(Continudfrompge 1553)Non-Classical Continuum Mechanics. R. J. Knops

and A. A. Lacey, Eds. Cambridge University Press, NewYork, 1987. xii, 335 pp., illus. Paper, $37.50. LondonMathematical Society Leture Note Series, vol. 122.From a symposium, Durham, U.K., July 1986.Nonequlfbrlum Phase Tranefions In Semicon-

ductors. Self-Organization Induced by Generation andRecombination frocesses. E. Sch6ll. Springr-Verlag,New York, 1987. xii, 313 pp., illus. $98. Sprnger Senesin Synergetics, vol. 35.Nuclear Power. Policy and Prospects. P. M. S. Joncs,

Ed. Wile-Intrscience, New York, 1987. xviii, 416 pp.,illus. $154. World Energy Options.Nuclear Weapons and ScientMfic ResponsibIlty.

C. G. Weeramantry. Longwood Academic (Longwood),Wolfeboro, NH, 1987. Xiv, 188 pp. + index and appen-dices. $25.

Nutrients and Brain Function. W. B. Essman, Ed.Karger, Basel, 1987. viii, 252 pp., illus. $146. Based on aconference, Scottsdale, AZ, Feb. 1986.Purina Basins of Peninsular India (Middlc to Late

Proterozoic). B. P. Radhakrishna, Ed. Geological Socie-ty of India, Bangalore, 1987. xvi, 518 pp., illus. $60.Memoir 6. Based on a seminar, Hyderabad, India, Dec.1984.Quantum Field Theory and Quantum Statistics.

Essays in Honour of the Sixtieth Birthday of E. S.Fradkin. I.A. Batalin, C. J. Isham, and G. A. VilkoviskyEds. Hilger, Bristol, U.K., 1987 (U.S. distributor, Tay-lor and Francis, Philadelphia). Two volumes. Vol 1,Quantum Statistics and Methods of Field Theory. xxi,697 pp. illus. Vol. 2, Models of Field Thoory. xxii, 599pp., ilus. $385.Statiscal Methods for the Analysis of Blomedi-

cal Data. Robert F. Woolson. Wiley, New York, 1987.mxii, 513 pp., illus. $49.95. Wiley Series in Probabilityand Mathiematical Statistics.

Statistical Procedures In Food Rearoh. J. R.Piggott, Ed. Elsevier Apolied Science, Barking, U.K.,1987 (U.S. distributor, Eltrier, New York). x, 415 pp.,illus. $90.Without the Bomb. The Politics ofNudear Nonpro-

liferation. Mitchell Reiss. Columbia University Press,New York, 1988. xxii, 337 pp. $35.

Temple DatatapTM Graph 3.1for IBM and HP90, SUN3

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POSITIONS WANTED

Bi, Ph.D. with broad acadnic training,17 years of ing expeience all levelsfidds biology InUSA and Africa; exnsive i seeldng acigand/or research position. Box 84, SCIENCE.

Immunologis-,Ph.D. Research and development spe-cialist in hybridoma technology, monodonal antibodies,cancer/infectious disease immunology, and tissue culture.Broad academic and biotechnology expenence in allphases of laboratory operations. Seeng roup lead/supervisory position in indusal, academc, or dinicallaboratory. Box 91, SCIENCE.

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ACADEMIC PATHOLOGISTWe are seeking an academic pathologist with experi-

ence in immunopathology or a related field such asimmunocytochuemcal diagnosis, immunohematology,cell diagnostic markers, etc. The applicant should have anM.D. degree, be experienced in teaching, be capable ofserving m diagnostic anatomical pathology and be agraduate of an LCGME-approved pathology residencyprogram. Prence will be given for independent re-search capability, and, prefcrably, extramural researchfunds. Salary is commensurate with experience. Mailcurriculum vitae to: IL Clarke Anderson, M.D., De-partment of Pathology and Oncology, University ofKansas Medical Center, Kansas City, KS 66103.

An Equal Opportunity/Afirnative Action Employer.

ANDROLOGISTThe Division of Reproductive Endocrinology in the

Department of Obstetrics and Gynecology, Health Sci-ence Center, Syracuse, Ncw York is seeking a qualifiedandrologist. ae plicant should have expenence intissue culture, semen analysis, sperm antibody testing,sperm washing techniques, and sperm cryopreservation.Previous experience in IVF is preferred but is notnecessary The applicant will be responsible for the dailyfunctions of the Andrology Laboratory and the develop-ment of research protocols in that field. Pleasc forwardyour curriculum vitae to: Michael B h, M.D.,Chairman, or Shawky Badawy, MD.,Dir, Divi-sion of Reprodctive Endocrinolo, Department ofObstetricsGynecology, Health Scince Center, Syra-cuse, NY 13210.

