presentación de powerpoint - jamaica kidney kids...
TRANSCRIPT
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1ST JAMAICAN PAEDIATRIC NEPHROLOGY CONFERENCE
Jamaica Conference Centre
Kingston Jamaica October 4th 2014
in association with
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DR. JOY WILLIAMS
TYPICAL NEPHROTIC
SYNDROME
2014 MANAGEMENT
GUIDELINES
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CASE SCENARIO
A 4 year old boy presents with a 6/7 h/o swelling around his eyes which initially improved during the course of the day.
He was seen by his doctor who diagnosed him as having allergies and was prescribed antihistamines
The swelling progressed to involve his entire body
He had been passing normal volumes of urine with no discoloration
Abdominal Swelling √ / Painº
Haematuria º
Sore throat º/ skin rashº / joint painsº
Previous History of Renal Diseaseº
Family History of Renal Diseaseº
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EXAMINATION
Growth parameters
Blood pressure / CCF
Oedema / ascites / effusions
Anaemia
Skin – Rash, sepsis
Infection / peritonitis
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INVESTIGATIONS
BLOOD URINE
CBC,Hb
electrophoresis,
Urea, creatinine,
electrolytes
Total Proteins, albumin,
globulin
Cholesterol,
Triglycerides
C3, ASTO, ANA, VDRL,
Hepatitis B surface antigen,
HIV,
HTLV-I
Dipstick
+/- SSA
(Sulphosalicylic
acid) test
Microscopy
Culture
Spot urine protein :
creatinine (mg/mg)
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NEPHROTIC SYNDROME - DEFINITION
Oedema
Hypoalbuminaemia < 25g/l
Heavy Proteinuria - Nephrotic Range
>40mg/m2/hr
> 50mg/kg/day
Spot Urine Protein/Creatinine > 2 (units mg/mg)
Proteinuria > 2+
+/- Hypercholesterolemia
+/- Hypertriglyceridemia
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MCNS FEATURES Age 2-6 years
No-gross haematuria (1%) or PH of nephritis
(microscopic haematuria -25%)
No-severe hypertension / CCF
(may be transient mild hypertension)
No - secondary disease
- e.g. skin sepsis, auto-immune, Arthritis
No sickle cell disease
Normal renal function tests, Hb, C3
Negative serology
Urinalysis – +/- hyaline casts only
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EPIDEMIOLOGY- MCNS
Incidence (literature) 2-3/100,000
AGE Peak: 2-6 years
SEX Male: Female – 2:1
RACE United Kingdom – ⇧ Incidence in Asians and Indians
IDIOPATHIC – 90%
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PATHOGENESIS IN MCNS T cell function abnormality
Susceptibility to Pneumoccocal infection
Occurrence in patients with Hodgkins disease
Allergic Phenomenon
High incidence in Atopic Children
34 -60% of NS have Atopy
Alteration in Basement Membrane Charge
Albumin leak due to loss of anionic charge in the glomerular basement membrane
Urinary albumin loss >>hypoalbuminaemia >>> oedema , intravascular volume depletion
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HISTOPATHOLOGY
Normal light microscopy
Effacement of foot
processes on EM
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NEPHROTIC SYNDROME
TREATMENT - GENERAL
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NEPHROTIC SYNDROME – GENERAL
TREATMENT MCNS
Admit for first episode
Fluids
Diet
Protein –normal (not
high) protein
No added salt diet
Maintenance for weight
Fluid restriction only
if nephritic
in renal failure
Monitor fluid balance
accurate intake output
Catheterize/ weigh diapers
Daily weights
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NEPHROTIC SYNDROME – GENERAL
TREATMENT MCNS
BP measurement q 4hrly
Hypertension/hypotension
Monitor Proteinuria
Daily urinalysis
SSA
Protein: Creatinine ratio
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NEPHROTIC SYNDROME –
TREATMENT MCNS
+/- Thiazide
Bendrofluazide 0.1- 0.2 mg/kg divided od or bd
Hydrochlorothiazide 1- 2mg /kg /day od or bd
Spironolactone 3-5 mg/kg/day (divided t.i.d)tics
Avoid Furosemide (unless with colloid)
Especially if volume depleted
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NEPHROTIC SYNDROME –
TREATMENT
MCNS
Indications for colloid and Furosemide
Anasarca
Ascites / pleural effusions embarrassing
respirations
Pre renal azotaemia and oliguria
Abdominal pain suggesting mesenteric ischemia
Massive oedema in areas likely to become
infected or have skin breakdown e.g. scrotum
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NEPHROTIC SYNDROME –
TREATMENT
MCNS
Colloid and Furosemide
25% salt poor Albumin 1g/kg IV over 2-4 hours
Furosemide 1mg /kg IV half way through
Fresh frozen plasma 20cc/kg IV over 4 hours
Furosemide 1mg/kg IV half way through
Monitor for volume overload during infusion
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NEPHROTIC SYNDROME –
MONITORING
MCNS
Treat infection
Must be treated before initiating steroids
Monitor for complications
Patient education
Record keeping
Early morning urine testing – SSA, Dipstix
Treatment plan for relapse – dose
Treatment plan for remission – dose
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TREATMENT - SPECIFIC
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NEPHROTIC SYNDROME -RX MCNS
SPECIFIC - PREDNISONE
ONLY children with MCNS
presentation have steroids before
biopsy!!
