ppt penisilin

7/23/2019 PPT PENISILIN

1/22

PENISILIN

Nama Kelompok :1. DIFANDINI RIZKY FIRDAUS (

2. YOESHINTA MAYDINA (150!1"012"2#


2/22

1. PENGERTIAN $e%&'&l&% me)paka% kelompok a%*&+&o*&ka ,e*a -ak*am a%/ *ela lama &ke%al.

$e%&'&l&% a*a) a%*&+&o*&k +e*alak*am aala kela' a%*&+&o*&k a%/ me)'ak&%&%/ 'el +ak*e& 'aa* +ak*e& 'ea%/ alam po'e' epo)k'&.

$aa *a)% 1324 & -o%o% Ale6a%e Flem&%/ me%em)ka% a%*&+&o*&ka pe*ama

a&*) $e%&'&l&% a%/ 'a*) ekae kem)&a% &kem+a%/ka% ole Floe a&

+&aka% $e%&7&ll&)m %o*a*)m )%*)k pe%//)%aa% '&'*em&k. Kem)&a% &/)%aka% $.

7'o/e%)m a%/ me%/a'&lka% $e%&'&l&% le+& +a%ak.

$e%&'&l&% a%/ &/)%aka% alam pe%/o+a*a% *e+a/& alam:

1. $e%&'&l&% alam

2. $e%&'&l&% 'em&'&%*e*&k

$e%&'&l&% 'em&'&%*e*&k &peole e%/a% 7aa me%/)+a '*)k*) k&m&a $e%&'&l&%

alam a*a) e%/a% 7aa '&%*e'&' a& &%*& $e%&'&l&%. ,e+eapa $e%&'&l&% aka% +ek)a%/ ak*&8&*a' m&ko+a%a alam ')a'a%a a'am

'e&%//a $e%&'&l&% kelompok &%& a)' &+e&ka% 'e7aa pae%*eal.

$e%&'&l&% la&% &la%/ ak*&8&*a'%a +&la &pe%/a)& e%&m ,e*alak*ama'e

($e%&'&l&%a'e# a%/ meme7a 7&%7&% ,e*alak*am.


3/22

2. Mekanisme kerja

A%*&+&o*&ka ; lak*am I +ekeak*) pem+elaa% 'el 'e+a/&a% a& &%&%/

'el &%)k &l&'&' ole e%&m asetil muramidase.

E%&m transpeptidasea%/ &pel)ka% )%*)kpem+e%*)ka% &%&%/ 'el +a) &+lok& olepe%&'&l&% 'e&%//a pem+e%*)ka% &%&%/ 'el *&ak'emp)%a 'e&%//a +ak*e& ma*&.


4/22

3. Farmakokinetik

Absorpsi:

?$e%&'&l&% @ *&ak *aa% *eaap ')a'a%a a'am (pH 2#. a&a% lam+)%/ (pH !# *&ak *elal) me)'ak.

@aam Na $e%&'&l&% @ oal &a+'op'& & )oe%)m.

Aa%a maka%a% aka% me%/am+a* a+'op'&.

Kaa mak' alam aa *e7apa& alam 0"0 me%&*. $em+e&a% &.m kaa mak' alam aa 150 me%&*.

?$e%&'&l&% B >ala)p)% ela*&= *aa% a'am 0C me%/alam& peme7aa%& +a/&a% a*a' 'al)a% 7e%a 'e&%//a *&ak 'empa* &a+'op'&

?Amp&'&l&% a+'op'&%a *e/a%*)%/ aa *&ak%a maka%a%.

Aa%a maka%a% alam 'al)a% 7e%a me%/am+a* a+'op'&.

?Amok'&'&l&% a+'op'&%a & 'al)a% 7e%a


5/22

4. Distribsi

$e%&'&l&% @ &&'*&+)'& l)a' alam *)+)


6/22

Jenis Pemberia

n

Dosis Bioavilibilita

s

Kadar T1/2

Penisilin G i.m 300.000

IU

- 8 g 30

Penisilin V Oral - 49% -

Ampisilin Oral 0,5 g 49% 3 60-90

Amosisilin Oral 0,5 g 65-!8% 6 60-90

"ar#enisilin i.m $ g - $5-0 60

!. "arakteristik Farmakokinetik

Penisi#in


7/22

$. E%ek sampin& &o#on&an

penisi#in ? Reak'& ale/&'e&%/ &*&m+)lka% olepem+e&a% pe%&'&l&% k)')'%a pe%&'&l&% @.

,&'a *e


8/22

Penisi#in G

$e%&'&l&% @ me)paka% pe%&'&l&% alam a& +&aka%P.Chrysogenum.D&pea/a%/a% 'e+a/a& a*

a%/ +e'&=a* a'am. Dalam la)*a% apa* *e)a&paa pH 5 a% G4 a% & *empa* &%/&%.

