practical cardiology case studies wendy blount, dvm nacogdoches tx wendy blount, dvm nacogdoches tx

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Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX

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Page 1: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Practical CardiologyCase StudiesPractical CardiologyCase Studies

Wendy Blount DVMNacogdoches TXWendy Blount DVMNacogdoches TX

GingerGinger

Signalmentbull 12 year old SF cocker spaniel

Chief complaintbull Several episodes of collapse during the past

monthbull Description matches partial seizurebull Rear legs get weak on walksbull Lethargic and dull in general

GingerGinger

Exambull Dark maroon oral mucous membranesbull Rear foot pads cyanotic (heart sounds)bull Split S2bull Neurologic exam normal except dull mental

status

GingerGinger

Differential Diagnosis ndash Split S2bull Pulmonic and aortic valves donrsquot close at the same time

ndash Pulmonary hypertensionndash Normal variation in giant dogsndash Reverse PDA

Differential Diagnosis - cyanosisbull Respiratory hypoxiabull Cardiac hypoxia

GingerGinger

Initial Diagnostic Planbull CBC GHP electrolytesbull Arterial blood gases Pulse oximetrybull ECGbull Thoracic radiographs

Bloodworkbull Tech couldnrsquot get enough serum for serologybull CBC ndash PCV 73bull GHP and electrolytes - normal

GingerGinger

DDx Differential Cyanosisbull FATE ndash Femoral Artery ThromboEmbolism

ndash Lack of femoral pulsesndash Feet cool to the touch

bull Right to Left shunt ndash ductus is distal to the brachiocephalic trunkndash Reverse PDAndash AV fistula with pulmonary hypertensionndash Tetralogy of Fallot

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 2: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Signalmentbull 12 year old SF cocker spaniel

Chief complaintbull Several episodes of collapse during the past

monthbull Description matches partial seizurebull Rear legs get weak on walksbull Lethargic and dull in general

GingerGinger

Exambull Dark maroon oral mucous membranesbull Rear foot pads cyanotic (heart sounds)bull Split S2bull Neurologic exam normal except dull mental

status

GingerGinger

Differential Diagnosis ndash Split S2bull Pulmonic and aortic valves donrsquot close at the same time

ndash Pulmonary hypertensionndash Normal variation in giant dogsndash Reverse PDA

Differential Diagnosis - cyanosisbull Respiratory hypoxiabull Cardiac hypoxia

GingerGinger

Initial Diagnostic Planbull CBC GHP electrolytesbull Arterial blood gases Pulse oximetrybull ECGbull Thoracic radiographs

Bloodworkbull Tech couldnrsquot get enough serum for serologybull CBC ndash PCV 73bull GHP and electrolytes - normal

GingerGinger

DDx Differential Cyanosisbull FATE ndash Femoral Artery ThromboEmbolism

ndash Lack of femoral pulsesndash Feet cool to the touch

bull Right to Left shunt ndash ductus is distal to the brachiocephalic trunkndash Reverse PDAndash AV fistula with pulmonary hypertensionndash Tetralogy of Fallot

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 3: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Exambull Dark maroon oral mucous membranesbull Rear foot pads cyanotic (heart sounds)bull Split S2bull Neurologic exam normal except dull mental

status

GingerGinger

Differential Diagnosis ndash Split S2bull Pulmonic and aortic valves donrsquot close at the same time

ndash Pulmonary hypertensionndash Normal variation in giant dogsndash Reverse PDA

Differential Diagnosis - cyanosisbull Respiratory hypoxiabull Cardiac hypoxia

GingerGinger

Initial Diagnostic Planbull CBC GHP electrolytesbull Arterial blood gases Pulse oximetrybull ECGbull Thoracic radiographs

Bloodworkbull Tech couldnrsquot get enough serum for serologybull CBC ndash PCV 73bull GHP and electrolytes - normal

GingerGinger

DDx Differential Cyanosisbull FATE ndash Femoral Artery ThromboEmbolism

ndash Lack of femoral pulsesndash Feet cool to the touch

bull Right to Left shunt ndash ductus is distal to the brachiocephalic trunkndash Reverse PDAndash AV fistula with pulmonary hypertensionndash Tetralogy of Fallot

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 4: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Differential Diagnosis ndash Split S2bull Pulmonic and aortic valves donrsquot close at the same time

ndash Pulmonary hypertensionndash Normal variation in giant dogsndash Reverse PDA

Differential Diagnosis - cyanosisbull Respiratory hypoxiabull Cardiac hypoxia

GingerGinger

Initial Diagnostic Planbull CBC GHP electrolytesbull Arterial blood gases Pulse oximetrybull ECGbull Thoracic radiographs

