CURRICULUM VITAE NAME: Wayne Rodney Giles September 2015 PRESENT POSITION AND ADDRESS: Professor Faculties of Kinesiology and Medicine University of Calgary KNB 2228, 2500 University Drive NW Calgary, Alberta, Canada, T2N 1N4 Phone: (403) 220-2840 Fax: (403) 220-0448 wgiles@ucalgary.ca BIOGRAPHICAL:

Born: November 28, 1947 Lloydminster, Saskatchewan, Canada

Married Residence: 103 Varsity Estates Grove NW Calgary, Alberta T3B 4C8 Canada Phone: 403-247-3575 (home) 403-220-2840 (office) 403-836-8825 (cell) EDUCATION: 1969 Physiology B.Sc. (Honours) University of Alberta, Edmonton,

Canada. 1970 Physiology M.Sc. University of Alberta, Edmonton,

Canada. 1971 M.Phil. Yale University, New Haven,

Connecticut. 1974 Physiology / Biophysics Ph.D. Yale University, New Haven,

Connecticut.

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PROFESSIONAL AND TEACHING EXPERIENCE: 2012 – Present Professor, Faculty of Kinesiology University of Calgary, Calgary, Alberta, Canada 2006 - 2012 Dean, Faculty of Kinesiology University of Calgary,

Calgary, Alberta, Canada 2003 – 2006 Professor, Departments of Bioengineering and Medicine University of California San Diego, La Jolla, California 1998 - 2003 Head, Department of Physiology and Biophysics University of Calgary School of Medicine, Calgary, Alberta, Canada

1989 - 1992 Chairman, Cardiovascular Research Group University of Calgary School of Medicine, Calgary, Alberta, Canada 1986 - Present Professor, Departments of Physiology and Pharmacology

University of Calgary School of Medicine, Calgary, Alberta, Canada.

1983 - 1986 Associate Professor, Departments of Physiology and Medicine,

University of Calgary School of Medicine, Calgary, Alberta, Canada. 1981 - 1983 Associate Professor, Department of Physiology and

Biophysics, U.T. Galveston Medical Branch, Galveston, Texas.

1979 - 1981 Assistant Professor, Department of Physiology and

Biophysics, U.T. Galveston Medical Branch, Galveston, Texas.

1978 - 1979 Research Assistant Professor, Department of

Paediatrics, University of Washington, Seattle, Washington

1977 - 1978 Research Associate, Centre for Bioengineering,

University of Washington, Seattle, Washington 1974 - 1976 Postdoctoral Fellow, Physiology Laboratory,

Oxford, England. 1970 - 1974 Graduate Student, Department of Physiology, Yale

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University, New Haven, Connecticut 1969 - 1970 Graduate Student, Department of Physiology,

University of Alberta, Edmonton, Alberta, Canada RESEARCH FUNDING: I. Past Awards: A.H.A. Established Investigator Award 81-243. "Electrophysiology and Pharmacology of Single Cardiac Cells." 07/01/81 - 08/30/86. (Salary support withdrawn 07/01/84, when moved to Calgary) Canadian MRC Program Grant. "Electrophysiology/Pharmacology of Cardiac Muscle." 07/01/88 - 06/30/96. C.I.H.R. Group Grant. "Functional Regulation of Ion Channels and Transporters: Biophysical Analysis and Signal Transduction Mechanisms." approx $750,000/year. 10/01/96-09/30/01. W. Giles, Principal Investigator: Project 1 - W. Giles $115,000/year Alberta Heritage Foundation for Medical Research, Salary Support: 1. 07/01/83 - 07/01/88: Scholarship Award 2. 07/01/88 - 06/30/93: Medical Scientist Award 3. 07/01/93 - 06/30/98: Medical Scientist Award 4. 07/01/98 - 06/30/03: Medical Scientist Award Grant-in-aid, Heart and Stroke Foundation of Canada (HSFC) (Principal Investigator) (07/01/02 – 06/30/05) $ 165,000 ‘Cardiac Pacemaker Mechanisms’ Endowed Chair: Heart and Stroke Foundation of Alberta, $130,000/yr (1996-2006) Relinquished in 2004 after move to UCSD CIHR Operating Grant (Principal Investigator) (04/01/01 – 03/31/06) $ 220,000 ‘Molecular Interactions between Emigrated Neutrophils and Cardiovascular Targets” CIHR Operating Grant (group grant) (Principal Investigator) (07/01/01 – 06/30/06) $ 445,000 ‘Effects of C-type Natriuretic Peptides on Mammalian Heart” Whitaker Center Grant, University of California (San Diego) (Co-investigator) (08/01/03 – 06/30/06) $ 350,000 ‘Whitaker Professor UCSD’ National Institutes of Health (Co-applicant with Dr. W. Dillmann at University of California, San Diego). (09/03/99-08/30/07) $250,000/yr 'Molecular Aspects of Thyroid Hormone-induced Modulation of Cardiac Ion Channels'.

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W. Giles allotment $55,000/yr. 2RO1 HL 25022 - 23 (09/01/03 - 08/31/07) National Institutes of Health (Principal Investigator) (07/01/05 - 06/30/07) $175,000/yr 'Electrophysiology of the Bovine Chondrocyte' NIH R21 EB004364-01 American Heart Association (Principal Investigator) (07/01/05 - 06/30/08) $70,000/yr 'Effects of Sphingosine-1-Phosphate on Mammalian Cardiac Electrophysiology' AHA 0555040 Y CV Therapeutics (01/01/07 – 06/30/08) $100,000 ‘Modelling the Cardiac Action Potential’ GlaxoSmithKline (Principal Investigator) (03/01/07 – 02/28/09) $135,000/yr ‘Ion Channels in Human and Murine Chondrocytes’ National Institutes of Health (Co-applicant with Dr. W. Dillmann at University of California, San Diego) (06/01/04 - 05/30/09) $250,000/yr 'Diabetic Cardiomyopathy and Calcium Flux” W. Giles allotment $50,000/yr approx. 5RO1 - HL 66917 - 04 (09/30/04 - 08/31/09) Heart and Stroke Foundation of Alberta, NWT & Nunavut (07/01/2007 – 06/30/2010) $57,000/yr ‘Electrophysiological and Biophysical Mechanisms of Sphingosine-1-Phosphate Effects in Mammalian Myocardium’ Gilead Sciences, Inc. (03/01/09 – 02/28/10) $100,000 ‘Mathematical Models of the Human Atrium’ CV Therapeutics (03/01/09 – 02/28/10) $ 240.000 ‘A Systems Biology Approach to Understanding [Na+]: and [Ca2+] Fluxes and Regulations in Cardiac Diseases Canadian Institutes of Health Research (Principal Investigator) (04/01/07 – 03/31/12) $105,544/yr ‘Physiological and Pharmacological Responses of Adult Cardiac Fibroblasts’ MOP 82803 Heart and Stroke Foundation of Alberta, NWT & Nunavut Principal Investigator

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(07/01/2010 – 06/30/2013) $57,000/yr ‘Biophysical analyses of electrophysiological effects of ATP on cardiac fibroblasts and myocytes’ Gilead Sciences Ltd. Principal Investigator (01/01/12 – 12/31/13) $60,000/yr. Drug Development Principles for Human Cardiac Arrhythmias Canadian Foundation for Innovation Principal Investigator Co-investigators: Tannin Schmidt and Andrea Clark 2009 – 2013 ‘Confocal Microscope for Combined Spectroscopy and Electrophysiology of Mesenchymal Cells’ Operating $170,000 Equipment $950,000 Alberta Heritage Foundation for Medical Research (AHFMR) Interdisciplinary Team Grant – Member (04/01/08 – 03/31/14) ‘Creating Bone and Joint Health from the Bedside to the Bench and Back Again – Designer Therapies to Reduce the Burden of Osteoarthritis (OA) – from Mechanisms to Prevention’ 200700596 Alberta Innovates – Technology Futures (AITF) (04/01/2012 – 03/31/2014) $100,000 ‘Novel application of nanotechnology for measuring electrophysiological parameters in target cells and intracellular organelles: Opportunities for Alberta life sciences.’ Alberta Innovates – Health Solutions (AIHS) (04/01/2012 – 03/31/2014) $100,000 ‘Novel application of nanotechnology for measuring electrophysiological parameters in target cells and intracellular organelles: Opportunities for Alberta life sciences.’ II. Current Funding: AIHS Alberta Innovates - Health Solutions, former Alberta Heritage Foundation for Medical Research (AHFMR) Medical Scientist Award (07/01/08 – 06/30/15) Salary Support $160,000/yr ‘Cell-Cell Communication in the Mammalian Heart: Fibroblast, Myofibroblast, Myocyte Interactions’

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Canadian Institutes of Health Research Principal Investigator (10/01/12 – 09/31/17) $122,395/yr ‘Communication and Crosstalk Between Fibroblasts and Heart Cells in Mammalian Myocardium’ MOP 82803 Gilead Sciences Ltd. Principal Investigator (01/01/14 – 12/31/15) $70,000/yr. Drug Development Principles for Human Cardiac Arrhythmias Alberta Diabetes Institute (ADI) (09/24/2013 – 09/01/2015) $ 30,000 Cardiac Fibroblasts/Myofibroblasts Contribute to Diabetic Cardiomyopathy Principal Investigators: Yves Sauve, Gavin Oudit, Wayne Giles Pure North S’Energy Foundation (06/01/2013 – 05/31/2015) $ 70,000/yr. Electrophysiological Analyses of the Effects of Vitamin D on Bone Metabolism Award to Dr. W. Giles and Dr. M. Doshak, placed at University of Alberta National Institute of Health (NIH) Consultant 5%, Principal Investigator: Dr. Sanjiv Narayan, Stanford University (2014 – 2018) $375,000/yr. The Dynamics of Human Atrial Fibrillation RESEARCH PERSONNEL: 1. Former Graduate Students

a. Master of Science: T. Drury K. Hicks E. Shibata K. Robinson R. Rasmusson R. Murphey D. Lindblad M. Grattan L. Melashenk B. Hu A. Chu D. Dederko

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S. Soleymani J. Thurston

b. Doctor of Philosophy:

E. Shibata (University of Iowa) D. Campbell (NYU Buffalo) A. Tse (University of Alberta) A. Juhasz (DVM Private Practice) J. Shumaker (Vanderbilt University) S. Demir (University of Memphis and NSF) V. Lowes (private publishing business) A. Nygren (University of Calgary) S. Pandit (NYU Syracuse) R. Rose (Dalhousie University) D. MacCannell (University of Hawaii) L. Landeen (Smith and Nephew Ltd, San Diego)

2. Former Post-Doctoral Fellows

B.P. Fleming Research Associate Professor Department of Biomedical Engineering University of Kentucky Lexington, Kentucky

J.R. Hume Professor

Dept. of Pharmacology University of Nevada Reno, Nevada

K. Kanai Assistant Professor Dept. of Physiology Shinshu University School of Medicine Matsumoto, Japan

A. van Ginneken Associate Professor

Department of Medical Physiology University of Amsterdam Academic Medic Centre AMC-MO1 Meibergdreef 15 1105 AZ Amsterdam, The Netherlands

E.F. Shibata Associate Professor

Department of Physiology & Biophysics 5-610 Bowen Science Building University of Iowa

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Iowa City, Iowa

D.L. Campbell Associate Professor Department of Physiology SUNY - Buffalo Buffalo, New York

Y. Imaizumi Professor and Head, and Vice President (Research)

Department of Pharmacology and Therapeutics Nagoya City University Nagoya 467, Japan

Y. Momose Professor and Head School of Pharmaceutical Sciences Toho University Chiba 274, Japan

T. Nakajima Assistant Professor

Department of Internal Medicine Faculty of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku-Tokyo, Japan T113

M. Kaibara Assistant Professor

Department of Medicine (III) University of Nagasaki Nagasaki, Japan 852

K. Ono Assistant Professor

Department of Pharmacognosy & Phytochemistry National Institute of Hygienic Sciences 1-18-1 Kami-Yohga Setageya ward, Tokyo 158, Japan

E. Salinas- Assistant Professor

Stefanon Department of Pharmacology University of Pueblo Pueblo, Mexico

D. Fedida Professor

Department of Pharmacology and Anaesthesia University of British Columbia Vancouver, BC, Canada

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R. Rasmusson Professor Departments of Bioengineering and Medicine State University of New York Buffalo, New York

A. Braun Assistant Professor

Departments of Pharmacology and Physiology University of Calgary Calgary, AB, Canada

H. Banno Research Scientist

Mitsui Pharmaceutical Ltd. Mobara, Japan

H. Akbarali Professor

Department of Physiology University of Oklahoma Oklahoma City, OK

Y. Habuchi Associate Professor

Division of Cardiology Kyoto Prefectural Medical University Kyoto, Japan

H. Tanaka Assistant Professor

Division of Cardiology Kyoto Prefectural Medical University Kyoto, Japan

R. Bouchard Research Associate, Department of Physiology Queens University Kingston, Ontario, Canada

X. Han Research Assistant Professor

Division of Cardiology University of Pittsburgh Pittsburgh, PA

L. Firek Head

Marketing & Development Bio-Sense / Johnson & Johnson Ltd. Brussels, Belgium

N. Sato Assistant Professor First Department of Internal Medicine Asahikawa Medical College Asahikawa, Japan

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C. Fiset Associate Dean (Research), Professor

