ppt 0000006

8/6/2019 Ppt 0000006

http://slidepdf.com/reader/full/ppt-0000006 1/21

The Captain

The Goal of Antimicrobial Therapy

WHO press release, June 2000:Drug resistance threatens to reverse medical progress

The Captain

³The most effective strategy against

antimicrobial resistance is to get the jobdone right first time ± to unequivocally

destroy microbes ± thereby defeating

resistance before it starts.´

Resistance

Recurrence

8/6/2019 Ppt 0000006


The Captain� Competent

� Consistent

� Convenient

8/6/2019 Ppt 0000006


Extensive spectrum against gram-positive and gram-negative micro-

organisms (including anaerobes).

Excellent bioavailability of 93%.

Well distributed in the body.

Rapidly bactericidal.

Competent

The Captain

Anthony R. White; Journal of Antimicrobial Chemotherapy 2004

Peter Ball; International Journal of Antimicrobial Agents 2007Michael D. Reed; The Pediatric Infectious Disease Journal 1998

8/6/2019 Ppt 0000006


When choosing an antimicrobial it is important that all the major pathogens are

considered, including the possibility of resistant strains.

Mihaela Peric; Clinical Therapeutics 2003, Vol. 25 (1): 169-177

The Captain

When choosing an antimicrobial «

Curam Cefprozil Cefdinir Azithromycin

0

10

20

30

40

50

60

70

80

90

100

Penicillin-SusceptiblePneumococci

Penicillin-IntermediatePneumococci

Penicillin-ResistantPneumococci

Beta-LactamasePositive H, influenzae

MoraxellaCatarrhalis

8/6/2019 Ppt 0000006


Objectives :To determine the antimicrobial susceptibility (S) patterns for

S.pneumoniae (SPN), H. influenzae (HI) and M. catarrhalis (MCAT) from 1997±

2006 in 13 European nations.

Jones, M. Stilwell, T. Fritsche, H. Sader; International Journal of Antimicrobial Agents, Volume 29, Supplement 2, March 2007, Pages S7-S8R.

Susceptibility of major RT pathogens

Worldwide Susceptibility (%)

Agent SP HI MC

Amoxicillin/ clavulanic 96.1 97.5 99.3

Ceftriaxone 96.5 100 100

Cefprozil 76.9 15.5 14.8

Azithromycin 69 0.9 100

Curam® is ideal empirical therapies for infections involving:

S. pneumoniae, H. influenzae and/or M. catarrhalis

The Captain

8/6/2019 Ppt 0000006


S. pneumoniae is the most common causative pathogen in paediatric AOM.

Curam has the highest overall coverage of any oral agent for penicillin intermediatestrains of S.pneumoniae and is the only oral agent to provide adequate coverage for

penicillin resistant S.pneumoniae.

Well distributed into most body tissues and extracellular fluids, including middle ear mucosa and middle ear effusions.

Figure adapted from: Harrison et al. Pediatr Infect Dis J 1997;16:S12±S16

Curam ® in Acute Otitis Media

Curam® is the only oral

antibacterial that achieved MEF

concentrations greater than the

MIC90 against common otitis

media pathogens.

The Captain

0

2

6

10

12

1

16

Curam Azithromycin Cefprozil

Penicllin-susceptible S.pneumoniae

Penicllin relatively resistant S.pneumoniae

-lactamase positive H. influenzae

-lactamase negative H. influenzae

M.Catanhalis

Horizontal lines, peak middle ear fluidconcentrations of the various drugs

8/6/2019 Ppt 0000006


Journal of Antimicrobial Chemotherapy

2009

Journal of Antimicrobial Chemotherapy,

Advance Access published January 27, 2009

AOM pathogen prevalence have produced higher rates of antibiotic

resistance among S. pneumoniae and H. influenzae.

The most active drugs across the board against all isolates

in this study were ceftriaxone and high-dose amoxicillin

plus clavulanic acid.

8/6/2019 Ppt 0000006


Consistently included in recommendations.

Extensive clinical use in patients of all ages.

Established safety profile.( Published clinical trials including 32,440 patients show that the incidence of

diarrhea is only 3.4%)

Consistent

The Captain

Anthony R. White; Journal of Antimicrobial Chemotherapy 2004Michael D. Reed, Pharmd; The Pediatric Infectious Disease Journal 1996

8/6/2019 Ppt 0000006


8/6/2019 Ppt 0000006


Friendly packages.

Unique taste of fruits.

Simple and optimal dosage regimen.

Can be taken without regard to meals.

Convenient

The Captain

Jane Easton; Drugs 2003

8/6/2019 Ppt 0000006


8/6/2019 Ppt 0000006


Preferred choice

The Captain

8/6/2019 Ppt 0000006


In recent years, an important factor affecting the

management of Acute Otitis Media ( AOM) has been the

increasing development of antimicrobial resistance.

Among the common pathogens that cause AOM ,

particularly the worldwide prevalence of resistant

streptococcus pneumoniae.

The development of new dosage forms of Curam allows

it to continue to fill its important role in therapy.

Competent

The Captain

8/6/2019 Ppt 0000006


Curam 642 allows dosing with 90/6.4 mg/ kg

Oral dosing regimen of 90/6.4 mg /kg

amoxicillin/clavulanic acid per day in Two divided dosesproduces serum concentration of 4 mg/L for at least 40%

of dosing interval

Consequently pathogens ( mainly Strept. Pneumoniae )with MIC up to 4 mg/L are susceptible and likely to be

eradicated with Curam 642

Why 642?

The Captain

8/6/2019 Ppt 0000006


Curam 642 doses

Body weight (Kg)

Volume of amoxicillin and clavulanate

potassium for oral suspension 600 mg/

42.9 mg per 5ml providing 90 mg / kg

/day

8 3 ml twice daily

12 4.5 ml twice daily

16 6 ml twice daily

20 7.5 twice daily

24 9 ml twice daily28 10.5 ml twice daily

¾ body weight daily divided on 2 doses

8/6/2019 Ppt 0000006


Convenient

The Captain

High bacteriological & clinical cure

Optimal dosage regimen

Unique taste of fruits

Excellent safety profile

8/6/2019 Ppt 0000006


CuramCuram 228228

SuspSusp..CuramCuram 642642

SuspSusp..

Twice daily forms

8/6/2019 Ppt 0000006


Curam forms

8/6/2019 Ppt 0000006


8/6/2019 Ppt 0000006


Preferred choice

The Captain

Thanks

ppt 0000006

Documents