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Cadila Healthcare Limited 0
Pre-Feasibility Report
Cadila Healthcare Limited 1
1. INTRODUCTION
M/s. Cadila Healthcare Limited proposes to manufacture Bulk Drugs at Masar
Block No –1162-1164, 1171-1174, 1181-1183 and Kanzat Block No –1115-
1120, 1122, 1126, 1159-70, 1207, Masar-Kanzat, Tehsil: Padra, Dist.
Vadodara.
2. COST OF PROJECT
The estimated cost of the project for the proposed project is estimated around
Rs. 200 crores. Out of this around Rs. 11.38 crores will be invested for
pollution control measures.
3. PRODUCTION CAPACITY
Production capacity is prescribe below:
List of products
Sr.
No.
List of product Quantity
(MTPM)
Quantity
(MTPA)
1 Acotiamide hydrochloride
20 240
2 Agomelatine
3 Anagrelide Mono hydrochloride
Monohydrate
4 Anastrozole
5 Apixaban
6 Apomorphine HCl
7 Apremilast
8 Aripiprazole
9 Atenolol
10 Atomoxetine HCl
11 Trazodone
12 Atorvastatin Calcium
20 240
13 Atovaquone
14 Avanafil
15 Azelastine HCl
16 Azilsartan Medoxomil
17 Bisacodyl
18 Bosentan
19 Brexpiprazole
20 Bupropion HCl
21 Buspirone HCl
22 Brivaracetam
23 Canagliflozin
24 Candesartan Cilexetil
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25 Carvedilol
26 Clindamycin
27 Clonidine
28 Clopidogrel Bisulphate/ besylate
20 240
29 Colestipol Hydrochloride
30 Cinacalcet HCl
31 Dapagliflozin
32 Darunavir
33 Desloratadine
34 Desvenlafaxine succinate
35 Dimethyl Fumarate
36 Donepezil HCl
37 Duloxetine Hydrochloride
38 EdoxabanTosylate Monohydrate
39 Eltrombopagolamine
40 Empagliflozin
41 Entecavir
42 Escitalopram Oxalate
43 Esomeprazole Magnesium
44 Ethacrynic acid
20 240
45 Etoricoxib
46 Famotidine
47 Fingolimod
48 Flibanserin
49 Fluconazole
50 Fosphenytoin Sodium
51 Gabapentine
52 Glimepiride
53 Hydrochlorothiazide
54 Hyoscyamine Sulfate
55 Ivabradine Hydrochloride
56 Levomilnacipran
57 Hydroxychloroquine sulfate
20 240
58 Lamotrigine
59 Lansoprazole Sulphide
60 Ledipasvir
61 Letrozole
62 Levofloxacin Hemihydrate
63 Linagliptine
64 Loratidine
65 Lorcaserin HCl
66 Losartan Potassium
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67 Lurasidone hydrochloride
68 Macitentan
69 Meloxicam
70 Mesalamine
20 240
71 Metoprolol succinate
72 Midodrine HCl
73 Mirabegron
74 Nicronadil
75 Olmesartane
76 Omeprazole / Omeprazole Magnesium
77 Pantoprazole Sodium
78 Paroxetine Hydrochloride
79 Phenteramin
80 Pramipexole Dihydro Mono Hydrate
81 Pregabalin
20 240
82 Propefenone
83 Polmacoxib
84 Quetiapine Hemifumarate
85 Ranolazine
86 Rasagilinebesylate
87 Risperidone
88 Rivastigmine
89 Roflumilast
90 Rosuvastatin calcium
91 Rosuvastatin ethanol amine
92 Sacubitril Valsartan Trisodium
93 Saroglitazar
94 Saxagliptin
95 Setraline Hydrochloride
96 Sildenafil citrate
97 Silidosin
98 Sitagliptin phosphate
Anhydroous/Besylate
99 Sparfloxacin
100 Tamsulosin HCl
101 Tebipenem pivoxil
102 Telapvir
103 Telmisartan
104 Tenegliptin
105 Amlodipine Beyslate
25 300 106 Etodolac
107 Tirofiban HCl
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108 Tofacitinib Citrate
109 Tolvaptan
110 Topiramate
111 Tramadol Hydrochloride
112 UDCA (India Market)
113 Valdecoxib
114 Valsartan
115 Venlafaxine Hydrochloride
116 Vilazodone hydrochloride
117 Vildagliptin
118 Vortioxetine Hydrobromide
119 Warfarin sodium clathrate
120 Ziprasidone HCl
121 Azathioprine
10 120
122 Febuxosate
123 Lacosamide
124 Refaximin
125 Tolperison
126 Udenafil
127 R&D Products /Pilot Plant
batches/Development Batches 2 24
TOTAL 177 2124
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4. List of Raw Materials
Sr.
No.
List of Product List of Raw Material Quantity
(MT/MT)
1. Acotiamide HCl 2,4,5-Trimethoxy Benzoic acid 0.870
Toluene 0.380
Thionyl Chloride 1.200
DMF 0.590
Ethyl 2-Amino Thiazole-4-carboxylate 0.520
Pyridine HCl 0.620
Pyridine 0.550
Acetic acid 6.990
N,N Diiso propyl ethylene diamine 1.460
MDC 0.660
Ethyl acetate 0.210
Isopropanol 3.160
IPA-HCl 0.830
Ethanol 4.000
2. Agomelatine 7-methoxy naphthyl acetic acid 1.160
Methylene dichloride 0.560
Thionyl chloride 0.760
Aqueous ammonia 0.980
Trifluoro acetic anhydride 2.580
Tetrahydrofuran 0.300
Methanol 0.380
Raney Nickel 0.200
Ammonia 0.350
Hydrogen 0.050
Hyflow 0.200
Pyridine 2.910
Acetyl chloride 0.660
3. Anagrelide
Monohydrochloride
Monohydrate
2,3 dichloro-6-Benzonitryl derivative 2.000
Bf3 etharate 1.480
Hydrochloric acid 2.800
Sodium Borohydride 1.200
Ethyl acetate-HCl 2.920
Tetrahydrofuran 0.300
Ethyl acetate 0.900
Ethyl bromo acetate 0.920
Catalyst 0.240
Sodium carbonate 0.700
NN DMF 2.000
Isopropyl alcohol 0.050
Stannous Chloride 0.520
Con. HCl 1.000
Sodium hydroxide 0.500
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Cyclizing agent 0.800
Toluene 0.080
Triethyl amine 0.800
Ethyl alcohol 0.250
Activated Charcoal 0.160
Celite 0.400
4. Anastrazole 4-Amino-1,2,4-triazole 0.310
Isopropanol 0.230
3,5-Dicyanotertramethyl-alpha-bromo
Toluene 1.300
Sodium Nitrite 0.500
HCl 1.000
Toluene 0.520
Cyclohexane 0.390
Ethyl acetate 0.130
5. Apixaban MNDP 0.570
CMPHEA 0.580
TEA 0.400
Ethyl acetate 0.500
Isopropyl alcohol 0.120
HCl 0.300
Iron Powder 0.570
Ammonium chloride 0.300
Methanol 0.820
MDC 0.200
cyclohexane 0.030
Hyflow 0.580
Ammonia gas 1.600
5-CVC 0.820
TEA 0.640
NaOH 0.370
DMAc 1.220
activated carbon 0.060
DMSO 5.280
6. Apomorphine
Hydrochloride
Morphine HCl 1.250
Ammonia 0.400
Phosphoric acid 5.460
Phosphorus pentoxide 1.770
Sodium Sulphate 10.000
Isopropyl Acetate 2.000
Sodium meta bisulfite 6.000
IPA HCl 2.400
Isopropyl Acetate 2.200
Ethanol 0.500
7. Appremilast 3-Nitrophthalic acid 0.370
(S)-1-(3-ethoxy-4-methoxyphenyl)-2- 0.250
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(methyl sulfonyl)-ethan-1-amine [(S)-
EMME]
Acetic Acid 0.380
IPA 0.100
10% Palladium Charcoal 0.300
Ethyl Acetate 0.300
Dichloromethane 0.040
Acetyl chloride 0.500
Potassium Carbonate 0.200
Methanol 0.060
Sodium Bicarbonate 0.300
THF 0.050
Activated Charcoal 0.300
Isopropyl Alcohol 0.050
Acetone 0.900
8. Apriprazole 7-Hydroxy-3,4-Dihydrocarbostyryl 0.650
1,4 Dibromo butane 3.450
Potassium carbonate 0.600