ASSISTANT PROFESSORNORTHWESTERN UNIVERSrrY

DEPARTMENT OFMICROBIOLOGY-IMMUNOLOGY

Applications are invited for a tenure-track position atthe rank of assistant professor in the Department ofMicrobiology-Immunology Northwestern UniversityMedical andDental School. The department is undergo-ing substantial growth in rcsearch space, facilities, andfaculty positions as part of Northwestern University'scommitment to enhance excellence in the basic biomedi-cal sciences. Applicants are being sought whose researchinterests compiement ongomg programs in molecularvirology, immunology, and microbial pathogenesis. Ofparticular interst are research on immunopathogenicityor microbial pathogenicity in mammalian systems, orresearch on reccptor biology as itpertuins to the functionof the immune system or to microbe-cell interactions.Primary criteria for appointment will be previous post-doctoral xperience with the tools and techniques ofmodern molecular biology, demonstratedr abili-ty, potential for developing an internationally recognizedresearch program, and commitment to effectve teachingat the postgraduate level. Please send curriculum vitae,summary of research interests, and the names of threereferences to: Search Committee Chairman, Depart-ment of uicrobiolo- logy, NorthwesternUnivenrsity Medical School, 303 East Chicago Ave-nue, Chicago, IL 60611. Northwestern University is anAfirnative Action/Equal Opportunity Employer.

ASSISTANT PROFESSOR, tenure-track, radio-pharmacy. Responsibilities: Maintain active etramurallyfunded researh program; participate in graduatc andundergraduate teachng. Ph.D. in radiopharm adevelopment, radiopharmaceutical chemistry, or relateddiscipline roquired. Preferencc to candidates with B.S.degrec in pharmacy. Twelve-month appointment; start-ing date of 1 January 1989. Salary commcnsurate withexperience. Deadline: 1 September 1988. Send letters,curriculum vitac, sntement of career objcctives, andthree refrences to: William B. Hiadik m, Chair,Rhq,-I.-mu7 Search Com ee, lege ofPhar-

macy, Js OfNew Medco, Albuquerque, NM87131. Ajlrmative Adion/Equal Opportunity Employer.

Circle No. 228 on Readers' Service CardPERSONNEL PLACEMENT 1555

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Mihalisin Assoc. (215) 646-3814600 Honey Run Rd, AmblerPA 19002

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POSITIONS OPEN

ASSISTANT PROFESSORThe Department ofPharmacology and the Program in

Biological Scienes of the School ofMedicine, Universityof Calforinia, San Francisco, seek to fill a tenure-trackposition at the assistant professor level. The search is notconfined to candidates in a single area ofresearch; rather,we seek an investigator who works in an area broadlyrelevant to pharmacology-e.g., signal transduction,protein structure, neurobiology, cell biology, or molecu-lar biology. Successful candidates should also be able toteach pharmacology to professional and graduatc stu-dents. Lers of application should be accompanied bycurriculum vitae and bibliography, a narrative descnp-tion of plans for future research, and the names, address-es, and telephonc numbers of three references. Pleasesend all materials by 30 September 1988, to: Chairman,Searc Committee, Department of Ph coloy,UCSF, San Francisco, CA 94143-0450. The Universi-ty of California is an Affirmative Action/Eqgual OpportunityEmployer.

ASSISTANT PROFESSOR-Thc Department ofChemistry and Biochemisty and the Ccnter for Agricul-tural Biotechnology of the Univcrsity of Marland,Collegc Park, announce the opening of a tenure-trackjoint assistant professorship. The successful candidatewill be expc to initiate a competitive sarch pro-gram in the area of plant bio , and to establishan interfacc betwecn the Department and the Center.Investigators whosc research interests indude the bio-physical and/or enzymological aspects of plant biochem-stry are especially cncouraged to apply. The joint ap-pointce w have modern laboratory space in chemistryand biochemistry, a one-half teaching load and full accessto departmental facilities and graduate students. A r6su-

a synopsis of research interests, and three lettcrs ofrecommendation should be sent by 15 August 1988 to:John W. rih, Center for.. Biotech-nology, H. J. Patterson Hall, University ofMaryland,College Park, MD 20742. The University ofMaryland isan Equal Opportnity Employer.