Montreal Heart Institute Montreal, Canada

C. Ward Associate Professor

Department of Physiology Queens University Kingston, Ontario, Canada

J. Cordeiro Research Associate

Masonic Medical Institute Utica, NY

K. MacDonell Research Associate

Howard Hughes Medical Institute Seattle, Washington, USA

J. Magga Assistant Professor

Division of Cardiology Oulu, Finland

A. Nygren Associate Professor

Dept. of Electrical and Computer Engineering Associate Dean (Academic and Planning) Schulich School of Engineering University of Calgary

Y. S. Shibukawa Associate Professor

Dept of Physiology and Biophysics Tokyo Dental College

N. Hatano Assistant Professor Laboratory of Chemical Pharmacology School of Pharmacy, Aichi Gakuin University Nagoya, Japan L. Landeen Manager, Process Development Smith and Nephew Ltd. San Diego, California, USA L. Chilton Reader of Physiology School of Veterinary and Biomedical Sciences James Cook University Townsville, Queensland, Australia M. Fink Project Scientist

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Novartis Ltd. Basil, Switzerland J. Wilson Technology Analyst Innovate Calgary Calgary, Alberta Y. Ajiro Assistant Professor Paediatric Cardiology Tokyo Women’s Medical School Tokyo, Japan

R.B. Clark Research Associate Faculty of Kinesiology University of Calgary

U. Banderali Research Associate Faculty of Kinesiology University of Calgary 4. Present Postdoctoral Fellows University of Calgary Dr. Ryan Cunnington (co-supervision) 5. Present Ph.D. Students

University of Calgary Dr. Holly Mewhort (co-supervision)

6. Visiting Professors:

1982 -1983 M. Ohba, Associate Professor, Fukuoka School of Medicine,Fukuoka, Japan (3 months)

1983 - 1984 R.D. Nathan, Associate Professor, Texas Tech School of

Medicine, Lubbock, Texas (4 months)

1985 - 1986 H. Refsum, Professor of Physiology, Tromso, Norway (1 year)

1985 -1986 J. Clark, Professor, Dept. of Electrical Engineering, Rice University, Houston, Texas (6 months)

1985 - 1986 D. Lathrop, Assistant Professor, Dept. of Pharmacology and

Cell Biophysics, University of Cincinnati, School of Medicine, Cincinnati, Ohio (3 months)

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1986 - 1990 Y. Shimoni, Associate Professor, Haddasah Medical School,

Jerusalem, Israel

1986 - 1988 T.D. Tsai, Professor, Institute of Physiology, Shanghai University, Shanghai, Federal Republic of China (2 years)

1988 - 1989 H. Irisawa, Professor, Institute of Physiology, Okazaki, Japan

1988 - 1989 J. Sanchez-Chapula, Professor, University of Colima School of

Medicine, Colima, Mexico

1989 - 1990 G. Christie, INSERM Research Professor, Lyon, France

1996 - 1997 T.S. Larsen, Professor and Chairman, Department of Medical Physiology, Tromso, Norway

1998 – 1999 H. Tanaka, Associate Professor, Department of Pharmacology,

Toho University, Japan

1998 - 1999 D. Saint, Research Officer, University of Adelaide, Australia

1998 - 1999 B. Sasyniuk, Professor, Department of Pharmacology, McGill University, Montreal, Canada

2000 - 2001 A. Leuger, Professor, Department of Medicine, University of

Graz, Graz, Austria

2004 - 2006 R. Ochi - Tokyo Medical and Dental University

TEACHING RESPONSIBILITIES:

Medical Physiology (1st yr Medicine) Medical Science 751 - Ionic Channels of Excitable Membranes Cardiovascular Physiology (Graduate Course) Cardiology Residents Training Program Medical Science 502 - Integrative Human Physiology (Course Co-ordinator) Introductory Physiology for Biotechnology Students Physiology 404 (Honors Undergraduate Course, University of Alberta) Physiology for Bioengineers Zoology 463 (Comparative Physiology) Bioengineering 230C (Cardiovascular Physiology) Bioengineering 140A (Integrative Physiology) Bioengineering 87 (Freshman Seminar) BNAT 205 (Pharmacology / Physiology) Zoology 363 (Comparative Physiology)

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Kinesiology 495 – Physiological Aspects Of Aging, Disease & Physical Activity Kinesiology 465 – Environmental Physiology

EDITORIAL BOARD MEMBERSHIPS:

Circulation Research (1983 – l989) Journal of General Physiology (1983 – 1988) American Journal of Physiology (1987 – 1993) Journal of Physiology (1987 – 1994) British Journal of Pharmacology (1994 – 1999) American Journal of Physiology (1996 – present) Circulation Research (1994 – present) Journal of Molecular and Cellular Cardiology (2007 – present) Experimental Physiology (2008 – present) Journal of Physiology (2013 – present)

EDITORIAL APPOINTMENTS:

American Journal of Physiology (Heart and Circulation), Associate Editor, 1990 - 1993 Section Head, Circulation/Cardiovascular Physiology, Current Opinion Reviews 2004 – Present The Faculty of 1000 (2006 – present)

MEMBERSHIP IN SCIENTIFIC SOCIETIES:

Senior Member of Biophysical Society American Heart Association Council on Basic Science Foreign Member of the Physiological Society The American Physiological Society

COMMUNITY/PHILANTHROPIC BOARD RESPONSIBILITIES

Scientific Advisory Committee Nora Eccles Harrison Centre for Cardiovascular Research and Education Faculties of Medicine and Bio-Engineering, University of Utah Salt Lake City Contact: Dr. K Spitzer Scientific Advisory Committee Snyder Institute for Cardiovascular Disease Faculty of Medicine, University of Calgary Contact: Dr. Paul Kubes

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Board Member Brenda-Strafford Foundation for Seniors Care (06/2012 – 06/2015) Contact. Dr. Barry Strafford

COMMITTEE MEMBERSHIP AT UNIVERSITY OF CALGARY:

Medical Academic Computing Committee, Chairman (1984 - 1991). Committee on Research, Member (1984 - 1986). Executive Faculty Council Committee, Member (1984 - 1986). Research and Development Committee (1988 - 1990). Planning Committee for AHFMR International Board of Review Meeting (1993) Committee on Research, Member (1991 - 1993) Recruitment Priorities Committee (1992 - 1994) Executive Faculty Council Committee, Member (1994 - 1996). Planning Committee for AHFMR International Board of Review Meeting (1999) Planning and Priorities Committee (1998 - 2002) Task Force for Medical Faculty Accreditation (1999) Planning Committee for Health Innovation Centre (2000 - 2003) Planning Committee for C.F.I. Infrastructure Support (2000 - 2003) Business Development Committee (2000 - 2003) Interim Head, Public Health Initiative (2006 - 2008) Advisory Board, Alberta Ingenuity Centre for Carbohydrate Science (2007 – 2009) Chair, Planning Committee for U of C Bioengineering Program (2007 - 2009) Deans’ Council (2006 - 2012) Advisory Committee, Alberta Children’s Hospital Foundation (2010 – 2013) Institute of Maternal and Child Health Executive Committee (2010 – 2013) Biomedical Engineering Initiative Executive Committee (2010) Joint planning Committee Population and Public Health Selection Committee for Cuthbertson and Fischer Chair In Paediatric Mental Health Selection Committee, Heart and Stroke Professorship in Stroke Research Selection Committee, Roy and Vi Baay Chair in Kidney Research Selection Committee, The Merck Frosst Chair in Cardiovascular Research Executive Committee, Biomedical Engineering Executive Committee, Alberta Children’s Hospital Research Institute for Child

and Maternal Health (2010 – 2013) Selection Committee, Cal Wenzel Foundation Chair in Hepatology (2010 – 2014) Adjudicator, Faculty of Graduate Studies Scholarship Committee for Graduate Award Competition (GAC) (2014-2015) Faculty of Kinesiology Representative to the Faculty of Veterinary Medicine Council (2014-2015) Alberta Diabetes Institute/Johnson and Johnson Research Fund (2015 – 2018)

COMMITTEE MEMBERSHIP AT UNIVERSITY OF CALIFORNIA SAN DIEGO

Member, Management Board, Institute of Molecular Medicine

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Member, Selection Committee, University of California San Diego Medical Scientist Training (MD/Ph.D.) Program Medical Scientist Training (MD/Ph.D.) Program (2003 – present) Departmental Representative, California Regenerative Medicine Initiative (2005

– 2007) SCIENTIFIC PEER REVIEW COMMITTEES: 1981 - 1984 Member of the Selection Committee for the A.H.A. Louis Katz Young

Investigator's Award 1984 - 1989 Canadian Heart Foundation Scientific Review Committee, Section B,

Clinical Cardiology, Antiarrhythmic Drugs, Electrophysiology and Computers

1988 Ad Hoc Member N.I.H. Cardiovascular `B' Study Section 1988 Member of Selection Committee for American Heart Association

Established Investigators Award 1989 - 1994 Member of Selection Committee for American Heart Association Basic

Science Abstracts 1989 - 1992 Member of Canadian MRC Cell Physiology Grants Review Committee 1995 - 1998 Chairman, Canadian MRC Cell Physiology Grants Review Committee 1997 - 2000 Chairman, Heart and Stroke Foundation of Canada Review Committee

on Cellular Electrophysiology and Pharmacology 1999 National Institutes of Health, SCOR Group Review: Committee

Member 2000 National Institutes of Health, Cardiovascular Study Section, ad hoc

Member 2000 Member, Canadian Institutes for Health Research, Cardiovascular B

Review Committee 2005 Member NIH Study Section (HLB1) Electrical Signalling, Ion Transport, and Arrhythmias HONORS:

Alberta Hotel Association Scholarship, 1965. Province of Alberta Scholarship, 1965.

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Province of Alberta Grant, 1966. Province of Alberta Scholarship, 1967. Province of Alberta Grant, 1968. Yale Graduate Fellowship, 1970-1972. Canadian Heart Foundation Fellowship, 1972 - 1973. Canadian Heart Foundation Fellowship, 1973 - 1974. Canadian Medical Research Council Fellowship, 1974 - 1976. American Heart Association Established Investigator Award, 1981 - 1986. Alberta Heritage Foundation for Medical Research Scholarship, 1983 - 1988. Japan Society for Promotion of Science Visiting Professorship, April, 1985. Adjunct Professor of Electrical and Computer Engineering, Rice University,

Houston, Texas (July 1, 1987 - Present). Panel Member: Novartis Symposium on Nuclear Receptors

INVITED ADDRESSES AT INTERNATIONAL MEETINGS OR SYMPOSIA: October 1981 A Review of Autonomic Transmitter Actions in Cardiac Muscle.

American Physiological Society, Anaheim, U.S.A. April 1982 Pre- and Post-synaptic Actions of Cadmium in Cardiac Muscle.

American Pharmacological Society, New Orleans, U.S.A. September 1983 Pacemaker Currents in the Heart. A Single Cell Approach.

International Union of Physiological Sciences. Sydney, Australia.

November 1983 Pacemaker Currents in Isolated Cardiac Pacemaker Cells.

American Heart Association. Anaheim, U.S.A. September 1984 A Comparison of K+ Currents in Myocytes from the Atrium and

Sinus Venosus. British Physiological Society Symposium `Electrophysiology of Single Cardiac Cells.' Oxford, U.K.

July 1986 Properties of Calcium Channels in Excitable Cells. Smooth

Muscle Satellite Symposium of the International Union Physiological Sciences, Banff, Canada.

September 1987 Ionic Currents Underlying Pacemaker Activity and Action

Potentials in Mammalian Heart Cells. In: Symposium on Electrophysiology. 40th Annual Conference on Engineering in Medicine and Biology. Niagara Falls, New York.

October 1987 Comparison of K+ Currents in Single Cells from Rabbit Atrium

and Ventricle. Fall American Physiological Society Symposium `Selected Ionic Currents of the Heart'. Anaheim, California.

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November 1988 α- and β-Adrenergic Effects on K+ Currents in Heart. Basic Science Symposium, American Heart Association Meeting, Washington, D.C.

May 1990 K+ Currents which Repolarize Mammalian Heart.

American Heart Association Meeting on 'Ion Channels'. Chicago, Illinois.

August 1991 Cholinergic Modulation of K+ Currents in Mammalian Heart.

Symposium on the Physiology, Pharmacology and Biophysics of Ganglionic Transmission: Muscarinic K+ Currents in Heart. University of Alberta, Edmonton, AB. Canada

October 1991 Autonomic Modulation of Cardiac Ionic Currents in Symposium

on Autonomic Modulation of Cardiac Rhythms. University of Montreal, Quebec

July 1992 α1-Adrenergic Control of Cardiac Electrophysiology and

Contractility in: II International Symposium on the Mammalian Myocardium, Leeds, U.K.

August 1992 Adrenoceptors in the Mammalian Myocardium and their

Cellular Signalling Mechanisms. ASPET Meeting on Ion Channel and Transporter Pharmacology, Orlando, FL.

September 1992 Modulation of K+ Currents in Heart. NIH, HL&B Institute

Symposium on Ion Channels in the Cardiovascular System February 1993 Electrophysiological Properties and Ionic Currents in Myoyctes

from Rabbit A-V Node. Conference on Biomedical Engineering Research, Houston, TX.

August 1993 Muscarinic Effects of Acetylcholine in Mammalian Heart.