Acetone 0.240
Dichloromethane 0.800
Charcoal 0.240
Ethyl acetate 0.060
Cyclohexane 0.130
1-(2,3-Dichlorophenyl) piperazine HCl 1.150
Potassium carbonate 0.750
Methanol 0.800
IPA HCl 0.960
Sodium hydroxide solution 0.250
Ethanol 0.280
9. Atenolol 4-Hydroxy Phenyl Acetamide 0.520
Sodium Hydroxide 0.490
Epichlorohydrin 0.630
Isopropyl amine 5.020
TEBAC 0.020
Hydrochloric acid 0.550
Celite 0.180
Activated charcoal 0.060
10. Atomoxetine HCl N,N-dimethyl-3-phenyl-3-hydroxy-3-
propyl amine 1.040
Thionyl chloride 0.550
Dichloromethane 0.360
Acetone 0.300
Isopropyl alcohol 0.160
2-Methyl phenol 0.250
Sodium hydroxide 0.300
Toluene 0.400
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Triethyl amine 0.260
Phenyl chloroformate 0.730
Potassium carbonate 0.160
Potassium hydroxide 0.230
Methanol 0.080
Oxalic acid 0.260
Liq. Ammonia 1.080
n-Butyl acetate 3.920
L-(+)-Mandelic acid 0.250
Sodium carbonate 0.150
Ethyl acetate 0.180
IPA-HCl 0.150
11. Trazodone TVA-Chloro propyl phenyl piperazine 0.910
TVA-Triazolo pyridine 0.410
Sodium carbonate 0.530
IPA 0.620
HCl 0.670
Methanol 0.280
12. Atorvastatin Calcium Isopropyl alcohol 0.500
Z/E Compound 1.000
p-floro Benzaldehyde 0.450
Triethyl amine 0.360
Toluene 0.250
Raney Ni 0.300
H2 (g) 0.200
NH3 (g) 1.200
Methanol 1.980
Hyflow 0.500
Pivalic acid 0.110
THF 0.100
Cyclohexane 0.110
Sodium bicarbonate 0.080
1N HCl 1.590
Sodium Hydroxide 0.160
Di isopropyl ether 0.090
Calcium chloride 0.140
13. Atovaquone 4-(4-chlorophenyl)cyclohexane-
carboxylic acid 0.830
2-chloro-1,4-nepthaquinone 0.660
Silver Nitrite 0.170
Ammonium persulphate 1.590
Acetonitrile 6.230
MDC 0.710
Charcoal 0.100
Hyflow 0.920
KoH 0.650
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Methanol 0.350
HCl 2.050
Xylene 0.200
Acetone 0.500
14. Avanafil Acid compound (KSM-I) 0.900
ANK-KSM-II 0.570
EDC HCl 0.530
HOBT 0.030
Tri ethyl amine 0.300
DMF 0.180
Sodium carbonate 0.130
15. Azelastine HCl Sodium Hydroxide 1.210
ATA-02 1.000
2-(2-Chloroethyl)-1-methyl
pyrrolodone Hydrochloride 0.730
Toluene 3.080
Charcoal 0.010
Acetone 0.230
HCl 0.190
Acetonitrile 0.200
16. Azilsartan
Medoxomil
OTBN 1.000
Sodium Ethoxide 1.900
Hydroxyl amine Hydrochloride 1.870
DMSO 4.720
ECF 0.620
TEA 0.670
MDC 0.170
HCl 0.020
DMF 5.310
DBDMH 1.130
AIBN 0.040
Ethyl acetate 0.110
Cyclo Hexane 0.300
2-Etoxy benzimidazole 7-carboxylic
acid methyl ester 0.020
Methanol 0.100
Sodium Hydroxide 0.050
Toluene 0.030
MMA 0.350
p-Toluene sulfonyl Chloride 0.620
Potassium Carbonate 0.870
Acetone 0.110
17. Bisacodyl Toluene 0.250
HCl gas 0.020
Phenol 2.250
Pyridine 2-aldehyde 1.250
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Sodium carbonate sol 0.630
Methanol 0.400
Acetic acid 1.750
Acetic anhydride 0.460
18. Bosentan 2-Methoxy phenol 0.640
2-Chloro dimethyl malonate 0.920
Methanol 0.420
sodium metal 1.100
Toluene 0.370
1 % NaOH 0.630
2-pyrimidine imidamide 0.770
HCl 8.660
Acetonitrile 0.100
POCl3 0.050
MDC 0.320
Saturated Sodium bicarbonate 1.000
Sulphonamide 0.770
DMSO 0.240
Ethyl acetate 0.480
Ethylene glycol 0.140
19. Brexpiprazole 1-(benzo[b]thiophen-4-yl)piperazine
Hydrochloride (KSM-I) 0.730
1,4-dibromobutane 0.650
Sodium carbonate 0.320
Methanol 0.120
Toluene 0.400
7-Hydroxy quinolinone (KSM-II) 0.650
Potassium carbonate 0.080
Dimethyl formamide 0.240
THF 0.220
20. Bupropion HCl 3-Chloropropiophenone 0.150
Liquid Bromine 0.150
Dichloromethane 0.770
Sodium Thiosulphate 0.040
Celite 0.010
Tertiary Butyl amine 0.650
Iso Propyl Alcohol 0.370
IPA: HCl 0.060
Charcoal 0.010
Celite 0.010
21. Buspirone HCl 2-(piperazin-1-yl) pyrimidine 0.420
1,4-dibromo butane 0.160
Potassium Carbonate 0.080
Dimethyl Formamide 0.050
HCl 0.030
Isopropyl alcohol 0.100
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8-azaspirol[4.5]decane-7,9 dione
(1,2,3,4-tetra methylene glutamide) 0.450
n-butyl acetate 0.550
22. Brivaracetam S-+-2-phenylglycinol 0.450
Diethyl Carbonate 0.160
Potassium Carbonate 0.440
Ethyl acetate 1.640
Pivaloyl chloride 0.330
n-Valeric acid 0.660
Triethyl amine 0.830
Dichloromethane 0.100
Conc. HCl 0.610
1M NaHMDS 1.230
Tert-butyl bromo acetate 0.880
Ammonium chloride 0.470
Cyclohexane 0.040
Hydrogen peroxide (30%) 0.470
Lithium Hyrdroxide monohydrate 0.640
Sodium sulfite 0.170
Sodium hydroxide 0.700
Toluene 1.760
S-(-)-α-Methyl benzyl amine 0.580
Toluene 0.200
S-(-)-α-Methyl benzyl amine 0.620
Toluene 0.620
Ethyl chloro formate 0.180
Triethyl amine 0.070
Sodium Borohydride 0.370
Methanol 0.060
Trifluoro acetic acid 1.000
HBr 0.330
(S)-2-Aminobutyramide hydrochloride 0.200
Thionyl Chloride 0.060
TEA 0.330
Ethanol 0.200
Sodium Chloride 0.150
Sodium sulfate 0.130
n-Heptane 0.380
THF 0.230
Potassium-tert butoxide 0.080
Ammonium chloride 2.500
Ethyl acetate 0.450
Isopropyl acetate 0.160
23. Canagliflozin CGA-02 0.950
CGA-03 1.140
THF 0.140
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n-Butyl lithium 0.060
Methane Sulfonic acid 0.670
Methanol 0.320
Toluene 0.910
Sodium bicarbonate 1.060
n-heptane 2.770
Sodium Chloride 0.570
TMSCl 0.280
MDC 4.960
NMM 0.030
NaH2PO4.2H2O 0.500
Sodium Sulfate 0.210
Hyflow 0.860
BF3 Etherate 1.200
Triethyl silane 0.880
BHT 0.070
Sodium bicarbonate 0.770
Ethyl acetate 0.480
Activated Charcoal 0.130
Hyflow 0.300
Beta cyclodextrin 0.290
isopropyl acetate 0.470
MTBE 4.020
Ethanol 0.220
L-proline 0.370
24. Candesartan
Cilexetil
CN-13 1.000
Cilexetil 0.350
Potassium Carbonate 0.200
DMSO 2.500
Pivalic acid 0.240
Methanol 8.500
MDC 8.720
P.W. 4.100
Sodium bicarbonate 0.200
Ethanol 0.170
Cyclohexone 0.220
25. Carvedilol 4-(2,3-Epoxy)-9H-Carbazole 0.063
2-(2-2-Methoxyphenoxy) Ethyl Amine 0.045
Isopropyl alcohol 0.052
Salicylic acid 0.036
Ethyl Acetate 0.044
Caustic Flakes Soda 0.008
Hyflow Super cell 0.003
Activated Carbon 0.012
26. Clindamycin Lincomycin HCl 1.110
Chloroform 1.420
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DMF 0.030
Thionyl Chloride 1.150
Sodium Hydroxide 0.810
MDC 0.080
Ethanol 1.400
HCl 4.660
Charcoal 0.010
Acetone 0.060
27. Clonidine 2,6-Dichloro Aniline 1.170
Ammonium thiocyanate 1.100
Trifluoro acetic acid 2.480