ASSISTANT PROFESSOR, tenure-track, beginning1 January 1989. Ph.D. in biochemistry or molecularbiology, commitment to libeed education, teachingin biology and chemistry departments at undergraduateand Masters' levels, development of rsarch progaminterfacing biology and chemistry required. Submit rdsu-

i, description of proposed research, three ktters ofrecommendation, and oE}icialtransai ts to: Chairman,Biology Department, James Madsn Uniesty,Harrisonburg, VA 22807, by 30 June 1988. Scarchwill continue until position fillcd. The University is anEqual Opportunity/Afimtive Adion Employer.

The Seattle Biomedical Research Institute (SBRI)invites applcations for a permanent position at theSTAFF OR SEINIOR SCIENTIST level which isequivalent to assistant or associate professor. SBRI is asmall, non-profit institute dedicated to basic biomedicalresearch in a coperative, scientist-oriented environment.Interactions with other Seattle research institutions areencouraged. Current programs focus on basic molecularbiology, immunology, and molccular and immunologicalparasitology. The successful candidate will cstablish anexternally funded independent research program that isrelated to infectious dis s and that employs molecularand/or iunmunolosical approachcs. Limited initial sup-port from the institute is available. Candidates interestedmn molecular pathogenesis of viral and bacterial disease orin intercellular interactions are encouraged to apply.Applicants should send their curriculum vitae, a briefstatement of proposd research, and names of threereferences by1July 1988 to: Dr. Kenneth Stuart,Scattle Biomedical Research Institute, 4 NickersonStrect, Seattle, WA 98109-1651. Equal Opportnity.Employer.

ASSISTANT OR ASSOCIATE PROFESSOR,PHARMACOLOGY/TOXICOLOGY Two tenure-track positions are open for an outstanding cardiac orvascular pharmacologist. Applicants should send curricu-lum vitae, a statement of research pElam, and three lettersof reference to: K E. Moore, Ph.D., Chairman, De-partentofPharmacology and Toxicology, MichiganState University, East Lansing, MI 48824. An EqualOpportunity/Affirmative Action Employer.

I556

POSITIONS OPEN

ASSISTANT PROFESSOR AND POSTIDOC-TORAL POSrTIONS. Immediate opportunities tostudy the molecular genetics of autoimmune diseases inhumans and appropriate animal models. Ongoing pro-jects concern genomic org tion and expresslon ofautoimmune B and T cell antigen receptors, inmuno-globulin and autoantibody regulation, molecular aspectsof tolerance, and antigen-binding/presentation. Candi-dates should have a good background in immunologyand molecular biology. Send curriculum vitae and threereferences to: Dr. A1ry s N. Theolilopouls, Mem-ber, ImmunologyDIS ment, Scripps Clinic andResearch Foundation, 10666 NodToe PinesRoad/IMM3, La Jolla, CA 92037.

ASSISTANT PROFESSOROF PHARMACOLOGY

A tenure-track faculty position of assistant professor isavailable in the Departmcnt ofPhannacology, Universityof California, Los Angeles (UCLA), for an individualwith strongpromis for research and teaching in the areaof molecuPlar mchanisms of drug action. Applicantshould have significant postdoctoral research accom-plishments, a solid background in molecular pharmacolo-gy, and the ability to respond to new challenges. Appoin-tee is expected to establish a strong research program andeffectively educate medical and graduate students inmolecular pharmacology. Send curriculum vitae, bibliog-raphy, summary of professional accompLishments andgoals, and names of three references to: Chair, SearchCommittee, Dr. Louis J. Ignarro, Department ofPharmacology, UCLA School of Medicine, Centerfor the Heth Sciences, Los Angeles, CA 90024. AnAffitmative Action/Equal Opportunity Employer.

ASSISTANT PROFESSOR, PHARMACOLO-GY/TOXICOLOGY. This is a tenure-track positionavailable immediatcly. A Ph.D. or M.D. with postdoc-toral rsearch expericnce is required. The appointee willbc expctd to develop a strong research prram in ad-dition to teacding and student advisn responsibilities.Qualified applicants of any research discplinc in pharma-clogy/toXiolo0gy may appl, but persons whose researchintets are in molecular biology and/or immuophar-maaco are especially urged to apply. The deparm iswdlt-podi with basic resarch quipment and ful-equippe tissue/cell cutkure facilities are available Applica-tions incudin a dtiked curriculum vitae, statement offutr reeac direcion, and thr lete s of referenceshould bc sent to: Dr. Beth Hodsins, De of

and Taogy, Universy o£MispiMedical , 2500 North State Stroet, Jacon,MS 39216-4505. The University of Mississippi MedicalCenter is an Equal Opportunity Employer, M/F/H/V.