International Union of Physiological Sciences. Symposium 09. Autonomic Neurons System. Glasgow, Scotland

July 1994 Nitric Oxide is an Obligatory Mediator of some Muscarinic

Cholinergic Effects in Mammalian S-A Node. International Symposium on Ion Channels in Heart. Tokyo, Japan.

July 1995 Cl- Conductance in A-V Node and Ventricle of Rabbit Heart.

ISHR International Symposium. London, ON. Canada. September 1995 Ionic Mechanisms for Spontaneous Pacing in Mammalian

Heart. 17th Annual IEEE/EMBS Conference. Montreal, PQ, Canada.

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November 1996 Normal and Abnormal Pacemaker Activity in Mammalian Nodal Tissue and Human Atrium. Organizer: International Conference: Banff, AB. Canada.

November 1999 Mathematical Models of Human Atrial Electrophysiology – A How To Session American Heart Association, Atlanta, GA. November 1999 Electrophysiological and Optical Studies of Repolarization in

Adult Mouse Heart. In: Ion Channels in Genetically Modified Mouse Hearts –a State of the Art Session American Heart Association, Atlanta, USA August 2000 Electrophysiological studies of normal and genetically altered

mouse hearts. in: A Special Symposium on Functional Genomics– A new approach to understand cardiovascular and renal dysfunction. Acta Physiol Scand./Stockholm, Sweden.

November 2000 Electrophysiology Defects in the HF-1b Knockout Mouse.

Department of Cell Biology and Anatomy, University of South Carolina Health Sciences Centre, Charleston, South Carolina.

January 2004 Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss Muscular Dystrophy. (Novartis Symposium, January, 2004, submitted). March 2006 The Transcription Factor SNAIL Regulates Sodium Current in Mammalian Ventricular Myocytes. International Society for Applied Cardiovascular Biology, San Diego, CA. April 2006 Myocyte Fibroblast Interactions in Human Heart. FASEB Meeting, April 4, 2006, San Francisco, CA. April 2006 K+ Channels in Articular Chondrocytes Glaxo Smith Kline Research Conference, April 21, 2006 Philadelphia, PA. May 2007 Comparison of Repolarization Mechanisms and Excitation Contraction Coupling in RV vs LV Myocytes American Thoracic Society International Conference, May 21, 2007, San Francisco, CA. February 2009 Electrotonic Interactions Between Myocytes and Fibroblasts in the Mammalian Heart. Gordon Research Conference, February 16, 2009, Turin, Italy.

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April 2009 Electrophysiological Effects of S-1-P in the Cardiovascular System. Biogen Idec. Inc., April 6, 2009, Boston, Ma. May 2010 Models of Human Cardiac Electrophysiology ‘Phenotyping the Adult Mouse Heart’. Jackson Laboratories, May 10, 2010, Bar Harbor, Me. April 2011 Electrotonic Interactions between Myocytes and Fibroblast in the Mammalian Heart. Society of Experimental Biologists, April 12, 2011, Washington, DC. April 2011 Models of Human Cardiac Electrophysiology ‘Phenotyping the Adult Mouse Heart’. International Workshop, Jackson Laboratory, April 18, 2011, Bar Harbor, Maine. May 2012 Models of Human Cardiac Electrophysiology ‘Phenotyping the Adult Mouse Heart’. International Workshop, Jackson Laboratory, May 15, 2012, Bar Harbor, Maine. May 2013 Models of Human Cardiac Electrophysiology ‘Phenotyping the Adult Mouse Heart’. International Workshop, Jackson Laboratory, May 14, 2013, Bar Harbor, Maine. June 2013 Electrophysiological Properties of the Human Chondrocyte Queen Mary University of London, School of Engineering and Materials Science, June 17, 2013, London, UK. June 2013 Electrophysiological Interactions Between Myocytes and Fibroblasts. University of Nevada, Department of Physiology and Cell Biology, June 25, 2013, Reno, NV.

March 2015 Functional Consequences of Fibroblasts and Myofibroblasts in Mammalian Myocardium. Japanese Pharmacological Society International Symposium on Ion channels, transporters and Small molecules as key regulators of homeostatic systems: Frontiers of Cardiovascular Cation Channel Research, March 19, 2015, Nagoya, Japan.

BIBLIOGRAPHY

ARTICLES IN JOURNALS: 1. Tsien RW, Giles WR & Greengard, P (1972). Cyclic AMP mediates the effects of

adrenaline on cardiac Purkinje fibres. Nature (New Biol) 240, 181-183. 2. Lynne-Davies P, Bowden JA & Giles W (1975). Effect of hypoxia on immediate

ventilatory load response in dogs. J Appl Physiol 39, 367-371.

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3. Cohen I, Giles W & Noble D (1976). Cellular basis for the T wave of the

electrocardiogram. Nature 262, 657-661. 4. Giles WR & Noble SJ (1976). Changes in membrane currents in bullfrog atrium

produced by acetylcholine. J Physiol 261,103-123. 5. Banister J, Brown H, Giles W, Hutter OF & Noble SJ (1976). W.H. Gaskell's

demonstration of "the electrical changes in quiescent cardiac muscle which accompany stimulation of the vagus nerve". J Physiol 263, 60-63.

6. Brown HF, Giles WR & Noble SJ (1977). Membrane currents underlying activity in frog

sinus venosus. J Physiol 271, 783-816. 7. Fleming BP, Giles W & Lederer W (1981). Are acetylcholine-induced increases in 42K

efflux mediated by intracellular cyclic GMP in turtle cardiac pacemaker tissue? J Physiol 314, 47-64.

8. Fleming BP & Giles W (1981). Changes in 42K efflux produced by alterations in

transmembrane calcium movements in turtle cardiac pacemaker tissue. J Physiol 314, 65-77.

9. Lee KS, Hume JR, Giles W & Brown AM (1981). Sodium current depression by

lidocaine and quinidine in isolated ventricular cells. Nature 291, 325-327. 10. Hume JR & Giles W (1981). Active and passive electrical properties of single bullfrog

atrial cells. J Gen Physiol 78, 19-42. 11. Giles W & Shibata E (1981). Autonomic transmitter actions on cardiac pacemaker

tissue: A brief review. Faseb J 40, 2618-2625. 12. Hume JR & Giles W (1983). Ionic currents in single isolated bullfrog atrial cells. J Gen

Physio 81, 153-194. 13. Giles W, Hume JR & Shibata E (1983). Presynaptic and postsynaptic actions of

cadmium in cardiac muscle. Faseb J 42, 1994-1998. 14. Momose Y Giles W & Szabo G (1984). Acetylcholine-induced K+ current in amphibian

atrial cells. Biophys J 45, 20-22. 15. Shibata EF, Giles W & Pollack GH (1985). Threshold effects of acetylcholine on

primary pacemaker cells of the rabbit sino-atrial node. Proc Roy Soc B223, 355-378.

16. Ganapathy N, Clark JW, Wilson OB & Giles W (1985). Forward and inverse potential

field solutions for cardiac strands of cylindrical geometry. IEEE, Bioeng 32, 566-577.

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17. Giles WR & van Ginneken A (1985). A transient outward current in isolated cells from the crista terminalis of rabbit heart. J Physiol 368, 243-264.

18. Giles W & Shibata EF (1985). Voltage clamp of bullfrog cardiac pacemaker cells: A

quantitative analysis of potassium currents. J Physiol 368, 265-292. 19. Shibata EF & Giles WR (1985). Ionic currents that generate the spontaneous diastolic

depolarization in individual cardiac pacemaker cells. Proc Natl Acad Sci 82, 7796-7800.

20. Moore LE, Clark RB, Shibata EF & Giles WR (1986). Comparison of steady-state

electrophysiological properties of isolated cells from bullfrog atrium and sinus venosus. J Memb Biol 89, 131-138.

21. Hume JR, Giles W, Robinson K, Shibata EF, Nathan R, Kanai K & Rasmusson R

(1986). A time- and voltage-dependent potassium current in single cardiac cells isolated from bullfrog atrium. J Gen Physiol 88, 777-798.

22. Robinson K & Giles W (1986). Data acquisition, display, and plotting programs for the

IBM PC. Comput Meth Prog Bio 23, :319-327. 23. Clark RB & Giles W (1987). Na+ current in single cells from bullfrog atrium: voltage-

dependence and ion transfer properties. J Physiol 391, 235-265. 24. Imaizumi Y & Giles W (1987). Quinidine-induced inhibition of a transient outward

current in cardiac muscle. Am J Physiol Heart Circ Physiol 253, H704-H708. 25. Shimoni Y & Giles W (1987). Separation of Na-Ca exchange current and transient

inward current in heart cells. Am J Physiol Heart Circ Physiol 253, H1330-H1333. 26. Nathan RD, Kanai K, Clark RB & Giles W (1988). Selective block of calcium current by

lanthanum in single bullfrog atrial cells. J Gen Physiol 91, 549-572. 27. van Ginneken ACG, Bouman LN, Jongsma HJ, Duivenvoorden JJ, Opthof T & Giles

WR (1988). Alinidine as a model of the mode of action of specific bradycardic agents on SA node activity. Eur Heart J 8, 25-33.

28. Belardinelli L, Giles W & West A (1988). Ionic mechanism of adenosine action in

pacemaker cells from rabbit heart. J Physiol 405, 615-633. 29. Campbell DL, Giles W & Shibata EF (1988). Ion transfer characteristics of the calcium

current in bullfrog atrial myocytes. J Physiol 403, 239-266. 30. Campbell DL, Giles W, Hume JR, Noble D. & Shibata EF (1988). Reversal potential of

the calcium current in bullfrog atrial myocytes. J Physiol 403, 267-286. 31. Campbell DL, Giles WR, Hume JR & Shibata EF (1988). Inactivation of calcium current

in bullfrog atrial myocytes. J Physiol 403, 287-315.

22

32. Campbell DL, Giles W, Robinson K & Shibata EF (1988). Studies of Na+/Ca2

exchanger in bullfrog atrial myocytes. J Physiol 403, 317-340. 33. Giles W & Imaizumi Y (1988). Comparison of potassium currents in rabbit atrial and

ventricular cells. J Physiol 405,123-145. 34. Clark RB, Giles WR & Imaizumi Y (1988). Properties of the transient outward current in

rabbit atrial cells. J Physiol 405, 147-168. 35. Fedida D, Shimoni Y & Giles WR (1989). A novel effect of norepinepherine on cardiac

cells is mediated by α1-adrenoceptors. Am J Physiol 256, H1500-H1504. 36. Giles W, Nakajima T, Ono K & Shibata EF (1989). Modulation of the delayed rectifier

K+ current by isoprenaline in bull-frog atrial myocytes. J Physiol 415, 233-249. 37. Giles W & Shimoni Y (1989). Slow inward tail currents in rabbit cardiac cells. J Physiol

417:447-463. 38. Giles W & Shimoni Y (1989). Comparison of sodium-calcium exchanger and transient

inward currents in single cells from rabbit ventricle. J Physiol 417, 465-481. 39. Ono K, Delay M, Nakajima T, Irisawa H & Giles W (1989). Calcitonin gene-related

peptide regulates calcium current in heart muscle. Nature 340, 721-723. 40. Nakajima T, Clark RB, Momose Y, Szabo G & Giles WR (1989). Two distinct types of

inwardly rectifying K+ channels in bull-frog atrial myocytes. J Physiol 424, 229-251.

41. Shibata EF, Drury T, Refsum H, Aldrete V, & Giles W (1989). Contributions of a

transient outward current in human atrium. Am J Physio 257, H1773-H1781. 42. Fedida D, Shimoni Y & Giles WR. α-Adrenergic modulation of the transient outward

current in rabbit atrial myocytes. J Physiol 423, 257-277. 43. Rasmusson R, Clark JW, Giles WR, Shibata EF & Campbell DL (1990). A

mathematical model of a bullfrog cardiac pacemaker cell. Am J Physiol Heart Circ Physiol 259, H352-H369.

44. Rasmusson R, Clark JW, Giles WR, Robinson K, Campbell DL, Clark RB & Shibata

EF (1990). A mathematical model of electrophysiological activity in the bullfrog atrial cell. Am J Physiol Heart Circ Physiol 259, H370-H389.

45. Shumaker JM, Clark JW, Giles WR & Szabo G (1990). A model of the muscarinic

receptor-induced changes in the electrical activity of the bullfrog atrial cell. Biophys J 57:567-576.

23

46. Clark RB, Giles WR & Tse A (1990). Electrophysiology of parasympathetic neurones isolated from the interatrial septum of bullfrog heart. J Physiol 427, 89-125.

47. Tse, A, Giles WR & Clark RB (1990). Muscarinic modulation of calcium current in

neurones from the interatrial septum of bull-frog heart . J Physiol 427, 127-149. 48. Nakajima T, Wu S, Irisawa H & Giles W (1990). Mechanism of acetylcholine-induced

inhibition of Ca current in bullfrog atrial myocytes. J Gen Physiol 96, 865-885. 49. Nakajima T, Irisawa H & Giles W (1990). N-ethylmaleimide uncouples muscarinic

receptors from acetylcholine-sensitive potassium channels in bullfrog atrium. J Gen Physiol 96, 887-903.

