ppt dopamin fiks
TRANSCRIPT
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RESEPTOR
DOPAMINERGIK DANOBAT-OBATNYA
BROMOKRIPTIN (by Edi Sutarmanto)
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Pendau!uan
Dopamin ada!a "a!a "atu "enya#a$ate$o!amin yan% &a!in% "i%ni'$an da!ammemain$an &eranan "eba%ai neurotran"miter
yan% da&at mem&en%arui un%"i ota$ Dopaminergik reseptor atau bia"a di "ebut
A%oni" re"e&tor do&amin yan% memi!i$i a$"i!an%"un% &ada re"e&tor do&amin
"e&erti bromokriptin, kabergolin, lisurid,pergolid, pramipeksol, ropinirol, danrotigotin* (IONI+ ,./)
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Me$ani"me $er0a re"e&tor do&amin
http://var/www/apps/conversion/tmp/scratch_7/Dopamine%20and%20the%20Brain.mp4http://var/www/apps/conversion/tmp/scratch_7/Dopamine%20and%20the%20Brain.mp4
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Me$ani"me a$"i Bromo$ri&tin
Bromo$ri&tin meran%"an% re"e&tordo&aminer%i$* (ater 1+ a! ,2)
Bromo3ri&tine me"y!ate ada!a a%oni" re"e&tor
do&amin+ yan% men%a$ti$an &o"t-"yna&ti3re"e&tor do&amin (4DA)
Bromo3ri&tine dan &er%o!ide ada!a turunaner%ot dari a%oni" do&amin yan% meran%"an%
re"e&tor do&amin-D,5 di "am&in% itu+ &er%o!id"timu!an dan bromo3ri&tine "eba%iananta%oni" re"e&tor D. (67DD+ ,,)
http://var/www/apps/conversion/tmp/scratch_7/Parkinson's%20Disease%20Treatment%20Mode%20of%20Action%20Animation.mp4http://var/www/apps/conversion/tmp/scratch_7/Parkinson's%20Disease%20Treatment%20Mode%20of%20Action%20Animation.mp4
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Re"e&tor do&amin dan obat-obatnya
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4arma$o$ineti$Bromo$ri&tin 6anya 28 Bromo$ri&tin yan% ter
ab"or&"i me!a!ui &erora!* Obat inimen%a!ami metabo!i"me !inta" a#a!
"e3ara e$"ten"i "ein%%a "edi$it "e$a!ira$"i do"i" yan% "am&ai ditem&at $er0a*Kadar &un3a$ &!a"ma ter3a&ai da!am.+1-2 0am+ men%a!ami metabo!i"memen0adi men0adi 9at tida$ a$ti dan"eba%ian be"ar die$"$re"i $eda!amem&edu*
(ater 1+ ,2)
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Pen%%unaan "e3ara $!ini"
Bromo3ri&tine ada!a deri:ati er%ot* do"i" tin%%i (2-;1 m% <ari "e3ara ora!) di%una$an da!am &enya$it Par$in"on* (MSED+a! 11=)
Par$in"oni"m> Ora!> .*,1 m% t#i3e dai!y+ in3rea"ed by ,*1
m%
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To$"i"ita"
Kar"ino%ene"i" &ada e#an 3oba
Da!am "ebua "tudi ;/-min%%u &emberian obat dima$ananti$u" &ada do"i" in%%a 1 m% < $% < ari (1 $a!i do"i"arian manu"ia /+@ m%+ berda"ar$an m% < m,
&erbandin%an) tida$ ada bu$ti dari tumori%eni"ita"*Da!am "ebua &ene!itian $ar"ino%eni"ita" .-min%%u &ada
ti$u" &ada do"i" .+@+ =+= dan //+1 m% < $% < ari (in%%a. $a!i manu"ia /+@ m% do"i" arian+ berda"ar$an m% <m, &erbandin%an) ada &enin%$atan yan% "i%ni'$an da!am
in"iden ter"ebut neo&!a"ma %ana" uteru" &ada $e!om&o$do"i" menen%a dan tin%%i (,/-. $a!i do"i" arian /+@m% manu"ia+ berda"ar$an &erbandin%an m% < m,)*
Muta%eni"ita"
Bromo3ri&tine tida$ muta%eni$ da!am u0i in :itro* (4DA)
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Penurunan Ke"uburan &ada e#an 3oba
Pada ti$u" betina diobati den%an do"i" ora! . dan 2m% < $% (,-; $a!i do"i" arian /+@ m% manu"ia+berda"ar$an m% < m, &erbandin%an) dari , min%%u
"ebe!um $a#in "am&ai , min%%u &a"3a $a#in atau"e!ama !a$ta"i tida$ ada ee$ &ada $e"uburan*
Pada ti$u" 0antan diobati den%an do"i" ora! ,+ .+ dan1 m% < $% < ari (in%%a ., $a!i do"i" arian /+@
m% manu"ia+ berda"ar$an m% < m, &erbandin%an)tida$ ada ee$ &ada $a#in atau $e"uburan* (4DA)
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Datar Pu"ta$a
Ander"on Pi!i&* ,,* Handbook Of Clinical Drug Data 10th Ed* M3%ra#-i!!7om&anie"5 nited State" O Ameri3a
Aron"on* ,1* Meyler's Side Eects Of Drugs* O"!o5 Nor#ay
BPOM* ,./. nfor!atoriu! Obat "asional ndonesia* A:e!ab!e a" (tt&>