Pharmaceutical Sciences Research

Naresuan University

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NNaarreessuuaann UUnniivveerrssiittyy Naresuan University is located in Phitsanulok Province, 350-km to the North of Bangkok. The university has made its strong commitment to provide quality education to the population in the area and contribute to innovative research in health, technological, social and humanity sciences. The Faculty of Pharmaceutical Sciences has been established since 1992. The faculty was the first in Thailand to offer a 6-year educational program for new-entry students, commencing the Doctor of Pharmacy (Pharm. D.) degree after graduation. We have also offered an undergraduate program, leading to the Bachelor of Science in Cosmetic Sciences degree since the year 2006. Additionally, the faculty has been providing opportunities for graduates to pursue their advanced degrees (both master and doctoral levels) in many areas of specialization: community pharmacy, pharmaceutical care, pharmaceutics, cosmetic sciences, pharmaceutical chemistry and natural products, as well as pharmacology and biomolecular sciences. Our graduates have successfully occupied competitive positions in well-known public and private organizations.

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Currently, the faculty members have been working collectively in 15 research units:

Bioscreening Research

Natural Products

Medicinal Chemistry

Basic Physicochemical Studies

Pharmaceutical Biotechnology

Drug Delivery System

Pharmaceutical Technology

Pharmacological Research

Biotechnology and Molecular Biology Research

Biomaterial and Regenerative Medicine

Pharmacokinetics

Cellular Biology and Toxicology

Pharmaceutical Outcomes

Pharmaceutical Care

Tobacco Control.

Two technical research units, namely animal cell culture and radioactive research units, also provide facilities for researchers if needed. Research in the Faculty of Pharmaceutical Sciences at Naresuan University is well-funded by funding agencies in the country and internationally. We have secured research funding from governmental agencies, non-governmental organizations, pharmaceutical industries, professional organization and International Foundation of Sciences.

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For more information, please contact:

Assoc. Prof. Dr. Chanthonrat Sitthiworanan Dean

Faculty of Pharmaceutical Sciences Naresuan University Muang, Phitsanulok 65000 THAILAND Tel +66-55-96-3603 Fax +66-55-96-3731

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Bioscreening Research Unit Faculty of Pharmaceutical Sciences

Naresuan University

We aim at exploring biologica l act ive compounds from natura l resources such as plants used in Asian tradit ional medicines and marine organisms. The research act ivity includes in v i t ro b iologica l act ivity test , isolat ion and identif icat ion of bioact ive compounds from crude extracts. Analyt ica l method development for phytochemicals is a lso of our interest .

Our ongoing research involving with the search for lead compounds for degenerat ive diseases from natura l sources such as anti-oxidants, acetylcholinesterase inhibitors, phosphodiesterase-5 inhibitors and anti-androgens. HPLC, ELISA, online-LC/MS/MS coupled with DPPH assay are used as tools for analysis of bioact ive compounds. SELECTED PUBLICATIONS

1. Ingkaninan, K. Temkitthawon, P., Chuenchom, K., Yuyaem, T., Thongnoi, W. (2003): Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J. Ethonopharmacol 89: 261-264.

2. Nuengchamnong, N., de Jong, C.F., Bruyneel, B., Niessen W.M.A., Ingkaninan, K., Irth I (2005) HPLC on-line coupled to mass spectrometry

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and bioactivity for screening the radical scavenger compounds in Butea superba Roxb. Phytochemical Analysis. 16: 422-428.

3. Markmee, S., Ruchirawat, S., Prachyawarakorn, V, Ingkaninan, K., Khorana, N. (2006) Isoquinoline Derivatives as Potential Acetylcholinesterase Inhibitors. Bioorg. Med. Chem. Lett., 16: 2170-2172.

4. Ingkaninan, K, Phengpa, P., Yuenyongsawad, S., Khorana, N. (2006) Acetylcholinesterase inhibitors from Stephania venosa Tuber. J. Pharm. Pharmacol., 58:695-700.

5. Ingkaninan, K., Changwijita, K., Suwanborirux, K. (2006) Vobasinyl-Iboga Bisindole Alkaloids, Potent Acetylcholinesterase Inhibitors from Tabernaemontana divaricata root. J. Pharm. Pharmacol. 58: 847-852.

6. Phrompittayarat, W., Putalun, W., Tanaka, H., Wittaya-Areekul, S., Jetiyanon, K., and Ingkaninan, K. (2007) An enzyme-linked immunosorbant assay using polyclonal antibodies against bacopaside I. Anal. Chim. Acta 584: 1-6.

7. Phrompittayarat, W., Putalun, W., Tanaka, H., Wittaya-Areekul, S., Jetiyanon, K., and Ingkaninan, K. (2007) Determination of pseudojujubogenin glycosides from Brahmi based on immunoassay using a monoclonal antibody against bacopaside I. Phytochemical Analysis. 18: 411-418.

8. Nuengchamnong, N., Ingkaninan, K., Kaewruang, W., Wongareonwanakij, S., Hongthongdaeng B. (2007) Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 15: 853-858.

9. Temkitthawon, P., Viyoch, J., Limpeanchob, N., Pongamornkul, W., Sirikul, C., Kumpila, A., Suwanborirux, K., Ingkaninan K. (2008) Screening for phosphodiesterase inhibitory activity of Thai medicinal plants. J. Ethnopharmacol. 119, (2): 214-217.

10. Phrompittayarat, W., Wittaya-areekul, S., Jetiyanon, K., Putalun, W., Tanaka, H., and Ingkaninan, K. (2008) Stability studies of saponins in Bacopa monnieri dried ethanolic extracts. Planta Med. 74:1756-1763.

11. Nuengchamnong, N., Ingkaninan, K. (2009) On-line characterization of phenolic antioxidants in fruit wines from family myrtaceae by liquid chromatography combined with electrospray ionization tandem mass spectrometry and radical scavenging detection. LWT - Food Sci. Technol. 42, (1): 297-302.

12. Nuengchamnong, N., Krittasilp, K., Ingkaninan, K. (2009) Rapid screening and identification of antioxidants in aqueous extracts of Houttuynia cordata using LC-ESI-MS coupled with DPPH assay. Food Chem. 117: 750-756

13. Nuengchamnong, N., Ingkaninan, K. (2010) On-line HPLC-MS-DPPH assay for the analysis of phenolic antioxidant compounds in fruit wine: Antidesma thwaitesianum Muell.” Food Chem. 118: 147-152

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14. Paibon, W., Yimnoi, C.A., Tembab, N., Boonlue, W., Jampachaisri, K., Nuengchamnong, N., Waranuch, N., Ingkaninan, K. (2010) Comparison and evaluation of volatile oils from three different extraction methods for some Thai fragrant flowers. Int J Cosmet Sci. 23: 1-9.

15. Nuengchamnong, N., Krittasilp, K., Ingkaninan, K. (2011) Characterisation of phenolic antioxidants in aqueous extract of Orthosiphon grandiflorus tea by LC–ESI-MS/MS coupled to DPPH assay. Food Chem. 127: 1287- 1293.

16. Tothiam, C., Phrompittayarat, W., Putalun, W., Tanaka, H., Sakamoto, S., Khan, I.A., Ingkaninan, K. (2011) An enzyme-linked immunosorbant assay using monoclonal antibody against Bacoside A3 Phytochem Anal. In press.

17. Changwichit, K., Khorana, N., Suwanborirux, K., Waranuch, N., Limpeanchob, N., Wisuitiprot, W., Suphrom, N., Ingkaninan, K. (2011) Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G.Don Fitoterapia. In press.