50. Akbarali H, Nakajima T, Wyse DG & Giles W (1990). Ca2+-activated K currents in

smooth muscle. Can J Physiol Pharmacol 68, 1489-1494. 51. Braun A, Fedida D, Clark R.B & Giles W (1990). Intracellular mechanisms for the

alpha-1 adrenergic regulation of the transient outward current in rabbit atrial myocytes. J Physiol 431, 689-712.

52. Kavanagh KM, Duff HJ, Clark R, Robinson KV, Giles WR & Wyse DG (1990).

Monophasic versus biphasic cardiac stimulation: Mechanism of decreased energy requirements. PACE 13, 1268-1277.

53. Kaibara M, Irisawa H, Nakajima T & Giles W (1991). Regulation of spontaneous

opening of muscarinic K+ channels in rabbit atrium. J Physiol 433, 589-613. 54. van Ginneken A & Giles WR (1991). Voltage clamp measurements of the

hyperpolarization-activated inward current If in single cells from rabbit sino-atrial node. J Physiol 434, 57-83.

55. Nakajima T, Kaibara M, Irisawa H & Giles W (1991). Inhibition of muscarinic receptor-

activated K+ current by N-ethylmaleimide in rabbit heart. Naunyn Schmiedebergs Archiv for Pharmacology 343, 14-19.

56. Ono K & Giles WR (1991). Electrophysiological (analysis) effects of calcitonin gene-

related peptide in bull-frog and guinea-pig atrial myocytes. J Physiol 436, 195-217.

57. Gotoh Y, Imaizumi Y, Watanabe M, Shibata EF, Clark RB & Giles WR (1991).

Inhibition of transient outward K current by 1,4-dihydropyridine Ca-antagonists and -agonists in rabbit cardiac myocytes. Am J Physiol 260, 1737-1742.

58. Fedida D, Braun A & Giles W (1991). α-1-Adrenoceptors reduce background K+

current in rabbit ventricular myocytes. J Physiol 441, 673-684.

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59. Fedida D & Giles W R (1991). Regional variations in the action potentials and transient outward current in myocytes isolated from rabbit left ventricle. J Physiol 442, 191-209.

60. Shumaker JM, Clark JW & Giles WR (1991). A model of the phase sensitivity of the

pacemaking cell in the bullfrog heart. J Theor Biol 151, 193-221. 61. Murphey CR, Clark JW Jr, Giles WR, Rasmusson RL, Halter J, Hicks K & Hoyt B

(1991). Conduction in bullfrog atrial strands: Simulations of the role of disc and extracellular resistance. Math Biosci 106, 39-84.

62. Murphey CR, Clark JW Jr. & Giles WR (1991). A model of slow conduction in bullfrog

atrial trabeculae. Math Biosci 106, 85-109. 63. Shumaker JM, Clark JW, & Giles WR (1991). A model of β-adrenergic effects on

calcium and potassium current in bullfrog atrial myocytes. Am J Physiol 261, H1937-1945.

64. Shimoni Y, Clark RB & Giles W (1992). Role of an inwardly rectifying K+ current in the

rabbit ventricular action potential. J Physiol 448, 709-727. 65. Akbarali HI, Wyse DG, & Giles WR (1992). Ionic currents in single cells from human

cystic artery. Circ Res 70, 536-545. 66. Ti-Dao, C, Delay M. & Giles, W (1992). Decrease of inward rectifier K+ currents by

intracellular acidification in rabbit myocytes. Chinese J Physiol Sc 7, 334-339. 67. Braun AP, Fedida D & Giles WR (1992). Activation of α1-adrenoceptors modulates the

inwardly rectifying potassium currents of mammalian and atrial myocytes. Pflugers Archiv 421, 431-439.

68. Akbarali HI & Giles WR (1993). Ca2+ and Ca2+-activated Cl- currents in rabbit

oesophageal smooth muscle. J Physiol 460:117-133, 1993. 69. Irisawa H, Brown HF & Giles W (1993). Cardiac pacemaking in the sinoatrial node.

Physiol Rev 73, 197-227. 70. Fedida D, Braun AP & Giles WR (1993). α1-adrenoceptors in myocardium: Functional

aspects and transmembrane signalling mechanisms. Physiol Rev 73, 469-487. 71. Shumaker JM, Clark JW & Giles WR (1993). Simulations of passive properties and

action potential conduction in an idealized bullfrog atrial trabeculum. Math Biosci 116, 127-167.

72. Bouchard RA, Clark RB & Giles WR (1993). Regulation of unloaded cell shortening by

sarcolemmal sodium-calcium exchange in isolated rat ventricular myocytes. J Physiol 469, 583-599.

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73. Bouchard RA, Clark RB & Giles WR (1993). Role of sodium-calcium exchange in activation of contraction in rat ventricle. J Physiol 472, 391-413.

74. Clark RB, Bouchard RA, Sanchez-Chapula JA, Salinas-Stefanon E & Giles W (1993).

Heterogeneity of action potential waveforms and potassium currents in rat ventricle. Cardiovasc Res 27, 1795-1799.

75. Han X, Habuchi Y, & Giles WR (1994). Relaxin increases heart rate by modulating

calcium current in cardiac pacemaker cells. Circ Res 74, 537-541. 76. Han X, Shimoni Y, & Giles WR (1994). An obligatory role of nitric oxide in autonomic

control of mammalian heart rate. J Physiol 476, 309-314. 77. Demir SS, Clark JW, Murphey CR & Giles WR (1994). A mathematical model of rabbit

sinoatrial node cell. Am J Physiol 266, 832-852. 78. Shimoni Y, Firek L, Severson D, & Giles WR (1994). Short-term diabetes alters K+

currents in rat ventricular myocytes. Circ Res 74, 620-628. 79. Clark RB, Kinsberg E & Giles WR (1994). Histochemical localization of nitric oxide

synthase in bullfrog intracardiac ganglion. Neurosci Lett 182, 255-258. 80. Shimoni Y, Han X, Giles WR (1995). Nitric Oxide: An important mediator of muscarinic

effects on ICa in mammalian sino-atrial node. Heart Vessels 9, 86-90. 81. Habuchi Y, Han X, Giles WR (1995). Comparison of the hyperpolarization-activated

and delayed rectifier currents in rabbit atrioventricular node and sinoatrial node. Heart Vessels 9, 203-206.

82. Bouchard RA, Clark RB & Giles WR (1995). Effects of action potential duration on

excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements. Circ Res 76, 790-801.

83. Clark RB, Sanchez-Chapula JA, Salinas-Stefanon E, Duff H & Giles W (1995).

Quinidine-induced open channel block of K+ current in rat ventricle. Brit J Pharmac 115, 335-343.

84. Han X, Shimoni Y & Giles WR (1995). A cellular mechanism for nitric oxide-mediated

cholinergic control of mammalian heart rate. J Gen Physiol 106, 141-163. 85. Firek L & Giles WR (1995). Outward currents underlying repolarization in human atrial

myocytes. Cardiovasc Res 39, 31-38. 86. Muraki K, Imaizumi Y, Watanabe M, Habuchi Y, & Giles WR (1995). Delayed rectifier

K+ current in rabbit atrial myocytes. Am J Physiol 269, H524-H532. 87. Shimoni Y, Severson D & Giles W (1995). Thyroid status and diabetes modulate

regional differences in potassium currents in rat ventricle. J Physiol 488, 673-688.

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88. Han X, Light PE, Giles WR & French RJ (1996). Identification and properties of an

ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells. J Physiol 490, 337-350.

89. Clark RB, Bouchard RA & Giles WR (1996). Action potential duration modulates

calcium influx Na+-Ca2+ exchange, and intracellular calcium release in rat ventricular myocytes. Ann of N Y Acad Sci 779, 417-429.

90. Tanaka H, Clark RB & Giles WR (1996). Positive chronotropic responses of rabbit

sino-atrial node cells to flash photolysis of caged isoproterenol and cyclic AMP. Proc Biol Sci 263, 241-248.

91. Lindblad D, Murphey CR, Clark JW & Giles WR (1996). A model of the action potential

and underlying membrane currents in a rabbit atrial cell. Am J Physiol Heart Circ Physiol 271, H1666-1696.

92. Shimoni Y, Han X, Severson D & Giles WR (1996). Mediation by nitric oxide of the

indirect effects of adenosine on calcium current in rabbit heart pacemaker cells. Brit J Pharm 119, 1188-1195.

93. Fiset C, Clark RB, Shimoni Y & Giles WR (1997). Shal-type channels contribute to the

Ca2+-independent transient outward K+ current in rat ventricle. J Physiol 500, 51-63.

94. Shimoni Y, Fiset C, Clark RB & Giles WR (1997). Thyroid hormone regulates postnatal

expression of transient K+ channel isoforms in rat ventricle. J Physiol 500, 65-73. 95. Ward CA & Giles WR (1997). Ionic mechanism of the effects of hydrogen peroxide in

rat ventricular myocytes. J Physiol 500, 631-642. 96. Ward CA, Ma Z, Lee SS & Giles WR (1997). Potassium currents in atrial and

ventricular myocytes from a rat model of cirrhosis. Am J Physiol 273,G537-G544. 97. Spitzer KW, Sato N, Tanaka H, Firek L, Zaniboni M & Giles WR (1997). Electrotonic

modulation of electrical activity in rabbit atrioventricular node myocytes. Am J Physiol 273, H767-H776.

98. Reinhardt PH, Ward CA, Giles WR & Kubes P (1997). Emigrated neutrophils adhere to

cardiac myocytes via α4-integrin. Circ Res 81, 196-201. 99. Fiset C, Clark RB, Larsen TS & Giles WR (1997). A rapidly activating sustained K+

current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J Physiol 504, 557-563.

100. Nygren A, Fiset C, Firek L, Clark JW, Lindblad DS, Clark RB & Giles WR (1998).

Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization Circ Res 82, 63-81.

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101. Witkowski FX, Clark RB, Larsen TS, Melkinov A & Giles WR (1997). Voltage-

sensitive dye recordings of electrophysiological activation in a Langendorff-perfused mouse heart. Can J Cardiol 13, 1077-1082.

102. Firek L, Giles WR (1997). Electrophysiological analyses of threshold conditions and

rate-dependent failure of excitation in single myocytes from rabbit ventricle. Can J Cardiol 13, 1113-1124.

103. Ohya M, Tanaka T, Oku Y, Asai Y, Watanabe M, Giles WR & Imaizumi Y (1998).

Molecular cloning and tissue distribution of an alternatively spliced variant of A-type K+ channel α-subunit, Kv4.3 in the rat. FEBS Letts 420, 47-53.

104. Witkowski FX, Leon LJ, Penkoske PA, Spano ML, Ditto WL & Giles WR (1998). A

method for visualization of ventricular fibrillation: design of a cooled fibreoptically coupled image intensified CCD data acquisition system incorporating wavelet shrinkage based adaptive filtering. Chaos 8, 94-102.

105. Witkowski FX, Leon LJ, Penkoske PA, Giles WR, Spano ML, Ditto WL & Winfree AT

(1998). Spatiotemporal evolution of ventricular fibrillation. Nature 392, 78-82. 106. Light P, Shimoni Y, Harbison S, Giles WR & French RB (1998). Hypothyroidism

decreases the ATP sensitivity of K-ATP channels from rat heart. J Membr Biol 162, 217-223.

107. Cordeiro J, Spitzer KW & Giles WR (1998). Repolarizing K+ currents in rabbit heart

Purkinje cells. J Physiol 508, 811-823. 108. MacDonell KL, Severson DL & Giles WR (1998). Depression of excitability by

sphingosine-I-phosphate in rat ventricular myocytes. Am J Physiol 275, H2291-H2299.

109. Demir SS, Clark JW & Giles WR (1999). Parasympathetic modulation of sinoatrial

node pacemaker activity in rabbit heart: a unifying model. Am J Physiol 276, H2221-H2244.

110. Larsen TS, Dani R, Severson DL & Giles WR, Lopaschuk GD, Belke D & Tyberg JV

(1999). The isolated working mouse heart: methodological considerations. Pflugers Archiv 437, 979-985.

111. Poon BY, Ward CA, Giles WR & Kubes P (1999). Emigrated neutrophils regulate

ventricular contractility via α4 integrin. Circ Res 84, 1245-1251. 112. Guo J, MacDonell KL & Giles WR (1999). Effects of sphingosine-l-phosphate on

pacemaker activity in rabbit sino-atrial node cell. Pflugers Archiv 438, 642-648.

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113. Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J Jr, Kranias EG, Giles WR & Chien KR (1999). Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99, 313-322.

114. Akbarali HI, Thatte H, Dao He X, Giles WR, & Goyal RK (1999). Role of HERG-like

K+ currents in opossum osophageal circular smooth muscle. Am J Physiol 277, C1284-C1290.

115. Nguyen-Tran VTB, Minamisawa S, Kubalak SW, Barrere-Lemaire S, Fiset C, Wollert

KC, Brown AB, Buckingham M, Rahme MM, Feld GK, Clark RB, Giles WR & Chien KR (2000). A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell 102, 671-682.

116. Nygren A & Giles WR (2000). Mathematical simulation of slowing of cardiac

conduction velocity by elevated extracellular [K+] in a human atrial strand. Ann Biomed Eng 28, 951-957.

117. Sheng JZ, Prinsen CFM, Clark RB, Giles WR & Schnetkamp PPM (2000). Na+-Ca2+-

K+ currents measured in insect cells transfected with the retinal cone or rod Na+-Ca2+-K+ exchanger cDNA. Biophys J 79, 1945-1953.