Bloodworkbull Tech couldnrsquot get enough serum for serologybull CBC ndash PCV 73bull GHP and electrolytes - normal

GingerGinger

DDx Differential Cyanosisbull FATE ndash Femoral Artery ThromboEmbolism

ndash Lack of femoral pulsesndash Feet cool to the touch

bull Right to Left shunt ndash ductus is distal to the brachiocephalic trunkndash Reverse PDAndash AV fistula with pulmonary hypertensionndash Tetralogy of Fallot

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 5: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Initial Diagnostic Planbull CBC GHP electrolytesbull Arterial blood gases Pulse oximetrybull ECGbull Thoracic radiographs

Bloodworkbull Tech couldnrsquot get enough serum for serologybull CBC ndash PCV 73bull GHP and electrolytes - normal

GingerGinger

DDx Differential Cyanosisbull FATE ndash Femoral Artery ThromboEmbolism

ndash Lack of femoral pulsesndash Feet cool to the touch

bull Right to Left shunt ndash ductus is distal to the brachiocephalic trunkndash Reverse PDAndash AV fistula with pulmonary hypertensionndash Tetralogy of Fallot

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 6: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

DDx Differential Cyanosisbull FATE ndash Femoral Artery ThromboEmbolism

ndash Lack of femoral pulsesndash Feet cool to the touch

bull Right to Left shunt ndash ductus is distal to the brachiocephalic trunkndash Reverse PDAndash AV fistula with pulmonary hypertensionndash Tetralogy of Fallot

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 7: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Arterial blood gasesbull pO2 ndash 52 mmHg

bull pCO2 ndash 36 mmHg

bull all else normal

Pulse oximetrybull Lip ndash O2 sat 89

bull Vulva - O2 sat 67

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 8: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 9: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 10: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Thoracic radiographsbull Normal great vesselsbull Normal heart size (VHS 95)bull aortic bulge on VDbull No evidence of severe respiratory disease

which might cause hypoxiabull No evidence of heart failure

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 11: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

ECGbull S wave mildly deep in leads I II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 12: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 13: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

ECGbull S wave mildly deep in leads II III aVFbull MEA 90o

bull Arrhythmia doesnrsquot seem likely

Differential Diagnosesbull Right to left shuntbull Pulmonary hypertension

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 14: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 15: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 16: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)

ndash Eisenmeingerrsquos physiology

bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogram

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 17: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Right to Left Shuntbull Reverse PDA (right to left)bull Tetralogy of Fallotbull AV fistula with pulmonary hypertension

Echocardiogrambull RV thickeningbull RV normally thinner than LVbull No PDA seen without Doppler

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 18: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GingerGinger

Bubble Studybull Place venous catheterbull Shake 5-10 cc saline vigorouslybull Place US probe where you can look for shunting

ndash Long 4 chamber viewndash Abdominal aorta

bull Inject IV quicklybull Bubbles normally appear on the right (video)bull Watch for bubbles on the left (this means R to L shunt)bull False negatives when bubbles disperse quickly

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 19: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Reverse PDAReverse PDA

bull Reverse PDAs are usually large providing no resistance to blood flowndash Ductus is often as large in diameter as the great vessels it

connects

bull increase in pulmonary artery pressure combined with the increase in pulmonary blood flow creates pathologic responses in the pulmonary arteries over time

bull a continuous murmur is heard during the first days to weeks of life but disappears before the eighth week

bull Often do well until polycythemia develops late in life

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 20: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Reverse PDAReverse PDA

Treatmentbull Ligation of right to left shunting PDA results in death

due to pulmonary hypertensionndash Has been ligated in stages without causing deathndash Cyanosis and symptoms usually persist

bull Managed Medically by periodic phlebotomyndash Remove 10 mllb and replace with IV fluidsndash Eliminate hyperviscosity without inducing hypoxiandash Goal for PCV is 60-65ndash Excellent blood for RBC transfusion -)ndash Repeat when clinical signs return

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 21: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Reverse PDAReverse PDA

Treatmentbull Hydroxyurea

ndash 30 mgkgday for 7 to 10 days followed by 15 mgkgday

ndash CBC q1-2 weeksndash DC when Bone marrow suppressionndash Resume lower dosendash Some dogs require higher dosesndash side effects ndash GI and sloughing of the nails

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 22: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Reverse PDAReverse PDA

Prognosisbull Can do well short termbull Poor prognosis long term

ndash Survival months to a year or twobull Phlebotomy interval is progressively shorter

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
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  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
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  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
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  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
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  • Ike - Echo (4)
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  • Ike - Echo (7)
  • Ike - Echo (8)
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  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
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  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 23: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GabbyGabby