ASSISTANT/ASSOCIATE PROFESSORPHYSIOLOGY AND BIOPHYSICSUNIVERSITY OF WASHINGTON

A tenure-track position is opcn for outstanding candi-dates working at the molecular, ccllular and/or mtegra-tive level in all areas ofcontemporary physiology. Appli-cants applying modern methods to study of thc auto-nomic nervous system (induding developmcnt and signaltransduction) or to the cardiovscular system and itscomponents (such as the cndothelium) are particularlycncouraged. Candidates are expected to develop a strongindependent research program and to teach effectively atthe graduate leve. Submit curriculum vitae, statement ofresearch intcrests and goals, and names and addresses ofthree references before 31 August 1988 to:.WofflardAlmers, Chair of Search Committee, Physiology andBiophysics, SJ-40, University of Washi0=ngo choolof Medicne, Seattlc, WA 98195. The University ofWashington is an Equal Opportunity/Afirnative Action Em-ployer.

BIOLOGY/HEALTH SCIENCES. Tenure-track.ASSISTANT/ASSOCIATE PROFESSOR Fall 1988or fall 1989. Salary conmnensurate with qualificationsand expericnce. Ph.D., cxcellence in teaching, research,and a firm commitment to working with students re-quired. Teach kinesiology, exercise physiology, nutri-tion, and courses relat to gerontology. Send r&sum,hree letters of reference, and evidence of scholarship andteaching to: Chair, Department of Biology/HealthSciences, Chapman College, Orange, CA 92666 by 15July 1988. Ajtrmative Action Institution/Equal OpportunityEmployer.

POSITIONS OPEN

BIOLOGIST OR PHYSICALOCEANOGRAPBER

The Harbor Branch Oceanographic Institution(HBOI) is seeking to fill an entry-level position on theResident Scientific Staff of the Division of Marine Sci-ences. Applicants should have 2 years of postdoctoralexperiencc in at least one ofthe following areas ofmarinescience: Microbial ecology, comparative animal physiolo-gy, deep-sea ecology, coed reef ecology, or blue-waterphysical oceanography. Research areas that involve theuse of HBOrs unique resources, particularly the John-son-Sea-Link submersibles, will be given special prefer-ence. This is a full-time research position with someinternal support. The chosen candidate is expected,however, to aggressively pursue external research fund-ing. Interested applicants should send a letter outliningresearch background and current research interests, to-gether with curriculum vitae and the names of threereferences to: G. R. Harbison, Director, Division ofMarine Sciences, Harbor Branch Oceanographic In-stitution, 5600 Old Dixie Highway, Ft. Pierce, FL34946. Application deadline: 31 August 1988. TheHarbor Branch Oceanographic Institution is an Equal Opportu-nity Employer.

CELL BIOLOGIST: The Department of Neurolo-gy, Columbia University, seeks cellbiologist at assistantprofessor level to develop novel cell lines for potential usem neural transplantation as part of multidisciplinaryresearch effort im Parkinson's disease and Alzheimer'sdisease. Applicants must have M.D. or Ph.D., minimumof2 years ofpostdoctoral research experience, and abilityto obtain extramural funding. Send curriculum vitae andnames of three references to: Dr. Robert E. Burke,Neurologcal Institute 710 West 168th Strect, NewYork, NY 10032. Columbia University takes AffirmativeAction to ensure Equal Opportunity.

CELLULAR BIOPHYSICS AND MOLECU-LAR PHYSIOLOGY: Several TENURE TRACKPOSMONS (Assistant-Associate-Full Professor) willbe available in the Department of Physiology at theUniversity of Virginia School of Medicine that is to beexpanded in these areas with the appointment of Dr. A.P. Somlyo as the new Chairman of the Department.Applications are invited from individuals with demon-strated accomplishments in applying the methods ofmolecular genetics, light optical, clectron optical, spec-troscopic and modern electrophysiological approaches tocell physiology. Potential areas of interest inc[udc subcel-lular transport and transporting membrane proteins,intracellular signaling and cell motility. Some preferencemay be given to individuals with an interest in the cell

ysiology of the cardiovascular system and contractility.Send curriculum vitae and a list of four references to:Physioloy Departmental Search Committee, SchoolOf Medicine, Box 449, Charlottesville, VA 22908.The University of Virginia is an Equal Opportunity/Affirma-tive Action Employer.