118. Guo J, Giles WR, & Ward CA (2000). Effect of hydrogen peroxide on the membrane

currents of sinoatrial node cells from rabbit heart. Am J Physiol 279, H992-H999. 119. Nygren A, Clark RB, Belke D, Kondo C, Giles WR & Witkowski FX (2000). Voltage-

sensitive dye mapping of activation and conduction in adult mouse hearts. Ann Biomed Eng 28, 958-967.

120. Sato N, Tanaka H, Habuchi Y, & Giles W (2000). Electrophysiological effects of

ibutilide on the delayed rectifier K+ current in rabbit sinoatrial and atrioventricular node cells. Eur J Pharmacol 404, 281-288.

121. Gloss B, Trost SU, Bluhm WF, Swanson EA, Clark R, Winkfein R, Janzen KM, Giles

WR, Chassande O, Samarut J & Dillman WH (2001). Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor α or β. Endocrinology 142, 544-550.

122. Poon BY, Ward CA, Cooper CB, Giles WR, Burns AR, & Kubes P (2001). α4-Integrin

mediates neutrophil-induced free radical injury to cardiac myocytes. J Cell Biol 152, 857-866.

123. Cordeiro JM, Spitzer KW, Giles WR, Ershler PE, Cannell MB & Bridge JHB (2001).

Location of the initiation site of Ca2+ transients and spikes in rabbit heart Purkinje cells. J Physiol 531, 301-314.

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124. Ohya S, Tanaka M, Oku T, Furuyama T, Mori N, Giles WR, Watanabe M & Imaizumi Y (2001). Regional expression of splice variants of Kv4.3 in rat brain and effects of C-terminus deletion on expressed K+ currents. Life Sciences 68, 1703-1716.

125. Nygren A, Leon LJ & Giles WR (2001). Simulations of the human atrial action

potential. Phil Trans R Soc Lond 356, 1111-1125. 126. Clark RB, Tremblay A, Melnyk P, Allen BG, Giles WR & Fiset C (2001). T-tubule

localization of inward-rectifier K+ channel in mouse ventricular myocytes: a role in K+ accumulation. J Physiol 537, 979-992.

127. Pandit SV, Clark RB, Giles WR & Demir SS (2001). A mathematical model of action

potential heterogeneity in adult rat left ventricular myocytes. Biophys J 81, 3029-3051.

128. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyen-Tran VTB, Gu Y,

Ross J Jr, Giles WR & Chien KR (2001). A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of Ito and confers susceptibility to ventricular tachycardia. Cell 107, 801-813.

129. Oehmen CS, Giles WR & Demir SS (2002). A mathematical model of the rapidly

activating delayed rectifier potassium current, IKr, in rabbit sinoatrial node. J Cardiovasc Electrophysiol 13, 1131-1140.

130. Pandit SV, Giles WR & Demir SS (2003). A mathematical model of the

electrophysiological alterations in rat ventricular myocytes in Type-I diabetes. Biophys J 84, 832-841.

131. Nygren A, Kondo C, Clark RB & Giles WR (2003). Voltage-sensitive dye mapping in

Langendorff-perfused rat heart. Am J Physiol Heart Circ Physiol 284, H892-H902. 132. Hatano H, Ohya S, Muraki K, Giles W & Imaizumi Y (2003). Dihydropyridine Ca2+

channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K+ channels expressed in HEK293 cells. Brit J Pharmacol 139, 533-544.

133. Lomax AG, Sharkey KA & Giles WR (2003). Neuropeptide Y modulates L-type Ca2+

current during heart development. Circ Res 93, 891-892. 134. Fox JE, Magga J, Giles WR & Light PE (2003). Acyl Coenzyme A esters

differentially activate cardiac and β-cell adenosine triphosphate-sensitive potassium channels in a side-chain length specific manner. Metabolism 52, 1313-1319.

135. Baczko I, Giles WR & Light PE (2003). Resting membrane potential regulates Na+-

Ca2+ exchange-mediated Ca2+ overload during hypoxia-reoxygenation in rat ventricular myocytes. J Physiol 550, 889-898.

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136. Rose RA, Lomax AE & Giles WR (2003). Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: NPR-C mediated effect. Am J Physiol Heart Circ Physiol 285, 2454-2462.

137. Lomax AE, Kondo CS & Giles WR (2003). Comparison of time- and voltage-

dependent K+ currents in myocytes from left and right atria of adult mice. Am J Physiol Heart Circ Physiol 285, H1837-H1848.

138. Lomax AE, Rose RA & Giles WR (2003). Electrophysiological evidence for a

gradient of G protein-gated K+ current in adult mouse atria. Br J Pharmacol 140, 576-584.

139. Hatano N, Ohya SG, Muraki K, Clark RB, Giles WR & Imaizumi Y (2004). Two

arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current through Kv 4 channel subfamily. J Biol Chem 279, 5450-5459.

140. Clark RB, Mongoni ME, Lueger A, Nargeot J & Giles WR (2004). A rapidly activating

delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells. Am J Physiol Heart Circ Physiol 286, H1757-H1766.

141. Baczko I, Giles WR & Light PE (2004). Pharmacological activation of plasma-

membrane KATP channels reduces reoxygenation-induced Ca2+ overload in cardiac myocytes via modulation of the diastolic membrane potential. Brit J Pharm 141, 1059-1067.

142. Rose RA, Lomax AE, Kondo CS, Anand-Srivastava MB, & Giles WR (2004). Effects

of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: A role for the NPR-C receptor. Am J Physiol Heart Circ Physiol 286, H1970-H1977.

143. Bouchard R, Clark RB, Juhasz AE & Giles WR (2004). Changes in extracellular K+

concentration modulate contractility of rat and rabbit cardiac myocytes via the inward rectifier K+ current IK1. J Physiol 556, 773-790.

144. Pashmforoush M, Lu JT, Kondo R, Evans S, Clark RB, St. Amand T, Feramisco JR,

Giles WR, Ho SY, Benson DW, Silberbach M & Chien KR (2004). Nkx2-5 pathways and congenital heart disease: Loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 117, 373-386.

145. Wilson JR, Duncan NA, Giles WR & Clark RB (2004). A voltage-dependent K+

current contributes to membrane potential of acutely isolated canine articular chondrocytes. J Physiol 557, 93-104.

146. Nygren A, Lomax AE & Giles WR (2004). Heterogeneity of action potential durations

in isolated mouse left and right atria recorded using voltage-sensitive dye mapping. Am J Physiol Heart Circ Physiol 287,H2634-H2643.

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147. Brouillette J, Clark RB, Giles WR & Fiset C (2004). Functional properties of K+ currents in adult mouse ventricular myocytes. J Physiol 559, 777-798.

148. Chilton L, Ohya S, Freed D, George E, Drobic V, Shibukawa Y, MacCannell KA,

Imaizumi Y, Clark RB, Dixon IMC & Giles WR (2005). K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. Am J Physiol Heart Circ Physiol 288, H2931-H2939.

149. Baczko I, Jones L, McGuigan C, Manning Fox JE, Gandhi M, Giles WR, Clanachan

AS & Light PE (2005). Plasma-membrane KATP channel-mediated cardioprotection involves post-hypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. Faseb J 19, 980-982.

150. Grattan MJ, Kondo C, Thurston J, Alakija P, Burke BJ, Stewart C, Syme D & Giles

WR (2005). Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss muscular dystrophy. In: Nuclear Organization in Development and Disease, Novartis Symposium 264, pp. 118-139. John Wiley & Sons, Ltd.

151. Shibukawa Y, Chilton EL, MacCannell KA, Clark RB & Giles WR (2005). K+ currents

activated by depolarization in cardiac fibroblasts. Biophys J 88, 3924-3935. 152. Rose RA, Anand-Srivastava MB, Giles WR & Baines JS (2005). C-type natriuretic

peptide inhibits L-type Ca 2+ current in rat magnocellular neurosecretory cells by activating the NPR-C receptor. J Neurophysiol 94, 612-621.

153. Giles WR (2005). Supraventricular pacemaker activity in the canine heart:

Contributions from HCN channels in control conditions and in a model of heart failure. Cardiovasc Res 66, 430-432.

154. Ward CA, Bazzazi H, Clark RB, Nygren A & Giles WR (2006). Actions of emigrated

neutrophils on Na+ and K+ currents in rat ventricular myocytes. Prog Biophys Mole Biol 90, 249-269.

155. Fink M, Giles WR & Noble D (2006). Contributions of inwardly-rectifying K+ currents

to repolarization assessed using mathematical models of human ventricular myocytes. Philos Transact A Math Phys Eng Sci 364, 1207-1222.

156. Nygren A, Baczko I & Giles W (2006). Measurements of electrophysiological effects

of components of acute ischaemia in Langendorff-perfused rat hearts using voltage-sensitive dye mapping. J Cardiovasc Electrophysiol 17, S113-S123.

157. dos Santos RW, Campos FO, Ciuffo LN, Nygren A, Giles W & Koch H (2006). ATX-

II effects on the apparent location of M cells in a computational model of a human left ventricular wedge. J Cardiovasc Electrophysiol 17, S86-S95.

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158. Bazzazi H, Clark RB & Giles WR (2006). Mathematical simulations of the effects of altered AMP kinase activity on INa and the action potential in rat ventricle. J Cardiovasc Electrophysiol 17, S162-S168.

159. Kondo RP, Dederko DA, Teutsch CA, Chrast J, Catalucci D, Chien KR & Giles WR (2006). Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: A role for repolarization waveform. J Physiol 15, 131-146.

160. Ochi R, Momose Y, Oyama K & Giles WR (2006). Sphingosine-1-phosphate effects

on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. Cardiovas Res 70, 88-96.

161. Fiset C & Giles WR (2006). Transmural gradients of repolarization and excitation-

contraction coupling in mouse ventricle. Circ Res 98, 1237-1239. 162. Baudino T, Carver W, Giles W & Borg TK (2006). Cardiac Fibroblasts: friend or foe?

Am J Physiol Heart Circ Physiol 291, H1015-H1026. Review 163. Flaim SN, Giles WR & McCulloch AD (2006). Contributions of sustained INa and

IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. Am J Physiol Heart Circ Physiol 291, H2617-H2629.

164. Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S &

Omens JH (2006). Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys 46, 113-122.

165. Wu BN, Luykenaar KD, Brayden JE, Giles WR, Corteling RL, Wiehler WB & Welsh

DG (2007). Hyposmotic challenge inhibits inward rectifying K+ channel in cerebral arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 292, H1085-H1094.

166. Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien KR & Giles WR (2007). Spatial

distributions of Kv4 channels and KChiP2 isoforms in the murine heart based on laser capture microdissection. Cardiovasc Res 73, 739-749.

167. MacCannell KA, Bazzazi H, Chilton L, Shibukawa Y, Clark RB & Giles WR (2007). A

mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts. Biophys J 92, 4121-4132.

168. Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HSV, Akasaka T, Yasuda S,

Metzger J, Giles WR, Posakony JW & Bodmer R (2007). : KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging . Proc Natl Acad Sci (USA) 104, 3943-3948

169. Rose RA, Hatano N, Ohya S, Imaizumi Y & Giles WR (2007). C-type natriuretic

peptide activates a non-selective cation current in acutely isolated rat cardiac

33

fibroblasts via natriuretic peptide C receptor-mediated signalling. J Physiol 580, 255-274.

170. Landeen LK, Aroonsakool N, Hu BS, & Giles WR (2007). Sphingosine-1-phosphate

receptor expression in cardiac fibroblast cells is modulated by in vitro culture conditions. Am J Physiol Heart Circ Physiol 292, H2698-H2711.

171. Hu BS, Landeen LK, Aroonsakool N & Giles WR (2007). An analysis of the effects of

stretch on IGF-1 secretions from rat ventricular fibroblasts. Am J Physiol Heart Circ Physiol 293, H677-H683.

172. Hesse M, Kondo CS, Clark RB, Su L, Allen FL, Geary-Joo CT, Kunnathu S,

Severson DL, Nygren A, Giles WR & Cross JC (2007). Dilated cardiomyopathy associated with reduced expression of the major cardiac sodium channel Scn5a. Cardiovasc Res 75, 498-509.

173. Flaim SN, Giles WR & McCulloch AD (2007). Arrhythmogenic consequences of

Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: An analysis of the I1768V SCN5A mutation. Heart Rhythm 4, 768-778.

174. London B, Albert C, Anderson ME, Giles WR, Van Wagoner DR, Balk E, Billlman

GE, Chung M, Lands W, Leaf A, McAnulty J, Martens JR, Costello RB & Lathrop DA (2007). Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research. A report from the National Institute and Office of Dietary Supplements omega-3 fatty acids and their role in cardiac arrhythmogenesis workshop. Circulation 116, e320-e335.

175. Chilton L, Giles WR & Smith GL (2007). Evidence of intercellular coupling between

co-cultured adult rabbit ventricular myocytes and myofibroblasts. J Physiol 583, 225-236.

176. Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W,

Naviaux RK, Giguere V & Evans RM (2007). ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab 6, 13-24.

177. Fink M, Noble D, Virag l, Varro A & Giles WR (2008). Contributions of HERG K+

current to repolarization of the human ventricular action potential. Prog Biophys Mol Biol 96, 357-376.

