potent pyrimidinetrione-based inhibitors of mmp-13 with enhanced selectivity over mmp-14

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2005 Pyrimidine derivatives R 0510 Potent Pyrimidinetrione-Based Inhibitors of MMP-13 with Enhanced Selectivity over MMP-14. — Compound (VII) shows strong activity and the highest selectivity of all tested compounds. — (REITER*, L. A.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 7, 1807-1810; Groton Lab., Pfizer Global Res. Dev., Groton, CT 06340, USA; Eng.) — C. Oppel 29- 163

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Page 1: Potent Pyrimidinetrione-Based Inhibitors of MMP-13 with Enhanced Selectivity over MMP-14

2005

Pyrimidine derivativesR 0510 Potent Pyrimidinetrione-Based Inhibitors of MMP-13 with Enhanced Selectivity

over MMP-14. — Compound (VII) shows strong activity and the highest selectivity of all tested compounds. — (REITER*, L. A.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 7, 1807-1810; Groton Lab., Pfizer Global Res. Dev., Groton, CT 06340, USA; Eng.) — C. Oppel

29- 163

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Indicadores Económicos - cefp.gob.mx · -440.5 Mmp (-89.9% Real) Requerimientos Financieros del Sector Público (RFSP) (Mmp) 313.2 Mmp Observado Ene-May 2017 -84.6 Mmp Observado

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CLOSTRIDIAL TOXINS - POTENT POISONS, POTENT … · CLOSTRIDIAL TOXINS - POTENT POISONS, POTENT MEDICINES ... Clostridium botulinum Clostridium botulinum spores commonly occur in soil,

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DynamicInterdomainInteractionsContributetothe ... · type MT1-MMP (WT), MMP-2, and MMP-9 cDNAs. The sequences coding for the PEX of MMP-2-(470–659) and MMP-9-(517–703) were each