STAFF Main Researchers Associate Professor Dr. Kornkanok Ingkaninan

Associate Professor Dr. Jarupa Viyoch Graduate students Prapapan Temkitthawon

Nunruthai Suprom

Sontaya Sukying

Kanokwan Changwichit

Juranya Onlom

Jukkarin Srivilai

Nattayaporn Reamyindee

Research assistant Narumon Singkwang CONTACT INFORMATION Kornkanok Ingkaninan, PhD. Associate Professor Department of Pharmaceutical Chemistry and Pharmacognosy Faculty of Pharmaceutical Sciences, Naresuan University Muang, Phitsanulok 65000 THAILAND Tel +66-55-963618 Fax +66-55-963731 E-mail: k_ingkaninan@yahoo.com

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Biomaterial for Regenerative Medicine Research Unit

The focus of our work is to develop biomaterials derived from natural

sources, including chitosan, starches and silk cocoon, as carriers and scaffolds for biomolecules and cell delivery in cosmetics and tissue engineering applications. Additionally, searching natural compounds that can promote function and/or differentiation of skin cells and/or stem cells attracts our attention.

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SELECTED PUBLICATIONS (2011-2005) 1. Buranajaree S, Donsing P, Jeenapongsa R, Viyoch J (2011) Depigmenting

action of nanoemulsion containing Artocarpus incisus’s heartwood extract on UVB-induced hyperpigmentation in C57BL/6 mice . Journal of Cosmetic Science 62: 1-14.

2. Muangton W, Donsing P, Ounaroon A, Khorana N, Viyoch, J (2011). Sun protection efficacy of the gel formulation containing thanaka bark extract-loaded solid lipid particles and aloe gel extract-loaded liposomes coated with chitosan. (Submitted in International Journal of Cosmetic Science)

3. Kongros K, Sila-asna M, Bunyaratvej A, Viyoch J. (2011) The effects of the seed extract of Mucuna gigantea on the expressions of neuronal markers in mesenchymal stem cells. (Preparing for submitted in Journal of Natural Product)

4. Ngoenkam J, Faikrua A, Yasothornsrikul S, Viyoch J (2010) Potential of an

injectable chitosan/starch/ -glycerol phosphate hydrogel for sustaining normal chondrocyte function. International Journal of Pharmaceutics 391: 115-124.

5. Viyoch J, Tengamnuay I, Phetdee K, Tuntijarukorn P, Waranuch N (2010) Effects of trans-4-(aminomethyl) cyclohexanecarboxylic acid/potassium azeloyl diglycinate/niacinamide topical emulsion in Thai adults with melasma : A single-center, randomized, double-blind, controlled study. Current Therapeutic Research: Clinical and Experimental 71: 345-359.

6. Viyoch J, Buranajaree S, Grandmottet F, Robin S, Binda D, Viennet C, waranuch N, Humbert P (2010) Evaluation of the effect of Thai breadfruit’s heartwood extract on biological functions of fibroblasts from wrinkles. Journal of Cosmetic Science 61: 311-324.

7. Pansang S, Maphanta S, Tuntijarukorn P, Viyoch J. (2010) Skin irritation test of a microemulsion containing essential oil isolated from Ocimum basilicum. ScienceAsia 36: 355-358.

8. Faikrua A, Jeenapongsa R, Sila-asnac M, Viyoch J (2009) Properties of _-glycerol phosphate/collagen/chitosan blend scaffolds for application in skin tissue engineering. ScienceAsia 35: 247-254.

9. Manthaisong R, Chiyakunapruk N, Warnnissor P, Viyoch J (2009) Cleansing lotion containing tamarind fruit pulp’s extract: III Study of lightening efficacy and skin irritation on Asian skin type. ScienceASia 35: 24-31.

10. Donsing P, Limpeanchob N, Viyoch J (2008) Effect of the effect of Thai breadfruit’s heartwood extract on melanogenesis-inhibitory and antioxidation activities. Journal of Cosmetic Science 59: 41-85.

11. Boriwanwattanarak P, Ingkaninan K, Khorana N, Viyoch J (2008) Development of hydrogel patch for controlling the release of curcuminoids by using chitosan as controlled-release matrix. International Journal of Cosmetic Science 30: 205-218.

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12. Phetdee M, Polnok A, Viyoch J (2008) Development of liposomes and chitosan-coated liposomes for sustained delivery of tamarind fruit pulp’s extract to the skin. International Journal of Cosmetic Science 30: 285-295.

13. Temkitthawon P, Viyoch J, Limpeanchob N, Pongamornkul, Sirikul C, Kumpila A, Suwanborirux K, Ingkaninan K (2008) Screening for phosphodiesterase inhibitory activity of Thai medicinal plants. Journal of Ethnopharmacology 119:214-217.

14. Srichaiya A, Longchoopol C, Oo-puthinan S, Sayasathid J, Sripalakit P, Viyoch

J (2008) Bioequivalence of generic lamotrigine 100-mg tablets in healthy Thai male volunteers : A randomized, single-dose, two-period, two-sequence crossover study. Clinical Therapeutics 30: 1844-1851.

15. Manthaisong R, Viyoch J, Chiyakunapruk N, Warnnissor P (2007) Cleansing lotion containing tamarind fruit pulp’s extract: Study of cumulative irritant contact dermatitis in human. Journal of Cosmetic Dermatology 6: 178-182.

16. Temkitthawon P, Viyoch J, Ingkaninan K (2006) Screening for PDE inhibitory activity from Thai traditional plants used as rejuvenating and aphrodisiac agents. Planta Medica 72: 998.

17. Viyoch J, Matsunaga N, Yoshida M, To H, Higuchi S, Ohdo S. (2005) Effect of haloperidol on mPer1 gene expression in mouse SCN. Journal of Biological Chemistry 280: 6309-6315.

18. Viyoch J, Sudemek T, Srema W, Suwongkrua W. (2005) Development of hydrogel patch for controlled delivery of alpha-hydroxy acid contained in the extract of tamarind’s fruit pulp. International Journal of Cosmetic Science 27: 89-99.

Petty Patent (Thailand) 1. Viyoch J, Faikrua A, Sila-asana M. Blending Collagen/Chitosan Scaffold for

Application in Skin Tissue Engineering. Approved Number: 4905, Approved Date: 10 June 2009. Applicant: National Research Council of Thailand

2. Viyoch J, Ngoenkam J. Thermosensitive Hydrogel of Blending Crab Chitosan/Starch for controlled release of therapeutic agents or biomaterials. Approved Number: 4943, Approved Date: 2 July 2009. Applicant: National Center for Genetic Enginnering and Biotechnology (BIOTEC), Thailand

Patent (International) 1. Viyoch J, Naresuan University, Thailand Research Fund and Axis IP Holding

LTD., System and Method for Preparing a Controlled Release Preparation, International Application Number: WO2008SG00457 20081129 , Application Date: November 29, 2008, Applicant: Thailand Research Fund

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STAFF Main Researchers Associate Professor Dr. Jarupa Viyoch

Associate Professor Dr. Kornkanok Ingkaninan Graduate students (2010-2011) Kunchit Kongros (PhD) Khwanjit Itsarasook (MS)

Atchahriya Faikrua (PhD) Sawanya Yakaew (MS)

Khemjira Phetdee (PhD) Tammanoon Rungsang (MS)

Narisara Tiraravesiy (PhD) Racharat Rukchay (MS)

Wongnapa Nakyai (PhD) Sirintip Intaraprasit (MS)

Paveena Amornnopparattanakul (MS) Paichit Intpanya (MS)

Jutatip Kwankaew (MS)

CONTACT INFORMATION Jarupa Viyoch, PhD. Associate Professor Faculty of Pharmaceutical Sciences Naresuan University Muang, Phitsanulok 65000 THAILAND Tel ++66-55-963618 Fax ++66-55-963731 E-mail: jarupaviyoch4@yahoo.com

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Pharmaceutical Technology Research Unit Faculty of Pharmaceutical Sciences

Naresuan University

We aim to develop delivery systems that enhance drug bioavailbility and

improve drug stability for pharmaceutics and cosmetics. The main research

focuses on nano/microencapsulation employing lipid and polymer as a carriers,

gastroretentive DDS, time-controlled pulsatile release DDS. Vaccine and tissue

engineering are also our interests. Recently, the curcuminoids stability was

improved by incorporation into solid lipid nanoparticles (SLN) using hot melt

microemulsion technique. The clinical results also revealed that compared to the

cream base, curcuminoids loaded SLNs cream significantly improve skin wrinkles,

hydration, biological elasticity and viscoelasticity. The polymeric nanoparticle

system based on chitosan and dextran sulfate has been successfully developed to

incorporate amphotericin B, a model drug, to reduce nephotoxicity. Examples of

current research are as followed:

- Development of 3-dimension scaffold from silk fibroin for chondrocyte

cultivation

- Development of cosmetic products based on Thai natural products such

as pigment extract of silk cocoon, pomegranate peel extract and long

pepper extract

- Development of delivery systems for lutein extract from silk cocoon

- Development of floating drug delivery system (pellets, tablets, capsules)

- Development of pulsatile release drug delivery systems.

