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    READINGRetrospective Analysis of Corticosteroid

    Treatment in tevens!Jo"nson yndrome and#or

    To$ic Epidermal Necrolysis over a Period of %&'ears in (a)ira *ospital+ Navamindrad"ira)University+ ,an-.o.

    Dis/s/n Ole"

    Anisah Noviariyanti

    NIM 2011730008

    Pro-ram Pendidi.an ProfesiDo.ter

    0a./ltas 1edo.teran dan1ese"atan

    Pem5im5in-dr6 ,o7o 8a"y/di+ p611

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    Steven-Johnson syndrome (SJS) and/or toxie!iderma" nero"ysis (#$N) are %nommondiseases &ith an inidene a'o%t 1 ases !ermi""ion !er year

    SJS and/or #$N are !otentia""y morta" diseases*harateri+ed 'y extensive '"isterin,

    exanthema and e!ithe"ia" s"o%,hin,* o%rrin,&ith m%osa" invo"vement

    TRODUCTION

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    J#TEN CLAI0ICATIONSJS and/or #$N are !art o a s!etr%m* &hih is

    divided into 3 ,ro%!s .

    J 7"en t"e total detac"ment is less t"an %&9of t"e 5ody s/rface area

    J!TEN overlap 7"en it is 5et7een %&9 and:&9

    TEN 7"en it is over :&9

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    ETIOLOG'$ven tho%,h many ators have 'een

    !ro!osed as a%ses o these diseases*hy!ersensitivity to mediations re!orts orthe most o ases -"atam anti'iotis*s%"onamides* antionv%"sants* anda""o!%rino" &ere re%ent tri,,ers o SJSand/or #$N

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    #raditiona""y systemi ortiosteroids &ereadvoated %nti" ear"y 10s* a"tho%,h no 'enethas 'een demonstrated in ase-ontro""edst%dies

    ho&ever there are some st%dies have s%,,ested

    that the administration o dexamethasonethera!y %sed in the short term !rovide a 'enet

    so* the !%r!ose o this st%dy &as to !resent theetio"o,y* treatment* and "inia" o%tome o SJSand / or #$N aira os!ita"* Navamindradhira4niversity in 5an,6o6* #hai"and

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    2ET*O

    A retros!etive revie& &as !erormed on !atientsadmitted to aira os!ita"* Navamindradhira 4niversity

    emo,ra!hi inormation %"!rit dr%,s extent om%o%taneo%s invo"vement %nder"yin, diseases "a'oratory data

    treatments om!"iations morta"ity

    #he e"etroni media" data'ase and in!atient harts&ere revie&ed #he o""o&in, data &ere o""eted are.

    #he data &ere o""eted into t&o ,ro%!s rom 2003 to

    2007 and 2008 to 2012

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    TATITICAL

    ANAL'I

    Statistia" ana"ysis&as !erormed &ith

    the SSS version 180

    9om!arisons o

    ate,oria" varia'"esamon, ,ro%!s &ere!erormed %sin, 2test or :isher;s test

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    REULT

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    ;mean a-e 7as

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    Anti5iotics+anticonv/lsants+ andallop/rinol7ere t"e ma)orc/lprit dr/-sin 5ot" -ro/ps

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    2any patientss"o7ed or-aninvolvement

    and ot"er

    complicationsRespiratoryfail/re 7ast"emostinternalor-an fail/re in

    5ot" -ro/ps6

    epsis 7asmore in t"e rst-ro/p t"an in

    t"e second

    7"ile s.ininfection and"ospital!ac/iredpne/monia7ere more int"e second-ro/p t"an int"e rst -ro/p

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    4! ti"" no&* a s!ei treatment or SJS or #$N that hassho&n e

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    ONCLUION#he most ommon dr%,-re"ated SJSand/or #$N in aira hos!ita" &asa""o!%rino" and the most ommon dr%,,ro%! &as anti'iotis

    Short-term ortiosteroids mayontri'%te to a red%ed morta"ity rate inSJS and/or #$N &itho%t inreasin,

    seondary inetion

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    T*AN1 'OU