polarstar pharma otc-md products available no pricev. …€¦ · cervicobrachialgia tunnel tarsale...

PolarStarpharma

AVAILABLE PRODUCTS (OTC - MD)

Year 2018

FERRONAM®: the complete “Fe” solution in pregnancyINDICATIONS

Iron deficiency treatment during pregnancyand prevention of neural tube

defects.

COMPOSITION1 orosoluble sachet contains:

Iron Fumarate 20 mgFolic Acid 400 mcgVitamin C 70 mg.

THANKS TO ITSUNIQUE

OROSOLUBLEFORMULATION ITSPOSSIBLE TOAVOID THE

COMMON SIDEEFFECT:NAUSEA

a

REGISTERED in RUSSIA

as Food Supplement

PRODUCTRUSSIAN

REGISTRATIONACTIVE

INGREDIENTINDICATION SHELF LIFE

PHARMAFORM

(POSOLOGY)

PACK SIZE

MIN. BATCH

SUPPLY PRICE

€/pack (EXW Italy)

FERRONAMFood

SupplementIron, Folic Acid,

Vitamin CIron Deficiency

24 monthsOrosoluble

Sachets (1-2/day)

28 sachets

15.000 3,80

30.000 3,60

POLAR STAR - SUPPLY CONDITIONS

FERRONAM TO AVOID THE MOST COMMON SIDE EFFECTOF THE IRON SUPPLY:

----

NAUSEAVOMITGASTRIC DISCOMFORTBAD IRON TASTE

+ Vitamin C at acid pH

Bind to thetransferine

Tissue (citocrome)

Marrow

Liver

Binding and stocking ofIron into ferritine

Gluten FREE

Tissue

Marrow

NVP’s treatmentPregnancy is for woman a very special moment in which is usually removed any kind ofmedicine. The doctor often opposes to the use of drugs, recommended instead indifferent situations, especially in the first quarter during which the first structures areformed and the nervous system of the unborn child begins to develop.

DOSILEN®: a natural remedy for nausea during pregnancy

• 85% of pregnant women suffer of nausea during the firsttrimester of pregnancy

• 52% of cases it is associates with vomiting

Food Supplementsand Naturalapproaches

A remedy promoted by the Italian Ministry ofHealth and listed in "Substances andpreparations allowed" is Ginger or ZingiberOfficinalis, defined as non-pharmacological remedy effective in reducing nausea and vomiting in pregnancy.

Antiemeticdrugs

COMPONENTS & CLAIMSPer 1 tablet Claim Approved by

Zingiber dry extractof which gingerols

5mg250μg Antiemetic

Annex1 DM 27marzo2014

Vitamin B6 2,3mgContributes to thereduction of tiredness and fatigue

Regulation(EU) No.432/2012

In accordance with the ministerial guidelines, themaximum intake for vitamin B6 is 9,5 mg so therecommended intake is from one to four chewabletablet as needed.

- Gingerols is cholinergic M3 and serotonergic 5-HT3 receptor antagonist- Vit. B6 is cofactor of the glutamic acid decarboxylase enzyme, responsible for

GABA synthesis and, reducing the excitability of the NS, result in an antiematic effect

ØØØØ

ØØØØØØ

KEEP IN MIND

Any TimeAny PlaceWithout waterLet the tablet slowly dissolve in your mouth or chew and swallow it, according to yourpreferencePleasant orange flavourGold standard treatment for NPVNatural non-pharmacological remedy, also suitable for vegansLactose freeGluten freeUp to 4 tablets per day, when needed

PRODUCTRUSSIAN

REGISTRATIONACTIVE INGREDIENT

INDICATION SHELF LIFEPHARMA

FORM(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE


DOSILENFood

SupplementZingiber officinalis

extract + Vit. B6

Treatment of nausea & vomiting during pregnancy

24 monthschew. tab(1-4/day)

20 tabs650mg

10.000 4,00


DOSILEN

DIKIROGEN®: a natural remedy for PCOS syndrome

Polycystic ovary syndrome (PCOS)Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 10%of the female population of reproductive age and is one of the most commoncauses of infertility in women.

It often begins in adolescence with menstrual irregularities and it ismanifested by metabolic dysfunction with age, mainly in perimenopause.

Polycystic ovary syndrome (PCOS)PCOS is a syndrome that "involves the whole life" of the woman, whichbegins in the utero in genetically predisposed individuals, it manifests itselfclinically at the time of puberty, endures bearing age, and exhibits, especiallyafter menopause, a higher risk of developing cardiovascular disease,hypertension,diabetes and other metabolic complications.