UNIVERSITY OF OTAGODUNEDIN, NEW ZEALANDCHAIR IN MARINE SCIENCE

Applications are invited for appointment to a newlyesta6bished Chair in Marine Science. Applications wouldbe welcomed from candidates with a substantial record ofresearch in any area or areas of basic or applied marinesciences. Proven ability in leadership of intcrdisciplinaryteaching and research may be an advantage.A new, well-appointed and equipped building costing

$NZ4.5 million has recently been opened at the Porto-bello Marine Laboratory 20 km from Dunedin. Thefacilities of the Laboratory, which include a 14-metreresearch vessel, offer excellent opportunities for marineresearch.

Salary will be within a range between $NZ68,000 and$NZ85,000 per annum.

Intending applicants can obtain further information,including a detailed description of the facilities of thePortobello Marine Laboratory and duties and responsi-bilities of the Professor of Marine Science, from TheRegisar, P.O. Box 56, Dunedin, New Zealand.

Applications quoting reference number A88/11 closewith the Registrar on 31 July 1988. D. W. Girvan,Registrar.

SCIENCE, VOL. 240

POSITIONS OPEN

CHAIRPERSON, DEPARTMENT OF PHYSI-OLOGYAND BIOPHYSICS: The University ofMis-sissippi Medical Center invites nominations for the posi-tion of professor and dcairperson of the Department ofPhysiology and Biophysics. Candidates should have ex-tensive teaching experience and be established investiga-tors with a record of scholarly contributions and partici-pation in appropriate professional organizations. Candi-dates with admnisttive background are prefcrred. TheMedical Center in Jackson is Mississippi's only academichealth center. There are four health professional schoolson the campus-Schools of Medicine, Nursing, HealthRelated Professions and Dcntistry; graduate programs in

the medical sciences; and the 541-bed Univcrsity Hospi-tal, teaching hospital for all prgrams. The Departmentof Physiology and Biophysics has campuswide teaching

responsibilities. The deparment is partiularly noted for

itS research in cardiovascular, renal and endocrne physi-

ology and for its quantitative approach to physiology,

especially in the application of control systems analysis

and computer simulation of physiological mechanisms.

There are also active research progrms in the areas ofcellular, respiratory and neurophysilogy. Nominationsfor the position should indude the nominee's name,currculum vitae, and names and telephone numbers ofthrec refirences, and should be addressd to: I. IL Ho,PhD., Chairman, Sar Commit c/o the Depart-mcat ofPharmcolgy and Toxicokly, the Universi-tyof Misaissippi Medial Cea, 2500 North StateStroet, Jakson, MS 39216-4505. Application dcad-line is 1 August 1988.

The Deparnent of Patholgy of the SUNY HealthScience Center at Syracuse announces a position in theDivision of Clinical Pathology as CO-DIRECTOR OFCYTOGENETICS at Umvcrsity Hospital. Applicantmust meet the requirement for Ncw York State Certifica-tion ofQualification as a Laboratory Director ofCytogc-nctics. Applications will bc acccpted through 1 July1988. Submit a letter describing interest and expencncein cytogeneiics, curriculum vitae and the names of threereferences to: Lawrene P. Gordon, MD., Deatment

of SUNY Healh Scenc Cener,S

NY 13210. An Equal Opportunity/Ajirmaive ActionEmployer.

Senior tenure-track faculty appointment (full-time) inthe Department of Psychiatry as DIRECTOR of theUniversity of Michigan Substance Abuse Center of Ex-celence. Responsibilities indude the coordination andmonitoring of research efforts across university pro-grams, facilitation ofcollaborative rmsarch relationships,itegration of basic rsarch efforts with clinical andteaching operations, strengthening cxisting resourcesand attractig new resources and talent, and the dissem-ination of information about university activities insubstance abuse. Candidates must have documentedtrack record in research, teaching, clinical leadership andadministration; demonstrated ability to cstablish andcarry out funded research; Medical Deg with BoardCertification in Psychiatry or Doctoral Degree in ClinicalPsychology from an accredited training program; cligiblefor licensure in Michigan. Send a letter of intcrest andcurriculum vitae to: John F. Greden, MD., Professorand Chairman, Departmeat of Psychiatry, B2963Clinical Facult Offce Building (Box 0704), 1500East Medical Center D Ann Arbor, MI 48109-0704. The University of Michigan is a Non-discriminato.y/AJfinnative Action Emnployer.