178. Landeen LK, Dederko DA, Kondo CS, Hu BS, Aroonaskool N, Haga JH & Giles WR

(2008). Mechanisms of the negative inotropic effects of sphingosine-1-phospate on adult mouse ventricular myocytes. Am J Physiol Heart Circ Physiol 294, H736-H749.

179. Rose RA & Giles WR (2008). Natriuretic peptide C receptor signalling in the heart

and vasculature. J Physiol 586, 353-366.

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180. Fiset C & Giles WR (2008). Cardiac troponin T mutations promote life-threatening arrhythmias. J Clin Invest 118, 3845-3847.

181. Maleckar MM, Greenstein JL, Giles WR & Trayanova NA (2008). Mathematical

simulations of ligand-gated and cell-type specific effects on the action potential of human atrium. Prog Biophyd Mol Biol 98, 161-170.

182. Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte JC, Giles W,

Bodmer R & Ocorr K (2009). A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 46, 101-113.

183. Figura M, Chilton L, Liacini A, Viskovic MM, Phan V, Knight D, Millar TM, Patel K,

Kubes P, Giles WR & Tibbles LA (2009). Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia. Am J Transplant 9, 1-10.

184. Maleckar MM, Greenstein JL, Giles WR & Trayanova NA (2009). K+ current

changes account for the rate dependence of the action potential in the human atrial myocyte. Am J Physiol Heart Circ Physiol 297, H1398 – H1410.

185. Maleckar MM, Greenstein JL, Giles WR & Trayanova NA (2009). Electrotonic

coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization. Biophys J 97, 2179 – 2190.

186. Weber dos Santos R, Nygren A, Octaviano Campos F, Koch H & Giles WR (2009).

Experimental and theoretical ventricular electrograms and their relation to electrograms and their relation to electrophysiological gradients in the adult rat heart. Am J Physiol Heart Circ Physiol 297, H1521 – H1534.

187. Funabashi K, Ohya S, Yamamura H, Hatano N, Muraki K, Giles W & Imaizumi Y

(2010). Accelerated Ca2+ entry by membrane hyperpolarization due to Ca2+-activated K+ channel activation in response to histamine in chondrocytes. Am J Physiol Cell Physiol 298, C786 – C796.

188. Banderali U, Juranka PF, Clark RB, Giles WR & Morris CE (2010). Impaired stretch

modulation in potentially lethal cardiac sodium channel mutants. Channels 4, 1-10.

189. Clark RB, Hatano N, Kondo C, Belke DD, Brown BS, Kumar S, Votta BJ & Giles WR

(2010). Voltage-gated K+ currents in mouse articular chondrocytes regulate membrane potential. Channels 4, 1-13.

190. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo

B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS & Roth DM (2010). Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase anchoring peptide reduces cardiac function. J Biol Chem 285, 27632-27640.

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191. Corrias A, Giles W & Rodriguez B (2011). Ionic mechanisms of electrophysiological

properties and repolarization abnormalities in rabbit Purkinje fibers. Am J Physiol Heart Circ Phys 300, H1806-H1813.

192. Banderali U & Giles WR (2011). Repolarization of the mammalian heart action

potential is modulated by changes in osmotic strength. Cardiovasc Res 91, 376-377.

193. Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton

RAB, Cerbai E, Chen PS, Delmar M, DiFrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, White E, Wilders R, Winslow RL & Kohl P (2011). Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol 107, 4-10.

194. Wilson JR, Clark RB, Banderali U & Giles WR (2011). Measurement of the

membrane potential in small cells using patch clamp methods. Channels 5, 1-8.

195. Clark RB, Kondo C, Belke DD & Giles WR (2011). Two-pore domain K+ channels

regulate membrane potential of isolated human articular chondrocytes. J Physiol 589, 5071-5089.

196. Ajiro Y, Saegusa N, Giles WR, Stafforini D & Spitzer KW (2011). Platelet activating

factor stimulates sodium-hydrogen exchange in ventricular myocytes. Am J Physiol Heart Circ Phys 301, H2395-H2401.

197. Banderali U, Belke D, Singh A, Jayanthan A, Giles WR & Narendran A (2011).

Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1. Cell Physiol Biochem 28, 1169-1180.

198. Yi T, Wong J, Feller E, Sink S, Taghli-Lamallem O, Wen J, Kim C, Fink M, Giles W,

Soussou W & Vincent Chen HS (2011). Electrophysiological mapping of embryonic mouse hearts: Mechanisms for developmental pacemaker switch and intermodal conduction pathway. J Cardiovasc Electrophysiol 23, 309-318.

199. Banderali U, Jayanthan A, Narendran A & Giles WR (2012). Ion channels in

pediatric CNS-Atypical-teratoid/rhabdoid (AT/RT) tumor cells: Potential targets for novel therapeutics. J Neurooncol 107, 111-119.

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200. Rose RA, Belke DD, Maleckar MM, Giles WR (2012). Ca2+ entry through TRP-C

channels regulates fibroblast biology in chronic atrial fibrillation. Circulation 126: 2039-2041.

201. Trenor B, Gomis-Tena J, Cardona K, Romero L, Rajamani S, Belardinelli L, Giles,

WR, Saiz J (2012). In silico assessment of drug safety in human heart applied to late sodium current blockers. Channels (Austin) 7(4): 1-14.

202. Trenor B, Cardona K, Saiz J, Rajamani S, Belardinelli L, Giles WR (2013). Carbon

monoxide effects on human ventricle action potential assessed by mathematical simulations. Front Physiol 4: Article 282.

203. Koivumäki J, Clark RB, Belke D, Kondo C, Fedak P, Maleckar MM, Giles WR

(2014). Na+ current expression in human atrial myofibroblasts: its identity and functional consequences. Front Physiol 5: Article 275.

204. Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S,

Clancy C (2015). A computational modeling approach combined with cellular electrophysiology data predicts therapeutic benefit of targeting late INa. J Physiol 593.6, 1429-1442.

205. Belardinelli L, Giles WR, Rajamani S, Karagueuzian HS, Shryock JC (2015).

Cardiac late Na+ current: proarrhythmic effects, roles in long QT syndromes, and pathologic relationship to CaMKII and oxidative stress. Heart Rhythm. 12: 440-448. doi.org/ 10.1016/j.hrthm.2014.11.009

206. Inayama M, Suzuki Y, Kurita T, Yamamura H, Ohya A, Giles WR, Imaizumi Y

(2015). Orai1-Orai2 complex initiates store-operated calcium entry in chondrocytes. Cell Calcium. 57:337-347. doi.org/10.1016/j.ceca.2015.02.005

207. Kurita T, Yamamura H, Suzuki Y, Giles WR, Imaizumi Y. The CIC-7 cloride channel

is downregulated by hypoosmotic stress in human chondrocytes. Mol Pharmacol Fast Forward (published online May 2014) DOI: 10.1124/mol.115.098160

208. Hatano N, Ohya A, Imaizumi Y, Clark RB, Giles WR (2013). ATP activates a

chloride current and regulates proliferation in short-term cultured rat cardiac fibroblasts. J Physiol Accepted.

209. Inayama M, Suzuki Y, Yamada S, Kurita T, Yamamura H, Ohya S, Giles WR,

Imaizumi Y(2015). Orai1-Orai2 complex is involved store-operated calcium entry in chondrocyte cell lines. Cell Calcium 57, 337 – 347.

210. Kurita T, Yamamura H, Suzuki Y, Giles WR, Imaizumi Y (2015). The CIC-7 chloride

channel is downregulated by hypoosmotic stress in human chondrocytes. Mol Pharmacol 88, 113 – 120.

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SUBMITTED MANUSCRIPTS:

1. Cardona K, Trenor B, Romero L, Gomez J, Saiz J, Rajamani S, Belardinelli L Giles WR. (2013) Low Plasma [K+]o is pro-arrhythmic in human ventricle: an illustration with mathematical simulations. Circulation Arrythmia Electrophysiol (Aug 2014)

2. Banderali U, Jayanthan A, Ruan Y, Perinpanayaga MA, Belke DD, Giles WR.

Identification of the differential expression and functional consequences of potassium currents for potential therapeutic intervention in pediatric acute leukemia. BMC Cancer (submitted Dec 2014)

3. Trenor B, Cardona K, Saiz J, Noble D, Giles WR. Repolarization Dynamics in the

Mammalian Heart. J Physiol Topical Review (submitted, May 2015) MANUSCRIPTS IN PREPARATION: 1. Maleckar MM, Narayanan H, Clark RB, Giles WR. Functional roles of K+ currents in the

human articular chondrocyte. Biophys J

2. Yang PC, Romero-Perez L, El-Bizri N, Giles WR, Rajamani S, Belardinelli L, Clancy

CE. A computational model predicts adjunctive pharmacotherapy for cardiac safety via inhibition of the late Na current. Am J Physiol Heart Circ Physiol

3. Yang PC,Romero-Perez L, El-Bizri N, Giles WR, Rajamani S, Belardinelli L, Clancey

CE. A computational Model predicts effective antiarrhythmic adjunctive therapy by pharmacological targeting of late Na current by the preclinical drug GS-458967. Am J Physiol Heart Circ Physiol

4. Cardona K, Trenor B, Giles W. Assessment of Intracellular Na+ Levels as a

Consequence of Activation/Enhancement of Late Na+ Current in Human Ventricle. J Physiol

5. Schmidt t, Clark RB, Sasche F, Boyle D, Firestein G, Giles WR. Cellular electro

physiology can provide insights into excitation secretion coupling in human synovial fibroblasts. Topical Review. J Physiol

CHAPTERS AND MONOGRAPHS: 1. Eisner D, Lederer W & Giles W (1982). Pacemaker activity in cardiac Purkinje

fibers. In: Cellular Pacemakers, ed. Carpenter DO, pp. 67-91. John Wiley and Sons, New York.

2. Giles W, Lederer W & Eisner D (1982). Sinus pacemaker activity in the heart. In:

Cellular Pacemakers, ed. Carpenter DO, pp. 91-127. John Wiley and Sons, New York.

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3. Giles W, Brown AM (1983). Heart Muscle. In: Textbook of Physiology, ed. Brown AM & Stubbs D, pp. 97-117. John Wiley and Sons Inc., New York.

4. Giles W (1982). Smooth Muscle. In: Textbook of Physiology, ed. Brown AM &

Stubbs D., pp. 117-129. John Wiley and Sons Inc, New York. 5. Shibata EF, Momose Y & Giles W (1984). Nitrendipine actions on atrial tissue in the

heart. In: Nitrendipine, ed. Scriabine A, pp. 199-208. Urban and Schwarzenberg Ltd, Baltimore, MD.

6. Giles W, van Ginneken A, & Shibata EF (1985). Ionic currents underlying cardiac

pacemaker activity: A summary of voltage clamp data from single cells. In: Cardiac Muscle: The Regulation of Excitation and Contraction, ed. Nathan RD, pp. 1-27. Academic Press Inc, New York.

7. West GA, Giles W & Belardinelli L (1987). The negative chronotropic effect of

adenosine in sinus node cells. In: Topics and Perspectives in Adenosine Research, ed. Gerlach E & Becker BF, pp. 336-344. Springer-Verlag (1987).

8. Giles W (1988). Intracellular electrical activity in heart. In: Textbook of Physiology

and Biophysics, Vol. 2, ed. Patton H, Fuchs E, Hille B, Scher AM & Steiver A, pp. 782-796. W.B. Saunders Company Ltd.

9. Campbell DL & Giles W (1989). Calcium currents in cardiac muscle. In: Calcium

and the Heart, ed. Langer GA, pp. 27-83. Raven Press, New York. 10. Irisawa H & Giles W (1990). Sinus and atrio-ventricular node cells: Cellular

electrophysiology. In: Cardiac Electrophysiology and Arrhythmias from Cell to Bedside, ed. Zipes DP & Jalife J, pp. 95-103. W.B. Saunders Company Ltd, New York.

11. Billette J & Giles W (1991). Conduction refractoriness and ionic currents in the

atrioventricular node. In: Basic and Clinical Electrophysiology and Pharmacology of the Heart, ed. Dangman KH & Miura DS, pp 141-160. Marcel Dekker Inc, New York.

12. Braun AP, Walsh MP, Clark RB & Giles WR (1992). α1-adrenergic effects on K+

currents and membrane-associated GTPase activity in single cells from rabbit atrium and ventricle. In: Ion Channels in the Cardiovascular System, ed. Brown AM, Spooner P, Catterall W, Kaczorowski GJ & Strauss HC, pp 221-236. Futura Publishing Company Inc, Armonk, New York.

13. Clark JW, Shumaker JM, Murphey CR & Giles WR (1991). Mathematical models of

pacemaker tissue in the heart. In: Theory of the Heart: Biomechanics, Biophysics and Nonlinear Dynamics of Cardiac Function. ed. L Glass L, Hunter P & McCulloch A pp. 256-288. Springer-Verlag, New York.

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14. Giles W (1995). Generation of Pacemaker Activity in the Mammalian Sino-atrial Node. In: Pacemaker Activity and Intracellular Communication, ed. Huizinga JD, pp 21-34. CRC Press Inc, Boca Rotan, Florida, U.S.A.

15. Giles W, Clark RB & Braun A (1996). Ca2+-independent transient outward current in

mammalian heart. In: Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters, ed. Morad M, Kurachi Y, Noma A & Hosada M, pp 141-168. Kluwer Press Ltd, Amsterdam.