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SELECTED PUBLICATIONS

1. W. Tiyaboonchai, P. Chomchalao, S. Pongcharoen, M. Sutheerawattananonda, P. Sobhon. (2011) Preparation and characterization of blended Bombyx mori silk fibroin scaffolds. Fibers and Polymers, 12(3): 324-333

2. N. Limpeanchob, K. Trisat, A. Duangjai, W. Tiyaboonchai, S. Pongcharoen, M. Sutheerawattananonda. (2010). Sericin reduces serum cholesterol in rats and cholesterol uptake into caco-2 cells. J Agric Food Chem, 58:12519-522

3. W. Tiyaboonchai, P. Nimtrakul, and N. Limpeanchob. ( 2010). Development of Pasteurella multosida loaded alginated based microspheres. Naresuan University Journal, 18:19-25.

4. A.P. Nayak, W. Tiyaboonchai, S. Patankar, B. Madhusudhan, E.B. Souto. (2010). Curcuminoids-loaded lipid nanoparticles: Novel approach towards malaria treatment. Colloids and Surfaces B: Biointerfaces, 81:263-373

5. W. Tiyaboonchai, P. Srisopa, J. Viyoch and K. Ingkaninan. (2008). Solid lipid microparticles as a drug delivery carrier for turmeric crude extract containing curcuminoids. Naresuan University Journal, 16:43-55.

6. P. Plianbangchang, W. Tungpradit, and W. Tiyaboonchai. (2007). Efficacy and safety of curcuminoids loaded solid lipid nanoparticles facial cream as an anti-aging agent. Naresuan University Journal, 15:73-81.

7. W. Tiyaboonchai, W. Tungpradit, and P. Plianbangchang. (2007). Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International Journal of Pharmaceutics, 337:299-306

8. W. Tiyaboonchai, and N. Limpeanchob. (2007). Formulation and characterization of amphotericin B-chitosan-dextran sulfate nanoparticles. International Journal of Pharmaceutics, 329:142-149

9. W.Tiyaboonchai, J. Woiszwillo and R.C. Middaugh. (2003). Insulin containing polyethylenimine- dextran sulfate nanoparticles. International Journal of Pharmaceutics, 255(1-2):139-51.

10. W.Tiyaboonchai, J. Woiszwillo and R.C. Middaugh. (2003). Formulation and characterization of DNA-Polyethylenimine-dextran sulfate nanoparticles. European Journal of Pharmaceutical Sciences, 19 (4):191-202

11. W.Tiyaboonchai, J. Woiszwillo and R.C. Middaugh. (2001). Formulation and characterization of amphotericin B-Polyethylenimine-dextran sulfate nanoparticles. Journal of Pharmaceutical Science, 90 (7):902-914.

12. N. Wattanakorn, P. Asavapichayont, J. Nunthanid, S. Limmatvapirat, S. Sungthongjeen, D Chantasart, P Sriamornsak. (2010). Pectin-based bioadhesive delivery of carbenoxolone sodium for aphthous ulcers in oral cavity . AAPSPharmSciTech, 11 : 743-751.

13. S. Sungthongjeen, P. Sriamornsak, S. Puttipipatkhachorn. (2008 . Design and evaluation of floating multi-layer coated tablets based on gas formation. European Journal of Pharmaceutics and Biopharmaceutics, 69 : 255-263.

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14. P. Sriamornsak, S. Sungthongjeen. (2007). Modification of theophylline release with alginate gel formed in hard capsules. AAPSPharmSciTech, 8 (3), 8 Page.

15. P. Sriamornsak, N. Thirawong, Y. Weerapol, J. Nunthanid, S. Sungthongjeen . (2007). Swelling and erosion of pectin matrix tablets and their impact on drug release behavior . European Journal of Pharmaceutics and Biopharmaceutics, 67 : 211-219.

16. P. Sriamornsak, S. Sungthongjeen, S. Puttipipatkhachorn. (2007). Use of pectin as a carrier for intragastric floating drug delivery: Carbonate salt contained beads . Carbohydrate Polymers, 67 : 436-445.

17. S. Wittaya-areekul, C. Prahsarn , S. Sungthongjeen. (2006). Development and in vitro evaluation of chitosan–Eudragit RS 30D composite wound dressings . AAPS PharmSciTech, 7 (1), 6 Page.

18. T. Pongjanyakul, S. Sungthongjeen, S. Puttipipatkhachorn. (2006). Modulation of drug release from glyceryl palmitostearate–alginate beads via heat treatment . International Journal of Pharmaceutics, 319 : 20-28.

19. S. Sungthongjeen, O. Paeratakul, S. Limmatvapirat, S. Puttipipatkhachorn. (2006) . Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique . International Journal of Pharmaceutics, 324 : 136-143.

20. S. Sungthongjeen, S. Puttipipatkhachorn, O. Paeratakul, A. Dashevsky, R. Bodmeier. (2004). Development of pulsatile release tablets with swelling and rupturable layers . Journal of Controlled Release, 95 : 147-159.

21. S. Sungthongjeen, P. Sriamornsak, T. Pitaksuteepong, A. Somsiri, S. Puttipipatkhachorn. (2004). Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets . AAPS PharmSciTech, 5 (1), 8 Page.

22. S. Sungthongjeen , T. Pitaksuteepong, A. Somsiri, P. Sriamornsak. (1999). Studies on pectins as potential hydrogel matrices for controlled-release drug delivery . Drug Development and Industrial Pharmacy, 25 : 1271-1276.

23. T. Oguchi, S. Limmatvapirat , C. Takahashi, S. Sungthongjeen, WS. Choi, E. Yonemochi , K. Yamamoto. (1998). Effect of guest species on inclusion compound formation of deoxycholic acid by co-grinding . Bulletin of the Chemical Society of Japan, 71 (7) : 1573-1579.

24. S. Sungthongjeen. ( 2003). Application of Arrhenius equation and Plackett-Burman design to ascorbic acid syrup development . Naresuan University Journal , 12 (2) : 1-12.

25. W.Boontha, H.E. junginger, N. Waranuch, A. Polnok, T. Pitaksuteepong (2010) Chitosan and Trimethyl Chitosan Particles as Oral Vaccine Delivery Systems: Comparison the Potential to Initiate Immune Responses. Journal of Metals, Materials and Minerals (Article in press).

26. W.Boontha, H.E. junginger, N. Waranuch, A. Polnok, T. Pitaksuteepong (2010) Formation of particles prepared using chitosan and their trimethyl chitosan derivatives for oral vaccine delivery: Effect of molecular weight and

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degree of quaternization. Songklanakarin Journal of Science and Technology, 32 (4) : 363-371.

27. W.Boontha, H.E. junginger, N. Waranuch, A. Polnok, T. Pitaksuteepong (2008) Preparation and characterization of particles from chitosan with difference molecular weights and their trimethyl chitosan derivatives for nasal immunization. Journal of Metals, Materials and Minerals, 18(2) : 59 - 65.