ELECTRON MICROSCOPISTJohns Hopkins University Medical School seeks an

expenenced electron microscopist to supervise, maintain,

and provide instruction in a new electron microscopecore facility. Duties indude maintainin.g and supervisingthe use of4 TEMs, 1 SEM and associated evaporators,microtomes and freeze-fracture apparatus; instructingand assisting both cxperienced and novice investigaorswith EM use and preparation methods; implementmg anEM image analysis system; maintaining light micro-scopes and a new confocal fluorescenc microscope.Rank and salary commenst with experience. Anestablished record of contributions and experience in

microscopy are required. Send curnculum vitae and thenames of three to: EM Search

Department of Cel Biology and Anatomy, JohnsHopksins Medial School, 725 North Wolfe Street,

Baltimore, MD 21205.

10 JUNE I988

Join A Group Of Biotechnology ScientistsDedicated To Improving The Environment.

As one of the world's foremost agricultural companies, the Agricultural Divi-sion of CIBA-GEIGY Corporation is putting science to work. We're known forour commitment to research and the calibre of scientific professionals who shareit. Our Biotechnology research facility in Research Triangle Park, NC, now seeksthe expertise of a Tissue Culture Scientist.Joining our genetic engineering and crop improvement program, you'll assistin the propagation and engineering of plant tissue cultures. Ideal candidate isa multi-faceted scientist with interest in culturing and engineering various typesof plant tissues. A BS or MS in Botany or a crop science is required, as is 2-5years of tissue culture lab experience, preferably with major crop species.We'll reward your commitment with advancement opportunities, a competitivesalary and generous company-paid benefits. Please forward your resume, in-cluding salary history and requirements, in confidence, to: Mary-Dell Chilton,CIBA-GEIGY Corporation, P.O. Box 12257, Research Triangle Park, NC 27717. Weare an equal opportunity employer m/t/h/v.

Science Serving Mankind

BA-GEIGYss

Our Spirit Of TeamworkFosters A Winning AttitudeAmerican Cyanamid Company's Agricultural Research Division hasa long-standing and highly successful commitment to the discoveryand development of products to improve worldwide crop and livestockproduction. We are growing rapidly and currently have opportunitiesat our laboratory and experimental farm complex ideally located nearPrinceton, New Jersey in the following:Plant MolecularBiology/PathologyOur expanding Plant Biotechnology program has openings for in-dividuals at the BS, MS and PhD levels in the areas of plant pathologyand molecular biology. Applicants should have experience inmolecular pathology of fungal pathogens or host plant responses,plant transformation systems, gene isolation, and/or the analysis ofgene expression in higher plants.American Cyanamid offers a competitive compensation and benefitspackage. For prompt and confidential consideration, forward yourresume, an outline of research interests, career goals and the namesand addresses of three references to the Employment Office.

American Cyanamid CompanyAgricultural Research DivisionP.O. Box 400Princeton, NJ 08540An Equal Opportunity Employer M/F/HN

1--

POSITIONS OPEN

DEVELOPMENTAL BIOLOGIST: The Depart-ment of Embryology of the Carneie Insttution ofWashington secks a Staff (Faculty) Member who willcarry out independent h in some aspect of Devel-opmental Biology. Our Department is part ofa nonprof-

it research institution and is situated on the Johns

HopkQins University Homewood campus. Applicantsshould send curriculum vitac, a statement of researdcinterest, and have threc letters of recommendation sentto: Director, De!rtient of Emnryo1gy, CMInstitution of Waahmgton 115 West UniversityParkway, Balimore, MD 21210. An Equal OpportunitylAJfrmative Action Employer.

DIRECI"OR,OFFICE OF RESEARCH SAFETY

NORTIIWESTERN UNIVERSITYNorthwestcm University is seeking a Director for its

Office of Research Safety, a centrally admini unitthat has responsibilities on both the Chicago and Evans-ton campuses. The Office's duties encompass radiationsafcty, chemical, biological and rDNA safety, and hazard-ous waste management. The Director is responsible forprogram planning and development as well as maiain-ing regulatory compliance with applicable federal andstate regulations and university polioes. Candidat

should have a Ph.D., or equivalent degree, in healthphysics, environmentl hea chemistry or rd field,and at least 5 years of experience, incuding admini-

tion, in an environmental heakh program or officc. IheDirectr reports to the Vice President for Research andDean of the Graduate School through the Director ofResearch Services Administrtion. The position is arail-able on 1 July 1988. The applicnt should submit ar&sumd, including the names of at least thre references,to: Search Commte Resear.h Srvies Administr

tion, Northwetern University, 633 Clark Stroet,Evanston, IL 60208. Northweste University is an EqualOppornity Employer.