6 month female DSH

Presented for OHE

PreAnesthetic Exam - HR 100

bull No other abnormal findings

bull Preanesthetic bloodwork normal

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
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  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
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  • Ike
  • Ike (2)
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  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 24: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GabbyGabby

Pre-Anesthetic ECG

bull Heart ratendash P rate is 160 bpm QRS rate is 100 bpm

bull Rhythmndash no consistent PR intervalndash P and QRS complexes are disassociated but each regular

25 mmsec

3rd Degree AV block

20mm = 1 mV

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
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  • Reverse PDA
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  • Gabby
  • Gabby (2)
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  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
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  • Trip (4)
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  • Trip (7)
  • Trip - Echo
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  • Trip - Echo (8)
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  • Trip (8)
  • Valvular Endocarditis
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  • Ike - Echo (11)
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  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
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  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
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  • Hank (6)
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  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 25: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GabbyGabby

bull Gabby was not spayed at 6 months of agebull When she reached 7 years of age she had her 4th litterbull She was referred to Drs Miller and Gordon at TAMU for

spayndash When induced her heart rate immediately fell to 40 and was

progressively droppingndash A temporary pacemaker was placedndash Gabby was spayed and recovered uneventfullyndash Gabby turned 17 years old in 2010 and has since passed on

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 26: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

GabbyGabby

Dear Doc

Because you took away my favorite pastime I have turned to a life of substance abuse

Itrsquos your fault

Love Gabby

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
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  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
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  • Trip
  • Trip (2)
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  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 27: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

3rd degree AV block3rd degree AV block

3rd Degree AV block is the most common cause of bradycardia in the cat

Treatment- catsbull Often no treatment needed for cats

ndash AV node pacemaker is 100 per minutendash AV node pacemaker is 40-60 per minute in the dog

bull Cats do well unless they undergo anesthesiabull Avoid drugs that increase vagal tone

ndash Alpha blockers ndash Dexdomitor Rompun

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
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  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
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  • Trip - Echo (8)
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  • Maximus
  • Maximus (2)
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  • Ike (2)
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  • Ike - Echo (2)
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  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
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  • Ike - Echo (13)
  • Ike - Echo (14)
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  • Pericardial Effusion (2)
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  • Pulmonic Stenosis
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Page 28: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

3rd degree AV block in Dogs3rd degree AV block in Dogs

bull Usually presents for syncope (HR 20-40 per minute)bull ldquoCannon waverdquo jugular pulses (bradycardia)bull Treated with pacemaker implantationbull Drug therapy not usually successful

ndash Usually no response to atropinendash Atropine often makes 2nd degree block go awayndash Some have tried theophylline

bull Prognosis poor without pacemakerbull If lactate is high emergency pacemaker is needed

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
  • Ginger (12)
  • Ginger (13)
  • Ginger (14)
  • Ginger (15)
  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
  • Gabby (3)
  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 29: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

3rd degree AV block in Dogs3rd degree AV block in Dogs

50 mmsec

Pre-Operative ECGbull Atrial rate = 200 per minutebull Ventricular rate = 40 per minute

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
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  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
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  • Gabby (4)
  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
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  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
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  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 30: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

3rd degree AV block in Dogs3rd degree AV block in Dogs

Post-Operative ECGbull Ventricular rate = 100

50 mmsec

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
  • Ginger (9)
  • Ginger (10)
  • Ginger (11)
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  • Ginger (14)
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  • Ginger (16)
  • Ginger (17)
  • Reverse PDA
  • Reverse PDA (2)
  • Reverse PDA (3)
  • Reverse PDA (4)
  • Gabby
  • Gabby (2)
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  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
  • Trip - Echo (4)
  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 31: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

Signalmentbull 2 year old castrated male border collieChief ComplaintHistorybull Productive Cough weight loss for 2 monthsbull Breathing hard for a 2 daysbull Energy good did well in agility 4 days agobull Owner thinks has had lifelong PU-PDbull Has wanted to be in AC this summer ndash unlike

last summer when he enjoyed being outside

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
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  • Pericardial Effusion
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
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Page 32: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

Exambull T 1022 P 168 R 42 CRT 3 secbull BCS 25bull BP 100bull Bounding pulses notable in dorsal pedal arterybull Precordial ndash exaggerated left apical heavebull Lung sounds clear

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 33: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

Exambull 3 murmurs

1 PMI left base ndash To-and-fro murmur 36ndash aortic stenosis in systole regurg in diastole

2 PMI left apex but heard all over chest ndash Holosystolic murmur 36 ndash Mitral regurgitation due to LHF

3 PMI Carotid artery ndash 26 ejection murmurndash aortic stenosis

>
>

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 34: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

Differential Diagnosesbull Aortic endocarditisbull SAS with aortic regurgitationbull Mitral regurgitation (endocarditis)