Toluene 0.750
TEA 1.470
Ethyl acetate 0.380
Isopropanol 0.500
Methyl Iodide 0.620
Acetone 0.070
Cyclohexane 0.990
Ethylene diamine 3.700
DMSO 1.870
28. Clopidogrel
Bisulphate/ besylate
2-CPG 0.830
Methanol 0.310
thionyl chloride 0.250
toluene 1.580
Liquid ammonia 2.030
acetone 0.440
L(+) tartaric acid 0.720
15% NaCl solution 2.790
K2HPO4 0.620
acetonitrile 0.180
Ethyl acetate 2.990
HCl solution 0.650
Sulfuric acid 0.270
Charcoal 0.090
29. Colestipol
Hydrochloride
Diethyl enteric amine 0.830
Sodium dodecyl benzene sulphonate 0.020
Toluene 0.130
Epichlorohydrin 1.410
NaOH solution 0.430
30. Cinacalcet HCl R--1-Napthalen-1-yl)ethylamine 0.550
4-(3-(trifluoro methyl ethyl)
phenyl)butane-2-one 0.650
Titanium(IV) isoperoxide 0.880
Dichloromethane 0.360
Tetrahydrofuran 0.120
Pd/C 0.040
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Ethanol 5.070
HCl 0.170
31. Dapagliflozin DGA-Ethoxy benzyl 0.860
Tetrahydrofuran 0.080
n-BuLi(23% in hexane) 0.820
Methane sulphonic acid 0.650
DGA-Glucono Lactone (KSM-2) 0.210
Methanol 3.750
sodium bi carbonate 0.510
n-heptane 0.170
charcoal 0.090
MDC 0.210
Sodium chloride solution 0.520
Triethyl silane 0.730
Boronitriflouride diethyl ether 1.210
ethyl acetate 1.860
Sodium chloride 0.330
Hyflow 0.560
MTBE 0.380
DIPE 0.570
Butanediol for seeding 0.010
1,2 Butanediol 0.870
Isopropyl alcohol 0.020
32. Darunavir Methanol 0.070
KSM-1 (BOC-07) 0.110
con HCl 0.410
Sodium carbonate solution 0.360
Dichloromethane 0.100
Triethyl amine 0.110
KSM-02 0.630
Ethyl Acetate 0.390
10% Pd/c 0.120
Activated Charcoal 0.040
33. Desloratadine Loratadine 1.000
Ethyl Chloroformate 0.490
Toluene 0.160
Sodium hydroxide 0.130
Methanol 0.330
34. Desvenlafaxine
Succinate
venlafaxine 5.320
PEG-400 3.740
Sodium thiophenolate 6.330
H3PO4 2.400
n-Heptane 3.750
Liquid Ammonia 0.660
Succinic acid 0.380
Acetone 0.350
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35. Dimethyl Fumerate Fumaric Acid 1.000
Methanol 3.000
Thionyl Chloride 0.360
36. Donepzil HCl 5,6-Dimethoxy 1- indanone 0.660
Tetrahydrofuran 0.130
1-Benzyl 4-piperidine carboxaldehyde 0.830
sodium methoxide solution 0.040
Methanol 1.980
Dichloromethane 0.960
IPA HCl 0.130
Diisopropyl ether 3.550
DNZ 1.130
5% NaOH solution 0.560
Methanol 0.980
Acetic acid 4.720
10% Palladium on charcoal 0.020
Hyflow 0.200
Liquor ammonia 1.500
5% Acetic acid solution 3.400
5% NaCl solution 1.100
Activated Charcoal 0.790
37. Duloxetine HCl 2-Acetyl Thiophene 0.640
Pera formaldehyde 0.180
Dimethyl amine Hydrochloride 0.500
IPA 0.170
Conc. HCl 0.030
Sodium Borohydride 0.160
NaOH 0.230
Methanol 0.090
1-Fluoro Naphthol 0.540
KOH 0.320
DMSO 1.550
Toluene 0.900
Hyflow 0.130
Triethyl Amine 0.440
Phenyl Chloroformate 0.600
K2CO3 1.350
L(-)DBTA 0.680
Ethanol 0.440
NaOH 0.110
MDC 0.410
38. Edoxaban Tosylate
Monohydrate
ACO 0.900
CPA 0.700
TEA 0.070
DMAc 4.250
Isopropyl alcohol 0.250
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IPA HCl 2.320
TPC 0.540
DIPEA 0.060
TBTU 0.730
MDC 0.070
Sodium carbonate 0.820
Hyflow 0.170
Ethanol 0.730
PTSA.H2O 0.280
Activated charcoal 0.020
39. Eltrombopagalamine Sodium Nitrite solution 0.420
sulphuric acid 1.020
4-chloro 2-bromo phenol 1.010
Methanol 0.080
potassium carbonate 0.910
Benzyl Chloride 0.770
DMF 0.090
3 carboxy phenyl boronic acid 0.550
Isopropyl alcohol 0.560
Palladium tetrakis triphenylphosphine 0.050
toluene 0.160
HCl 3.940
Palladium carbon 0.100
Acetone 8.130
Acetic acid 2.300
3,4-dimethylphenyl hydrazine HCl 0.600
Sodium acetate 0.280
Ethyl aceto aetate 0.450
MDC 0.080
Sodium bicarbonate solution 0.290
Diisopropyl ether 0.080
Amino biphenyl 3.600
ELA- KSM-3 1.200
Sodium Nitrite 0.600
Sodium Bicarbonate 1.300
Ethanol 2.580
THF 0.050
Ethanol amine 0.060
40. Empagliflozin Dichloromethane 1.040
4-bromo 1- chloro 2-(4-
ethoxybenzyl)benzene 0.800
boron tri bromide 0.390
Triethyl chloride 0.700
triethyl amine 0.360
MTBE 0.200
EMA-Trityl 1.700
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Tetrahydrofuran 0.180
Methanol 0.550
Methane sulfonic acid 1.320
Sodium bicarbonate 0.400
Heptane 0.120
Toluene 1.000
Ethyl Acetate 0.710
Acetonitrile 0.300
Boron Trifluoride.Et2O 0.710
Triethysilane 0.640
Methyl Ethyl Ketone 4.330
Methyl tertiary butyl ether 1.380
Cyclohexane 0.110
EMA-Condensed Phenol 0.500
EMA-Tosylate 0.500
Cesium Carbonate 0.450
N,N-dimethyl formamide 0.190
Sodium Hydroxide 0.300
Activated charcoal 0.060
Ethanol 0.150
L-Proline 0.750
41. Entecavir
Monohydrate
Entecavir KSM 1.820
Boron trichloride 1.660
MDC 0.220
Methanol 0.400
Ethyl acetate 0.290
NaOH 0.360
Activated charcoal 0.560
Hyflow 0.200
42. Escitalopram
Oxalate
Potassium Carbonate 0.620
CDO-Hydrobromide 1.810
Dichloro Methane 0.810
Isopropyl alcohol 0.410
(+)DI-tolyl tartaric acid 0.820
Methylene Chloride 0.590
Potassium Carbonate 0.210
Methane Sulphonyl chloride 0.190
Triethyl amine 0.160
Oxalic acid 0.130
Acetone 0.400
43. Esomeprazole
Magnesium
chloro compound (NRD-17) 0.680
methanol 0.680
mercapto compound 0.570
NaOH flakes 0.280
MDC 0.200
Ethyl acetate 0.450
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Diethyl-L-tartarate 1.300
Titanium Isopropoxide 0.880
Diiso propyl ethylamine 0.030
Cumene Hydroperoxide 1.040
Isooctane 0.110
10 % NH3 Solution 1.350
30% HCl Solution 0.990
MDC 0.480
44. Ethacrynic Acid 2,3-Dichlorophenol 1.110
Sodium Hydroxide 0.950
Dimethyl sulfate 3.010
Dichloromethane 0.670
n-Butyryl chloride 1.390
Anhy. Aluminum chloride 3.480
HCl Solution (3.0%) 3.310
Diisopropylether 0.230
N,N-Dimethyl formamide 1.400
Ethyl chloro acetate 0.460
Potassium Carbonate 0.600
Ethyl 2-(4-Butyryl-2,3-
Dichlorophenoxy) acetate (Stage-3) 1.000
Sodium hydroxide 0.300
Methanol 0.620
Dimethyl amine hydrochloride 0.580
Paraformaldehyde 0.220
Acetic acid 0.100
Sodium bicarbonate 1.640
Toluene 0.500
Activated Charcoal 0.050
Celite 0.180
45. Etoricoxib Chloro acetic acid 0.380
Dimethyl formamide 0.130
Hexafluoro phosphoric acid 1.170
1-(6-Methyl-3-pyridinyl)
2-[4-(methyl sulfonyl)
phenyl]ethanone
1.000
Potassium butoxide 0.400
Isopropyl acetate 0.190
46. Famotidine Methanol 0.070
