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PREMIUM QUALITY FEED-ENHANCER
Cleaner feed, improved productivity
GENEX POULTRY
SPECIES
POULTRY
Background
With the advent of ‘greener’, more environmentally
friendly farming practices there has been a distinct
move towards the production of more natural food
stuffs for human consumption. A major aspect of this
is the inevitable trend in favour of food produced under
more acceptable conditions, including animals which
have been fed diets free from inappropriate additives.
Recently, there has been a growing concern over the
irresponsible use of antibiotics in animal production
causing cross-resistance to the generation of
antibiotics intended for use in human medicine.
The consequences for food production are serious and
the industry will have to find an alternative method of
maintaining modern levels of production and routinely
controlling microbial populations - but in a way that
is consistent with a natural and ‘green’ approach.
The answer lies in Genex Poultry – a unique blend
of organic acids, essential oils and plant extracts.
By combining all of these components, Genex Poultry provides excellent protection against feed borne pathogens, collectively known as enterobacteria such as E. coli, salmonella, campylobacter etc.
The unique blend of active ingredients used in Genex Poultry is born of intensive R&D. It is not just the ingredients themselves that give the product its unique properties, it is the ratio and balance between them that achieve the optimal synergistic effect present in Genex Poultry. By examining the potential of each material and considering how it may enhance the efficacy of the other components, the researchers at Optivite designed the ultimate formulation that makes Genex Poultry so effective.
• Multiple synergistic associations: bacteriostatic and bactericide effect in feed
• Protects intestinal mucosa and villi from harmful bacteria consumed via the feed
• Helps the animal achieve the optimal intestinal microbial balance by reducing exposure to contaminated feed
• Supports animal health and digestive function
• Phyllosilicate carrier known to adsorb mycotoxins and endotoxins
• Phyllosilicate carrier enables slow release of active components
The effects of pathogenic infection:HEALTH PROBLEMS
• Diarrhoea
• Wet litter
• Secondary infections
• Mortality
PRODUCTION PROBLEMS
• Low growth rates
• Poor FCR
• Uneven growth
• Lack of uniformity
GENEX POULTRY do?What does
GENEX
ESSENTIALS OILS
PLANT EXTRACTS
ORGANIC ACIDS PhYLLOSILICATES
Organic acids – Their effect on lactobacilli bacteria
A similar process also takes place in lactic acid producing bacteria – lactobacilli. However, our acids target the harmful bacteria, not the beneficial bacteria that contribute to a healthy gut.
GENEX POULTRY:
HOW DOES GENEX POULTRY WORK?
The ScienceThe challenge from enterobacteriaEnterobacteria such as salmonella and E. coli are a major threat to the performance of poultry. There are many possible sources of infection of which feed is one of the main route.
Intestinal wall microvilli, microscopic cellular membrane protrusions, that are responsible for a wide variety of functions including absorption of nutrients, can be seriously damaged by enterobacteria. This can lead to the malabsorption of nutrients reducing the efficiency of digestion and inhibiting animal performance.
Organic acidsOrganic acids are used to control potentially pathogenic bacteria. Genex Poultry is formulated using a unique blend of organic acids combined with a stable carrier. It’s the types of acids used in Genex Poultry that make the difference.
Why use organic acids?Organic acids are used to control potentially pathogenic bacteria due to their ability to penetrate the bacterial cell wall of Gram-negative bacteria. Once the cell has been compromised the organic acids disrupt cell metabolism, thus killing the bacteria.
The essential oils in Genex• Stimulate feed intake
• Damage microorganism cell wall structure - Cell contents lost - Disrupts cell homeostasis/genetic material replication - Allows more organic acid into cell
• Prevent flagella formation - Limits movement - Limits growth & multiplication
The plant extracts in Genex• Natural surfactants
- Coats bacteria - Damages bacterial cell wall - Cell contents lost - Allows more organic acid into cell - Enhances essential oil effect
By combining all of these components, Genex Poultry provides excellent protection against enterobacteria.
The table below demonstrates the efficacy in feed of Genex Poultry at 4kg/t against a range of pathogens.
Organic acids – their effect on Gram-negative enterobacteria e.g. E. coli:
Organic acids (AH) consist of two components, negatively charged anions (A-) and positively charged hydrogen ions or cations (H+).
CONTROL
o
20
40
60
80
100GENEX POULTRY
% S
URV
IVA
L A
FTER
48h
rs
SALMO
NELLA
ENTER
ITIDIS
ESCHERIC
HIA
COLI
STREPT
OCOCCUS
FAECALIS
STAPHYLO
COCCU
S
AUREU
S
CAMP
YLOBACTE
R
JEJUN
I
PASTEU
RELLA
MULTO
CIDA
BACTERIA
E. coli adheres to the intestinal mucosa causing the destruction of intestinal microvilli
Reference: Dr David Dean, Institute of Cell & Molecular Biosciences, University of Newcastle, UK
Healthy microvilli
Challenged microvilli
Untreated cells (control)(After Burt & Reinders, Letters in Applied Microbiology (2003) 36: 162–167)
Cells damaged after treatment with essential oil
= Hydrogen/Cations (Positively charged)
= Anions (Negatively charged)
KEY:
STEP 1 – The acid penetrates the cell wall
AH move into the cell & split, acidifying the internal cell environment.In order to maintain the neutrality of the internal environment, the cell moves to step 2.
STEP 1 – The acid penetrates the cell wall
Lactobacilli are acid tolerant, so are able to cope with a greater pH shift.