DIRECrOR, MOLECULAR AND CELLULARBIOLOGY GRADUATE PROGRAM. University ofMaqland, College Park. The Univers of Marylnd isseeking a director for a newly formed inter mntal

graduatc program in molecular and cellular biology. Thedirectr will:* be a tenured full professor in onc ofthe deparmts

ofthe College ofLife Scicnces or the Collge ofAgricul-

ture, and be the program director.*work closely with the chairs of the departm ts

involved in the p m and report directly to the Deanof the Colleges of Sciencs and Agriculure

* represent Collec Park in a University-wide nolecu-lar and celular biology graduate progrmThe individual selected for director should denon-

stratc significant sustained contributions to molecularand/or cellular biology as well as an abiliq to direct andkad a lre inter-departmental program. the individualis expected to maintain his/her own active rescarchprograrn,tach appropratc courscs in the program, andtestr developmcnt ot thc.progmam.Applicants for the position should send their curricu-

lum vitac, a statement of research intersts, and thenames and addresscs of at kast threc potential refncesto: Dr. Arthur N. Popper, Cairman, Search Com-mittoe, Moleloar an Cd uar Bioogy Prognm,Depranent of Zolokr, Unversity of Mar*ned,Co Park, MD2742. T one : 301-454-3202.

Closing date is 17 October 1988, or until suitabkapplicants are found. Equal Opponwnity Employer/AJfima-tive Action.

ECOLOGICAL DATABASE ANALYSTPennanent position as database analyst and program-

mer for the Smithsonian Tropical Research Institute inthe Republic of Panama, a bureau of the SmithsonianInstitution. Duties indude managemnt and statisticalanalysis of several large databases on tropical forestecology and related areas. Statical pga ming ecpe-rience required. Salay based on qualifications. Sendcurriculum vitae and three ktters of cm menidation to:Director, Smithsoni Tropical Resarch Institute,APO Miami 34002-0011. Deadline: 15 July 1988. AnEqual Opportunity/Ajimnnative Ation Employer.

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REPRODUCTIVE

TOXICOLOGISTContinued expansion at The Parke-Davis Pharmaceutical ResearchDivision has created the need for a scientist in our ReproductiveToxicology section.The duties of the successful candidate will be to assist in the design,execution and analysis of studies which focus on drug effect on fer-tility and reproduction as well as effect on the embryotfetus, newbornsand weanlings. The position will also involve supervisory responsi-bilities and drug discovery team participation.Requirements for this position include a Ph.D. in Reproductive Biol-ogy or closely allied field, one to three years post-doc experience inreproductive toxicology, knowledge of GLPs, experience in main-tenance of animal colonies and in animal care and handling.This position is located at our research facilities in Ann Arbor,Michigan. The successful candidate will participate in dynamic drugdiscovery and development teams, and enjoy an excellent salary,benefits, professional development, living and working environment.Qualified candidates send response, salary requirements and refer-ence list in confidence to: Ms. M. Wolin, Warner-Lambert/Parke-Davis, 2800 Plymouth Road, Ann Arbor, Ml 48105.

"Equal Opportunity In Action"

PARKE-DAVIS

POSTDOCTORAL ASSOCIATE POSITIONSUNIVERSITY OF IOWA

Please contact the appropriate department to express your specific interest:ANATOMY- Dr. Joe Dan Coulter, Professor and Head, Bowen Science Building.ANESTHESIA John H. Tinker, M.D., Professor and Head.BIOCHEMISTRY Alan G. Goodridge, Bowen Science Building.DERMATOLOGY -John S. Strauss, M.D., Professor and Head; or Kenzo Sato, M.D., Associate Professor;

Boyd Tower, General Hospital. A postdoctoral research associate for the study of electrophysiology ofcultured cells.

INTERNAL MEDICINE -Openings available in all disciplines in the Intemal Medicine Department, Collegeof Medicine, University of Iowa. Contact Francois M. Abboud, M.D., Professor and Head; or DarrisGoerdt, Administrator. Phone (319) 256-2850.

MICROBIOLOGY- Dr. Irving P. Crawford, Professor and Head, Bowen Science Building.NEUROLOGY- Postdoctoral associate positions are available in Cognitive Neuroscience, Neurophysiology,

Neurobiology, Cerebrovascular Disease, Epilepsy, Sleep, and Neuromuscular Diseases. Antonio R.Damasio, M.D., Professor and Head, 2151 Roy Carver Pavilion.

PATHOLOGY Dr. Richard G. Lynch, Professor and Chairman, 144 Medical Laboratories. Research activityin all areas of pathology.