Caustic flakes 0.750
Isothiourea HCl 1.170
Propionamide derivative 1.040
Acetic acid 0.380
Ammonia gas 0.180
charcoal 0.080
Celite 0.040
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Liquid Ammonia 1.020
47. Fingolimod Iodo Compound 1.250
Diethyl acetamidomalonate 1.650
Sodium hydride 0.300
Dimethyl Formamide 0.680
Diiso propyl ether 0.260
Trifluoroacetic acid 2.270
Triethylsilane 0.730
Sodium hydroxide 1.810
Sodium Borohydride 3.160
Dipothydrogen Phosphate 2.720
Ethanol 0.400
Ethyl acetate 0.220
Lithium Hydroxide 0.600
Methanol 0.260
Acetonitrile 1.280
Ethereal HCl 2.700
48. Flibanserin Orthophenylene diamine 1.000
Ethyl acetoacetate 1.320
KOH (85%) 1.100
Acetic acid 1.660
Methanol 0.300
Mix. Xylene 0.180
1,2-dichloro ethane 3.480
Potassium carbonate 1.730
TBAB 0.020
Toluene 3.260
FSK-pip.deriv. 0.950
DMF 0.150
KI 0.060
FSK-alkene 1.000
IPA HCl 1.770
IPA 0.260
Caustic flakes 1.170
MDC 0.210
49. Fluconazole CT Base 1.400
TMSI 1.400
IPA 0.150
KOH 1.000
1:2:4 Triazole 0.700
MDC 0.280
Hydrose 0.010
Carbon 0.140
Hyflow 0.300
Acetone 0.650
Ethyl acetate 0.750
Cadila Healthcare Limited 20
Methanol 1.390
50. Fosphenytoin
Sodium
Sodium phonytoin 1.000
HCl 0.700
K2CO3 0.010
HCHO 0.500
SDS 1.440
Thionyl Chloride 0.550
DMF 0.020
NaHCO3 0.400
EtOAC 1.030
Sodium Sulfate 0.480
Hexane 0.650
Phosphorus Trichloride 0.710
Benzyl Alcohol 1.110
dimethyl aniline 1.250
Benzene 0.160
brine Solution 1.300
Ammonia Solution 0.780
Carbon tetra chloride 0.860
NaOH solution 2.180
Silver nitrate 0.560
Nitric Acid 0.110
Toluene 0.220
Sodium Chloride 0.720
Potassium Carbonate Solution 2.600
51. Gabapentine Gaba Mesylate 4.000
Triethyl amine 2.000
HCl 1.500
Methanol 0.190
Acetone 0.170
Dichloro methane 0.200
Ethyl amine 0.800
Celite 0.010
Charcoal 0.010
52. Glimepiride Triethyle Amine 0.330
4 MCH amine hydrochloride 0.430
Carbamate pure 1.000
Toluene 1.310
Dilute HCl 0.400
Caustic soda Pallets 0.120
Methanol 1.770
53. Hydrochlorothiazide caustic soda 1.630
sulfonamide 6.420
carbon 0.110
sulphuric acid 0.110
54. Hyoscyamine Toluene 0.250
Cadila Healthcare Limited 21
Sulfate Ethyl phenyl acetate 0.710
Sodium Hydride 0.390
Acetic acid 0.780
Tropine 0.550
Ethyl formate 0.960
Sodium Bicarbonate 0.210
Sodium Borohydride 0.510
Dichloromethane 2.640
Sodium Sulfate 0.550
Dibenzoyl-L-tartaric acid monohydrate 1.450
Ethanol 0.440
Activated Charcoal 0.110
Hyflow 0.330
acetone 0.450
Hyoscyamine Sulfate 0.010
sulfuric acid 0.200
55. Ivabradine HCl S(+)benzo cyclo butene 0.830
Bromo chloro propane 3.750
K2CO3 0.820
HCl 2.500
MDC 1.270
NH3 1.660
ID-B 0.560
DMSO 2.410
Pot. Tert. Butoxide 0.320
Ethyl acetate 0.150
Aceto nitrite 0.230
IPA HCl 1.630
56. Levomilnacipran Toluene 1.820
aluminium chloride 0.620
Dimethyl amine 0.710
Lactone compund 0.680
HCl 0.200
DMF 0.070
Thionyl chloride 0.470
Potassium Phthallamide 0.940
Cyclohexane 1.270
IPA 0.080
Monomethyl amine 1.500
( R)' Mandelic acid 0.560
LEA Mandelate salt 0.010
ethyl acetate 0.310
MDC 0.350
NaOH Solution 0.260
IPA-HCl 0.070
57. Hydroxychloroquino 4,7-DCQ 1.250
Cadila Healthcare Limited 22
ne Sulfate HNDA 1.060
Sod. Carbonate 0.620
Pot. Iodide 0.050
Ethyl acetate 0.280
Aq. NH4)2SO4 soln. 5.370
Gl. Acetic acid 0.330
Charcoal 0.060
Celite 0.190
Toluene 0.200
IPA 0.050
58. Lamotrigine AGB 1.100
2,3 dichloro benzyl cyanide 1.100
Sulphuric acid 3.300
NaOH Flakes 0.310
40% NaOH solution 0.770
Methanol 1.250
Acetic acid 4.460
Activated charcoal 0.050
Liquid Ammonia 3.240
Isopropanol 0.120
59. Lansoprazole
Sulphide
LN-01 0.780
methanol 3.980
2-Mercaptobenzimidazole (LN-02) 0.430
Sodium hydroxide solution 0.340
Sodium thiosulphate 0.270
Sodium carbonate 0.130
MDC 7.670
m-Chloroperbenzoic acid 0.820
Dilute Acetic acid 0.420
MDC 3.250
IPA 5.670
liquid ammonia 0.600
Activated Charcoal 0.060
Potassium Hydroxide 0.270
Acetic acid 0.140
60. Ledipasvir LSA KSM-01 0.760
LSA KSM-02 0.740
K2CO3 0.390
Pd Tetrakis 0.030
1,4-dioxane 5.930
Acetone 7.280
Methanol 0.080
Sodium Chloride 0.380
IPA-HCl 3.020
MDC 0.600
Moc-L-Valine 0.540
Cadila Healthcare Limited 23
EDC-HCl 0.590
HOBt 0.430
DIPEA 0.050
Dimethyl foramide 0.220
Ethyl Acetate 0.370
Acetone 0.260
Na2CO3 0.920
Sodium Sulphate 0.100
Activated Charcoal 0.100
Copovidone 0.750
Methanol 0.560
61. Letrozole 4-Bromo methyl Benzonitrile 1.170
1,2,4-triazole 0.450
Triethyl amine 0.750
Methylene chloride 0.130
di isopropyl ether 0.210
Isopropyl alcohol 1.170
4-Fluoro Benzonitrile 0.840
DMSO 5.370
potassium-t-butoxide 0.960
Toluene 0.310
Acetone 0.130
62. Levofloxacin
Hemihydrate
Absolute alcohol 6.000
DMSO 3.800
Levo acid 0.950
N-methyl piperazin 0.330
Tri ethyl amine 0.340
IPA 0.180
Ethanol 1.240
Liq. Ammonia 1.250
Acetic acid 0.750
63. Linagliptine BMP 0.080
2 bromo butyne 0.530
DIPEA 0.550
DMF 0.150
BMQ 0.640
Sodium Carbonate 0.350
NMP 0.270
Ethanol 0.220
acetic acid 0.030
R-BOC3-AP 0.440
Potassium Carbonate 0.330
DMSO 1.500
TFA 2.500
MDC 0.600
64. Loratidine 3CPAN 0.660
Cadila Healthcare Limited 24
Sodium Methoxide 1.080
Methyl nicotinate 0.660
HCl 0.680
Acetic acid 0.140
Sulphuric acid 1.660
liquid ammonia 0.970
Toluene 0.430
hydrazine hydrate 0.470
Sodium hydroxide 0.070
MEG 1.000
MDC 0.250
Acetic acid 0.940
H2O2 1.500
THF 0.170
Mg 0.120
Iodine 0.020
N-M4CPB 0.740
EDB 0.010
HCl 1.530
NaOH 0.720
HF 0.120
BF3 gas 0.060
KOH 0.760
ECF 0.720
TEA 0.770
NaHCO3 Solution 2.340
Acetonitrile 0.170
charcoal 0.080
Hyflow 0.100
65. Lorcaeserin HCl Dichloromethane 0.350
thionyl chloride 0.660
4-chloro phenyl acetic acid 0.780
DMF 0.110
Phosphorous pentachloride 1.460
1-amino 2-propanol 0.520
Sodium carbonate 0.980
Tetrahydrofuran 0.120
Sodium borohydride 0.270
LLA-Chloro amide 1.170
BF3 etharate 1.350
HCl 1.180
Aqueous NaOH Solution 0.820
Toluene 0.240
1,2 Dichlorobenzene 2.290
Aluminium chloride 1.860
Chloro amine 1.500
Cadila Healthcare Limited 25
Ethyl acetate 0.200
Sodium chloride 1.000
Methyl ethyl ketone 1.800
L(+) tartaric acid 0.640
Sodium hydroxide 0.330
66. Losartan Potassium Ortho tolyl benzonitrile 1.510
Triethyl amine HCl 2.180
Xylene 0.250
Toluene 0.370
Trityl chloride 2.380