28. W.Boontha, H.E. junginger, N. Waranuch, A. Polnok, T. Pitaksuteepong (2007) Chitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbumin in mice following nasal administration. Journal of Controlled Release, 121: 168-175 .

29. T. Pitaksuteepong, A. Somsiri, N. Waranuch (2007) Targeted transfollicular delivery of artocarpin extract from Artocarpus incisus by means of microparticles. European Journal of Pharmaceutics and Biopharmaceutics, 67(3): 639-645.

30. K. Krauel, T. Pitaksuteepong, N.M. Davies, T. Rades (2004) Entrapment of Bioactive Molecules in Poly (Alkylcyanoacrylate) Nanoparticles. American Journal of Drug Delivery, 2(4): 251-259.

31. T. Pitaksuteepong, N.M. Davies, M.A Baird, T. Rades (2004). Uptake of antigen encapsulated in polyethylcyanoacrylate nanocapsules by D1-dendritic cells. DIE PHARMZIE, 59: 134-142.

32. T. Pitaksuteepong, N.M. Davies, I.G. Tucker, T. Rades. (2002). Factors influencing the entrapment of hydrophilic compounds in nanocapsules prepared by interfacial polymerisation of water-in-oil microemulsions. European Journal of Pharmaceutics and Biopharmaceutics, 53: 335-342.

33. S. Rujivipat, R. Bodmeier. (2010). Modified release from hydroxypropyl methylcellulose compression-coated tablets. International Journal of Pharmaceutics, 402: 72-77.

34. S. Rujivipat, R. Bodmeier. (2010). Improved drug delivery to the lower intestinal tract with tablets compression-coated with enteric/nonenteric polymer powder blends. European Journal of Pharmaceutics and Biopharmaceutics, 76: 486-492.

Patent

Paraksa, N., Songsaem, T., Songsaem, O., Sindhuvanich, S., Wittaya-areekul, S., Phumala, Morales, N., Pitaksuteepong, T., Ounarun, A., Tangsumranjit, A., Wichai, U., and Axis IP Holding LTD., Feed For Poultry and Swine, Apply for Patent Cooperation Treaty, PCT/SG2008/000283.

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STAFF Main Researchers Assistant Professor Dr.Waree Tiyaboonchai

Assistant Professor Dr.Soravoot Rujivipat

Associate Professor Dr.Tasana Pitaksuteepong Associate Professor Dr.Srisagul Sungthongjeen

Assistant Professor Dr.Anothai Tangsumranjit Graduate students Wanachat Chaiyasan

Nukanya Tokton

Pataranapa Nimtrakul

Pattravee Niomprem

Ingdao Rodleang

Chawonkorn Kasetvetin

Worawut Kriangkrai

Sakonjan Treesingchai

Research assistants Wilaiwan Phlongmee

Sanipon Chanburee

Chanattanapol Yenyu

Pratthana Chomchalao

CONTACT INFORMATION Waree Tiyaboonchai PhD. Assistant Professor Department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences, Naresuan University Phitsanulok 65000, THAILAND Tel ++66-55-961873 Fax ++66-55-963731 E-mail: wareet@nu.ac.th Tasana Pitaksuteepong PhD. Associate Professor Department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences, Naresuan University Phitsanulok 65000, THAILAND Tel ++66-55-961877 Fax ++66-55-963731 E-mail: tasanap@nu.ac.th

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Srisagul Sungthongjeen PhD. Associate Professor Department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences, Naresuan University Phitsanulok 65000, THAILAND Tel ++66-55-961885 Fax ++66-55-963731 E-mail: sungts2000@yahoo.com Soravoot Rujivipat PhD. Assistant Professor Department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences, Naresuan University Phitsanulok 65000, THAILAND Tel ++66-55-961876 Fax ++66-55-963731 E-mail: soravootr@nu.ac.th, soravoot_rujivipat@hotmail.com

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Pharmacology Research Unit Faculty of Pharmaceutical Sciences

Naresuan University

Our group is interested in two primary research areas: drug discovery and

nutraceuticals. We particularly focus on investigating the pharmacological activities of natural compounds that have potentials for use as medicinal and/or nutraceutical agents. The experiments have been conducted both in vitro (enzymatic or cell culture-based assays) and in vivo (animal models). Currently, our research include:

- Chemopreventive effects of silk protein against colorectal cancer - Hepatoprotection of tumeric in ethanol-induced liver damage - Neuroprotection of herbal plant extract against oxidative stress - Retina protection of lutein against free radicals and UV irradiation - Cholesterol lowering effects of silk protein and plant extract - Antioxidant of natural compounds - Immunomodulatory activity of beta-glucans from wild mushroom - Role of LDL and oxidized LDL on neurodegenerative disease/Alzheimer’s - Effects of plant extract on dopamine and NMDA receptors in animal brain

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SELECTED PUBLICATIONS

1. Changwichit K, Khorana N, Suwanborirux K, Waranuch N, Limpeanchob N, Wisuitiprot W, Suphrom N, Ingkaninan K. (2011). Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don. Fitoterapia (in press)

2. Duangjai A, Ingkaninan K, Limpeanchob N. (2011). Potential mechanisms of hypocholesterolemic effect of Thai spices/dietary extracts. Natural Product Research, 25(4):341-352.

3. Limpeanchob N, Trisat K, Duangjai A, Tiyaboonchai W, Pongcharoen S, Sutheerawattananonda M. (2010). Sericin Reduces Serum Cholesterol in Rats and Cholesterol Uptake into Caco-2 Cells. Journal of Agricultural and Food Chemistry, 58 (23):12519-12522.

4. Tiyaboonchai W, Nimtrakul P, Limpeanchob N. (2010). Development of Pasteurella multocida loaded alginate based microspheres. Naresuan University Journal, 18(1):19-25.

5. Pengo P, Veggiani G, Rattanamanee K, Gallotta A, Beneduce L, Fassina G. (2010). Solid-phase preparation of protein complexes. Journal of molecular recognition, 23(6):551-558.

6. Nualkaew S, Rattanamanee K, Thongpraditchote S, Wongkrajang Y, Nahrstedt A. (2009). Anti-inflammatory, analgesic and wound healing activities of the leaves of Memecylon edule Roxb. Journal of Ethnopharmacology, 121(2):278-281.

7. Limpeanchob N, Jaipan S, Rattanakaruna S, Phrompittayarat W, Ingkaninan K. (2008). Neuroprotective Effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. Journal of Ethnopharmacology, 120(1):112-117.

8. Temkitthawon P, Viyoch J, Limpeanchob N, Pongamornkul W, Sirikul C, Kumpila A, Suwanborirux K, Ingkaninan K. (2008). Screening for phosphodiesterase inhibitory activity of Thai medicinal plants. Journal of Ethnopharmacology, 119(2):214-217.

9. Donsing P, Limpeanchob N, Vioch J. (2008). Evaluation of the effect of Thai breadfruit’s heartwood extract on melanogenesis-inhibitory and antioxidant activities. Journal of Cosmetic Science, 59:41-58.

10. Tiyaboonchai W, Limpeanchob N. (2007). Formulation and characterization of amphotericin B-chitosan-dextran sulfate nanoparticles. International Journal of Pharmaceutics, 329(1-2):142-149.

11. Wang X, Pal R, Chen XW, Limpeanchob N, Kumar KN, Michaelis EK. (2005). High intrinsic oxidative stress may underlie selective vulnerability of the hippocampal CA1 region. Brain Research; Molecular Brain Research, 140(1-2):120-126.

12. Teaktong T, Piggott MA, Mckeith IG, Perry RH, Ballard CG, Perry EK. (2005). Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies. Behavioural brain research, 161:299-305.

13. Hadkar V, Sangsree S, Vogel SM, Brovkovych V, Skidgel RD. (2004). Carboxypeptidase-mediated enhancement of nitric oxide production in rat longs

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and microvascular endothelial cells. American journal of physiology. Heart and circulatory physiology, 287(1):L35-45.