STEP 2 – Removal of cations
The cell uses energy to power the proton pumps which move H+ out of the cell.
STEP 2 – Removal of cations
Less energy used in moving H+ out of the cell.
STEP 3 – Cell dies
As the cell is using all of its available energy moving H+ out of the cell normal cell function is impaired.Inhibition of DNA replacement occurs leading to cell death.
STEP 3 – Cell survives
The energy expended is low meaning more energy is available for normal cell function and viability.
CONTROL
FCR MORTALITY (%)LIVEWEIGHT (KG)
-56KCAL/KG ME,+2KG/T GENEX 2.55
2.51
-112KCAL/KG,+4KG/T GENEX 2.52
NEGATIVE CONTROL,-112KCAL/KG 2.52
1.848
1.850
1.861
1.889
7.5
7.8
7.3
10.7
CONTROL INCAGP 2.51 1.850 7.8
NO AGP,+2KG/T GENEX 2.50 1.859 7.8
FCR MORTALITY (%)LIVEWEIGHT (KG)
Using GENEX POULTRYTo control bacterial levels in feed as part of an overall reduction strategy offers a number of
benefits as the results below demonstrate
Summary of trial results, comparing feed treated with Genex Poultry to a control feed
ConclusionsTotal birds involved -
1.5 million birdsImproved FCR -
Av -0.07 (-0.04 to -0.13)Improved liveweight -
Av 58g (7g to 150g)Reduced mortality -
Av 1.01% (-0.03% to -2.43%)Faster days to market weight -
Av 1.09 (0.8 to 1.34)
Performance benefits are reported when using Genex Poultry to treat feed.
Bacterial control of the feed leads to
• More available nutrients and energy
• Better intestinal health
The benefit of this is that additional nutrients and energy are available to the bird
Energy StudyAn energy study with growing broilers was undertaken to determine the validity of a proposed feed energy value to be given to Genex Poultry.
Replacement of Antibiotic Growth Promoters (AGPs)The ability of Genex Poultry treated feed to replace feed containing AGPs was investigated to determine if performance could be maintained or even improved.
ConclusionsGenex at 2kg/t can replace 56kCal/kg of dietary ME.
Genex at 4kg/t can replace 112kCal/kg dietary ME.
• This can be used in 2 practical ways :
(a) reduce dietary ME by 56 (or 112) kCal/kg and add 2 (or 4) kg/t Genex.
(b) give Genex an ME value of 28,000 kCal/kg and formulate the diet restricting Genex to 2 or 4 kg/t as required.
• Alternatively, Genex can be added to the diet without accounting for any energy effect and accept the improvements in performance.
ConclusionsThe results suggest that feed containing Genex Poultry at 2kg/tonne will perform as well as that containing an AGP.
Case Studypoultry
Benefits of GENEX POULTRY• To control bacteria in feed and protect it
from environmental recontamination
• Allows optimal digestibility thereby improving daily liveweight gain and feed conversion
• Anti-microbial feed treatment will reduce the potential for harmful bacterial growth in the bird’s environment and thus reduce the possibility of clinical and subclinical disease
• Will not interfere with therapeutic antibiotics
• Will leave no residues or contribute to the development of drug resistance
• Treated feed has been shown to give similar or improved performance to feeds containing antibiotic growth promoters
• Effective feed treatment helping control moulds and protect feed nutrients
• Has no withdrawal period
• All ingredients are officially approved by the European Union
• Can be included in feed without the need for special equipment
• Is stable under severe heat treatment
Inclusion rates
2-4kg/t
STARTER
2kg/t
GROWER
2kg/t
FINISHER
2kg/t
WITHDRAWAL
No. OF BIRDS
LOCATION
OBJECTIVE
CHANGEIN FCR(pts)
LIVEWEIGHTIMPROVEMENT
(g)CHANGE INMORTALITY
(%)SLAUGHTER AGEIMPROVEMENT
(days)
150K
-0.06
+34
-0.67
ME 1
MIDDLEEAST
25K
-0.04
+88
-0.25
IR 1
IRAN
120K
-0.13
+7
-0.03
SA 4
250K
-0.06
+14
-1.83
SA 3
250K
-0.05
+34
-2.43
SA 2
SOUTH AFRICA
360K
-0.06
+150
-0.89
SA 1B
360K
-0.07
+80
-0.94
SA 1A
1.341.14 - - 0.8 - -
TOP DRESS 2-4kg/t
CONTROL
FCR MORTALITY (%)LIVEWEIGHT (KG)
-56KCAL/KG ME,+2KG/T GENEX 2.55
2.51
-112KCAL/KG,+4KG/T GENEX 2.52
NEGATIVE CONTROL,-112KCAL/KG 2.52
1.848
1.850
1.861
1.889
7.5
7.8
7.3
10.7
CONTROL INCAGP 2.51 1.850 7.8
NO AGP,+2KG/T GENEX 2.50 1.859 7.8
FCR MORTALITY (%)LIVEWEIGHT (KG)
GENEX POULTRY:
The SupportOptivite distributor countries
ContactOptivite Manton Wood Enterprise Park Worksop, S80 2RS, UK www.optivite.com
Email: [email protected] [email protected]
t: +44 (0)1909 537380 f: +44 (0)1909 478919
Optivite provides cutting-edge, science based products plus the support you need. Optivite’s nutritionists and animal husbandry specialists are available with expert advice, service and product knowledge, with regional sales and technical support people on-hand to assist with day-to-day challenges. What’s more, our global distributor network is here to guide you to the right product choices wherever you are in the world.