Sodium hydroxide 1.140
Methanol 0.110
Sodium azide 1.270
Benzoyl peroxide 1.380
Chloroform 0.120
Dimethyl dibromo 0.910
Diisopropyl ether 0.130
Hyflow super cell 1.270
Caustic soda 0.290
TBAI (Catalyst) 0.020
Sodium borohydride 0.050
Carbon 0.370
Acetic acid 0.110
Ethyl acetate 0.070
Sulphuric acid 0.660
Acetonitrile 0.070
67. Lurasidone
hydrochloride
LNK- KSM-01 0.980
LNK- KSM-02 0.630
Sodium carbonate- 0.850
Toluene 0.130
LNK KSM-03 0.520
potassium carbonate 0.450
Xylene 0.080
Methanol 0.090
IPA HCl 0.820
68. Macitentan 5-(4-Bromophenyl)-4,6-dichloro
pyrimidine (KSM-02) 0.800
Potassium (N-Propyl sulfonyl) amide
(KSM-01) 1.160
N,N Dimethyl Formamide 4.180
Acetic Acid 0.920
Ethylene glycol 2.640
potassium tert-butoxide 1.240
acetic acid 0.860
Methanol 4.660
Sulfolane 1.040
Cadila Healthcare Limited 26
Sodium hydride (55% in mineral oil) 0.420
2-Chloro-5-bromo pyrimidine (KSM-
03) 0.800
isopropyl alcohol 0.240
Toluene 0.070
ethyl acetate 0.180
Activated carbon 0.220
Celite 0.120
69. Meloxicam Inter-A3 1.110
Inter-A5 0.510
Mix - xylene 0.200
NaOH 0.150
Acetic Acid 0.870
MeOH 1.860
DMF 0.060
Toluene 0.160
Methanol 0.060
70. Mesalamine NaOH 1.060
2 chloro 5 nitro benzoic 1.050
HCl 4.500
5 Nitro Salicylic acid 0.300
Potassium hydroxide 0.250
Raney Nickel 0.150
Hydrazine hydrate 0.350
Sodium hydrosulphide 0.010
Activated charcoal 0.180
Potassium carbonate 0.110
71. Metoprolol Succinate 4-(2-Methoxyethyl) phenol 0.650
Epichlorohydrin 0.810
Sodium Hydroxide 0.250
Ethyl Acetate 0.160
Isopropyl Amine 1.050
IPA 0.100
Acetone 0.140
Succinic Acid 0.200
72. Midodrine
Hydrochloride
1,4 Dimethoxy benzene 1.330
chloroacetyl chloride 1.330
Aluminium chloride 2.990
Sodium hydroxide 2.190
Sodium azide 2.460
Hydrochloric acid 2.980
Isopropyl alcohol 0.220
Acetone 0.120
Dichloro methane 0.260
Reducing agent 0.860
Sodium sulfate 1.460
Cadila Healthcare Limited 27
Tetra hydro furan 0.110
Toluene 0.150
Activated charcoal 0.200
Boc-NH glycine 1.930
Dehydrating agent 2.330
HCl 2.190
sodium bicarbonate 0.200
Ethyl acetate 0.140
Celite 0.660
73. Mirabegron (R )-2 Hydroxy-2-phenyl acetic acid 0.580
2-(4-nitrophenyl) ethane amine HCl 0.770
Triethyl amine 0.380
DMF 0.180
1-hydroxy benzotriazole (HoBt) 0.050
EDC. HCl 0.770
ethyl acetate 0.220
1 M HCl solution 1.890
20% K2CO3 solution 0.890
Toluene 0.130
1,3 dimethyl - imidazolidinone 3.650
THF 0.170
Methanol 0.460
1M Borane THF solution 1.840
HCl 0.930
30% K2CO3 Solution 0.520
Pd/c 0.120
DIPE 0.150
2-(2 aminothiazol-4-yl) acetic acid 0.470
NaOH solution 0.400
74. Nicorandil Methyl Nicotinate 1.000
Mono ethanol amine 0.530
Acetone 0.150
Nitric acid 3.000
caustic soda 0.860
HCl 0.530
Hyflow 0.100
Charcoal 0.240
MDC 0.080
75. Olmesartane 4-(1- hydroxy 1- methylethyl)- 2
propyl H-imidazole- 5 carboxylic acid 1.250
4-(chloromethyl)-5-methyl-2-oxo-1,3
dioxolane 1.870
ethyl acetate 0.120
K2CO3 0.850
DIPE 0.240
5-(4-(bromomethyl) [1,1-biphenyl]-2- 2.200
Cadila Healthcare Limited 28
yl]-2-(triphenyl methyl)-2H-tetrazole
methanol 0.300
MDC 0.440
15% NaCl 2.370
IPA 0.380
30% HCl 0.260
THF 0.110
n-butanol 0.310
76. Omeprazole
Magnesium
Omeprazol API 0.950
NaOH 0.120
MgCl2 0.310
77. Pantoprazole
Sodium
KSM-14 0.660
NaOH 0.370
IPA 0.540
Sodium Hypochlorite 2.680
Acetone 1.290
78. Paroxetine
Hydrochloride
Triethyl Amine 0.090
Toluene 0.140
(-)-Alcohol 0.120
Methane Sulfonyl Chloride 0.080
Sodium Hydroxide 0.020
Methanol 0.030
Sesamol 0.060
Dimethyle Sulfoxide 0.580
Phenoxy Chloroformate 0.080
Potassium carbonate 0.260
Isopropanol 0.110
Sodium Hydroxide 0.050
Activated Charcoal 0.010
Acetone 3.030
79. Phenteramin Acetic acid 2.500
NaCN 1.750
Sulfuric acid 1.620
Dimethyl benzyl carbinol 1.000
HCl 1.000
MDC 0.150
FeSO4 Solution 0.010
Ethyl acetate 3.500
Activated Charcoal 0.040
Dry HCl 2.200
80. Pramipexole Dihydro
Mono Hydrate
Trans-4-amino cyclo hexanol 0.490
Phthalic anhydride 0.690
p-Toluene sulfonic acid 0.010
Toluene 1.660
Ethyl acetate 1.640
Chromium trioxide.2H2O 0.390
Cadila Healthcare Limited 29
Sulphuric acid 0.510
Acetone 0.220
IPA 0.540
Celite 0.200
Sodium bicarbonate 0.560
Ethanol 2.130
Bromine 0.950
Thio urea 0.600
Mono methyl amine(40% w/w) 2.080
L(+)-Tartaric acid 0.950
Sodium hydroxide 0.640
Potassium bicarbonate 0.770
n-Propyl Bromide 0.690
Sodium hydroxide solution 2.480
Dichloromethane 0.220
Activated charcoal 0.070
IPA-HCl (15%) 1.540
81. Pregabalin MDC 0.110
Isovaleraldehyde 0.410
Di methyl malonate 0.740
Morpholine 0.080
Acetic Acid 0.070
Hydrochloric acid 1.250
NaHCO3 Solution 1.240
Hyflow 0.240
Ethanol 1.000
NaCN 0.200
Hexane 0.110
Acetic acid 0.270
Dimethyl sulfonide 3.680
NaCl 0.380
Methyl tertiary butyl ether 0.310
MeOH 3.390
KOH 0.790
Raney Nickel 0.410
Acetic acid 0.840
Liq. NH3 0.310
IPA 0.690
L(+) mandelic acid 2.480
THF 0.280
82. Propefenone O-Hydroxy acetophenone 0.760
Benzaldehyde 2.140
Sodium hydroxide 1.500
Conc. HCl acid (30%) 0.870
Hexane 2.910
Palladium charcoal 0.110
Cadila Healthcare Limited 30
Methanol 0.330
Acetone 0.580
Epichlorohydrine 1.690
Potassium carbonate 1.230
Isopropyl alcohol 0.310
Charcoal 0.030
Propyl amine 0.110
HCl 0.620
83. Polmacoxib 4(3-bromo-5,5-dimethyl-4-oxo-4,5-
dihydrofuran-2-
yl)benzenesulfonamide
0.600
3-fluorophenyl) boronic acid 0.300
Toluene 0.030
Ethanol 0.040
Palladium tetrakis 0.400
84. Quetiapine
Hemifumerate
Dibenzo(B,F)[1,4] 1.100
POCl2 0.900
DMA 0.410
Toluene 0.300
Hexane 0.240
Piperazine 1.300
Xylene 0.070
30% HCl 1.150
Ethyl Acetate 0.250
25% NaOH Solution 0.370
2-Choro ethoxy ethanol 0.500
Na2CO3 1.500
Ethanol 0.160
DMF 0.130
Flmeric Acid 0.270
THF 5.000
85. Ranolazine Chloro Acetyl Chloride 0.110
2,6 Xylidine 0.100
sodium Bicarbonate 0.110
Acetone 0.060
Piperazine 2.140
methanol 0.150
Toluene 0.350
Hexane 0.120
HCl 0.370
Iso propyl alcohol 0.180
Sodium Hydroxide 1.650
caustic soda 0.330
Guiacol 0.800
Carbon + Celite 0.120
86. Rasagiline Beyslate 1-Indanone 0.940
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Hydroxylamine Hydrochloride 0.540
Methanol 0.920
Sodium Hydroxide 0.280
Ammonia (gas) 0.570
Raney Nickel 0.250
Hyflow 0.180
