PHOS-ISTOSDEVELOPMENT OF BIOPHOTONIC DEVICE

BASED ON FLEXIBLE LIGHT EMITTING TEXTILE DEDICATED TO THE MONITORING

AND TREATMENT FOR DERMATOLOGIC DISEASES AND CARCINOMA

CONTEXT Actinic Keratosis (AK)

Cutaneous carcinoma in situ Scaly erythematous plaque Caused by sun damage

Epidemiology: In Europe a prevalence of 15 % in men and 6 %

in women has been documented Over the age of 70 years, 34 % of males and 18

% of females were found to have AKs

Evolution 10% risk to develop into invasive Squamous

Cell Carcinoma

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Localization on sun-exposed areas

CONTEXT

Photodynamic therapy (PDT) for Actinic Keratosis

Destruction of the AK cells by the interaction between three elements:

Photosensitizer: Protoporphyrin IX

• Generated from a topical photosensitizing agent

• Selectively accumulated in the target cells

Light of appropriate wavelength

Oxygen in sufficient quantities in the target cells

3

CONTEXT

Photodynamic therapy (PDT) for Actinic Keratosis

Benefits Cure rates between 69 and 93 % Excellent cosmetic results: no scare

Drawbacks Important variation in cure rates Perfectible Very painful therapy Half a day equipment occupancy per patient Cost and limited availability of equipment (only

available in specialized environment)

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OBJECTIVES

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Objective: To increase the efficiency of treatment

Solutions proposed by Phos-Istos: To ensure illumination homogeneity using a flexible light

emitting textile

To determine in real time the optimal treatment parameters by

monitoring the PDT reaction

Conventional rigid LED panels:

Flexible light emitting textile

proposed by Phos-Istos:

OBJECTIVES

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Objective: To manage patient pain

Solutions proposed by Phos-Istos: To ensure oxygen in sufficient quantities using light

fractionation (succession of illumination and rest periods)

To provide a cooling effect on the affected area

Fractionated illumination proposed by Phos-Istos:

Conventional continuous illumination:

ON

t

ON ON

OFF

tOFF

ON

Reoxygenation during rest

periods

OBJECTIVES

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Objective: To extend the use of PDT

Solutions proposed by Phos-Istos: To miniaturize the system for ambulatory use

To limit the cost of the ambulatory system

Conventional PDT systems:

Ambulatory

system

proposed by

Phos-Istos:

EVALUATION

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Comparative clinical evaluation of the light emitting textile for AK

Efficacy assessments: Complete (or not) disappearance of lesions 3 months after treatment

Safety assessments Pain assessment during treatment Assessment of adverse effects (erythema, crusting…) 1-3 days after

treatment.

PDT using conventional red light-emitting diode light

PDT using the light emitting textile

10 PARTNERS

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Institut National de la Santé et de la Recherche Médicale

REDEN

MODULIGHT

TEXINOV

KLINIKUM VEST GMBH

EREO

Centre Hospitalier Régional et Universitaire de Lille

FLUENCE THERAPEUTICS

Ecole Nationale Supérieure des Arts et Industries Textile (ENSAIT)

PROPLAST