In addition, during the fertile age can determine an ovulatory infertility and inpregnancy a higher incidence of gestational complications such asspontaneous abortion, gestational diabetes and preeclampsia.

InositolAmong the mediators of insulin action are known the inositol fosfoglican that,

once inside the cell, exert their metabolic effect.

Inositol is a key part of the vitamin B complexnaturally present in the human bodythat stimulates and activates the mitochondriafacilitating their breathing and activatingall the processes of detoxification of cells.

Inositol is a carbohydrate, but not a classic sugar.It is almost tasteless, a little sweetener.

IN WOMEN WITH PCOS, AS THEY OFTEN HAVE INSULIN RESISTANCE DUE TO A DEFECT INTHE INSULIN RECEPTOR PRESENT ON CELLS (THE INOSITOL FOSFOGLICAN), IS ESSENTIALTO ADMINISTER INOSITOL

Reduction of the insulin resistanceReduction of effects of androgenisationImprovement in ovarian functionImprovement of hormonal pattern

MYO-INOSITOLO1000 mg

D-CHIRO-INOSITOLO200 mg

Reduction of thelevels of plasmatichomocysteine

FOLICO ACID200 µg

Confidential

Contributes to thereduction of insulinresistance

MANGANESE5 mg

Confiential

METABOLICSYNDROME

ENDOCRINE ANDDERMATOLOGICAL

DISORDERS

DIKIROGENᵀᴹ is indicated as an adjunct in the treatment ofmanifestations attributable to:

• Central obesity (waist circumference ≥88cm)

• Impaired glucose regulation• Hypertension (BP ≥ 130/85)• Hypertriglyceridemia (≥ 150mg/dL)• Reduced HDL cholesterol (<50mg/dL)

HYPERANDROGENISM• Hirsutism• Hypertrichosis• Acne• Alopecia• Seborrhea

MENSTRUALIRREGULARITY:• Oligomenorrhoea• Metrorrhagias• Infertility

PRODUCTRUSSIAN


INDICATION SHELF LIFEPHARMA

FORM(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE


DIKIROGENFood

Supplement

Nyo-inositol, D-chiro-inositol, Folic Acid, Manganese

Policysticovarian syndrome(PCOS)

24 monthsSachet(1/day)

30 sachets 4g

20.000 6,75


DIKIROGEN

GINSANA®: the booster of immune system and vaccination

Ginsana in the immune system: what it doesand how – scientific background

Clinical trials with Ginsana

VIRUSProtectionagainstcommoncold andinfluenza

BACTERIABacterialclearance

after chronicbronchitisattack

COPDBetter

Pulmonaryfunctions,

possible anti-inflammatory

action

Ginsana in the immune system: what it doesand how – scientific background

Mechanisms of action

GINSANA IS ABLE TO ACTIVATE:

Natural KillerCells

Cellularinnatedefense

Antibodies

Humoralacquireddefense

Inflammatorycytokines

ThroughToll-LikeReceptors(TLR)

Market Overview and competitive scenario

ENERGY• sports nutrition products (excluding sport beverages) is US$4.7 bn• 6 Ginsana studies on athletes are available

IMMUNE SYSTEM• Adults may suffer 2 to 5 colds per year• School children may suffer 7 to 10 colds per year.• 4 Ginsana Studies on immune modulation (2 related to common cold and influenza, 2 related to chronic

bronchitis) are available

CONVALESCENSE• Reduce convalescence time need and elderly consumers increase• Convalescence is expected to see strong growth as the health benefits of a healthy lifestyle resonate with

increasing numbers of elderly consumers• Use of easy and convenient regular dietary supplements to maintain a healthy lifestyle is expected to rise.

Sources: Common Cold Center, Cardiff University, http://www.cf.ac.uk/biosi/subsites/cold/commoncold.html; Energy Drinks: An Assessment of their Market Size, ConsumerDemographics Ingredient Profile, Functionality, and Regulations in the United States, 2010


• Decreases tiredness, fatigue,exhaustion

• Enhances oxygen uptake• Improvement of hemoglobin

re-oxygenation• Improves physical endurance• Faster recovery time after

effort

Strictly Confidential © Soho Flordis International Pty Limited

ENERGY PRODUCTION

- Potentiates the effect of influenzavaccination

- Reduces the incidence of commoncold and influenza by increasingnatural defences such as naturalkiller cells and antibodies

- Reduces bacterial counts afterbronchitis acute attacs

- Improves pulmonary (lung)function in COPD patients possiblyby reducing inflammation