Dichloro methane 0.200
5% Hydrochloric acid 0.830
40% Sodium Hydroxide 1.120
Activated Charcoal 0.100
87. Risperidone Pyrimidine HCl 1.310
Benzisoxazole 1.090
Potassium Carbonate 3.590
Potassium Iodide 0.160
Toluene 0.070
Acetone 2.010
Methanol 0.060
Celite 0.100
Activated Charcoal 0.130
88. Rivastigmine (S)-3-(1-(dimethyl
amino)ethyl)phenol 1.360
S-(+) Camphor sulphonic acid 1.900
Methanol 0.220
Ethyl acetate 0.230
sodium carbonate solution 0.020
(KSM – 02) 0.640
sodium hydride 0.570
toluene 0.960
89. Roflumilast 3-(cyclopropylmethoxy)-4-(difluoro
methoxy) benzaldehyde 1.030
Sodium Chloride (80%) 0.480
Acetic Acid 0.260
Sulphamic Acid 0.410
Thionyl Chloride 1.160
Toluene 0.130
Hexane 0.140
4-amino 3,5-dichloro pyridine 0.600
Sodium hydride (60%) 5.680
Tetrahydrofuran 5.680
10% HCl 3.140
MIDC 4.200
Saturated NaHCO3 Solution 1.500
MgSO4 (anhydrous) 0.100
IPA 0.130
90. Rosuvastatin NRSC DMP Ester 1.170
Cadila Healthcare Limited 32
Calcium RO Aldehyde 0.710
Potassium tert Butoxide 0.270
THF 0.070
Acetic Acid 0.070
Sodium Chloride 0.500
Ethyl acetate 0.090
Charcoal 0.110
Hyflow 0.500
Methanol 0.490
Hexane 0.140
Toluene 0.110
Acetonitrile 0.040
HF (48% Aq.) 0.100
DIPE 0.060
NaHCO3 0.330
NaCl 0.780
THF 0.220
MlOH 0.980
DEMBO 0.160
NaBH4 0.050
Cyclohexane 0.240
NaOH 0.250
Sodium sulfate 0.720
t-Butyl Amine 0.500
2N HCl 1.700
MDC 0.100
CaCl2 0.020
BHT 0.020
91. Rosuvastatin
Ethanol Amine
Rosuvastatin condensed (RO-118) 1.000
HCl acid 0.560
Methanol 0.170
NaOH 0.200
Charcoal 0.500
Hyflow 0.500
ethyl acetate 0.510
Toluene 0.400
Sodium sulphate 0.500
Mono ethanol 0.120
92. Sacubitril Valsartan
Trisodium
(2R,4S) PA 1.200
HCl 2.000
Dichloromethane 1.050
Absolute Ethanol 4.070
Thionyl Chloride 0.520
Toluene 0.160
DIPE 0.390
Acetonitrile 0.110
Cadila Healthcare Limited 33
succinic anhydride 0.300
DMAP 0.040
TEA 0.730
DCM 1.430
NaOH 0.092
Methanol 0.130
MeOH 0.240
Valsartan 0.480
EtOAc 0.250
cyclohexane 1.450
93. Saroglitazar Hydroxy Compound 0.570
Mesylate Compound 0.850
Potassium Carbonate 0.330
Cyclohexane 0.120
Tetrahydrofuran 0.170
18-Crown-6-ether 0.020
Caustic flakes 0.290
Alkaline Charcoal 0.050
S-(-)-α-Methyl benzyl amine 0.350
Sodium chloride 0.170
Ethanol 0.090
MTBE 0.190
HCl 0.310
Celite 0.050
Isopropyl acetate 0.240
Sodium Hydroxide 0.190
n-Heptane 0.170
n-Butyl acetate 0.060
Magnesium acetate tetrahydrate 0.510
Magnesium sulfate (anhydrous) 0.200
Dichloromethane 0.120
94. Saxagliptin DIPEA 0.960
Acetonitrile 1.600
ethyl acetate 1.230
KSM-1 0.790
KSM-2 1.100
HOBt 0.500
EDC 0.710
2N HCl 0.770
IPA 1.740
Brine 0.950
KHCO3 1.300
Methanol 0.100
Ethyl nicotinate 0.950
TFAA 0.420
tetra methyl ethylene amide 0.170
Cadila Healthcare Limited 34
seeding 0.010
MDC 0.180
NaOH 0.420
K2CO3 1.880
NaCl 0.760
EtoAc 0.180
95. Sertraline
Hydrochloride
Tetralone 1.000
Methanol 0.440
Mono methyl mine 0.500
Toluene sulfonic acid 0.020
Methylene dichloride 0.420
Sodium borohydride 0.080
Acetic acid 0.150
Caustic soda flakes 0.510
Isopropanol Hydrochloride 1.690
Ethanol 4.520
D (-) mandelic acid 0.760
Hyflow super cell bed 0.790
Ethyl acetate 0.160
96. Sildenafil Citrate 1 - Methyl-3n- propyl pyrazole 5-
carboxylic acid 1.030
Oleum (65%) 0.750
nitric acid 0.400
thionyl chloride 0.730
Acetone 4.510
Aq. NH3 solution (20% w/w) 1.090
stannous chloride 1.350
ethanol 2.360
NaoH solution (20%) 1.020
MDC 0.970
MgSO4 1.680
DIPE 0.300
2-ethoxy benzoyl Chloride 1.190
Triethyl amine 0.810
Methanol 0.110
HCl 1.320
ethyl acetate 0.710
hexane 0.280
NaOH solution (40%) 0.290
H2O2 1.460
Sat. NaHCO3 Solution 1.380
Sat. NaCl Solution 1.950
chlorosulfonic acid 0.310
Na2SO4 solution 0.400
N-Methyl piperazine 0.270
dimethyl formamide 0.100
Cadila Healthcare Limited 35
97. Silidosin Silidosin Amine 2.250
Silodosin Bromo compound 2.050
Na2CO3 0.940
Ethanol 0.330
t-Dibutyl dicarbonate 1.250
MDC 0.520
5N NaOH 0.250
30% H2O2 0.120
DMSO 0.110
3 Bromo propanol 0.750
98. Sitagliptine
phosphate
Anhydrous/
Besylate
(3R)-3-[1,1-dimethyl
ethoxycarbonyl)amino-4-(2,4,5-
trifluro phenyl) butanoic acid
1.720
3-(trifluromethyl)-5,6,7,8-tetrahydro-
1,2,4-triazole [4,3 -alpha]pyrazine 1.350
EDC 1.180
HOBT 0.860
Dichloromethane 0.090
Methanolic HCl 1.250
99. Sparfloxacin Spar acid 1.000
Piperazine comp. 0.500
Triethyl amine 0.500
Acetonitrile 0.100
Con. HCl 0.040
Sodium Hydroxide 0.040
Activated charcoal 0.130
Celite 0.120
100. Tamsulosin HCl R-(-)- Tamsulosin Amine 1.210
Tamsulosin Bromo compound 1.210
KHCO3 0.740
IPA 0.210
IPA-HCl 5.130
Acetonitrile 0.180
NaOH 1.880
Celite 0.180
Charcoal 0.060
Conc. HCl 1.640
Methanol 0.150
Celite 0.160
101. Tebipenem Pivoxil Compound 25 0.570
Acetone 0.150
Chloroform 0.200
Diiso propyl ethyl amine 0.110
4-Nitrobenzyl(1R,5S,6S)-2-(diphenyl
phosphoryloxy)-6-[(R)-1-
hydroxyethyl]-1-methylcarbapen-2-
1.800
Cadila Healthcare Limited 36
em-3-carboxylate
Ethyl acetate 0.420
Saturated Sodium chloride solution 0.200
Tetrahydrofuran 0.020
Phosphate buffer 1.600
Zinc powder 0.400
Dimethyl formamide 0.050
Pivalic acid iodomethyl ester1 0.670
Sodium carbonate 0.220
102. Telapvir DMF 0.350
Pyrazine carboxylic acid 0.390
CDI 0.510
KSM-02 1.230
Potassium carbonate 0.060
MDC 1.110
HCl 1.850
Toluene 0.420
EDC HCl 0.720
HOBt hydrate 0.260
Sodium bromide (15%) 0.620
sodium bicarbonate 2.320
TEMPO 0.010
sodium hypochlorite 3.000
ethyl acetate 0.200
103. Telmisartan SM1 0.740
SM2 0.730
Potassium butoxide 0.230
Ethyl acetate 0.230
DMSO 0.100
104. Tenegliptin Boc Piperazine 0.800
Diketene 0.320
DMF 0.240
ethyl acetate 0.690
Brine 2.400
ethanol 0.120
phenyl hydrazine 2.880
MSA 0.370
Pyridine 1.410
Phosphorus oxychloride 0.530
HCl 2.040
Na2CO3 2.680
Dichloromethane 0.240
trifluroacetic acid 0.850
Diethyl ether 1.600
chloroform 1.600
Thiazolidine 0.510
Cadila Healthcare Limited 37
DMF 0.240
HOBT 2.960
EDC.HCl 1.120
Triethylamine 1.530
sulfur trioxide pyridine complex 1.740
Dimethyl sulfoxide 1.060
KSM-1 1.000
KSM-2 1.000
acetic acid 0.400
sodium triacetoxy borohydride 0.980
1,2 dichloro ethane 0.940
Methanol 0.150
chloroform 1.500
1,4 dioxane 1.000
105. Amlodipine Besylate Phthalic Anhydride 0.780
