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Dr.Jeevan Jacob JR in Pharmacology 48 th Batch 1

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Page 1: Pharmacology Spotters

Dr.Jeevan JacobJR in Pharmacology

48th Batch

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Page 2: Pharmacology Spotters

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Page 3: Pharmacology Spotters

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Page 4: Pharmacology Spotters

Write two indications of the drug?

1.Myasthenia gravis

2. Reversal of non-depolarising neuromuscular block.

3.Post-operative urinary rétention.

4.Cobra Bite

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Page 5: Pharmacology Spotters

a) Mention one advantage of this route of administration over oral route?

- ~100% Bioavailability- Provides Constant Dosage

b) Disadvantages of this route?-Costly-Skin allergy

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Page 6: Pharmacology Spotters

a) Mention two indications for its use.

Irritable bowel syndrome

minor diarrhea

Dysmenorrhea

Morning sickness, Motion Sickness

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Page 7: Pharmacology Spotters

Write the indications for its use.

- Treatment of Sialorrhea

- Treatment of Hyperhidrosis

- -treatment of COPD, Asthma

- Pre anaesthetic medication

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Page 8: Pharmacology Spotters

Write two metabolic abnormalities produced by this drug?

-Hypokalemia

-Hypomagnesemia

-Hypocalcemia

-Hyperuricemia

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Page 9: Pharmacology Spotters

a) Name a prodrug belonging to this group?

-Simvastatin,lovastatin

b) Mention one important adverse effect of this drug?

-Raised serum transaminases( hepatotoxicity)

-Myopathy

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Page 10: Pharmacology Spotters

a) To which class does this drug belong?

-Dihydropyridine CCB

b) Give an advantage over Nifidipine?

-Slow absorption and peaking

- Once daily dosage due to long half life

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Page 11: Pharmacology Spotters

a) Mention one mechanism of action of this drug?

Nitric oxide release

Potassium channel-opening action

b) Mention one use?

- Antihypertensive

- Antianginal

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Page 12: Pharmacology Spotters

a) Write its mechanism of action as an antianginal drug?

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Page 13: Pharmacology Spotters

a) Write its mechanism of action as an antianginal drug?

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a) Mention one indication for its use?

-Acid Peptic disease

-Zollinger Ellison syndrome

b) Write one advantage over Cimetidine?

- No anti androgenic side effects

- 5 times more potent14

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This is an area formed by the

1.junction of the cystic and common bile ducts posteriorly

2.the junction of the second and third parts of the duodenum inferiorly

3. the junction of the pancreatic neck and body medially

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Page 17: Pharmacology Spotters

a) To which group does this drug belong? -Bisphosphonates

b) Mention one indication?- Osteoporosis- Paget’s Disease- Malignancy

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Page 18: Pharmacology Spotters

a) What will happen if you administer a

non selective beta blockers with this drug?

-The hypoglycemic symptoms will be masked

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Page 19: Pharmacology Spotters

a) What is its mechanism of action? Acts on the anterior pituitary to inhibit the negative feedback action of oestrogen thus increasing gonadotropin release.

b) Write one adverse effect?Menopausal-like hot flushes; ovarian enlargement, GI disturbances

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Page 20: Pharmacology Spotters

a) Write one specific use of this drug?-Bipolar (manic-depressive) disorder

b) Why do we need to estimate its plasma level concentration?

-Because of a low therapeutic index, it is essential to measure the serum Li+ concentration

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Page 21: Pharmacology Spotters

a) Give two advantages over propranolol?

-Longer duration of action

-More potent

-More Cardioselective

-Less side effects( Flushing , Tremor, Dizziness)

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Page 22: Pharmacology Spotters

a) Name the receptor blocked by this drug?

-Angiotensin receptor

b) Write one advantage over Enalapril?

-No Brassy Cough

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Page 23: Pharmacology Spotters

a) Write its cardiac use?

- Anti Arrhythmic

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Page 24: Pharmacology Spotters

a) Write two advantages over tricyclic antidepressants?

-No sedation

-No anticholinergic side effects

-Seizure Threshold not lowered

-Does not depress cardiac function

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Page 25: Pharmacology Spotters

a) Mention the type of anaesthesia produced by it?

- Dissociative anaesthesia

b) Write one condition where the drug is preferred?

-Shock-Asthma

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a) Mention two uses other than as an antituberculous agent?

-Leprosy

-Meningococcal meningitis

-Brucellosis( along with doxycycline)

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Page 27: Pharmacology Spotters

a) Mention two advantages over heparin?

No thrombocytopenia

Monitoring not required

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Page 28: Pharmacology Spotters

a) Write two advantages over Ciprofloxacin?

-More potent

-Covers Gram positive bacteria and anaerobes

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Page 29: Pharmacology Spotters

a) Write two indications for its use?

-Pediculosis – 1% lotion

-Scabies – 5% lotion

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a) Mention two indications?

-Strongyloides, Onchocerciasis, Scabies

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a) What is the dose limiting toxicity of this drug?

-Hemorrhagic Cystitis

b) How is it prevented?

- Using MESNA

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Page 32: Pharmacology Spotters

a) Write its therapeutic uses?

-Allergy

-Rheumatoid Arthritis

-Asthma

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a) Which receptor is blocked by this drug?

-Nicotinic (Nm receptor)

b) How is its action reversed?

-Neostigmine

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a) What is the source of this drug?

-Ox lung, Pig intestine

b) Name its antidote?

-Protamine sulphate

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Page 35: Pharmacology Spotters

a) Write its mechanism of action?

-It blocks ADP receptors and prevent platelet aggregation

b) What is the advantage over ticlopidine?

-more potent

-minimal chance of bleeding tendency

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Page 36: Pharmacology Spotters

a) Mention two indications for its use?

- Parkinsonism

- Acromegaly

- Galactorrhea

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a) Write two advantages over erythromycin?

- Broader spectrum than erythromycin

- Once daily dosing possible

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a) On which phase of the cell cycle does it act?

-Synthetic phase

b) Name the drug given to reduce its toxicity?

-Folinic acid

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Page 39: Pharmacology Spotters

a) Use other than local anaesthetic?

-Class 1B Antiarrhythmic

-Inhaled lidocaine can be used as an antitussive acting peripherally to reduce the cough reflex.

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Page 40: Pharmacology Spotters

a) Mention its one indication?

-BPH

b) Mention one of its side effect?

-postural hypotension

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a) Give one indication?

-Urticaria, Atopic dermatitis

b) Write one advantage over older member of this group?

-No interaction with macrolides or antifungals and torsades de pointes

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a) What is its route of administration?

- Intravenous

b) Write indications for its use?

-Shock with Oliguria

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a) In what type of patients will this drug produce apnoea?

-Pseudocholinesterase deficient patients

b) How is it treated?The patient should be anaesthetized and ventilated. Neuromuscular transmission should be monitored with a nerve stimulator.The patient should remain ventilated and anaesthetized until breathing spontaneously.

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Page 44: Pharmacology Spotters

Thank You

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