- Potentiates the effect of influenzavaccination

16

IMMUNE SYSTEM

PRODUCT RUSSIANREGISTRATION

ACTIVE INGREDIENT INDICATION SHELF LIFE

PHARMAFORM

(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE

€/pack (EXW

Switzerland)

GINSANA OTCG115 100mg

extract of Panaxginseng roots

Boost of immune system, potentiate vaccination

36 months cps(2/day)

30 cps 2.400 5,80


SONGHA NIGHT®: the sleeping cycle normalizer

A GOOD DAY STARTS NATURALLY WITH A GOOD NIGHT

a good night’s sleep

Better sleep qualityIn a randomised, placebo-controlled clinical study, patientsit took to fall asleep.6,7

SafeSongha® Night has shown a good safety profile and alow risk of pharmacological interactions with other drugs.6,10No addiction events have been reported during post-marketing surveillance.10

Wake refreshedWake refreshed and fully alert with no hangover, no drowsiness,and no daytime tiredness reported. Songha® Night is a greatchoice for people who need to perform.7

DosageThe recommended dosage of 2–3 tablets a night is easy totailor to each patient’s individual needs.

Restores sleep cycleUnlike benzodiazepines which can reduce the duration ofREM sleep and eliminate the deep sleep phase,8 the calmativeproperties of Songha® Night regulates the body’s natural sleepcycles, ensuring good quality sleep.9

Clinically proven to provide6

Powerful double action

Neurotransmitters in the central nervous systemare responsible for regulating the sleep cycle.11The active ingredients in Songha® Night bringabout sleep in two ways.12

Lemon BalmLemon balmpreventsGABA, theneurotransmitterassociated withrelaxation andsleep, frombreaking down.12–14

ValerianValerian prevents

the releaseof excitatory

neurotransmitter,glutamate.12

EACH SONGHA® NIGHT TABLETCONTAINS TWO ACTIVE

INGREDIENTS WHICHWORKSYNERGISTICALLY TO IMPROVE

THE QUALITY OF SLEEP.12

The lower dose valerian with lemon balm in eachSongha® Night tablet is clinically effective, has a goodtolerability profile, and allows patients to easily titrateto their optimal dose.6

Safe for long or short-term useNo hangover feeling or next day bad mood6,7,15

No unpleasant valerian taste or smell

Gluten and lactose free

No reported addictive effects10

Low risk of interaction with other drugs16

Few reported adverse events6,15

Effective and versatilePowerful active ingredients that work synergistically12

Dosage can be tailored to individual needs

Trust Songha® NightSwiss-made

High quality

Monitored to ensure no heavy metal or pesticide contamination

Extracts are standardised to provide consistency and quality

Clinically proven traditional remedy6,7

Songha® Night

A good day starts naturally with a good night

PRODUCTRUSSIAN


INDICATION SHELF LIFEPHARMFORM

(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE

€/pack (EXW

Switzerland)

SONGHA NIGHT OTC

extract of Valeriana officinalis

(120mg) and Melissae officinalis

(80mg)

Normalization of the sleeping cycle

36 monthssugar

coated tab(2-3/day)

30 tabs 3.600 4,50


NEVRALCAR DUO®: Neuropathic pain? No anymore!

UNIQUE COMPOSITION:L-Acetil-carnitine 1.000 mgLipoic acid 600 mgVitamins

NEVRALCAR DUO is the solution for thePain of Neuropathic origin:ARTICULAR and ONCOLOGICAL

Thanks to its innovative formulation is ensuring:- Painkilling action- Reparation action- Neuroprotection action- Protection on mitochondrial DNA

THE OXIDATIVE STRESS IS PLAYINGA FUNDAMENTAL ROLE IN THE

PATHOGENESIS OF NEUROPATHIES

RIDUCE IL DOLOREDA NEUROPATIE COMPRESSIVE

E METABOLICHE

ACETILCARNITINA mg 1.000 + ACIDO LIPOICO mg 600SOLO CON DOSAGGI EFFICACI ➣ SINERGIA VINCENTE

NEUROPATIE COMPRESSIVE

NEUROPATIE METABOLICHE E IATROGENE

Associazione Farmacologica Innovativa mg 1.000 ACETILCARNITINA e ACIDO LIPOICO mg 600

agisce sulle cause del DOLORE NEUROPATICO

LOMBOSCIATALGIA

CERVICOBRACHIALGIA TUNNEL TARSALE

TUNNEL CARPALE

NEUROPATIEDIABETICHE

NEUROPATIEDA CHEMIOTERAPICI

0,0

0,5

1,0

1,5

2,0

2,5

3,0

3,5

2,63**

0,72

1,08

3,43*

VCM

LAC+ALA

VCS

*p<0,05 vs placebo**p<0,01 vs placebo

Placebo

Valu

tazio

ne ri

spet

to a

l bas

ale

(m/s

ec)

