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TRANSCRIPT
Hybrid Protein Tools Developed for Gene Cutting and Editing and Develop New Method to Identify
Glycosylated Proteins
Christian José Gil Pabón
folding
folding
Hybrid Protein Tools Developed for Gene Cutting and Editing
Hybrid Protein Tools Developed for Gene Cutting and Editing
DNA of bacteria is very important for the study, and advances in gene therapy.
will combine the DNA of two bacteria for this research.
Hybrid Protein Tools Developed for Gene Cutting and Editing
Thanks to these proteins can identify defective sites in the DNA.
other advances have allowed us to develop other enzymes that cut specific sites in DNA .
Hybrid Protein Tools
Developed for Gene Cutting and Editing
"This breakthrough could eventually make it possible to efficiently modify plant, animal and even human genomes," said Yang. "It should be effective in a range of organisms."
Hybrid Protein Tools Developed for Gene Cutting and Editing
were also able to show that the TAL effector
part of the hybrid protein can be
customized to target new DNA sequences.
should be faster and less expensive to make TAL effector nucleases,
and easier to design them to recognize
specific DNA sequences
observation
nuclease TAL effector is a major advance in gene therapy because it is cheaper and more effective, besides that is
faster, and more specifically the sections of DNA that are to be
trated .
Scientists Develop New Method to Identify Glycosylated Proteins
Scientists Develop New Method to Identify Glycosylated Proteins
Glycosylation of proteins is the process by which a carbohydrate binds to a protein, this specific purpose such as protein folding, and interactions with other proteins.
Scientists Develop New Method to Identify Glycosylated Proteins
When errors occur during the protein modification or in case it takes place in an unregulated way, this can contribute to diseases like Alzheimer's disease or Creutzfeldt-Jakob disease.
Scientists Develop New Method to Identify Glycosylated Proteins
N-glycosylation is a specific type of glycosylation, during which the carbohydrates bind on a certain component of a protein, the amino acid asparagine ("N").
Scientists Develop New Method to Identify
Glycosylated Proteins
this new method is based on a filter that allows access difficult to extract proteins, then used mass spectrometry to 6367 she could identify sites of protein N-glycosylated.
observationThe study of n-
glycosylation is a major breakthrough, since it is a crucial process in various enfermedadades such as Alzheimer's, with sites identified in the N-glycosylation, it may evalluar more specific treatments for these diseases.
Medical utility
Medical utilityNuclease TAL
effector constitutes an important advance in gene therapy because it is much cheaper, faster, and more specific, allowing defective DNA sequences cut more easily.
Medical utilityAlzheimer's disease with a crazy character,
which still is not treated more effectively, research with the N-glycosylation may represent a more effective alternative to new treatments for this pathology.
bibliography
Iowa State University (2010, August 31). Hybrid protein tools developed for gene cutting and editing. ScienceDaily. Retrieved September 3, 2010, from http://www.sciencedaily.com /releases/2010/08/100830114955.htm
Max-Planck-Gesellschaft (2010, September 3). Scientists develop new method to identify glycosylated proteins. ScienceDaily. Retrieved September 3, 2010, from http://www.sciencedaily.com /releases/2010/05/100528093210.htm
Man finds God behind every door that science is able to open..Albert Einstein