$e%&'&l&% ak*&= *eaap : Ne&''e&a /o%ooeae Ne&''e&a me%&%/&*&e' o%e+e7*e&)m &=*e&ae ,a7&ll)' a%*a7&'

-ep*o*&7&a +)77al&' S*aplo7o77)' a)e)' e'&'*e% *eaap +e%l

pe%&'&l&%. @o%o7o77)' me%)%


9/22


10/22

In'ikasi:

$e%&'&l&% @ me)paka% o+a* p&l&a% )%*)kpe%ak&* :

&%=ek'& k)l&*

&%=ek'& pe%a=a'a% 'e7aa &.8

&%=ek'& e%oka&*&' paa


11/22

S&=&l&' p&me 'ek)%e a% la*e% k)a%/ a& 1

*a)% a)' &o+a*& e%/a% o'&' *)%//al 2!


12/22

"ontrain'ikasi:

$em+e&a% oal me)paka% ko%*a&%&ka'& paa pe%ak&* +ea* kae%a

kaa pe%&'&l&% alam aa e%a.

H&pe'e%'&*&8&*a' *eaap pe%&'&l&% me)paka% ko%*a&%&ka'& )%*)k

pemaka&a%%a.


13/22

Penisi#in (

Spek*)m a%*&m&ko+a 'ama e%/a% pe%&'&l&% @ a&*) *eaap

+ak*e& /am po'&*= aeo+ k)a%/ e=ek*&= *eaap +ak*e& /am%e/a*&=.

Re'&'*e%'& *eaap pe%&'&l&% B 'e)pa e%/a% e'&'*e%'& *eaappe%&'&l&% @.

In'ikasi:

$e%&'&l&% B me)paka% o+a* p&l&a% )%*)k )*e oal &+a%&%/ka%pe%&'&l&% @ kae%a '*a+&l alam a'am lam+)%/ *e)*ama )%*)k

pe%/o+a*a%:

&%=ek'& '*ep*o7o77' po/e%e' paa =a&%/&*&'

Kolea

Demam ema*&k

E%oka&*&'

I%=ek'& 'al)a% pe%a=a'a%

I%=ek'& k)l&* a% m)ko'a.


14/22

"ontrain'ikasi:

$e%&'&l&% B *&ak apa* &+e&ka% paa &%=ek'& +ea*kae%a ko%'e%*a'& alam pla'ma e%a.

E%ek sampin&:

H&pe'e%'&*&8&*a' l&a 'epe*& &*)m+)&


15/22

Amoksisi#in

Amok'&'&l&% memp)%a& 'pek*)m a%*&+&o*&kaa%/ &e%*&k e%/a% amp&'&l&% ke7)al&amok'&'&l&% peka *eaap e%&m pe%&'&l&%a'e.

Resistensi:

M&ko+a a%/ e'&'*e% *eaap amok'&'&l&%aala +ak*e& a%/ mempo)k'& e%&mpe%&'&l&%a'e a&*): Enterobacterpylori,Peudomonas aureus, Clostridium tetani.

E%ek sampin&: M)al M)%*a emam D&ae Kelemaa%

&pe'e%'&*&8&*a' /a*al/a*al.


16/22


17/22

In'ikasi:

U%*)k me%/o+a*& pe%ak&* :

&%=ek'& paa k)l&*

&%=ek'&


18/22

Ampisi#in

Spek*)m ke


19/22


20/22

In'ikasi:

U%*)k &%=ek'& 'al)a% )&% m&': p&elo%e=&*&' k% E.7ol&.

I%=ek'& @o%ooe I%=ek'& 'al)a% pe%a=a'a% ole '*ep*o7o77)'

p%e)mo%&a

S&%)'&*&'

O*&*&' me&a I%=ek'& 'al)a% empe).

)e'iaan

$em+e&a% oal alam +e%*)k *a+le* a*a) kap')l 'e+a/a&

amp&'&l&% *&&a* 125 m/ 250 m/. 500 m/ a% 1000m/. ,e%*)k ')'pe%'& me%/a%)%/ 125 m/ a% 500m/5ml. Amp&'&l&% apa* +e+e%*)k ')%*&ka%.

Do'&' e>a'a )%*)k &%=ek'& &%/a% 'ampa& 'ea%/ 2! /'ea& &+a/& ! kal& &+e&ka% 'e+el)m maka% U%*)k

&%=ek'& +ea* &+e&ka% 'e&aa% pae%*eal !5 / 'ea&.


21/22

Kombinasi:

Kom+&%a'& pe%&'&l&% &mak')ka% )%*)kme%apa*ka% ke


22/22

Interaksi Penisi#in 'en&an *bat #ain

Kombinasi Interaksi

Penisilin&"loram'eniol,eri(romisin, (e(rasilin

A) #a(erisi*a (i*a #ole+ *iom#inasi *g#a(erios(a(ia rn #a(erios(a(ia

mengin+i#isi A) #a(erisi*aPenisilin V&eomisin eomisin Oral aan mengrangi a#sorpsi

penisilin V

"ar#enisilin&Gen(amisin )ila *i#erian #ersama-sama aanmenrnan a*ar gen(amisin *alam *ara+

Ampisilin&Aloprinol en/e#e#an malopaplar ras+

Amosisilin&As."lalina(

en/e#a#an mal *an mn(a+

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