Mono Ethanol Amine 0.320
Xylene 0.210
ethyl 4-chloro acetoacetate 0.080
Toluene 0.050
acetic acid 0.290
sodium hydride 0.040
methanol 0.040
Morpholine 0.040
O-chloro Benzaldehyde 0.320
Methanol 0.270
3-Methyl Amino Crotonate 1.000
Mono methyl amine 4.000
Benzene sulphonic acid 0.660
Activated charcoal 0.070
Ethyl acetate 0.280
106. Etodolac Ethyl tryptophol 0.620
Dichloro methane 0.060
Methyl 3-oxopentanoate 0.430
Boron trifluoride etherate 0.030
Sodium bicarbonate 2.490
10 % Brine solution 1.870
Methanol 0.080
Isopropanol 0.100
Sodium hydroxide 0.130
Cyclohexane 0.270
Activated carbon 0.020
107. Tirofiban HCl L-Tyrosin 0.800
Thionyl Chloride 0.460
Methanol 1.330
Diisopropyl ether 0.120
ACN 0.110
Cadila Healthcare Limited 38
Pyridine 1.470
1-butane sulfonyl chloride 1.380
MDC 0.200
Potassium bi carbonate 0.940
Hyflow 0.230
Carbon 0.230
Toluene 1.470
u-Picoline 0.840
n-Butyl lithium 0.930
THF 1.170
Bromo chloro Propane 1.490
Ethyl acetate 0.290
Brine Solution 0.500
Sodium Sulfate 0.080
IPA 0.080
Oxalic Acid 1.520
DMSO 5.730
KOH 0.740
Int. A 1.000
KI 0.010
NaOH Solution 3.050
Pa/C 0.500
Acetic Acid 1.220
H2 0.540
HCl 0.420
108. Toficitinab Citrate Acetone 2.080
PTSCI 0.650
TFA-KSM-1 0.470
K2CO3 1.470
TFA-KSM-2 1.000
NaOH 2.960
HCl 2.530
Methanol 0.580
Pd/c 0.030
MDC 3.130
Cyclohexane 0.080
THF 1.250
DBU 0.100
ECA 0.560
MeOH 0.980
citric acid 0.600
ethanol 0.100
Activated charcoal 0.040
109. Tolvaptan 2-methyl-4-nitro benzoic acid 1.960
Thionyl chloride 1.160
advanced intermediate (TIK 06) 1.780
Cadila Healthcare Limited 39
N,N-Dimethyl acetamide 5.280
Toluene 0.400
Stannous chloride dehydrate 1.810
HCl 2.500
Methanol 0.660
Caustic solution 1.760
MDC 0.130
Ethyl acetate 0.200
O-toluic acid 0.820
Potasium bicarbonate 1.140
Sodiium borohydride 0.100
Acetic acid 0.710
Activated charcoal 0.330
110. Topiramate Sulfuryl Chloride 0.510
o-xylene 0.060
Diacetone Fructose 0.680
Pyridine 0.170
ammonia gas 0.070
Citric acid 1.710
1,4 Dioxane 2.560
n-Hexane 0.040
Ethanol 0.300
charcoal 0.010
Celite 0.010
111 Tramadol HCl Toluene 0.260
Caustic flakes 3.580
Sodium Chloride 0.230
THF 0.120
Mg-T 0.140
m-Bromo anisole 1.090
Iodine 0.010
Ammonium Chloride 1.080
Salicylic Acid 0.130
IPA 0.080
Acetone 0.100
Hyflow 0.110
Charcoal 0.050
IPA. HCl 0.040
112 UDCA (India
Market)
7-KLCA 1.000
Raney Nickel 0.500
Potassium hydroxide 0.250
isopropyl alcohol 0.220
HCl 0.550
triethyl amine 0.350
2-Butanone 2.550
HCl 0.580
Cadila Healthcare Limited 40
113 Valdecoxib VLD-II 0.830
N-Butyl lithium 1.050
Acetic anhydride 0.480
Diisopropyl amine 1.160
Tetra hydro furan 0.150
Sodium chloride 0.830
Ethyl acetate 0.080
Toluene 0.170
Chloro sulfonic acid 2.410
Liquid NH3 2.160
Isopropyl alcohol 1.670
SDS 0.070
Celite 0.100
Activated Charcoal 0.060
114 Valsartan 4'-Bromo methyl 0.890
(L) Valine methyl ester HCl 0.570
K2CO3 0.680
DMF 0.100
Toluene 0.370
15% Brine 2.500
Valeroyl chloride 0.500
TEA 0.680
DCM 0.250
HCl 2.540
8% NaHCO3 solution 3.220
Na2SO4 solution 0.160
Tributyl tinchloride 0.520
Sodium azide 0.530
Xylene 0.220
Celite 0.840
Activated carbon 0.200
NaNO2 1.200
Na2CO3 solution 0.350
NaOH 0.680
115. Venlafaxine HCl n-heptane 0.100
NaOH 0.670
t-BuOH 0.440
PMPA 0.800
Toluene 0.180
Cyclohexane 0.590
Acetic Acid 0.960
MDC 0.150
MeOH 0.180
Raney Nickel 0.650
Hyflow 0.860
HCHO 1.130
Cadila Healthcare Limited 41
HCOOH 1.070
HCl solution 0.670
CHCl3 1.270
NaOH 0.790
CHCl3 0.190
MEK 0.190
Charcoal 0.100
IPA HCl 0.860
IPA 0.220
116. Vilazodone HCl VLA-KSM01 0.750
VLA-KSM02 0.750
Diso propyl ethyl amine 0.600
DMSO 7.500
Acetone 0.150
Hydrochloric acid 2.040
117. Vildagliptin Prolinamide 1.480
Chloro acetyl chloride 1.350
THF 0.410
Sodium sulfate 1.400
TFAA 1.200
Ethyl acetate 0.160
Amino adamantanol 0.010
K2CO3 0.380
MTBE 0.160
118. Vortioxetine
Hydrobromide
2,4-Dimethyl thiophenol 0.600
1-Chloro-2-nitrobenzene 0.720
DMF 0.150
Methanol 0.450
HH 0.860
Raney Ni 0.180
Ethyl acetate 0.710
Hyflow super cell 0.180
n-Butanol 0.090
K2CO3 1.780
BCA 0.660
KI 0.020
NH4OH 1.470
NaCl 0.430
Aqueous HBr 1.620
EtOAc 0.120
MDC 0.120
HPMC 0.270
119. Warfarin Sodium
Clathrate
4-Hydroxy coumarin 0.650
Benzylidiene acetone 0.770
TEBAC 0.080
Toluene 0.030
Cadila Healthcare Limited 42
Isopropanol 0.680
NaOH 0.180
Charcoal 0.020
Celite 0.100
120. Ziprasidone HCl 6-Chloro-5 -(2-Chloroethyl) Oxindole 0.820
3-(1-Piperazinyl)-1,2-benzisothiazole 1.090
Sodium carbonate 0.870
Acetic acid 2.360
Iso propanol 0.180
Ziprasidone Base Crude 1.190
Tetrahydrofuran 0.200
Dimethoxide Sulfoxide 1.540
Celite 0.130
Activated Charcoal 0.100
HCl 0.500
Iso propyl Alcohol 0.790
121. Azathioprine 6MP 0.060
CMNI 0.060
NH3 solution 0.300
Acetone 0.030
HCl 0.060
122. Febuxosate 4-Hydroxy 3-nitrobenzaldehyde 1.140
Hydroxyl amine 0.570
sodium formate 0.820
Formic acid 2.980
Thioacetamide 1.070
DMF 0.190
2N NaOH 1.530
Ethanol 0.100
Ethay 2-chloro acetoacetate 0.790
DMF 0.270
K2CO3 2.130
Isobutyl bromide 1.840
Ethyl acetate 0.300
NaCl solution 1.440
Pd/c 0.230
Methanol 0.220
Hyflow 0.040
NaNO2 0.530
HCl 1.500
CuCN 1.730
KCN 1.110
123. Lacosamide D-Sarine 1.180
Acetonitrile 0.250
Triethyl amine 1.350
BOC-Anhydried 1.950
Cadila Healthcare Limited 43
HCl 3.810
Ethyl acetate 1.920
N-Hexane 0.100
Toluene 0.350
TBAB 0.080
Aqueous NaOH 3.480
Dimethyl sulfate 2.890
Dichloro methane 2.200
Citric acid 1.810
N-Methyl morpholine 0.540
Isobutyl chloroformate 0.730
Benzyl amine 0.600
NaHCO3 solution 0.920
Acetic anhydride 0.860
Diso propyl ether 0.270
124. Refaximin RFM 1.100
Ethanol 0.220
RFM Z 0.010
125. Tolperisone Anhy.AlCl3 0.110
Toluene 2.370
Propionic anhydride 0.050
HCl 2.650
NaHCO3 1.150
IPA HCl 0.080
Piperidine HCl 1.000
Parafomaldehyde 0.190
n-Butanol 0.610
Ethyl Acetate 0.150
NaOH 0.270
Hyflow 0.060
126. Udenafil DCM 1.080
KSM-01 0.830
Chlorosulphonic acid 1.330
sodium sulfate 0.830
Sodium bicarbonate solution 1.250
Acetone 0.330
KSM-02 1.660
Methanol 1.000
Cadila Healthcare Limited 44
5. MANUFACTURING PROCESS
Please refer Annexure-II of Form No. 1 for process description, chemical reaction &
mass balance of all products.