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NEPHROTIC SYNDROME - TREATMENT
First presentation:
Induction of remission
Duration of daily steroid Rx crucial in determining future
outcome re: subsequent relapse frequency
Maintenance of remission
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NEPHROTIC SYNDROME -
DEFINITIONS
Remission
trace / negative proteinuria (clear on SSA)
5 consecutive days
Relapse
proteinuria > 2+ (cloudy urine on SSA)
For 5 consecutive days
> 2+ proteinuria with oedema
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NEPHROTIC SYNDROME - DEFINITIONS
•Frequent relapses: •> 2 relapses within first six months or > 4 within a year
•Steroid dependency: •2 consecutive relapses during corticosteroid treatment or within 14 days after its cessation
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NEPHROTIC SYNDROME -
DEFINITIONS
Steroid resistance:
Failure to remit
despite 4 weeks of high dose daily steroid therapy
Other definition
despite 8 weeks of high dose steroid therapy
Includes 4 weeks daily and 4 weeks alternate days
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OUR NEW PROTOCOL
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OUR NEW PROTOCOL
FIRST PRESENTATION - INDUCTION
Advantage of longer steroid Rx of initial presentation in
reducing relapse rate
Prednisone / Prednisolone
60mg/m2 or 2 mg/kg/day (max 80mg)
Single or divided doses
Daily for six weeks (vs. 4 weeks in initial
protocol)
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OUR NEW PROTOCOL
FIRST PRESENTATION -
MAINTENANCE
Prednisone / Prednisolone
40mg/m2 or 2 mg/kg (max 80mg)
Single alternate day dose for six weeks
(vs. 4 weeks)
Then taper slowly over the next 2-5 months
(usually 3 months)
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FIRST PRESENTATION KDIGO 2012 OLD JA
PROTOCOL
NEW JA
PROTOCOL
INDUCTION
PREDNISONE
60mg/m2/day
2mg/kg/day
60mg/m2/day
2mg/kg/day
60mg/m2/day
2mg/kg/day
4-6 weeks
4 weeks
6 weeks
MAINTENANCE 40mg/m2
1.5mg/kg alt
day
40mg/m2
2mg/kg alt day
40mg/m2
2mg/kg alt day
Tapering each
week
over 2-5 mo
4 weeks
Then taper
Over 2-5 mo
6 Weeks
Then taper
Over 2-5 mo
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OUR NEW PROTOCOL RELAPSES - INDUCTION
Prednisone / Prednisolone
2mg/kg/day ( or 60mg/m2/day) - max 80mg
od or divided bd or t.i.d
Until Remission (urine trace or negative for protein for
5 consecutive days)
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OUR NEW PROTOCOL RELAPSES –MAINTENANCE
Prednisone / Prednisolone 2mg/kg/day (OR 40mg/m2/day) - max 80mg
Single alternate day dose
For six (6) weeks
Then taper and discontinue over 2-5 months
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OUR NEW PROTOCOL
FR/ SS/ SD NEPHROTIC SYNDROME
Slower taper > 3 - 5 months
If not steroid toxic maintain on the lowest dose of
daily or alternate day steroids that can maintain
remission
Consider addition of steroid sparing drugs
REFER To Paediatric Nephrologist
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FR, SD, SSNS KDIGO 2012 OLD JA
PROTOCOL
NEW JA
PROTOCOL
Induction
Prednisone
60mg/m2/day
2mg/kg/day
60mg/m2/day
2mg/kg/day
60mg/m2/day
2mg/kg/day
Till remission
Till remission Till remission
Maintenance 40mg/m2
1.5mg/kg alt day
40mg/m2
2mg/kg alt day
40mg/m2
2mg/kg alt day
Taper over
>3months
4 weeks
Then slower
Taper > 3 mo
6 weeks
Then slower
Taper > 3 mo
Minimum daily or alt day
dose
Daily if infection*
Minimum alt
Day dose
*
Minimum alt
Day dose
*
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NEPHROTIC SYNDROME –
STEROID SPARING AGENTS
Steroid toxicity – SD, FR -SSNS
Alkylating agents: Cyclophosphamide
Chlorambucil
Levamisole
Calcineurin inhibitors Cyclosporin**, Tacrolimus
Mycophenolate mofetil
Rituximab
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COMPLICATIONS
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MCNS - COMPLICATIONS
Infection
o Urinary losses: Immunoglobuin, Properdin, Factor
B
o Abnormal cell mediated immune function
o Immunosuppressives
o Oedema/Ascites – Potential Culture media
o Spontaneous bacterial peritonitis – S. pneumoniae,
E. Coli
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NEPHROTIC SYNDROME
COMPLICATIONS Thromboembolic Events
Thrombosis – arterial / venous
Hypercoagulability ⇧ Prothrombotic Factors (Fibrinogen, Throbocytosis, Clotting Factors)
⇩Fibrinolytic Factors (Urinary Losses of Antithrombin III, protein S & C)
Prevention: Close attention to fluid balance
Replace extrarenal losses e.g. diarrhoea and vomiting
Avoid dehydration especially with
Diuretics
Remission induced diuresis
Encourage Mobilisation
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OUTPATIENT
MANAGEMENT
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NEPHROTIC SYNDROME –
MONITORING
Daily urinalysis
Dipstix or SSA (Sulphosalicylic acid)
First morning urine (avoid orthostatic proteinuria)
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NEPHROTIC SYNDROME –
ADVICE
No live virus vaccines when
on Prednisone and for 3 months after its cessation
on alkylating agents
Pneumococcal vaccine
Letter to school
VZIG for varicella infection on steroids
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INDICATIONS FOR RENAL BIOPSY-
REFER
Non MCNS presentation – nephritic presentation
Steroid resistance
Renal failure
Positive serology
Sickle cell disease
Secondary nephrotic syndrome
Older child
Frequent relapser / steroid dependent
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POINTS TO REMEMBER
Refer atypical patients at diagnosis
Avoiding dehydration helps prevent complications Acute kidney injury
Thromboses
Accurate fluid balance
Educate and communicate with parents
Outpatient home urine testing reduces admissions for relapses
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THANKS FOR YOUR ATTENTION.