Recent Investigationsof

Phyto-drugs curingTUBERCULOSIS

Presented by Dr. Sudhakar KokateDirector PPRC, India

Tuberculosis (TB)

1. Globally TB continues to be a major cause of disability

and death

2. 1/3 of world’s population is affected by Mycobacterium

tuberculosis (MBT)

PPRC/INDIA 01

Tuberculosis (TB)

3. 2 million deaths are caused / year in the world

4. TB is responsible for more human deaths than any

other single infectious agent

5. 26% of all preventable deaths, 7% all deaths

PPRC/INDIA 02

Tuberculosis (TB)

6. WHO 1993 declared TB – a global emergency

7. In developing countries the impact of TB has intensified

with the spread of HIV infection

8. Earlier therapy was costlier and longer duration

treatmentPPRC/INDIA 03

Tuberculosis (TB)

9. Multi-drug resistant TB evolved that’s why documented

in many countries

10. Herbs are rich sources of therapeutic agents for

Prevention and treatment of TB

PPRC/INDIA 04

Plant extracts exhibiting anti-TB activityPLANT PART TYPE OF EXTRACT

MIN. CONC AT WHICH NO GROWTH

Punica granatum Fruit peelings Methanolic 5 mg / ml

Punica granatum Fruit peelings Ethanolic 3 mg / ml

Coriandrumsativum

Fruits Ethanolic 2 mg / ml

Myristica fragrans Fruits Ethanolic 3 mg / ml

Syzygiumaromaticum

Buds Methanolic 1.5 mg / ml

Zingiber officinale Rhizome Ethanolic 1.5 mg / mlPPRC/INDIA 05

Punica granatum

PPRC/INDIA 06

Punica granatum

A shrub or small tree native of Iran, Afghanistan and Baluchistan

Cultivated throughout India

Seeds along with the fleshy portions are dried and commercially marketed as Anar dana

Edible portion 68% contain 78% moisture, protein 4.6, fat 0.1, fibre 5.1, carbohydrate 14.5 and minerals

PPRC/INDIA 07

Punica granatum Fruit: good source of sugars, Vitamin C and iron

Fresh rind of fruit contains: ___%Wax 0.8 Inulin 1.0

Resins 4.5 Mucilage 0.6

Mannitol 1.8 Rannin 10.4

Gums 3.2 Gallic acid 4.0

Non-crystallized sugars 2.7 Pectin 2-4

Calcium oxalate 4.0 Tannin upto 26% in dried rindPPRC/INDIA 08Dr. Thorpe 1958

Punica granatum

Rind of pomegranate….source of a dye (yellowish, brown shades)

Fruit peelings used for diarrhoea & respiratory infections

Extracts of fruits effective against:

Micrococcus pyogenes

Escherichia coli

Pseudomonas aeruginosa

Intestinal pathogenic bacilliPPRC/INDIA 09

Coriandrum sativum

PPRC/INDIA 10

Coriandrum sativum

Annual herb from Apiaceae family

Native to south-western Asia to North Africa

Medicinal plant is used as domestic remedy

Culinary properties and used in preparations of Indian food

items

PPRC/INDIA 11

Coriandrum sativum

It has several pharmacological effects such as anti-fertility,

anti-hyperglycaemic, anti-oxidant, anti-proliferative and

hypo-tensive activities

Chemicals: quercetin-3-glucuronide, linalool, camphor,

geranyl acetate, geraniol and coumarins

PPRC/INDIA 12

Myristica fragrans

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Myristica fragrans

Family: Myristicaceae

Evergreen, aromatic tree

Fruit is yellow, broadly pyriform orglobose, 6.9 cm long,

often drooping pericarp, fleshy, splitting into 2 halves at

maturity

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Myristica fragrans

Imported from South-east Asian countries & consumed in

India for culinary and medical purpose

Traditionally Myristica fragnans is used as anti-

inflammatory, hypolipidemic, hypocholesterolemic agent

Anti-cancer, anti-diabetic activities are also known

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Syzygium aromaticum

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Syzygium aromaticum

Family: Myrtaceae

Buds of Syzygium aromaticum are used as spice and

flavouring agents.

It’s oil (clove oil) is traditionally used in toothache, mouth

sores, rheumatism and arthritis

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Syzygium aromaticum

Used as carminative, to increase hydrochloric acid and

improve peristalsis

Said to be natural anthelmintic

Used in aromatherapy where stimulation and warming is

needed, especially for digestive tract

PPRC/INDIA 18

Zingiber officinale

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Zingiber officinale

10-gingerol is the main component of Ethanolic extract of

dried rhizome of ginger

Exhibits anti-bacterial, anti-fungal activity, anti-oxidant,

anti-inflammatory activity

Used as a stimulant & carminative for curing gastro-

intestinal disordersPPRC/INDIA 20

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