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Poster Presentations

Correlation between morphological and functionalchanges, life quality and ventricular dysrhythmias inpatients with dilated cardiomyopathy

Timur Abdullaev ∗, Ilkham Ikramov, Nurali Kurbanov,Bakhodir Mardanov

Republican Specialized Center of Cardiology

Aim: To study association between the prevalence andnature of ventricular arrhythmia (VA) and clinical andfunctional characteristics in DC patients.

Methods: Clinical examination, Holter’s ECG monitoring(HECGM), echocardiography with ejection fraction (EF),end-diastolic volume (EDV), end-systolic volume (ESV),ESP/ESV (where ESP is end-diastolic pressure) measur-

Predictors of mortality amongst recipients of implantablecardioverter defibrillators for secondary prevention of car-diac arrest

Sunil Agarwal a,b,∗, Ish Singla a,b, Haitham Hreybe a,b,Samir Saba a,b

a University of North Carolina at Chapel Hill, NC, USAb University of Pittsburgh Medical Center, PA, USA

Background: Implantable cardioverter-defibrillators(ICD) reduce mortality in survivors of cardiac arrest (CA).We investigated the predictors of mortality after ICDimplantation in survivors of CA.

Methods: Retrospective review of electronic clinicalrecords and social security death index of all patients

ing, life quality (LQ) by LWHF-questionnaire.Results: A total of 106 DC patients aged 16–61 (mean age

41.9 ± 0.5) years were evaluated. Patients were assignedto two groups: group I was composed of 63 patient withgrade II VE and group 2 was composed of 43 patients withgrade IVA and IVB VE. The disease duration as assessedon examination ranged from 1 month to 6 years. Ven-tricular extrasystoles (VE) as form of HRD were detectedin 102 (96%) patients. Frequency of VE ranged from 1 to1850 (mean 157.01 ± 34.24) VE per hour. High-grade VE

who received ICD implant subsequent to acute myocardialinfarction and CA and a random sample of patients withCA only, matched by age, gender, and myocardial function.Univariate analyses followed by multivariate Cox propor-tional hazard model, with backward elimination were usedto identify predictors, and Kaplan–Meier curves were plot-ted.

Results: 80 patients (64 males) with a mean (±S.D.) ageof 64.4 ± 12.5 years were followed for 4.7 ± 2.3 years afterICD implantation. Survival rates were 93.8%, 65% and 50%

were observed in 41 (40.2%) patients. Analysis of correla-tion between the prevalence and severity of HF symptomsshowed that clinical manifestations, such as syncopes (100

at 1, 5, and 10 years, respectively. Independent predictorsof time to death were determined to include age (haz-ard ratio (HR) = 1.91 per year increase, p = 0.003), serum

and 0%), dizziness (39 and 18%), dyspnoea (83 and 47%) atrest and weight loss (38 and 68%), are significantly morecommon when concomitant high-grade VA are present.Markedly compromised haemodynamics in both systemicand pulmonary circulation, which correspond with NYHAHF grades III and IV (÷2 = 6.004, p < 0.05) were significantlymore frequent in patient with high-grade VA. Evident dif-ferences, revealed by LQ analysis, showed, that total LQpoint in patients with complex VE was substantially andsignificantly higher than in control group (80.33 ± 1.74 vs.64.71 ± 3.85 respectively, p < 0.01).

Conclusions: DC patients with complex forms of arrhyth-mia have significantly increased myocardial dimensions,associated with severity clinical and functional character-istics (syncopes, dizziness, dyspnoea at rest and weightloss), which determine lower LQ in these patients.

doi:10.1016/j.hlc.2007.11.009

creatinine, d 1.3 mg/dL (HR = 2.56, p = 0.004), and QRScomplex > 120 ms (HR = 5.14, p = 0.012).

Conclusions: In this sample of ICD recipients secondaryto CA, age, serum creatinine and QRS duration were inde-pendent predictors of mortality. The coexistence of two ormore of these risk factors confers a higher mortality risk.Whether interventions such as biventricular pacing canoffset this increase risk of death warrants research.

doi:10.1016/j.hlc.2007.11.010

The protective effect of a purified extract of Withania som-nifera against doxorubicin-induced cardiac toxicity in rats

Amr Amin ∗, Alaa Hamza

UAE University

The therapeutic value of doxorubicin as an effective anti-neoplastic agent is limited by its cardiotoxic side effects.The administration of doxorubicin (10 mg/kg) to maleWistar rats induced necrosis and apoptosis in heart tis-sues. It also caused oxidative stress damage as evidenced

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