Diagnostic Planbull Thoracic radiographsbull EKGbull Echocardiography

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 35: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
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  • Ginger (4)
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  • Ginger (7)
  • Ginger (8)
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  • Reverse PDA
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  • Gabby
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  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
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  • Trip - Echo (8)
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  • Trip - Echo (10)
  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
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  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
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  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
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  • Taz (6)
  • Taz (7)
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  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
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  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 36: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
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  • Trip
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  • Trip (8)
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  • Maximus
  • Maximus (2)
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  • Ike (2)
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  • Ike - Echo
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  • Ike - Echo (13)
  • Ike - Echo (14)
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  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
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  • Taz
  • Taz (2)
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 37: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

EKGbull Normal sinus rhythm for 10 minutes

Thoracic Radiographsbull Interstitial pattern caudal lung fieldsbull Vertebral heart score 105bull Enlarged cranial pulmonary lobar veinbull Mildly enlarged left atriumbull Early left congestive heart failure

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
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  • Pericardial Effusion
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
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Page 38: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 39: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PM

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
  • Taz (5)
  • Taz (6)
  • Taz (7)
  • Taz (8)
  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 40: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash LV Apexbull No abnormalities noted

Short Axis ndash LV PMbull LVIDD ndash 573 (n 313-34)bull IVSTS ndash 155 mm (n 126-137)bull LVIDS ndash 411 mm (188-207)bull FS = (573-411)573 = 28 (n 30-46)bull EF = 54 (n gt70)

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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  • 3rd degree AV block in Dogs
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  • Trip (2)
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  • Pulmonic Stenosis
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Page 41: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
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  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
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  • Trip
  • Trip (2)
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  • Trip - Echo
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  • Maximus
  • Maximus (2)
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  • Ike
  • Ike (2)
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  • Ike - Echo (13)
  • Ike - Echo (14)
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  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
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  • Taz
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  • Cardiac Masses
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  • Hank
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  • Hank - Echo
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  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 42: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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Page 43: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash MVbull EPSS ndash 8 mm (n 0-6)

Short Axis ndash AoRVOTbull AoS ndash 202 (normal)bull LAD ndash 278 (n 190-205)bull LAAo ndash 278202 = 138 (n 08-13)bull Aortic valve leaflets are hyperechoic

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 44: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 45: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamber

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
  • Ginger (2)
  • Ginger (3)
  • Ginger (4)
  • Ginger (5)
  • Ginger (6)
  • Ginger (7)
  • Ginger (8)
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  • Reverse PDA
  • Reverse PDA (2)
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  • Gabby
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  • 3rd degree AV block
  • 3rd degree AV block in Dogs
  • 3rd degree AV block in Dogs (2)
  • 3rd degree AV block in Dogs (3)
  • Trip
  • Trip (2)
  • Trip (3)
  • Trip (4)
  • Trip (5)
  • Trip (6)
  • Trip (7)
  • Trip - Echo
  • Trip - Echo (2)
  • Trip - Echo (3)
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  • Trip - Echo (5)
  • Trip - Echo (6)
  • Trip - Echo (7)
  • Trip - Echo (8)
  • Trip - Echo (9)
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  • Trip - Echo (11)
  • Trip (8)
  • Valvular Endocarditis
  • Valvular Endocarditis (2)
  • Valvular Endocarditis (3)
  • Valvular Endocarditis (4)
  • Valvular Endocarditis (5)
  • Valvular Endocarditis (6)
  • Valvular Endocarditis (7)
  • Maximus
  • Maximus (2)
  • Maximus (3)
  • Maximus (4)
  • Maximus (5)
  • Maximus (6)
  • Maximus (7)
  • Ike
  • Ike (2)
  • Ike (3)
  • Ike (4)
  • Ike (5)
  • Ike (6)
  • Ike (7)
  • Ike (8)
  • Ike (9)
  • Ike (10)
  • Ike (11)
  • Ike (12)
  • Ike - Echo
  • Ike - Echo (2)
  • Ike - Echo (3)
  • Ike - Echo (4)
  • Ike - Echo (5)
  • Ike - Echo (6)
  • Ike - Echo (7)
  • Ike - Echo (8)
  • Ike - Echo (9)
  • Ike - Echo (10)
  • Ike - Echo (11)
  • Ike - Echo (12)
  • Ike - Echo (13)
  • Ike - Echo (14)
  • Ike - Echo (15)
  • Ike - Echo (16)
  • Ike - Echo (17)
  • Pericardial Effusion
  • Pericardial Effusion (2)
  • Pericardial Effusion (3)
  • Pericardial Effusion (4)
  • Pericardial Effusion (5)
  • Taz
  • Taz (2)
  • Taz (3)
  • Taz (4)
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  • Taz (6)
  • Taz (7)
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  • Cardiac Masses
  • Cardiac Masses (2)
  • Hank
  • Hank (2)
  • Hank (3)
  • Hank (4)
  • Hank (5)
  • Hank (6)
  • Hank (7)
  • Hank - Echo
  • Hank - Echo (2)
  • Hank - Echo (3)
  • Hank - Echo (4)
  • Hank - Echo (5)
  • Hank - Echo (6)
  • Hank - Echo (7)
  • Pulmonic Stenosis
  • Pulmonic Stenosis (2)
  • Pulmonic Stenosis (3)
  • Pulmonic Stenosis (4)
Page 46: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Short Axis ndash PAbull No abnormalities noted