14. Teaktong T, Graham AJ, Court JA, Perry RH, Jaros E, Johnson M, Hall R, Perry EK. (2004). Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology.Journal of the Neurological Sciences, 225:39-49.

15. Teaktong T, Graham AJ, Johnson M, Court JA, Perry EK. (2004). Selective changes in nicotinic acetylcholine receptor subtypes related to tobacco smoking: an immunohistochemical study. Neuropathology and applied neurobiology, 30:243-254.

16. Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M, Hall R, Perry E. (2003). Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia, 41:207-211.

17. Sangsree S, Brovkovych V, Minshall RD, Skidgel RA.(2003). Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists. American journal of physiology. Heart and circulatory physiology, 284(6):H1959-968.

18. Graham AJ, Martin-Ruiz CM, Teaktong T, Ray MA, Court JA. (2002). Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disorders. Current drug targets. CNS and neurological disorders, 1:387-397.

STAFF Main Researchers Assistant Professor Dr. Nanteetip Limpeanchob

Assistant Professor Dr. Sakonwan Praputbut (Sangsree)

Dr. Thanasak Teakthong

Dr. Kwanchai Rattanamanee Graduate students Ph.D. (Pharmaceutical Sciences)

Waraporn Kaewkon

Acharaporn Duangjai

Ponthipa Meepayung

Prayut Poowaruttanawiwit

Panit Yamcheun M.S. (Pharmacology and Biomolecular Sciences)

Kanittaporn Trisat

Pattachai Pinnak

Ruttiya Thongrung

Pataranapa Nimtrakul

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Pattravee Niamprem

Sathid Ieamjongjun

Choomphunut Aonsri

Phakhamon Lapphanichayakool

Thitiya Sanpundorn

Chanudom Wongmor

Kanlayanee Pholrachom

Oraya Khruangthip

Akachai Khuekankaew

Anusak Kruemuang

CONTACT INFORMATION Nanteetip Limpeanchob, Ph.D. Assistant Professor Department of Pharmacy Practice Faculty of Pharmaceutical Sciences Naresuan University, Phitsanulok 65000 THAILAND Tel: ++66-55-961822 Fax: ++66-55-963731 Email: nanteetipl@nu.ac.th

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Biotechnology and Molecular Biology Research Unit

Faculty of Pharmaceutical Sciences Naresuan University

RESEARCH FOCUS

The role of silk protein extracts and Thai medicinal plant constituents on wound healing using established ex-vivo porcine skin model.

The effects of herbal extracts coated scaffolds on wound healing using ex-vivo porcine skin model.

Application of the ex-vivo porcine skin model for melanoma study.

Development of cell-based model of NFAT nuclear-cytoplasm translocation for screening of immunosuppressant and immuno-enhancing agents.

Relationship between Single Nucleotide Polymorphisms and common diseases found in Thais.

Calcium siganling and apoptosis pathway.

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SELECTED PUBLICATIONS 1. Saelim, N. et al. (2004). Nontranscriptionsl modulation of intracellular Ca2+

signaling by ligand stimulated thyroid hormone receptor. J Cell Biol. 167(5): 915-24.

2. Suwanakitch P, Jeenapongsa R, Saelim N, Tohda M and Watanabe H. (2005). Altered mRNA expression in ischemic rat brain. Thai Journal of Pharmacology. 27: 52.

3. Hayashi H, Tohda M, Saelim N, Murakami Y and Matsumoto K. (2005). Influences of the mRNA expression of amyloid precursor protein and the related factors in primary cultured cortex cells. Journal of Pharmacological Sciences. 97: 261.

4. Saelim, N. (2007). Isolation of amyloid precursor protein (APP) gene from NG cell line. J. Health Res. 21(3): 185-194.

5. Saelim N, Holstein D, Chocron ES, Camacho P, Lechleiter JD. (2007). Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria. Apoptosis. 12: 1781-1794.

6. Suwanakitch P., Jeenapongsa R, Watanabe H, and Saelim N. (2008). Comparison of Alzheimer disease-related gene expressions in differentiated and undifferentiated NG108-15 cells. ScienceAsia. 34:35-42.

7. Sudchada P, Oo-puthinan S, Kerpin O, and Saelim N. (2010). ABCB1 gene expression in peripheral blood mononuclear cells in healthy Thai males and females. Genet. Mol. Res. 9(2): 1177-1185.

8. De-Eknamkul, W., Ounaroon, A., Tanahashi, T., Kutchan, T. M. and Zenk, M. H. (1997) Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii. Phytochemistry 45, 477-484.

9. Frick, S., Ounaroon, A. and Kutchan, T. M. (2001). Combinatorial biochemistry in plants: the case of O-methyltransferase. Phytochemistry 56, 1-4.

10. Ounaroon, A., Decker, G., Schmidt, J., Lottspeich, F. and Kutchan, T.M. (2003). (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum cDNA cloning and characterization of methyltransfer enzymes of alkaloid biosynthesis in opium poppy. Plant J. 36, 808-819.

11. Molecular Genetic Analysis of an O-Methyltransferase of the Opium Poppy Papaver somniferum. A. Ounaroon, S. Frick and Toni M. Kutchan. Proc. WOCMAP III, Vol. 1: Bioprospecting&Ethnopharmacology Eds. J. Bernath. E. Nemeth, L.E. Craker and Z.E. Gardner. Acta Hort 675, ISHS 2005.

12. Bualee, C., Ounaroon, A., Jeenapongsa, R. (2007). Antidiabetic and long-term effects of Elaeocarpus grandiflorus. Naresuan University Journal 15(1), 17-28.

13. Wungsintaweekul, J., Sirisuntipong, T., Kongduang, D., Losuphanporn, T., Ounaroon, A., Tansakul, P., and De-eknamkul, W. (2008). Transcription profiles analysis of genes encoding 1-deoxy-d-xylulose 5-phosphate synthase and 2c-methyl-d-erythritol 4-phosphate synthase in plaunotol biosynthesis from Croton stellatopilosus. Biol Pharm Bull 31(5):852-6.

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STAFF Main researchers Assistant Professor Anan Ounaroon Ph.D.

Assistant Professor Nuttawut Saelim Pharm.D., Ph.D. Graduate students Nikhom Naksupun

Ratchanee Kumlue

Eakkachai Kreukankeaw

CONTACT INFORMATION Nuttawut Saelim Pharm.D., Ph.D. Assistant Professor Faculty of Pharmaceutical Sciences Naresuan University, Phitsanulok 65000 THAILAND Tel ++66-84-6207980 Fax ++66-55-963731 Email: nut456zz@yahoo.com Anan Ounaroon, Ph.D. Assistant Professor Faculty of Pharmaceutical Sciences Naresuan University, Phitsanulok 65000 THAILAND Tel ++66-86-9982041 Fax ++66-55-963731 Email: ananounaroon@yahoo.com

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Pharmacokinetics Research Unit Faculty of Pharmaceutical Sciences

