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HYPERPLASTIC COLONIC POLYPS HEALTHY COLON Wallace et al. Miami classification for pCLE. Endoscopy, 2011 ADENOMATOUS COLONIC POLYPS ADENOCARCINOMA © Mauna Kea Technologies , February 2013 Optical Biopsy in the lower GI tract Crypt lumen Epithelial cells Blood vessels Goblet cells Regular crypts Star-shaped luminal crypt openings Regular crypts and epithelium surrounding the lesion Tortuous glands appearing doubled Normal goblet cells distribution Tubular and villous structures Thickening of epithelial lining Dark cells Distorted or elongated crypts Complete disorganization and loss of structures in the tissue

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HYPERPLASTICCOLONIC POLYPS

HEALTHY COLON

Wallace et al. Miami classification for pCLE. Endoscopy, 2011

ADENOMATOUS COLONIC POLYPS

ADENOCARCINOMA

© M

auna

Kea

Tec

hno

log

ies

, Feb

ruar

y 20

13

Optical Biopsyin the lower GI tract

Crypt lumen

Epithelial cells

Blood vessels

Goblet cells

Regular crypts

Star-shaped luminal crypt openings

Regular crypts and epithelium surrounding

the lesion

Tortuous glands appearing doubled

Normal goblet cells distribution

Tubular and villous structures

Thickening of epithelial lining

Dark cells

Distorted or elongated crypts

Complete disorganization and loss of structures

in the tissue