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Post-study caffeine administration enhances memory consolidation in humans

Qiujing Hu

introduction/background

Contents

11

rationale22

methods33

results 44

Discussion/Conclusions55

Introduction/Background

• Many previous studies have documented the effects of caffeine as a cognitive enhancer for the brain

• However, its effects on long-term memory on human have not been investigated in detail

• Caffeine has been always administered before learning therefore effects on memory are impossible to dissociate from other effects caused by it, such as increased arousal, vigilance, attention and processing speed etc.

• This is the first study of caffien on effects of human long term memory

Rationale

Diagram 2

Diagram 2

purpose of the study:To find out the effect of caffien on consolidation of long-term memories in humans

hypothesis: Caffeine enhanced consolidation of long-term memories in humans

Medthods

1. 2. 3.160 healthy, caffeine-naive subjects between the ages of 18 and 30 participated in the study. Participants incidentally studied images of objects, then given either 200 mg of caffeine or placebo. After administration, Salivary samples were collected at the baseline and 1 h, 3 h and 24 h after.

24 hours after the study session, participants' being eveluated by their recognition performance using some items they saw the previous day, some new items and some items that were similar but not identical to ones they saw before.

repeated the experiment with a placebo and different doses of caffeine (100 mg, 200 mg and 300 mg) to determine whether there is an optimal dose range

randomized, double-blind, placebo-controlled trial in caffeine - naive participants

Results

Results

Results shows that the caffeine group had a significant increase in caffeine metabolites at the 1 h and 3 h time points, however, returned to baseline amount at hour 24.

Participants who received caffeine were more likely to call lure items 'similar' rather than 'old' compared to participants who received the placebo

No significant differences in recongnition rates of target hits or foil rejection among groups, hence basic recognition memory was not altered.

A lure discrimination index (LDI) was calculated and found a significant difference between groups. The numnbers suggest that caffeine enhanced consolidation of the initial study session such that discrimination during retrieval was improved.

A two-way analysis of variance (ANOVA) was performed, the data showed a significant main effect of similarity and a significant main effect of caffeine with a nonsignificant interaction.

Dta from the repeated dose change experiments shows that a dose of at least 200 mg is required to observe the enhancing effect of caffeine on consolidation of memory.

disscusion/cnclusion

In conclusion, caffeine enhanced consolidation of long-term memories in humans specific to consolidation.Caffeine is somthing so common widly used, futhur studies should be conducted to understand the mechanisms of how faffeine can ptentiate memory, and detailed relationship between caffeine and human brain.

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Thank you