Naresuan University

Our Pharmacokinetics Research Unit consist of a group of pharmacokineticists who have been contributing to pharmacokinetic research. Our research areas include clinical pharmacokinetics, therapeutic drug monitoring, bioequivalence, drug-drug interaction, food-drug interaction and toxicokinetics. Various in vitro, in vivo and in silico techniques are employed. SELECTED PUBLICATIONS 1. Lohitnavy O., Lohitnavy M.,Taytiwat P., Polnok S. (2002) Bioequivalence study of enarapril tablets in healthy Thai male volunteers. Journal of the Medical Association of Thailand 85(6):716-21. 2. Lohitnavy M., Lohitnavy O., Chaijittiprasert K., Taytiwat P., Polnok S. (2002) Bioequivalence study of ondansetron tablet in healthy Thai male volunteers. Journal of the Medical Association of Thailand 85(7):808-13. 3. Lohitnavy M., Lohitnavy O., Chaijittiprasert K., Taytiwat P., Polnok S., Sareekan K. (2003) Pharmacokinetic and bioequivalence studies of generic clarithromycin tablets in healthy male volunteers. Pharmazie 58(1):72-73. 4. Lohitnavy M., Lohitnavy O., Wittaya-areekul S., Sareekan K., Polnok S. , Chaiyaput W. (2003) Average bioequivalence of clarithromycin immediate-released tablet formulations in healthy male volunteers. Drug Development & Industrial Pharmacy 29(6): 653-659. 5. Lohitnavy M., Lohitnavy O., Sareekan K., Chaiyaput W. (2003) Average bioequivalence study of clarithromycin tablets in healthy male volunteers. Journal of Clinical Pharmacy & Therapeutics 28 (3):187-190. 6. Lohitnavy O., Lohitnavy M., Sareekan K., Polnok S.,Taytiwat P. (2003) Average bioequivalence of generic clarithromycin tablets in healthy Thai male volunteers. Biopharmaceutics & Drug Disposition 24(6): 229-231. 7. Lohitnavy O., Lohitnavy M.,Taytiwat P., Polnok S. (2003) Relative bioavailability study of 20-mg enalapril tablets in healthy male volunteers. Journal of the Medical Association of Thailand 86(10): 947-52. 8. Lohitnavy M., Lohitnavy O., Chaijittiprasert K., Taytiwat P., Polnok S. (2004) Bioequivalence study of two formulations of simvastatin tablets in healthy Thai volunteers. Arzneimittel-Forschung 54(1): 31-34. 9. Lohitnavy M., Lohitnavy O., Thangkeattiyanon O., Srichai W. (2005) Reduced oral itraconazole bioavailability by antacid suspension. Journal of Clinical Pharmacy & Therapeutics 30(3): 201-206.

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10. Lu Y., Lohitnavy M., Reddy M.B., Lohitnavy O., Ashley A., Yang R.S.H. (2006) Physiologically based pharmacokinetic modeling for hexachlorobenzene: Incorporation of pathophysiological states following chemical treatment and partial hepatectomy. Toxicological Sciences 91(1):29-41. 11. Lohitnavy M., Lu Y., Lohitnavy O. (2006) A pharmacokinetic model consisting of 2 segments of the gastrointestinal tract can describe itraconazole concentration-time courses. International Journal of Clinical Pharmacology & Therapeutics 44(8):394-6. 12. Sermsappasuk P, Baek M, Weiss M. (2006) Kinetic analysis of myocardial uptake and negative inotropic effect of amiodarone in rat heart. Eur J Pharm Sci. 28(3):243-8. 13. Belfiore C.J., Yang R.S.H., Chubb L.S., Lohitnavy M., Lohitnavy O.S., Andersen M.E. (2007) Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling. Toxicology 234 (1-2):59-72. 14. Sermsappasuk P, Abdelrahman O, Weiss M. (2007) Modeling cardiac uptake and negative inotropic response of verapamil in rat heart: effect of amiodarone. Pharm Res. 24(1):48-57. 15. Sermsappasuk P, Abdelrahman O, Weiss M. (2008) Cardiac pharmacokinetics and inotropic response of verapamil in rats with endotoxemia. J Pharm Sci. 97(7):2798-804. 16. Lu Y., Lohitnavy M., Reddy M., Lohitnavy O., Eickman E., Ashley A., Gerjevic L., Xu Y., Conolly R.B., Yang R.S.H. (2008) Quantitative Analysis of Liver GST-P Foci Promoted by a Chemical Mixture of Hexachlorobenzene and PCB 126: Implication of Size-dependent Cellular Growth Kinetics. Archives of Toxicology 82 (2):103-116. 17. Lu Y., Rieth S., Lohitnavy M., Dennison J.E., El-Masri H., Barton H., Bruckner J., Yang R.S.H. (2008) Application of PBPK Modeling in Support of the Derivation of RfC/RfD for 1,1,1-Trichloroethane. Regulatory Toxicology & Pharmacology 50(2), 249-260. 18. Lohitnavy M., Lu Y., Lohitnavy O., Chubb L., Hirono S., Yang R.S.H. (2008) A Possible Role of Multidrug-Resistance-Associated Protein 2 (Mrp2) in Hepatic Excretion of PCB126, an Environmental Contaminant: PBPK/PD Modeling. Toxicological Sciences 104(1), 27-39. 19. Lee S.K., Hamer D., Bedwell C.L., Lohitnavy M., Yang R.S.H. (2009) Effects of PCBs on the lactational transfer of methyl mercury in mice: PBPK modeling. Environmental Toxicology & Pharmacology 27(1), 75-83. 20. Sermsappasuk P, Weiss M. (2009) Modelling of alpha1-adrenoceptor-mediated temporal dynamics of inotropic response in rat heart to assess ligand binding and signal transduction parameters. Br J Pharmacol. ;156(5):764-73. 21. Weiss M, Hassna R, Sermsappasuk P, Bednarek T. (2009) Pharmacokinetic-pharmacodynamic modeling of the effect of propofol on

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alpha 1-adrenoceptor-mediated positive inotropy in rat heart. Eur J Pharm Sci. 5;38(4):389-94. 22. Weiss M, Sermsappasuk P, Siegmund W. Modeling the Kinetics of Digoxin Absorption: Enhancement by P-Glycoprotein Inhibition. J Clin Pharmacol. (in press) STAFF Main Researchers Assistant Professor Dr. Manupat Lohitnavy Dr. Pakwawadee Sermsappasuk Dr. Oranun Kerdpin Dr. Sarawut Oo-Puthinan Instructor Ornrat Lohitnavy Graduate student Mr. Chanudom Wongmor CONTACT INFORMATION .Manupat Lohitnavy, PhD. Assistant Professor Department of Pharmacy Practice Faculty of Pharmaceutical Sciences, Naresuan University, Muang District, Phitsanulok 65000 THAILAND Tel +66-55-961807 Fax +66-55-963731 E-Mail: manupatl@gmail.com

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Center of Pharmaceutical Outcomes Research (CPOR)

CPOR is a research center established to coordinate research and graduate training efforts among faculty with an interest in pharmaceutical outcomes and policy research on pharmaceuticals, biopharmaceuticals and other health care technology. The center provides medical facilities, pharmaceutical and device companies and governmental agencies with analyses on the safety and cost-effectiveness of medicines in order to achieve a better understanding of the risks and benefits of medical and pharmaceutical interventions. Research works are focused on understanding the effects and uses of pharmaceuticals in real world populations. Research area covers not only evidence-based medicine (meta-analysis/ systematic review), retrospective database analysis, health economics but also other clinical research including. health services research, clinical effectiveness, drug safety research, rational use of drug, drug use evaluation/ review, medication safety management The mission of the program is to conduct research on the effects and uses of pharmaceuticals in populations in order to improve patient outcomes through population-based interventions, policy and system Previously organized trainings Sept 2009 Patient reported outcomes & outcomes research June 2010 Meta-analysis and systematic review Nov 2010 Meta-analysis and systematic review April 2011 Retrospective database analysis SELECTED PUBLICATIONS 1. Thavorn K, Chaiyakunapruk N. (2008). A cost-effectiveness analysis of a

community-based smoking cessation program in Thailand. Tobacco Control, 17:177-182.

2. Chirakup S, Chaiyakunapruk N, Chaikledkaew U, Pongcharoensuk P, Ongphiphadhanakul B, Roze S, Valentine WJ, Palmer AJ. (2008). Cost effectiveness analysis of thiazolidinediones in uncontrolled type 2 diabetic patients receiving sulfonylureas and metformin in Thailand. Value in Health, 11(supple 1):S43-51.

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3. Thananithisak C, Nimpitakpong P, Chaiyakunapruk N. (2008). Activities and perceptions of pharmacists providing tobacco control services in community pharmacy in Thailand. Nicotine and Tobacco Research, 10(5):921-925.