16. Banderali U, Clark RB, Morris CE, Fink M, Giles WR (2010). Effects of applied

stretch on native and recombinant cardiac Na+ currents. In: Mechanosensitivity of the Heart: Mechanosensitivity in Cells and Tissues. Kamkin A, Kiseleva I. Springer pp 169-184.

17. Giles, Wayne (2013) Electrophysiological properties of cardiac and synovial

fibroblasts modulate excitation-secretion coupling. International Innovation: Healthcare (Research Media, UK) 20: pp 115-117.

18. MacCannell KA, Chilton L, Smith GL, Giles WR (2015) Mathematical simulations of

sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes. In: Cardiac Fibrosis and Heart Failure: Cause or Effect? Dixon MC, Wigle, JT. Springer. In Press. pp 299 – 322.

19. Clark RB, Giles WG (2015). Current voltage relationship for late Na+ current in rat

ventricular myocyte. Elsevier.

Editorials 1. Noble D & Giles W (2006). Cellular Na(+) homeostastis in the mammalian heart:

relationship to altered contractility, rhythm disturbances, and defects in myocyte metabolism. J Cardiovasc Electrophysiol 17, Suppl 1:S1.

2. Giles WR, Campos FO, Davenport MH, dos Santos RW & Nygren A (2013) High heart rate in pregnancy is modulated by augmented expression of an ion channel, If, in pacemaker tissue. Circulation 127, 2003-2005.

Letters to the Editor Other Publications 1. Campos FO, Costa CM, dos Santos RW, Nygren A, Clark RB, Giles W. Modelling

the action potential in mouse sinoatrial node myocytes. Proceedings of the 2009 World Congress on Medical Physics and Biomedical Engineering (IFMBE Proceedings 25/IV), Munich, Germany, Sep. 7-12, 2009: 2211-2215.

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ABSTRACTS: (this is not a comprehensive list) 1. Giles WR, Tsien RW (1974). Effects of acetylcholine on membrane currents in

bullfrog atrial muscle. J Physiol 246, 64-66P. 2. Blood BE, Giles WR & Noble SJ (1975). Effects of atropine on membrane currents

and twitch tension in bullfrog atrium. J Physiol 254, 44-45P. 3. Brown HF, Giles W & Noble SJ (1976). Voltage clamp of frog sinus venosus. J

Physiol 258, 78-79P. 4. Brown HF, Giles W & Noble SJ (1977). Cholinergic inhibition of frog sinus venosus.

J Physiol 267, 38-39P. 5. Cohen I, Eisner DA, Giles WR & Noble D (1977). Effect of adrenaline on the

potassium current reversal potential in sheep cardiac Purkinje fibres. J Physiol 272, 53-55P.

6. Fleming B, Giles W & Lederer J (1979). Are acetylcholine-induced increases in

potassium efflux mediated by intracellular cyclic GMP in cardiac pacemaker tissue? J Physiol 292, 69-70P.

7. Fleming B & Giles W (1979). A23187 effects on 42K efflux in cardiac pacemaker

tissue. Faseb J 22:#4, 39p. 8. Giles W, Hume J & Noble SJ (1980). The ionic mechanism underlying the interval-

duration relationship in bullfrog atrium. J Physiol 305, 62-63P. 9. Shibata EF & GilesW (1980). Threshold effects of autonomic transmitters on primary

pacemaker cells in rabbit sino-atrial node. Faseb J 39, 2483. 10. Brown AM, Giles W, Hume J & Lee KS (1981). Voltage clamp analysis of lidocaine

and quinidine induced depression of the sodium current in isolated rat ventricular cells. J Physiol 307, 62-63P.

11. Giles W & Hume J (1981). Intracellular recordings from single isolated bullfrog atrial

cells. J Physiol 307, 3P. 12. Shibata EF & Giles W (1981). Effects of Ni++ and muscarine on primary pacemaker

cells in rabbit sino-atrial node. Biophys J 33, 34a. 13. Hume JR & Giles W (1981). Electrical constants of single frog atrial cells. Biophys J

33, 34a. 14. Hume J R & Giles W (1981). Inward current underlying the ̀ slow response' in single

bullfrog atrial cells. J Physiol 317, 53-54P.

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15. Giles W, Hume JR, Momose Y & Szabo G (1981). Acetylcholine-induced outward current in voltage-clamped bullfrog atrial cells. J Physiol 320, 37-38P.

16. Hume JR & Giles W (1982). Turn-off of a TTX-resistant inward current iCa in single

bullfrog atrial cells. Biophys J 37, 240a. 17. Hume JR & Giles W (1982). Outward current in single bullfrog atrial cells. Biophys J

37, 239a. 18. Momose Y, Szabo G & Giles W (1982). Acetylcholine-induced outward current in

single bullfrog atrial cells. Biophys J 37, 238a. 19. Baker D, Momose Y, Giles W & Szabo G (1983). 3H-QNB binding, voltage-clamp

and patch-clamp studies. Biophys J 41, 137a. 20. Nathan RD & Giles W (1983). La3+ selectively blocks calcium current in single cells

isolated from bullfrog atrium. Biophys J 41, 291a. 21. Momose Y, Szabo G & Giles W (1983). An inwardly rectifying K+ current in bullfrog

atrial cells. Biophys J 41, 311a. 22. Campbell DL, Robinson K & Giles W (1983). Voltage-dependent inactivation-

reactivation of TTX-resistant inward current in single cells from bullfrog atrium. Biophys J 41, 311a.

23. Shibata E & Giles W (1983). Transmembrane ionic currents in single cardiac

pacemaker cells. Biophys J 41, 310a. 24. Giles W, Shibata EF & Smith G (1983). A TTX-insensitive transient inward current in

isolated myocytes from rabbit atrium. J Physiol 345, 151p. 25. Giles W, Momose Y & Shibata E (1983). Nitrendipine actions on transmembrane

Ca++ and K+ currents in isolated atrial cells. The Physiologist 26, A-90. 26. Shibata EF, Momose Y & Giles W (1983). Measurement of an electrogenic Na+/K+

pump current in individual bullfrog atrial myocytes. Proc Int Union Physiol XV, 138.17.

27. Shibata EF, Giles W (1983). Ionic currents in isolated cardiac pacemaker cells from

bullfrog sinus venosus. Proc Int Union Physiol XV, 167.07. 28. Giles W, Robinson K, Shibata EF & Hume JR (1984). Repolarization in cardiac

muscle: An experimental and theoretical study using single cells from bullfrog atrium. Biophys J 45, 278a.

29. Shibata, EF, Giles W (1984). Cardiac pacemaker cells from bullfrog sinus venosus

lack an inwardly rectifying background K+ current. Biophys J 45, 136a.

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30. Shibata EF, Momose Y & Giles W (1984) An electrogenic Na+/K+ pump current in individual bullfrog atrial myocytes. Biophys J 45, 126a.

31. Clark RB. & Giles W (1984). Na+ currents in single bullfrog atrial myocytes. Biophys

J 45, 135a. 32. Campbell DL, Robinson K & Giles W (1984). Simulations of Ca++ buffering and Ca++

extrusion via an electrogenic Na+/Ca++ exchanger in bullfrog atrial cells. Biophys J 45, 54a.

33. Giles WR & van Ginneken A (1985). Identification of a transient outward current in

single myocytes from the crista terminalis of rabbit heart. J Physiol 358, 50p. 34. Clark RB & Giles WR (1985). Na current inactivation develops with a delay in

bullfrog atrial myocytes. J Physiol 358:56p. 35. Campbell DL, Shibata EF, Robinson K & Giles WR (1985). Experimental and

theoretical studies of the electrogenic Na+/Ca2+ exchanger in bullfrog atrial myocytes. Biophys J 47, 460a.

36. van Ginneken A & Giles W (1985). If in isolated cells from the rabbit S-A node.

Biophys J 47, 496a. 37. Moore LE, Shibata EF, Clark RB & Giles W (1985). Steady state properties of

isolated frog atrial and sinus venosus cells. Biophys J 47, 499a. 38. Campbell DL & Giles WR (1986). Possible roles of the Na+/Ca2+ exchanger and

ATP-dependent Ca2+ pump in bullfrog atrial myocytes. J Mole Cell Cardiol 17, R019.

39. Shibata EF, Northup JK, Momose Y & Giles W (1986). Muscarinic receptor and

guanine nucleotide mediated inhibition of ICa in single cells from bullfrog atrium. Biophys J 49, 349a.

40. Shibata EF, Refsum H, Aldrete V, Ilnicki T & Giles W (1986). A transient outward

current in single cells from human atrial muscle. Circulation 74(II), 254P. 41. Clark JW Jr, Murphey CR & Giles WR (1986). Modeling of propagated electrical

activity in the heart. Proc. of the Japan-U.S. Symposium on Biomedical Engineering, Baltimore, MD, organized by the Alliance for Engineering in Medicine and Biology and the Japan Society for Medical Electronics and Biological Engineering Sept 13-16, pp 3-4.

42. Imaizumi Y & Giles W (1987). Comparison of K+ currents in single cells from rabbit

atrium and ventricle. Biophys J 51, 256a.

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43. Shibata EF, Northup JK, Momose Y & Giles W (1987). Is diacylglycerol a second messenger for the muscarinic guanine nucleotide mediated inhibition of calcium current in bullfrog atrium? Biophys J 51, 413a.

44. Clark J, Murphy R, Giles W & Rasmusson R (1987). Propagation of electrical activity

in simulated atrial strands: The role of disc resistance. Biophys J 51, 255a. 45. Giles WR & Imaizumi Y (1987). Quinidine-induced inhibition of a transient outward

current in rabbit heart. J Physiol 390, 68P. 46. West A, Giles W & Belardinelli L (1987). Modulation of ionic currents by adenosine

in single isolated SA node cells from rabbit. Circulation 76(II), 105a. 47. Giles W, Imaizumi Y, Clark RB, Shibata EF, van Ginneken A & West GA (1987).

Pacemaker activity and action potentials in mammalian heart cells. Proceedings of the Annual Conference on Engineering in Medicine and Biology, September.

48. Tse A, Clark RB & Giles W (1987). Electrophysiology of isolated neurons from

bullfrog intracardiac ganglion. Neuroscience Abstracts 13(1), 535a. 49. Kavanagh KM, Duff HJ, Clark R, Robinson K, Gillis AM, Mitchell L, Wyse DG &

Giles WR (1987). Decreased energy requirements for cardiac pacing using biphasic stimulation. Circulation 76(II), 242a.

50. Tse A, Clark RB & Giles WR (1988). Ca current of a parasympathetic neuron.

Neuroscience Abstracts 14, 139a. 51. Clark RB, Tse A & Giles WR (1988). Muscarinic modulation of Ca current in a

parasympathetic neuron. Neuroscience Abstracts 14, 754a. 52. Kavanagh KM, Rahmberg M, Giles WR, Ilnicki T, Aldrete V, Shibata E & Duff HJ

(1988). Antiarrhythmic and electrophysiologic effects of Ba++. J Am Coll Cardiol II, 2.

53. Kavanagh KM, Giles WR, Imaizumi Y, Rahmberg M, Clark RB & Duff HJ (1988).

Differential epicardial-endocardial response to quinidine: It. J Am Coll Cardiol II, 2.

54. Kavanagh KM, Wyse DG, Mitchell LB, Giles WR, Gillis AM, Sheldon RS & Duff HJ

(1988). Cardiac memory and the ventricular effective refractory period. Clin Invest Med II, 5.

55. Murphey CR, Clark JW, Giles WR & Naccarelli CV (1988). Parameter estimation in

a model of the electrical activity of a single A-V nodal pacemaker cell. Phys Med Biol 33(Suppl 1), 230.

56. Fedida D, Shimoni Y & Giles WR (1989). Alpha adrenergic agonists reduce a

transient outward current in single cells from rabbit atrium. Biophys J 55, 100.

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57. Nakajima T, Ono K, Shibata EF & Giles W (1989). Modulation of K+ and Ca2+

currents by isoproterenol in bullfrog atrial myocytes. Biophys J 55, 99a. 58. Wong RY, Delay MJ & Giles WR (1989). Optical measurement of intracellular pH in

a single cells. Biophys J 55, 72a. 59. Juhasz AE, Clark RB & Giles WR (1989). Electrophysiology properties of adult rat

myocytes in short term primary culture. Proc CFBS Calgary 102a. 60. Tse A, Clark RB & Giles W (1989). Muscarinic modulation of neuronal Ca current

involves pertussis toxin sensitive GTP-binding proteins. Proc CFBS Calgary 549a.

61. Akbarali H & Giles W (1989). Ionic currents in single cells from rabbit oesophageal

smooth muscle. J Physiol 422, 43p. 62. Tse A, Clark RB & Giles W (1989). Muscarinic modulation of Ca current in bullfrog

intracardiac parasympathetic neurons involves pertussis toxin sensitive GTP-binding proteins. J Gen Physiol 94, 2a.

63. Kaibara M, Nakajima T, Irisawa H & Giles W (1989). Regulation of spontaneous

opening of the muscarinic K+ channel in rabbit atrium. J Gen Physiol 94, 3a. 64. Fedida D & Giles WR (1990). A phorbol ester increases the transient outward

current in rabbit atrial myocytes. J Physiol 415, 106p. 65. Nakajima T, Irisawa H & Giles W (1990). N-ethylmaleimide uncouples muscarinic

receptors from acetylcholine-sensitive potassium channels in bullfrog atrium. Biophys J 57, 110a.