Long Axis ndash 4 Chamberbull LA appeared mildly enlargedbull IVS bowed anteriorly toward RVbull No evidence of mitral encodarditis or

endocardiosisbull Vegetation on aortic valve

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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  • Pulmonic Stenosis
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Page 47: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 48: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Trip - EchoTrip - Echo

Long Axis ndash LVOT (video)bull Hyperechoic thickened mitral valve leaflets

Diagnosisbull Aortic endocarditis

Therapeutic Planbull Elected euthanasia due to poor prognosis

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 49: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TripTrip

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
  • Ginger
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  • Pericardial Effusion
  • Pericardial Effusion (2)
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Page 50: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Present for FUO weight loss or heart failurebull Aortic much more common than mitralbull Dogs much more common than catsbull Many bacteria including Bartonellabull Breed predisposition

ndash Rottweiler Boxer Golden retrieverndash Newfoundland German shepard

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 51: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

Clinical Featuresbull Abnormal valve + bacteremia = endocarditisbull Bacteremia caused routinely by

ndash Dental cleaningndash Brushing your teeth (chewing)ndash Constipation any GI illnessndash defecationndash Urinary catheterizationndash infection

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 52: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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Page 53: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

ECG abnormalities bull Tall wide P wave (LA enlargement)bull Tall R wave (LV enlargement)bull Ventricular arrhythmias common

ndash Treat if multiform of gt30 per minutendash Class I or III antiarrhythmicndash Sotalol 2-3 mgkg PO BID

Thoracic radiographsbull Left heart failure

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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Page 54: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

Echocardiographic abnormalitiesbull Thickened hyperechoic valvesbull Vegetation may flop around

ndash MV in diastole AV in systolebull Variable LV dilation (more with time)bull FS normal to low normal until myocardial failurebull MV endocarditis can be difficult to distinguish

from MV endocardiosis ndash Endocarditis dogs are systemically ill

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 55: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

Treatmentbull Based on urine and blood culture and sensitivity

Bartonella PCRbull Antibiotics

ndash IV 3-5 days ndash broad spectrum until culture resultsndash SCIM 3-5 daysndash Then PO long term ndash often for life

bull Treat Heart failure (severe)bull Treat ventricular arrhythmia if presentbull Watch for and treat bacterial embolization of abdominal

organs skin IVDiscs CNS joints etcbull Watch for and treat immune complex disease

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 56: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Valvular EndocarditisValvular Endocarditis

Prognosisbull lt20 survivalbull Antibiotic therapy often required for lifebull Median survival is 6 days from diagnosis for aortic

endocarditisbull Survival is longer for mitral endocarditis

ndash LHF due to MR not as severe as AoR

(Client Handout)

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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Page 57: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

18 month old male Boxer

Chief Complaintbull Drastic and rapid weight lossbull Not eating wellbull Coughing up blood tinged fluid since yesterday

Exam Chest rads ECGbull Similar to Trip except temp 1038bull And BCS 2

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 58: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

Diagnosticsbull Blood culture

ndash negative (2 samples 2 hours apart)

bull Urine culture ndash Enterobacter susceptible to all

bull CBCndash neutrophilia 23100ulndash Mild anemia ndash PCV 355

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 59: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

Diagnosticsbull General Health Profile electrolytes

ndash BUN ndash 55 (n 10-29)ndash ALT ndash 225 (n 10-120)ndash Albumin ndash 22 (n 23-37)

bull Urinalysisndash USG ndash 1045ndash WBC 7-10hpf rare bacteria seen

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 60: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

Treatment (58 lbs BCS 2 RR 66)bull Antibiotics

ndash IV - ampicillin 750 mg TID Baytril 150 mg BID x 3 daysndash IM ndash ampicillin 750 mg BID Baytril 150 mg x 3 daysndash PO ndash ampicillin 750 mg BID Baytril 136 mg PO for life

bull Furosemidendash 100 mg IV TID the first day - RR down to 28ndash Then 75 mg PO BID

bull Enalapril ndash 15 mg PO BID

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 61: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