4. Chaiyakunapruk N. Defining the scope of economic evaluation study. (2008). Journal of Medical Association Thailand, 91(suppl 2):S16-S20.

5. Chaiyakunapruk N, Upakdee N, Nimpitakpong P, Rerkmongkolkul P, Seatao P, Sriworrarat S. (2008). International comparisons in policy of smoking cessation services reimbursement system. Health Policy and Planning Journal (Thailand), 11:3-16.

6. Pitanusorn C, Karnchanakorn S, Nipatpimjai S, Chaiyakunapruk N, Nimpitakpong P, Upakdee N. (2008). Development and evaluation of measure to induce smokers for smoking cessation service at community pharmacy by the smoker's closely related person. Journal of Tobacco Control (Thailand), 2(2): 56-67.

7. Nimpitakpong P, Chaiyakunapruk N, Dhippayom T, Aromdee J, Chotbunyong S, Charnnarong S. (2010). Drugstores’ compliance with a National Smoke-free Law: A pilot survey. Public Health, 124:131-135.

8. Nimpitakpong P, Chaiyakunapruk N, Dhippayom T. (2010). A national survey of training and smoking cessation services provided by community pharmacies in Thailand. Journal of Community Health, 35:554-559.

9. Dilokthornsakul P, Chaiyakunapruk N, Nimpitakpong P. (2010). Effects of direct billing system on prescribing patterns in civil-servant medical benefit beneficiaries. Journal of Health System Research (Thailand), 4(1):53-62

10. Pornpinatepong S, Thavorncharoensap M, Ongphiphadhanakul B, Jongsareejit A, Chaiyakunapruk N. (2010). Diabetic retinopathy modeling: cost-effectiveness of varying screening intervals in type 2 diabetes mellitus in Thailand. Thai Journal of Opthalmology, 24(1):10-25.

11. Aroonsiriwat J, Dhippayom T, Chaiyakunapruk N, Sermhattakit A, Saelim S. (2010). Community pharmacy-based implementation of a diabetes risk assessment tool. Journal of Public Health and Development, 8(3): 334-345.

12. Prukkanone B, Vos T, Burgess P, Chaiyakunapruk N, Bertram M. (2010). Adherence to antidepressant therapy for major depressive patients ina psychiatric hospital in Thailand. BMC Psychiatry, 10:64 doi:10.1186/1471-244X-10-64

13. Saokaew S, Permsuwan U, Chaiyakunapruk N, Nathisuwan S, Sukonthasarn A. (2010). Effectiveness of pharmacist-managed warfarin therapy: a systematic review and meta-analysis. Journal of Thrombosis and Haemostasis, 8(11):2418-2427.

14. Insuk S, Chaiyakunapruk N, Saokaew S, Sukong K, Jaturavuttichai P, phoparm P, Sudcharda P, Buranachokpaisan P. (2010). Survey of citrus and herb consumption in Thai renal transplant recipients. Thai Pharmaceutical and Health Sciences Journal, 5(1):18-22

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15. Chaiyakunapruk N, Thanarungroj A, Cheewasithirungrueng N, Sirisupha-olarn W, Nimpitakpong P, Dilokthornsakul P, Jeanpeerapong N. (2010). Estimation of financial burden due to oversupply of chronic diseases medications. Asia Pacific Journal of Public Health 2010 Dec 15

16. Kongkaew C, Chaiyakunapruk N. (2011). Efficacy of Clinacanthus nutans extracts in patients with herpes infection: Systematic review and meta-analysis of randomised clinical trials. Complementary Therapies in Medicine, 19(1):47-53.

17. Dhippayom T, Chaiyakunapruk N, Jongchansittho T. (2011). Safety of nortriptyline at equivalent therapeutic doses for smoking cessation: a systematic review and meta-analysis. Drug Safety, 34(3):199-210.

18. Chaiyakunapruk N, Asuphol O, Dhippayom T, Poowaruttanawiwit P, Jeanpeerapong N. (2011). A retrospective evaluation of statins utilization pattern in a tertiary care hospital in Thailand. International Journal of Pharmacy Practice, 19(2):129-35.

19. Saokaew S, Suwankesawong W, Permsuwan U, Chaiyakunapruk N. (2011). Safety of herbal products in Thailand: An analysis of reports in the Thai Health Product Vigilance Center database from 2000 to 2008. Drug Safety, 34(4):339-350.

20. Nimpitakpong P, Chaiyakunapruk N, Dhippayom T. (2011). Smoking cessation education in Thai schools of pharmacy. Pharmacy Education, 11(1):8-11.

21. Kongkaew C, Sakunrag I, Chaiyakunapruk N, Tawatsin A. The effectiveness of citronella preparations in preventing mosquito Bites: A systematic review of controlled laboratory experimental studies. Tropical Medicine & International Health (In Press)

22. Luangasanatip N, Chaiyakunapruk N, Upakdee N, Wong P. Cost-effectiveness analyses of iron chelating therapies in transfusion dependent thalassaemia population in Thailand. Clinical Drug Investigation (In Press)

23. Nathisuwan S, Dilokthornsakul P, Chaiyakunapruk N, Morarai T, Yodting T, Piriyachananusorn N. (2011). Assessing evidence of interaction between smoking and warfarin: A systematic review. Chest, 139(5):1130-9.

24. Einerson B, Chaiyakunapruk N, Kitiyakara C, Maphanta S, Thamlikitkul V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. Journal of Medical Association Thailand (In Press)

25. Chotchaisuwatana S, Jedsadayanmata A, Chaiyakunapruk N, Jampachaisri K. Validation of electronic medical database in patients with atrial fibrillation in community hospitals. Journal of Medical Association Thailand (In Press)

26. Chaiyakunapruk N, Somkrua R, Hutubessy R, Henao AM, Hombach J, Melegaro A, Edmunds J, Beutels P. (2011). Cost-effectiveness of pneumococcal conjugate vaccines (PCV): A comparative assessment of decision making tools. BMC Medicine, 9:53 doi:10.1186/1741-7015-9-53

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STAFF Main researchers Nathorn Chaiyakunapruk PharmD, PhD

Sirada Maphanta PharmD, BCPS

Chanthonrat Sitthiworanun PhD

Piyarat Nimpitakpong PhD

Athargan Nakhum PharmD

Supachai Insuk PharmD

Chuenjid Kongkaew PhD

Arom Jedsadayanmata PharmD, PhD

Mungkorn Prapunwattana DrPH

Pakawadee Sermsulpasuk PhD

Suthathip Pongchaoren MD, PhD

Peerapon Wong MD

Teerapon Dhippayom PharmD, PhD

Nilwan U-pakdee PhD

Graduate students & Research Fellow Piyameth Dilokthornsakul PharmD

Surasak Saokaew PharmD

Prayut Peewaratanawinit PharmD

Rosarin Sruamsiri BPharm, MBA

Wimonchat Tangamornsuksan PharmD (CPOR fellow)

CONTACT INFORMATION Nathorn Chaiyakunaprk PharmD, PhD Associate Professor Director of Center of Pharmaceutical Outcomes Research Faculty of Pharmaceutical Sciences Naresuan University Muang, Phitsanulok 65000 THAILAND Mobile Phone: +66-84-009-4460 Office Phone: +66-55-961-826 Fax: +66-55-963731 E-mail: chaiyakunapr@wisc.edu http://www.pha.nu.ac.th/nathorn/

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Pharmaceutical Care Research Unit

FFaaccuullttyy ooff PPhhaarrmmaacceeuuttiiccaall SScciieenncceess

NNaarreessuuaann UUnniivveerrssiittyy

We a im at conducting researches through providing and developing pharmaceutica l care services. The research areas include internal medicine, crit ica l care, ambulatory care, primary care, community pharmacy, home health care, health policy, and health promotion e.g. smoking cessat ion. Pharmacy education and professional tra ining are a lso of our interests. Our ongoing research involves roles of “Pharmacy and Therapeutic Committee (PTC)” and other strategies on rat ional drug use policy.