0,0

0,5

VCM

Valu

tazio

ne ri

spet

to a

l bas

ale

(m/s

ec)

VCS

1,0

1,5

2,0

2,5

1,27

0,39

0,57

1,54*

LAC+ALA

Placebo

*p<0,05 vs placebo

Variazione media della velocità di conduzione nervosa (VCM) e sensitiva (VCS) dopo trattamento per 30 giorni con LAC (+ALA) o placebo nei pazienti con mononeuropatie. Nei pazienti affetti da mononeuropatie, LAC (+ALA) ha migliorato

significativamente sia la VCM sia la VCS.

Variazione media della velocità di conduzione nervosa (VCM) e sensitiva (VCS) dopo trattamento per 30 giorni con LAC (+ALA) o placebo nei pazienti con polineuropatie. Nei pazienti affetti da polineuropatie, LAC (+ALA) ha migliorato significativamente la VCS (p>0,05).

Azione antidolorifica

Azione riparatrice

Azione neuroprotettiva

Azione antiossidante

Genera maggiore espressionedei recettori mGlu2/3a livello sinaptico

Promuove l’espressione dei recettoriNGF e la rigenerazione assonale posttraumatica con recupero dellafunzione motoria sensitiva del nervoperiferico

Favorisce la formazione di fosfolipididi membrana, la conducibilità dellamembrana neuronale e la attivitàsinaptica

Contrasta potentemente l’azione deiradicali liberi e AGES (advanced glycation end-product)

CHEMIOTERAPIASTRESS OSSIDATIVO

INFIAMMAZIONENERVI PERIFERICI

DOLOREDISTURBI ARTICOLARI

ACETILCARNITINE mg 1.000 + LIPOIC ACID mg 600EFFECTIVE DOSAGE WINNING SYNERGYREDUCE PAIN FROM COMPRESSIVE AND

METABOLIC NEUROPATHIES

COMPRESSIVE NEUROPATHIES

DIABETIC NEUROPATHIES CHEMOTERAPY NEUROPATHIES

CHEMOTHERAPY OXIDATIVE STRESS

INFLAMATION PERIPHERAL NERVES

PAIN ARTICULAR DISORDERS

METABOLIC AND IATROGENIC NEUROPATHIES

NEVRALCAR DUO: RATIONALE

The association of AcetilCarnitine and Lipoic Acid shows a high pharmacological action againNeuropathy and Neuropathic pain thanks its remarkable antioxidant, neurotrophic and analgesic action.

The synergic action, also, control and reduce symptoms as paresthesia, tingling, numbness and sensibility reduction.

ACETILCARNITINE: - neurotrophic, analgesic and antioxidant action- help the fat acid transport into the mitochondria

the better cells tropism and the improvement of energy reserve make more resistant theneurons to traumatic and toxic events.

LIPOIC ACID: - natural, endogenous antioxidant - improving the cells metabolism and mitochondria’s energy production

the action of Lipoic Acid promote the regeneration of other endogenous antioxidant as theVitamin E, Vitamin C and Glutathione.

In all the clinic situation showing NEUROLOGICAL PAIN

L-Acetil-carnitineActing on the effect

Lipoic acidActing on cause

MODE OF USAGE:2 cps day

BOX 60 cps

PRODUCT RUSSIANREGISTRATION

ACTIVE INGREDIENT INDICATION SHELF LIFE

PHARMFORM

(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE


NEVRALCAR DUO

FS(to be

registered)

Actil L-Carnitine(1000mg) Lipoic Acid (600mg)

Pain of Neurological

origin24 months

slow release tab

(2/day)60 tabs 5.000 7,30


SYALOX ®: TRIVALENT ACTION FOR WOMEN’S WELLNESS

UNIQUE COMPOSITION:Hyaluronic acidHigh molecular weigh

+Proanthocyanidins

PERFECT FOR MENOPAUSE

SYALOX 150:- Promotes vaginal hydration

- Improves the structure of tissues- Prolonged action over time

REDUCTION OF INCREASE OF

OESTROGENS

NUTRIENTS

MOISTURES

COLLAGEN

PRURITO AND BURNS

VAGINAL ATROPHY

VAGINAL DRYING

INTERSTITIAL CYSTITE

PRODUCTRUSSIAN

REGISTRATION

ACTIVE

INGREDIENTINDICATION SHELF LIFE

PHARM

FORM

(POSOLOGY)

PACK

SIZE

MIN

BATCH

SUPPLY PRICE


SYALOX 150

FS

(to be

registered)

High molecular

weight HA(150mg)

Red

Grapevine(75mg)

Women

wellness24 months

Plant origin

cps.

