interfering with normal function or sleep.
Adults mg 3-4. Children between 6-12: 5-15 mg up to 4 times per day.
Children between 2 to 6: 2.5-5 mg 4 times per day.
Tusca Square Pharmaceutical Ltd. Guaiphenesin+
Pseudoephedrine +
Triprolidine HCl
Cough & Cold Remedies Symptomatic relief of upper respiratory tract disorders accompanied by productive cough.
Adults: 2 teaspoonful Children: Over 12 years: 2 teaspoonful 3. 6-12
years: 1 teaspoonful. 2-6 years: 1/2 tspn 3 times a day.
DuolaxTM Square Pharmaceutical Ltd. Magnesium Hydroxide & Liquid Paraffin
Laxative Constipation, Hyperacidity with constipation, Anorectal disorder.
Adults and over12 5-30 ml daily, Children over 7 7.5 ml - 15 ml daily,
Children over 3-7 5-10 ml
Unilin®
Opsonin Pharma Ltd. Theophylline sodium glycinate Antiasthmatics Theophylline is used in reversible airflow obstruction associated with chronic asthma.
Adult- 1/2 -1, 6-12 years- 1-11/2 tspn, >12 years- 2-4 every 6 hours after meal.
Purilin® Opsonin Pharma Ltd. Levosalbutamol Sulphate Antiasthmatics Levosalbutamol is indicated for the treatment and prevention of bronchospasm in adults, adolescents.
Children aged 6-11 years:5 ml Adults and Above 12 yrs 10 ml three times
daily.
XINC Eskayef Bangladesh Ltd. Zinc sulfate monohydrate Vitamins & Minerals Oral zinc therapy is indicated in zinc deficiency and/or zinc loosing conditions.
Child under 10 kg: 22.5 mgChild between 10-30 kg:22.5 mg 1-3
times.Adults and child over 30 kg: 45 mg
1-3 times daily.
SOLVITONE Eskayef Bangladesh Ltd Vitamin B-complex Vitamins & Minerals Prevention and treatment of vitamin B-complex deficiency states. It may be used in pregnancy, Lactation and in other
conditions where B-vitamin supplementation is useful.
Adults & Children: 1-2 teaspoonfuls thrice daily.
Infants: 1 teaspoonful daily or as recommended by the physician.
Kofen Opsonin Pharma Ltd. Ketotifen Fumarate Antiasthmatics It is effective in prophylaxis of bronchial asthma, allergic rhinitis and conjunctivitis.
Adult: 1-2 mg two times daily with food. Child: Over 2 years of age, 1
mg two times daily with food.
Pulmolin Opsonin Pharma Ltd. Salbutamol Sulphate Antiasthmatics Acute and chronic bronchial asthma, chronic bronchitis, bronchospasm, reversible airways obstruction.
Adults: 5 ml 3-4 times daily; maximum single dose 8 ml.
Children: 2-6, 1-2 ml 3-4 times daily.
Some SYRUPS PRESENT IN MARKET
I would like to express my special thanks of gratitude to our course instructor Ms. Irin Dewan, who
provided us with the opportunity to do this project on “Syrups” which made us do a lot of research and we came to know a lot about many new things, and acquired knowledge which we otherwise might not
have gained. We are really thankful to her".