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SELECTED PUBLICATIONS 1. Dhippayom T, Chaiyakunapruk N, Jongchansittho T. (2011). Safety of

nortriptyline at equivalent therapeutic doses for smoking cessation: a systematic review and meta-analysis. Drug Saf. 34:199-210.

2. Nimpitakpong P, Chaiyakunapruk N, Dhippayom T. (2011). Smoking cessation education in Thai schools of pharmacy. Pharmacy Education. 11: 8 –11.

3. Chaiyakunapruk N, Asuphol O, Dhippayom T, Poowaruttanawiwit P, Jeanpeerapong N. (2011). Statins utilization pattern: a retrospective evaluation in a tertiary care hospital in Thailand. Int J Pharm Pract. 19:129-35.

4. Dhippayom T, Thananithisak C. (2010). Nortriptyline for smoking cessation. Srinagarind Med J. 25(2): 147-55.

5. Aroonsiriwat J, Dhippayom T, Chaiyakunapruk N, Sermhattakit A, Saelim S. (2010). Community pharmacy-based implementation of a diabetes risk assessment tool (written in Thai). J Pub Health Dev. 8:334-45.

6. Nimpitakpong P, Chaiyakunapruk N, Dhippayom T. (2010). A national survey of training and smoking cessation services provided in community pharmacies in Thailand . J Community Health. 35:554-9.

7. Nimpitakpong P, Dhippayom T, Chaiyakunapruk N, Aromdee J, Chotbunyong S, Charnnarong S. (2010). Compliance of drugstores with a national smoke-free law: a pilot survey. Public Health. 124:131-5.

8. Kitikannakorn N, Sitthiworranan J. (2007). Knowledge and accessibility of self-medication among undergraduate students in Thailand. Int J Disabil Hum Dev. 6(3): 289-94.

9. Kitikannakorn N, Sitthiworranan J. (2006) Adolescent searching for health information on the Internet in Thailand. [proceeding]. The 11th World Congress on Internet in Medicine, 14th -19th October 2006. Toronto, CANADA.

10. Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C. (2006). The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol. 194(1):95-9.

SELECTED RESEARCH PRESENTATIONS 1. Kitikannakorn N, Hongprasit P, Rassamee A, Lalida Khamchuen.

Anaphylaxis due to salol (phenyl salicylate) in mist salol et menthol (over-the-counter (OTC) stomachic): Case report in Thailand. Oral presentation, 26th – 28th Sep 2009. The 9th Asian Conference on Clinical Pharmacy (ACCP) in Seoul, Korea.

2. Kitikannakorn N, Wangruengsatit N, Aree-wong K, Wongjumpa D. Patient Safety Initiative: A Reinforcement of adverse drug reaction monitoring and reporting system in a university-based hospital in Thailand. Poster presentation, 21st – 24th June 2009. The 6th Annual Meeting of Health Technology Assessment International (HTAI) 2009.

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3. Kitikannakorn N, Ruengbandit T, Thoopmongkol J. Community Pharmacist intervention in drug safety in intellectual, developmental, and hearing disability school, Thailand. National Medicines Symposium 2010. Oral presentation, 25th – 30th May 2010. Melbourne, Australia.

SELECTED PHARMACEUTICAL SERVICES 1. Phuwarattanavivit P, Sakunrak I, Kraiket B. Warfarin clinic at Naresuan

University Hospital. 2. Sakunrak I, Maphanta S, Thananithisak P. Medication

refill service at Naresuan University Hospital. 3. Unlamlert W, Maphanta S. Critical care service at

Intensive Care Unit (ICU), Naresuan University Hospital.

4. Thananithisak C, Kitikannakorn N, Ruengbandit T., Thoopmongkol J. Smoking cessation service at Naresuan Community Pharmacy.

5. Danwilai K. Internal medicine service at Naresuan University Hospital. 6. Kitikannakorn N, Sakunrak I, Teakthong T, Fuengchan A, Thananithisak C.

Home health care for Phitsanulok intellectual, developmental, and hearing disability school.

STAFF Main Researchers Dr. Sirada Maphanta

Dr. Nantawarn Kitikannakorn

Dr Teerapon Dhippayom

Dr. Chuanchom Thananithisak

Dr. Aulchana Fuangchan

Asst. Prof. Athagran Nakham

Itsarawan Sakunrak

Jeeraya Thoopmongkol

Graduate students Adinat Umnuaypornlert

Sirimas Pansang

Prayuth Phuwarattanavivit

Naruemon Bamrungsawad

Research assistant Tidawan Jeenkul

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CONTACT INFORMATION Nantawarn Kitikannakorn, PhD. Department of Pharmacy Practice Faculty of Pharmaceutical Sciences Naresuan University Muang, Phitsanulok 65000 THAILAND Tel ++66-55-961841 Fax ++66-55-963731

E-mail: nantawarnk@nu.ac.th

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Tobacco Control Research Unit Faculty of Pharmaceutical Sciences

Naresuan University

Tobacco Control Research Unit acts as a foca l point for tobacco research, education, cessa tion, and tra in ing for Naresuan Unive rs i ty as we ll as for the Thai land lower northern region. It encompasses several faculty members , the ir s tudents , fe llows, and sta ff, whose work extends from cessation and pharmacotherapy, su rvei llance and monitor ing of tobacco indus try , tobacco control project eva luation to action-or iented policy interventions . SELECTED PUBLICATIONS 1. Thananithisak C , Nimpitakpong P , Chiyakunapruk N . (2008).

Ac tivit ies and perception of pharmacists providing tobacco control services in community pharmacy in Thai land. Nico tine and Tobacco Research , 10(5): 921-925.

2. Nimpitakpong P , Chiyakunapruk N , Dhippayom T. (2010). A national su rvey of tr a ining rece ived and smoking cessation services provided in community pharmacy in Thai land. Jou rna l o f Communi ty Health , 35: 554-55.

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3. Nimpitakpong P , Dhippayom T, Chaiyakunapruk N , Aromdee J , Chotbunyong S, Charnnarong S. (2010). Compliance of drugstores with a national smoke-free law: A pi lot survey . Publi c Health . 124(3): 131-135, Ava ilable onl ine 20 February 2010.

4. Nimpitakpong P & Vateesa tokkit P. (2010) Thai land: ‘Greatest Tobacco Show’ has a nas ty shock. News analy s is . Tobacco Contro l , 19: 3-6 .

5. Pitanusorn C, Karnchanakorn S, Nipatpimjai S, Chaiyakunapruk N , Nimpitakpong P , Upakdee N. (2008). Development and evaluation of measure to induce smokers for smoking cessation service at community pharmacy by the smoker 's c lose ly re lated person . Journal o f Tobacco Con tro l (Thai land), 2: 56-67

6. Chaiyakunapruk N , Upakdee N, Nimpitakpong P , Re rkmongkolkul P, Seatao P, Sr iworrarat S. (2009). Interna tional comparisons in pol icy of smoking ces sation service s re imbursement system. Health Pol icy and Planning Journal (Thailand), 11: 1-4

7. Nimpitakpong P , Chiyakunapruk N , Dhippayom T. Tobacco control educa tion in Thai schools o f pharmacy, in review.

STAFF

Main Researchers Assistant Professor Dr. Piyarat Nimpitakpong

Associate Professor Dr. Nathorn Chaiyakunapruk

Assistant Professor Dr. Narongsak Noothong

Associate Professor Dr. Pinyupa Plianbangchang

Dr. Chuanchom Thananithisak

Research assistants Nara Thiamkee

Linda Keawluang CONTACT INFORMATION Piyarat Nimpitakpong, PhD. Assistant Professor Department of Pharmacy Practice Faculty of Pharmaceutical Sciences, Naresuan University Muang, Phitsanulok 65000 THAILAND Tel ++66-55-963618 Fax ++66-55-3731 E-mail: ohpiyarat@yahoo.com

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