Treatment ndash Day 3 ndash RR 30 eating wellbull Chest x-rays

ndash Pulmonary edema much improved but mild amount still present

bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Added Spironolactone ndash 25 mg PO BID

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 62: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

Diagnostics ndash Day 5 ndash RR 36 BP 150bull Chest x-rays - No changebull BUN ndash 43bull Electrolytes - normal

Treatment ndash Day 5bull Furosemide - 75 mg PO BIDbull Enalapril ndash 15 mg PO BID bull Spironolactone ndash increased to 50 mg PO BIDbull Added Hydralazine ndash 125 mg PO BID

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 63: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

MaximusMaximus

Diagnostics ndash Day 10 RR 30 BP 135 Wt 618 Temp 103bull Chest x-rays ndash perihilar edema resolvedbull BUN ndash 11 albumin 23bull Electrolytes ndash normalbull CBC ndash neutrophilia 23000ul

Continued this treatment for the rest of Maxrsquos life ndash 3 months

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 64: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Signalmentbull 7 year old castrated male Persian cat

Chief Complaintbull Recurring anemiabull Episodes of weakness anorexia dullness and

salivationbull Constipation often associated with episodesbull Tremendous hair loss and 2 lb weight loss over 6

months

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 65: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Exam ndash T 1003 P 180 R 40 BP 135bull Fleas++++bull Gallop rhythm followed by normal heart

sounds followed by 26 systolic murmurbull Hepatomegaly and mild to moderate ascitesbull Jugular vein distensionbull Did not do hepatojugular reflux testbull Tongue protrudes and tip is drybull Breathes with mouth open when stressed

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 66: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Diagnosticsbull CBC ndash normalbull FeLVFIV ndash negativebull GHPelectrolytes ndash

ndash ALT ndash 218 (n 10-100)ndash Bili ndash 03 (high normal)ndash Albumin 17 (n 23-34)ndash K ndash 25 (n 29-42)

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 67: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 68: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Diagnosticsbull Chest x-rays

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 69: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Diagnosticsbull Chest x-rays

ndash Elevated trachea (heart enlargement)ndash Generalized cardiomegaly ndash VHS 9ndash Distended caudal vena cavandash Hepatomegalyndash Ascites

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 70: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Diagnosticsbull Diagnosis - Right heart failure with cardiomegalybull DDx ndash cardiomegaly

ndash Diaphragmatic herniandash pericardial effusionndash heart enlargement

bull HCM DCM RCMbull VSDbull Valvular disease

ndash Hypoalbuminemialiver disease may be contributing to ascites

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 71: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

DDx Hypoalbuminemiabull Liver diseasebull PLNbull PLE unlikely with no clinical signsbull Sequestration in ascites

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 72: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Initial Treatmentbull No echo done because Ike became dyspneic

after chest radsbull Furosemide 5 mg PO BID (wt 5 lbs 7 oz)bull Potassium gluconate 2 mEq PO SIDbull Metronidazole 625 mg PO SID x 2 weeks

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 73: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Recheck Scheduled for 1 weekbull Echocardiogrambull Electrolytesbull Abdominal USbull UPCbull bile acidsbull Fluid analysis if ascites fails to resolve

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 74: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Recheck ndash 1 week - Exambull Ike tremendously improvedbull Weight gain of 5 ouncesbull Ascites has resolvedbull Hepatomegaly no longer presentbull P 160 RR 28 BP 110bull Haircoat seems improvedbull 26 systolic murmur loudest at the sternumbull No open mouth breathing or inc RR when stressed

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 75: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

IkeIke

Recheck ndash 1 week - Diagnosticsbull Electrolytes ndash K 27bull Albumin - 24 (normal)bull ALT - 134 (n 10-100)bull Bili - 03bull UPC ndash 05bull Bile Acids (fasting) - 157

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 76: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 77: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 78: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Short Axis ndash LV Apexbull Mild pericardial effusion

Short Axis ndash LV PMbull Mild pericardial effusionbull LV subjectively thickbull Papillary muscles really bigbull No evidence of pericardial hernia

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 79: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Short Axis ndash LV PMbull IVSTD ndash 102 (n 3-6)bull LVIDD ndash 141 (n 10-21)bull LVPWD ndash 695 (n 3-6)bull IVSTS ndash 1485 (4-9)bull LVIDS ndash 35 (n 4-10)bull LVPWS ndash 96 (n 4-11)bull FS ndash (141-35)141 = 745 EF = 98

Dx ndash HypertrophicCardiomyopathy

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 80: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 81: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 82: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOT

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 83: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Short Axis ndash LV MVbull EPSS ndash 2 mm

Short Axis ndash LARVOTbull RVOT looks subjectively enlargedbull LA and LA normalbull LAAo = 11188 = 126 (normal)