6. DETAILS OF MANPOWER
Total manpower required at all level of plant will be 120 nos.
7. WATER BALANCE
Water balance diagram is given below:
Cadila Healthcare Limited 45
Water Balance Diagram
Water consumption (KLD):1395 KLD
(Fresh: 440 KLD + Recycle: 955* KLD)
Domestic
100
Water treatment
595
595
Water treatment
560 Washing
50 Greenbelt
90
STP
90* Process
470
595
Utilities
450
595
Process
450
595
Scrubber
10
595
Lab
10
595
High COD
175
595
Low COD
310
595
ETP-1
150+310+10+10=480
595
Water retained
RM 35
1
595
Boiler
150
595
Cooling
300
595
ETP-2
15+100+50=165
595
15
595
100
595 50
595
Reject
125
1
595
Reject
110
1
595
RO
400
595
Permeate
320*
595
MEE-2
180
595
Condensate
165*
595
310
595
MEE-1
166
595
Stripping
175
595
Condensate
150
595
ATFD
31
595
RO
480
595
Permeate
380*
595
Reject
100
595
Reject
80
595
Salt 12.0 ton
595
Loss 19
595
Equalization
sump
400
595
Residue
9
595
Cadila Healthcare Limited 46
8. SOURCE OF POLLUTION:
Details of Air Pollution
The main source of emission will be of process emission. Proper stack height and APC
measure will be provided in order to achieve norms prescribed by statutory authority. The
details of stacks are given below:
Sr.
No.
Stack
attached to
Stack
Height
(m)
Fuel Type Fuel
consumption
rate
Stack
Dia.
APCM Probable
pollutants
Flue gas Emission/stack
1. Boiler-1
5 TPH
30 Coal/ white
coal/lignite/
imported coal
20 TPD 0.6 Cyclone
& Bag
Filter
PM <150
mg/NM3
SO2 <100
ppm
NOX <50
ppm
2. Boiler-2
6 TPH
30 Coal/ white
coal/lignite/
imported coal
25 TPD 0.6 Cyclone
& Bag
Filter
3. Boiler-3
12 TPH
30 Coal/ white
coal/lignite/
imported coal
48 TPD 0.6 Cyclone
& Bag
Filter
4. D. G. Set
500 kVA
11 HSD 125 LT/Hr 0.3 --
5. D. G. Set
750 kVA
11 HSD 175 LT/Hr 0.3 --
6. D. G. Set
1000 kVA
(2 nos)
21(Comm
on stack)
HSD 250 LT/Hr
each
0.45 --
Process gas Emission/stack
1 Process
vent-1
21 -- -- 0.3 Water &
Alkali
Scrubber
SO2<45
mg/Nm3
Cl2< 9
mg/Nm3
2 Process
vent-2
21 -- -- 0.3 Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
3 Process
vent-3
21 -- -- 0.3 Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
4 Process
vent-4
21 -- -- 0.3 Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
5 Process
vent-5 21 -- -- 0.3
Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
6. Process
vent-6 21 -- -- 0.3
Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
7. Process
vent-7 21 -- -- 0.3
Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
Cadila Healthcare Limited 47
8. Process
vent-8 21 -- -- 0.3
Water &
Alkali
Scrubber
HCl< 20
mg/Nm3
SO2<45
mg/Nm3
9. Vent of Spin
Flash Dryer
(8 Sets) 11 -- -- 0.3
In built
Cyclone
and Bag
filter
PM<150
mg/Nm3
Source of wastewater
Source of wastewater generation is from process, scrubber, boiler, lab, utility and
washing. Effluent from process will be segregated into 2 streams - high COD &
Low COD. High COD stream will be passed through solvent stripper followed to
MEE 1. Condensate of MEE 1 will be taken on ETP-1 along with stream of low COD,
scrubber and lab will be treated in ETP-1 followed to RO. RO permeate will be
reused and reject will be taken to MEE 2.
Effluent from water treatment, utility and washing will be treated in ETP-2 followed
to RO and then MEE. RO reject will be followed to MEE. ML of MEE-1 & MEE-2 will
be taken to ATFD. Salt from ATFD will be disposed to TSDF site. RO permeate and
MEE condensate will be reused. Domestic wastewater will be treated in in-house
STP and reused for greenbelt.
Source and disposal of Hazardous wastes
There will be 10 types of hazardous waste generation i.e. ETP sludge, MEE salt,
process residue, spent carbon, spent catalyst, spent solvent, distillation residue,
off specification product, date expired product used oil, discarded
containers/liners. Detail of hazardous waste is given below:
Sr.
No.
Type of
Waste
Category
of Waste
Quantity Disposal facility
1. ETP Sludge
+
MEE salt
35.3 200
Mt/Month
250
Mt/Month
Collection, Storage, Transportation &
Disposal at TSDF site.
2. Process
residue/
process sludge
(organic &
Inorganic)
28.1 75
Mt/Month
Collection, Storage, Transportation
and disposal by selling to cement
manufactures for co-processing or
Incinerated at CHWIF.
3. Spent carbon 28.3 75
Mt/Month
Collection, Storage, Transportation
and disposal by selling to cement
manufactures for co-processing or
Incinerated at CHWIF.
4. Spent Catalyst 28.2 0.5
Mt/Month
Collection, Storage, Transportation
and by back to supplier for
reactivation or reprocess.
Cadila Healthcare Limited 48
5. Spent solvent 28.6 2500
Mt/Month
Collection, Storage, Transportation
and distillation in-house for recovery
of solvent or send it to authorized
distillation facility approved by SPCB.
6. Distillation
Residue
36.1 640
Mt/Month
Collection, Storage, Transportation
and disposal by selling to cement
manufactures for co-processing or
Incinerated at CHWIF.
7. Off
specification
Product
28.4 What so
ever
generated
Collection, Storage, Transportation
and disposal by selling to cement
manufactures for co-processing or
Incinerated at CHWIF.
8. Date expire
Product
28.5 What so
ever
generated
Collection, Storage, Transportation
and disposal by selling to cement
manufactures for co-processing or
Incinerated at CHWIF.
9. Used oil 5.1 30
Kl/Year
Collection, Storage, Transportation
and sale to Registered recycler
10. Discarded
Drums
& containers/
Liners
33.1 25000
Nos./Month
15
Mt/Month
Collection, Storage, Transportation,
decontamination and sale to actual
users or vendors.
FUNDS FOR POLLUTION CONTORL MEASURES
The management is quite conscious of its responsibility for maintaining clear
environment adequate funds can be provided for the pollution control measures as
financing part of overall project.
Necessary provision for Environmental management system is in practice.
9. MONITORING FACILITES
Air sampling will be done by outside agency and will be part of practice in future
proposed projects.
10. CONCLUSIONS AND RECOMMENDATIONS
On the basis of information presented in the pre-feasibility report on pollution
control measures and after its implementation, there will be no discharge of
effluent and air emission from the plant beyond the norms specified by the Board
as per the provisions of Air (Prevention and Control of Pollution) Act, 1981 and
Water (Prevention and Control of Pollution) Act, 1974.