platelet rich plasma (prp) for treatment of knee arthritis
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Knee Arthritis - Treatment and Joint Preservation with PRPRegenerative Medicine andJoint Preservation Center of Santa RosaRaymond Severt, M.D.1144 Sonoma Avenue, Suite 121Santa Rosa, California, 90025(707) 978-4322
OrthoRegenSR.com
Heal Naturally
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Knee Arthritis is a BIG Problem
10 million in US have knee arthritis
$30 billion spend yearly on knee replacements
Should we keep treating it with the “traditional” methods?
Or should we treat it in a way that can use the body’s own healing ability without all the typical side-effects?
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Regenerative MedicineOffers groundbreaking techniques to treat and control arthritis
Avoid more invasive treatment options
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Normal KneeKnee is a critical joint
Commonly damaged
Commonly develops arthritis
Cartilage is smooth and strong/resilient
Ligaments maintain stability
Meniscus provides cushioning
Good viscosity of fluid
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Knee ArthritisCartilage wears out often to bone
Inflammation develops in joint
Reduced lubrication/cushioning - hyaluronic acid
Knee deforms and becomes unstable
Knee becomes painful, swollen, and stiff
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“Traditional” TreatmentWhat is typically offered to patients
Rest, Ice, Braces
Physical Therapy
Medications
NSAID
Corticosteroid Injections
Surgery
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Is There Something Wrong With These “Traditional” Treatment Methods?Rest, Ice, Braces - NO
Physical Therapy - NO
Medications - YES
Corticosteroid Injection - YES
Surgery - YES
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Rest, Icing, BracingCertainly helpful
No negative effects
Comforting
Reduces pain
Patient can do these on their own at their own discretion
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Physical TherapyCertainly helpful
Strengthens
Mobility
Home Exercise Program
Prevents further injury
Often invaluable for prevention and to help in recovery
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Medications- NSAIDsPrescription and OTCHave MANY side effect
Ulcers
Bleeding
Heart Attack
Stroke
Kidney
Liver
One of highest causes of hospitalization and death in elderly
Expensive
Many pulled off market because of safety issues (Vioxx, Bextra)
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Corticosteroid InjectionsDepo-Medrol, Kenalog, Celestone
Do reduce inflammation - but for a very limited timeframe
COMPLICATIONS - not trivial!
“flare reaction”
soft tissue damage - ligaments, tendons
cartilage deterioration - decreased cartilage cell viability - softens cartilage
osteoporosis - softens bone
skin atrophy - depigmentation
These complications produce effects that are completely contrary to what the patient needs and wants!
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Medications - Oral and Injectables
Produce effects in the body that are completely “unnatural”
Produce effects that are damaging
Block normal inflammatory cascades
Block healing mechanisms
Block biological pathways that are necessary for proper healing of damaged tissue
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SurgeryMay be needed in some situations - with proper indications!
Significant risks
Invasive
Once done is “irreversible”
Long recovery
Complications
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Surgery - CostKnee Replacement $40K - out of pocket cost - several $100’s or $1,000’s
Is surgery done too often?
Knee arthroscopy - indications, findings, results?
Repeat/Revision Surgery
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What About Platelet Rich Plasma Treatment - PRP
A natural way to stimulate the body to heal damaged tissue
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How Does PRP Work For Arthritis?Stimulates body's natural
healing process
Balances inflammation/anti-inflammatory cascades
Reduces inflammation and pain
Stimulates chondrocytes to strengthen cartilage
Increased hyaluronic acid secretion and superficial zone protein
Inhibits and reverses osteoarthritis pathogenesis pathways (interleukin, aggrecan, nuclear factor B)
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PRP Stops and Reverses the Arthritic Process
Strengthens cartilage - increases cartilage cell viability
Improves protective viscosity of joint fluid
Reverses osteoarthritic pathways
MRI and functional studies have shown that PRP halts the progressive thinning of cartilage and improves function. Halpern, et al., Clin J Sport Med, 2013
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PRP AdvantagesAutologous
Natural
Safe
Stimulates/activates the normal healing pathways that the body already has
Does not have the inherent negative effects seen with medications (oral or injectable)
Can avoid or delay surgery
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PRP AdvantagesCompletely outpatient setting
Can initiate rehabilitation quickly
Long lasting results
Can be safely repeated if needed
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PRP for Knee ArthritisNot all PRP’s are alike
Intra-articular PRP must be appropriately prepared
Reduce inflammation, stimulate chondrocytes, increase hyaluronic acid production
Proper experience and equipment needed
Reduce erythrocyte and granulocytes in preparation
Maintain high platelet and growth factor levels
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PRP for Knee ArthritisA natural way to treat the symptoms of knee arthritis and to help preserve the structure and function of the knee in its natural state for an extended period of time.
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Regenerative MedicineandJoint Preservation Center
1144 Sonoma AvenueSuite 121Santa Rosa, CA 95405(707) 978-4322
OrthoRegenSR.com
Maintain. Preserve. Sustain.