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 84: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 85: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 86: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Short Axis ndash PAbull Enlarged main pulmonary arterybull RV enlarged

Long Axis ndash 4 Chamberbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 87: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 88: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Long Axis ndash LVOTbull No apparent enlargement of LAbull LV thickened

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 89: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 90: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Abdominal USbull No fluid present in the abdomenbull Main bile duct tortuousbull Pancreas normalbull Did not do liver aspirate because Ike would not

tolerate it without general anesthesia

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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  • Pulmonic Stenosis (4)
Page 91: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Assessmentbull Hypertrophic Cardiomyopathy

ndash Biventricular failurendash Secondary pericardial effusion ascites hepatomegaly

bull Enlarged Pulmonary artery of unknown cause (DDx)ndash Heartworm diseasendash Pulmonary hypertension

bull Liver Dysfunction of unknown causendash Probable history of pancreatitisndash Possibly contributed to by passive congestion of RHF

bull Financial Resources for Ikersquos Diagnosis and Treatment have been depleted

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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  • Pulmonic Stenosis (4)
Page 92: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Ike - EchoIke - Echo

Treatment - Updatebull Finish metronidazole then start milk thistlebull Increase Kgluconate to 2 mEq PO BIDbull Continue furosemide 5 mg PO BIDbull Add enalapril 125 mg PO SID

ndash Recheck BUNlytes 5 daysndash If OK increase to BIDndash Recheck BUNlytes 5 days

bull Laxatone PRN for constipationbull Recheck echo chest rads in 6 months or sooner if RR

gt 40 at restbull Ike died acutely just prior to his 6 month recheck

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 93: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pericardial EffusionPericardial Effusion

Clinical Featuresbull DDx

ndash Pericarditisndash Chronic CHF (usually RHF)ndash Blood ndash left atrial tear HSA coagulopathyndash Pericardial cystndash Idiopathicndash 50 are neoplasia ndash carefully look at RA

bull ECG ndash electrical alternans

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 94: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful not to confuse pericardial fat with

pericardial effusionndash Look at relative echogenicity

bull Careful not to confuse normal anechoic structures with pericardial effusionndash Descending aortandash Enlarged left auricle

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 95: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Careful to distinguish pericardial from pleural

effusionndash Pericardium not visualized with pleural effusionndash Collapsed lung lobes may be seen with pleural

effusion (look like liver in US)ndash Careful not to confuse consolidated lung with liver in

a peritineopericardial diaphragmatic herniabull Heart may swing back amp forth in the

pericardium

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 96: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pericardial EffusionPericardial Effusion

Echocardiographic Abnormalitiesbull Cardiac tamponade

ndash Compression of RVndash Diastolic collapse of RVndash IVS may be flattened with paradoxical motionndash Pericardiocentesis is imperativendash Aggressive diuresis will reduce preload

bull Evaluation of heart base tumor prior to pericardiocentesis will be more thorough

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 97: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pericardial EffusionPericardial Effusion

Video Pericardial Effusion

Video Pleural Effusion

Video Consolidated Lung Lobe

Video Normal thorax

Video Mediastinal Mass

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 98: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

Signalmentbull 7 year old neutered male sharpeibull Annual vaccines 2 weeks ago

Chief Complaintbull Hasnrsquot felt good since vaccinesbull Breathing really hardbull Belly is swellingbull Not eating

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 99: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

Exam ndash RR 77 mm pale CRT 4 secbull Positive hepatojugular refluxbull Ascitesbull Peripheral edema ndash ventral legs and ventral abdomenbull Muffled heart sounds

CBC panel lytes heartworm test bull No abnormalities noted

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 100: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 101: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 102: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

Echocardiogrambull Pronounced pericardial effusion with cardiac

tamponadebull Pericardiocentesis ndash 1 L fluid that resembles blood

ndash Does not clot after 20 minutesndash PCV 38 cytology non-septic exudate (hypersegmented

neutrophils)

bull IV fluid bolus 500 mlbull Echo measurements after tap normal

PT PTT ACTbull normal

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 103: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

Abdominal USbull Normal

Sent pericardial fluid for culture and sensitivity

Emergency Referral to TAMU for Echocardiogrambull Taz was VERY painful on the ride to Bryanbull Small amount of pericardial effusion ndash not enough to tapbull No cardiac masses detectedbull Abdominal ultrasound NSAFbull Discharged with no medications to recheck in one week

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 104: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

Recheck 1 weekbull Taz doing exceptionally wellbull No growth on culture and sensitivitybull Signs of right heart failure have resolved

bull No ascites dyspnea peripheral edema jugular distensionbull Abdominal palpation normal

bull Chest x-rays show VHS 11bull Echo shows 2 cm pericardial effusionbull Tapped again and dispensed pain medsbull Rx doxycycline 10 mgkg PO BID x 3 weeksbull Rx prednisone 05 mgkg PO SID x 2 weeks then QOD