66. Ono K, Nakajima T, Irisawa H & Giles, W (1990). Calcitonin gene-related peptide

modulates Ca2+ current in bullfrog atrial myocytes. Biophys J 57, 308a. 67. Fedida D, Braun AP, Clark RB & Giles WR (1990). Alpha1-adrenergic modulation of

a transient K+ current in rabbit atrial myocytes is via a pertussis toxin insensitive G-protein and a diffusible second messenger. Biophys J 57, 132a.

68. Kilborn MJ, Fedida D & Giles WR (1990). Postnatal changes in background K+

current in ventricular myocytes of rat heart. J Physiol 426, 12p. 69. Akbarali H, Nakajima T, Wyse DG & Giles WR (1990). Ionic currents in single cystic

artery cells from human. Vancouver Biophys Soc Meeting, July. 70. Akbarali H & Giles W (1991). Ca2+ - activated Cl- currents in rabbit esophageal

smooth muscle cells. Biophys J 59, 236a.

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71. Fedida D, Clark RB & Giles WR (1992). Persistent activation of a chloride current in rabbit cardiac myocytes. J Physiol 446, 152p.

72. Demir SS, Clark JW, Murphey CR & Giles WR (1992). A mathematical model of the

SA node cell in rabbit. Biophys J 61, A446. 73. Murphey CR, Clark JW, Giles WR, Clark RB & Fedida D (1992). A mathematical

model of the rabbit ventricular myocyte. Biophys J 61, A445. 74. Lindblad DS, Clark JW, Murphey CR & Giles WR (1992). Temperature and stimulus

frequency effects on the action potential of the rabbit atrial myocyte. Biophys J 61, A446.

75. Fedida D, Clark RB & Giles W (1992). A rate-dependent chloride current in cardiac

myocytes. Biophys J 61, A405. 76. Demir SS, Clark JW & Giles WR (1992). The crista terminalis cell in the rabbit heart:

A model. Proceedings 14th Annual Conference of the IEEE Engineering in Medicine and Biology Society, Paris, France, 29 Oct - 1 Nov, pp 587-588.

77. Lindblad DS, Clark JW, Murphey CR & Giles WR (1992). A model of stimulus

frequency effects on the rabbit atrial myocyte. Proceedings 14th Annual Conference of the IEEE Engineering in Medicine Society, Paris, France, 29 Oct - 1 Nov, pp 586.

78. Bouchard RA, Clark RB & Giles WR (1993). Voltage-dependence of contraction in

isolated rat ventricular myocytes. Biophys J 64, A39. 79. Habuchi Y & Giles WR (1993). Electrophysiologic properties of spontaneously active

myocytes from rabbit AV node. Biophys J 64, A206. 80. Bouchard RA, Clark RB & Giles WR (1993). Regulation of unloaded cell shortening

by sarcolemmal Na/Ca exchange in isolated rat ventricular cells. Biophys J 64, A39.

81. Imaizumi Y, Kanai A, Matsusita M, Watanabe M & Giles WR (1993). Effects of Ca

antagonists and antiarrhythmic agents on transient and delayed rectifier potassium currents in rabbit atrial cells. Biophys J 64, A394.

82. Bouchard RA, Clark RB & Giles WR (1994). Effects of action potential prolongation

on Ca2+ current, [Ca2+]i and contraction studied using the action potential clamp technique. Biophys J 66, A91.

83. Bouchard RA, Clark RB & Giles WR (1994). EC-coupling and [Ca2+]i homeostasis in

rat ventricular myocytes studied using the action potential clamp technique. Biophys J 66, A91.

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84. Shimoni Y, Han X & Giles WR (1994). Nitric oxide modulates cholinergic slowing of heart rate. Biophys J 66, A238.

85. Firek L & Giles WR (1994). Properties of potassium currents from human atrial

myocytes. J Physiol June. 86. Shimoni Y, Severson DL & Giles WR (1994). Selective modification of the regional

disparity in potassium currents in rat ventricle. J Physiol 479, 135p. 87. Firek L & Giles WR (1994). Electrophysiological analysis of Wenckebach

phenomena in single myocytes from mammalian ventricle. J Physiol 479, 134p. 88. Demir SS, Clark JW Jr & Giles WR (1994). Cholinergic and adrenergic modulation

of ion channels in a rabbit sinoatrial node model. IFAC Symposium, March. 89. Lindblad DS, Clark JW Jr, Murphey CR & Giles WR (1994). A model of the rate

dependence of the atrial action potential in rabbit. IFAC Symposium, March. 90. Han X, Shimoni Y & Giles WR (1994). A cellular mechanism for nitric oxide-

mediated cholinergic modulation of heart rate. J Physiol 480, 92p. 91. Han X, Habuchi Y & Giles WR (1994). Effects of metabolic inhibition on action

potentials and ionic currents in cardiac pacemaking cells. Circulation 90, #3138, I-582.

92. Firek L & Giles WR (1995). Electrical and mechanical β2-adrenergic stimulation in

human atrial myocytes. Eur Cardiol Cong Mtg, June. 93. Shimoni Y, Qi A, Severson D & Giles WR (1995). Diabetes-induced changes in α-

adrenergic modulation of K+ currents in rat ventricle. Physiol Soc, June. 94. Giles WR (1995). Ionic mechanisms for spontaneous pacing in mammalian heart.

17th Annual IEEE/EMBS Conference. Montreal, Canada, September. 95. Nygren A, Firek L, Clark JW, Lindblad DS, Clark RB & Giles WR (1995). A model of

the adult human atrial cell. 17th Annual IEEE/EMBS Conference. Montreal, Canada, September.

96. Lowes VL, Stroeher VL, Clark RB & Giles WR (1997). Does MinK Underlie the

Delayed Rectifier K+ Current in Bullfrog Atrial Myocytes? Biophys J 72, A49. 97. Ward CA & Giles WR (1997). Ionic Mechanisms of the Effects of Hydrogen Peroxide

in Rat Ventricular Myocytes. Biophys J 72, A49. 98. Fiset C, Clark RB, Shimoni Y & Giles WR (1997). Kv4.2 and Kv4.3 Contribute to the

Ca2+-independent Transient Outward K+ Current in Rat Ventricle. Biophys J 72, A50.

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99. Cordeiro JM, Spitzer KW & Giles WR (1997). A Comparison of Repolarizing K+ Currents in Rabbit Purkinje Cells and Ventricular Myocytes. Biophys J 72, A49.

100. Sato N, Habuchi Y, Tanaka H, Spitzer KW & Giles WR (1997). Differences between

the delayed rectifier currents in myocytes from rabbit sinoatrial and atrioventricular nodes. Am Heart J, September.

101. Fiset C, Clark RB, Janzen KM, Winkfine R & Giles WR (1998). Molecular identity of

K+ currents in adult mouse atrium and ventricle. Biophys J, February. 102. Reinhardt P, Giles WR & Kubes P (1999). The role of inducible nitric oxide synthase

(iNOS) in heart function during endotoxemia. Fourth International Shock Congress, Philadelphia, June.

103. Guo J, Magga JN & Giles WR (1999). C-type natriuretic peptide activates a K+

current in rabbit right atrial myocytes via ANP-C receptor. Circulation. 104. Magga JN, Guo J & Giles WR (1999). Inotropic Effects of C-type natriuretic peptide

in rat heart. J Physiol, November (Santiago, Chile Meeting). 105. Cordeiro JM, Spitzer KW, Ershler PR, Giles WR, Bridge JHB (1999). Calcium sparks

are localized at the cell periphery in Purkinje myocytes. Biophys J 76, A465. 106. Poon BY, Ward CA, Giles WR & Kubes P (1999). Emigrated neutrophils reduce

ventricular contractility via α4 integrin. Faseb J 13, A178. 107. Sheng J.-Z, Prinsen CFM, Clark RB, Schnetkamp PPM (2000). Na-Ca+-K

Exchanger currents measured in insect cells transfected with the retinal cone NCKX cDNA. Biophys J 78, 308a.

108. Kodirov SA, Goyal RK, Hay R, Giles WR & Akbarali HI (2000). HERG-like K+ current

contributes to the resting potential of smooth muscle. Biophys J 78, 2134a. 109. Nygren A, Clark RB, Belke D, Kondo C, Giles WR & Witkowski FX (2000). Voltage-

sensitive dye recordings of activation and conduction in adult mouse hearts. Biomedical Engineering Society Annual Meeting, Seattle, WA.

110. Poon BY, Cooper CB, Ward CA, Giles WR & Kubes P (2000). α4-integrin mediates

emigrated neutrophil-induced oxidative injury to cardiac myocytes. Faseb J 14, A705.

111. Poon BY, Giles WR & Ward CA (2002). Very late antigen-4 (VLA4) antagonists

protect against neutrophil-induced damage to cardiac myocytes. Faseb J. 112. Grattan MJ, Syme DA, Burke B & Giles WR (2002). The phenotype of a murine

model of Emery-Dreifuss Muscular Dystrophy. Faseb J.

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113. Baczko I, Light PE & Giles WR (2002). Activation of sarcolemmal KATP channels reduces hypoxia/reoxygenation induced calcium overload via hyperpolarization of the resting membrane potential. Biophys J 84(2) Part 2 of 2, 422a.

114. Wu B-N, Giles WR, Brayden JE, Luykenaar KD & Welsh DG (2002). Mechanical

stimuli inhibit inward rectifying K+ channels in cerebral myocytes. Biophys J 84(2) Part 2 of 2, 107a.

115. Chilton L, George E, MacCannell D, Dixon IMC, Clark RB & Giles WR (2003).

Elevated [K+]o enhances cultured adult rat cardiac myofibroblast contraction. J Physiol 551P, PC35.

116. Chilton L, Kargacin G, Dixon I, Clark R & Giles W (2003). An inwardly rectifying K+

current modulates membrane potential in cultured rat cardiac fibroblasts. Biophys J 84(2) part 2 of 2, 225a.

117. Wu BN, Giles WR, Brayden JE, Luykenaar KD, Wiehler WB & Welsh DG (2003).

Inward rectifying K+ channels and the development of cerebral myogenic tone. Faseb J (ASPET Meeting, April, 2004).

118. Chilton L, Freed D, George E, Drobnic V, MacCannell KA, Dixon IMC, Clark RB, &

Giles WR (2004). Functional roles of membrane potential and K+ currents in adult rat ventricular myofibroblasts proliferation, migration, and contraction. J Physiol 557P, PC20.

119. Nygren A, Lomax AE & Giles WR (2004). Optical mapping system for recording

action potential durations in adult mouse left and right atrium. Conf Proc IEEE Eng Med Biol Soc 5, 3576-7.

120. Rose RA, Giles WR & Bains JS (2004). C-type natriuretic peptide inhibits L-type

Ca2+ current in hypothalamic magnocellular neurosecretory cells by activating the NPR-C receptor, 2004. Program No. 442.13, Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

121. Ochi R, Oyama K, Momose Y & Giles WR (2004). Sphingosine 1-phosphate and

acetylcholine converge to activate an inwardly rectifying population of K+ channels in guinea pig atrial myocytes. IUPS Meeting, April.

122. Fink M, Giles WR & Noble D (2004). Potassium currents and repolarization reserve

in mathematical models of human ventricle. Heart Rhythm December. 123. Brouillette J, Clark RB, Giles WR & Fiset C (2005). A method for separating and

discerning the functional properties of K+ currents in adult mouse ventricular myocytes. Biophys J 88, 2314a.

124. Kondo RP, Dederko D & Giles WR (2005). Differences in contractility between right

and left ventricular mouse myocytes: A role for potassium currents. Biophys J 88, 1567a.

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125. Nygren A, Baczko I & Giles WR (2005). Effects of cytochalasin-D on the

electrophysiological response to acute ischemia in rat ventricle. Biomed Eng Soc Meeting, September.

126. Landeen LK, Aroonsakool N & Giles WR (2005). Expression of sphingosine-1-

phosphate receptors in neonatal and adult mouse heart. Faseb J April. 127. Landeen LK, Aroonsakool N & Giles WR (2005). Presence of macrophages within

cardiac fibroblast cultures and methods for their removal. Faseb J April. 128. Hu BS, Landeen LK, Aroonsakool N, Giles WR & Omens JF (2005). Static

mechanical stretch induces IGF-1 secretion by cardiac fibroblasts. Faseb J April. 129. Chilton L, Giles WR, Smith GL (2005). Co-cultured cardiomyocytes and

myofibroblasts: evidence for functional coupling. J Mol Cell Cardiol 39, 174. 130. Maleckar MM, Greenstein JL, Giles WR, Trayanova NA (2008). Coupling of human

atrial myocytes and myofibroblasts can lead to conduction disturbances. Heart Rhythm Sessions May 2008.

131. Trenor B, Gomis-Tena J, Ferrero JM, Rajamani S, Belardinelli L, Saiz J, Giles WR

(2012). Mathematical models of the action potential in human ventricle in relation to safety pharmacology. Physiome Sciences Workshop, San Diego, CA, October, 2012.

132. Maleckar MM, Koivumaeki J, Belke D, Clark RB, Kondo C, Giles WR (2012).

Functional consequences of expression of heart sodium channel NaV1.5 in cardiac fibroblasts and myofibroblasts. Physiome Sciences Workshop, San Diego, CA, October, 2012.