(1/day)

30 cps 5.000 6,70


VAGINAL ATROPHYVAGINAL DRYINGINTERSTITIAL CYSTITE

SYALOX PLUS®: Articular pain? No thanks!

UNIQUE COMPOSITION:Hyaluronic acidHigh molecular weigh

+Boswellia Serrata (Acid 3.0-acetil-11 keto-beta-boswelic)inhibits inflammation mediators

THE HYALURONIC ACID IS AFUNDAMENTAL COMPONENTOF THE CONNECTIVE TISSUE:Its decreasing is generating

PAIN and REDUCED FUNCTIONAL MOBILITY

SYALOX PLUS: MECHANISM OF ACTION

The HYALURONIC ACID at high molecular weight, after ORAL ASSUMPTION is absorbed and start to be spread in the articular and tendon tissues:- After 15 minutes, significant concentrations in the blood and muscles- After 4 hours, significant concentrations in the shoulder joints and rachis- After 24 hours, significant concentrations in the connective, articular and tendon tissues

ONLY THE HYALURONIC ACID AT HIGH MOLECULAR WEIGHT IS RECOGNIZED BY THE CD44 RECEPTORS AND IS AN EFFECTIVE OPTION TO PREVENT AND CURE THE ARTICULAR DISEASES

SYALOX PLUS:

ANTI-INFLAMMATORY EFFECT

IMPROVED ARTICULAR MOBILITY

TENDON PROTECTION

SAFETY AND HIGH TOLERABILITY

COMPLEMENTARY TO

INFILTRATIVE THERAPY

PRODUCTRUSSIAN



(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE


SYALOX PLUSFS

(to be registered)

High molecular weight HA(300mg)

Boswelliaserrata(300mg)

Pain of articular

origin24 months

Patented triple layer tab slow rel.

(1/day)

20 tabs 5.000 7,50


SYALOSET 2000-SYALOSET PLUS®: Articular pain? No thanks!

UNIQUE COMPOSITION:Hyaluronic acidHigh molecular weigh(2.000 KDA)

THE HYALURONIC ACID IS AFUNDAMENTAL COMPONENTOF THE CONNECTIVE TISSUE:Its decreasing is generating

PAIN and REDUCED FUNCTIONAL MOBILITY

SYALOSET IS A SUBSTITUTE OF SYNOVIAL FLUID AND IT IS INDICATED FOR TREATING THE DECREASED MOBILITY AND PAIN IN PATIENTS WITH DEGENERATIVE OR TRAUMATIC JOINT DISEASE OF SYNOVIAL ARTICULATIONS OF HIPS AND KNEES, WITHOUT ACTIVE SYNOVITIS.THE PRODUCT ACTS BY PROVIDING LUBRIFICATION AND MECHANICAL SUPPORT. IT IS ESPECIALLY SUITABLE FOR TREATING THE SYMTOMS OF OSTEOARTRITIS.

SYALOSET PLUS: 1 INJECTION EVERY 6 MONTHSSYALOSET 2000: 2 INJECTION (SEPARATED BY 15 DAYS) EVERY 6 MONTHS

2 Mil DALTON

PRODUCTRUSSIAN



(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE


SYALOSET 2000MD

(to be registered)

High molecular weight HA

(30mg/2ml)

Pain of articular

origin24 months

Prefilled syringe

(2/6 months)1 p. syr. 500 15,00


PRODUCTRUSSIAN



(POSOLOGY)

PACK SIZE

MINBATCH

SUPPLY PRICE


SYALOSET PLUSMD

(to be registered)

High molecular weight HA

(60mg/4 ml)

Pain of articular

origin24 months

Prefilled syringe

(1/6 months)1 p. syr. 500 25,50

e-mail: [email protected] www.polarstar-pharma.com

PolarStarpharma

Moscow’Representative OfficeOffice Centre CDM

Office 619Volokolamskoje shosse 73125424 Moscow (Russia)

phone/fax: +7 495 780.36.59 (three lines)

polarstar pharma otc-md products available no pricev. …€¦ · cervicobrachialgia tunnel tarsale...

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