KHANG SINH PHENICOLO2NNHHO OHOClClCau truc cloramphenicol gom nhan benzen nitro hoa v tr para, chuoi amino-2 propaniol-!," nhom icloracet#l$ %&-' threo co hoa(t tnh )inh ho(c$CLORAMPHENICOLCloramphenicol co the* +,(c to*ng h(p hoa-n toa-n ba.ng ph,ng phap hoa ho(c t,- / 0-nitroacetophenon$1cetophenon$0-nitrobenzaleh#$2t#ren$1lcol cinamic$IEU CHENO2CHO+CH2 COOHNH2NO2CHOHCHNH2COOHNO2CHOHCHNH2COOCH3CH3OH/HClacid D (+) tartricNO2CCCOOCH3H HOH NH2Cl COCHCl2NO2CCCOOCH3H HOH NHCOCHCl2NO2CCCONHNH2H HOH NHCOCHCl2NH2-NH2NO2CCCOH HOH NHCOCHCl2HNO3NaBH4N3NO2CCCH2OHH HOH NHCOCHCl2cloramphenicolNhom nitro thmO2NNHHO OHOClClTNH CHAT HOA HOC!o nhom "i#$o%#&t'$0han ,ng 34567181 9 8:22+un cach thu# cloramphenicol vi p#riin va- ;a:n$0han ,ng cua Cl-O2NNHHO OHOClClTNH CHAT HOA HOC!o nhom %$#o$ (%)# nh%*t 0han ,ng ta(o e)te vi cac aci t,ng ,ng e)te palmitat, )tearat ?hong +a@ng, ?hong tan trong n,c u-ng cho tre em e)te )uccinat, glicinat tan +,(c u-ng la-m thuoc tiem$O2NNHHO OHOClClTNH CHAT HOA HOC?et nh AB 2 cua ribo)om t-18; ?hong giai maC +,(c ngaDn cha>n Eua trFnh )inh to*ng h(p proteinC+ CHE TAC O,NG0ho* ?hang ?hua*n t,ng +oi ro>ng nh,ng b +e ?hang rat nhanh, chu #eu tac u(ng tren vi ?hua*n gram am/ Gi ?hua*n gram ,ng/ Streptococcus pneumoniae, Cor#nebacterium$ Gi ?hua*n gram am/ Neisseria gonorhoea, N. eningitides, 2almonella, )higella, t ta(p ?hua*n ruo>t/ co the* b bo>i nhiem nam ma-ng niem ma(c &mie>ng va- am +a(o'$Ko>c tnh +oi vi mau/8oi loa(n tu# =,ng &u-ng lau nga-#, lieu cao', co the* phu(c hoi Lhieu mau ?hong tai ta(o &panc#topenia' chM =a# ra ca bie>t nh,Cng be>nh nhan +aNc ,ng o i tru#en &tM le> ?hoang !O"BBBB', ?hong phu(c hoiO,C TNH /A0 TAI 1IENLai bien loa(i