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 105: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

TazTaz

Recheck 30 daysbull Exam chest rads and echo are normalbull Taper off prednisone over the next 30 daysbull Taz has had no recurrence of pericardial effusion in the

past 6 years

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 106: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Cardiac MassesCardiac Masses

DDxbull Chemodectomabull HSAbull Myxosarcomabull Ectopic thyroid carcinomabull Mesotheliomabull LSAbull fibrosarcoma

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 107: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Cardiac MassesCardiac Masses

Echocardiographic Featuresbull Usually at the heart base or in the RAbull Careful not to confuse with

ndash Epicardial fat (especially on the AV groove when there is pericardial effusion)

ndash Trabeculae on the right auricle when floating in pericardial effusion

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 108: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

Signalmentbull 10 week old male schnauzer

Chief Complaintbull Loud heart murmur heard on examination for routine

vaccinationsbull Suspect congenital heart defect

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 109: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

Exambull mm pink CRT 2 secbull 46 ejection murmur loudest at left heart basebull Mild superficial pyoderma

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 110: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

Initial Differential Diagnosesbull Pulmonic stenosisbull Aortic Stenosis

Initial Diagnostic Planbull Chest x-raysbull EKGbull Echocardiogram

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 111: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 112: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 113: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

Thoracic radiographsbull Dorsally elevated tracheabull Vertebral heart score 95bull Right heart enlargementbull Right auricularatrial enlargementbull Distended caudal vena cavabull Bulge at main pulmonary artery

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 114: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

HankHank

EKGbull Tall P waves (05-06 mV)bull RA enlargementbull Deep S waves in leads I II and III (-13 to -15 mV)bull RV enlargementbull Tachycardia 200-210 bpmbull Under Buprenex-ace sedation

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

  • Practical Cardiology Case Studies
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Page 115: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 116: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Short Axis ndash LV Apexbull RV seems thickened

Short Axis ndash LV PM MV AoRVOTbull RV as thick as LV ndash markedly thickenedbull IVS is flattened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 117: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 118: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Short Axis ndash PAbull MPA dilatedbull RV as thick as LV ndash markedly thickened

Long Axis ndash 4 Chamberbull Aberrant septum dividing RA into 2 chambers ndash cranial

and caudal

Long Axis ndash LVOTbull RV as thick as LV ndash markedly thickened

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 119: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 120: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Diagnosisbull Likely Pulmonic Stenosisbull DDx RV thickening

ndash Heartworms impossible in a 10 week old puppyndash Pulmonary hypertension rare in a 10 week old puppy

bull Need Doppler to confirm and to determine gradientbull Cor triatriatum dexter

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 121: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Hank - EchoHank - Echo

Plan ndash updatedbull Referral to TAMU for balloon valvuloplastybull Atenolol 05 mgkg PO BID (monitor weight to

increased dose PRN until cath procedure)

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 122: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Many breed predispositions

ndash Bulldog chihuahua Beagle Cavalier

bull Often valvular and subvalvularbull Valvular defect can be corrected by valvuloplastybull Prognosis varies depending on severity

ndash Mild ndash less than 50 mm Hg gradientndash Moderate ndash 50-100 mm Hgndash Severe - gt100 mm Hg

bull Can be progressive

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

(Client Handout)

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Page 123: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pulmonic StenosisPulmonic Stenosis

Clinical featuresbull Bulldogs and Boxers can have left coronary artery

anomaly which can preclude balloon valvuloplastybull Arrhythmia is much more common than RHFbull May be part of Tetralogy of Fallot

ndash PSndash RV hypertrophyndash VSDndash Overriding aorta

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 124: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pulmonic StenosisPulmonic Stenosis

Coronary Artery Anomalybull Instead of R and L coronary

aa there is a single coronary a

bull It splits and the left branch encircles the pulmonary a

bull It can be ruptured if the PS is ballooned

bull These dogs may have normal PV and functional PS due to this anomaly

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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Page 125: Practical Cardiology Case Studies Wendy Blount, DVM Nacogdoches TX Wendy Blount, DVM Nacogdoches TX

Pulmonic StenosisPulmonic Stenosis

Echocardiographic abnormalitiesbull RV thickeningbull Post-stenotic dilatation of MPAbull Pulmonic valve may be thickened with poor movementbull Paradoxical septal motion may be noted in severe casesbull Tricuspid dysplasia is a common concurrent malformation

ndash RHF is rare in dogs with PS alonendash Many PS dogs that develop RHF also have tricuspid dysplasia

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