PEDIATRICS -Dr. Frank H. Morriss, Jr., Professor and Head.PHARMACOLOGY Dr. P. Michael Conn, Chairman and Head, Bowen Science Building. Openings available

in all areas of pharmacology and toxicology.PHYSIOLOGY & BIOPHYSICS- Positions available for cellular and molecular research in endocrinology,

neurophysiology and membrane biology. Contact Robert E. Fellows, M.D., Ph.D., Professor and Head,5-660 Bowen Science Building.

RADIATION BIOLOGY- Dr. J. William Osborne, Professor and Director, 14 Medical Laboratories.Biological effects of radiation; environmental carcinogenesis and immunology; free radicals and cancer;cell proliferation in hematological and gastrointestinal systems; and radiation biochemistry of DNA basedamage. Postdoctoral fellows also.

SURGERY- Dr. Robert J. Corry, Professor and Head, Colloton Pavilion. Research opportunities inneuroscience, oncology immunology, and organ transplantation.

UROLOGY-Dr. Richard D. Williams, Professor and Chairman, Carver Pavilion. A postdoctoral position isavailable for physicians interested in the study of immune modulation of genitourinary cancer cells invitro and in animal models.

The College of Medicine, University of Iowa, Iowa City, Iowa 52242, is an Equal Opportunity/AffirmativeAction Employer.

RESEARCH SCIENTISTSHYBRITECH, located in the biotechnologycenter of San Diego, is a recognized leader in theapplication of monoclonal antibody technologyto human health care needs. Several excellentcareer opportunities are available for innovativeresearchers to join our immunodiagnostic prod-uct development team, our newly-formedtherapeutic protein engineering group, or ourmedicinal chemistry department.CHEMISTS/1BIOCHEMISTS - Responsibilitiesinclude participation in a multidisciplinary re-search group devoted to the design, feasibilitytesting and development of new generation im-munoassay systems. Successful candidates willhave a Ph.D. in Chemistry, Biochemistry or Phys-ics with 1-5 years' postdoctoral experience in oneor more of the following areas: solid-phase im-munochemistry chemical modification of pro-teins, instrument applications of immunoassaysor reaction kinetics. Creativity and the ability toeffectively communicate and interact with fellowproject scientists and engineers are essential.Supervisory experience is desirable.MOLECULAR BIOLOGIST/PROTEIN CHEMISTResponsibilities of this scientist will be to predictand model structural/functional changes in pro-teins and analyze these changes in vivo throughsite-directed mutagenesis studies. Essential tothe success of this position are a high degree ofself-motivation and effectiveness in an inter-disciplinary group setting. Requirements in-clude a Ph.D. degree and two years' postdoctoralexperience in protein chemistry and molecularbiology. Additional experience in protein engi-neering, macromolecular physical chemistryand computer modeling are highly desirable.SYNTHETIC/RADIOCHEMIST - Responsibili-ties include the design and synthesis of novelmetal chelating agents to be used to deliverradioisotopes for cancer diagnosis and therapy.This chemist will have an M.S. and 3-5 years' ex-perience or a Ph. D. with up to two years' experi-ence. Candidates must have synthetic experi-ence and familiarity with TLC, HPLC, UV/VIS, IR,NMR and a willingness to work with radio-isotopes. The ability to communicate clearly andto work as a multidisciplinary team member isessential.HYBRITECH offers a stimulating work environ-ment, competitive salaries and excellentcompany-paid benefits. Please send your re-sume to: Human Resources Department,Hybritech Incorporated, P.O. Box 269006,San Diego, CA 92126.

INCORRORATEDAn Equal Opportunity Employer

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Opportunities InBiotechnologyRepligen Corporation is a leader in the applicationof Biotechnology to the health care and personalcare markets. We are currently developing an AIDSvaccine and AIDS therapeutic products, productsfor the treatment of infectious diseases, cancertherapies and novel biocompatible personal careproducts. We take pride in the high caliber of ourscientific staff and our collaborations with majorresearch institutions and corporate partners inEurope and the United States. The expansion of ourefforts has created the following opportunities:

Protein ChemistryResearch Scientist (A1003-4) Ph.D. with 2-4 yearspostdoctoral experience. We are seeking a creativeindividual to lead protein structure-function projectsin the area of retroviral infection and immuno-modulation. Experience with physical methods ofprotein characterization and computer modeling ofprotein structure is required. The successful candi-date will have a proven record of creative researchand accomplishment.

ProcessDevelopmentResearch Associate (R1006-2) B.S./M.S. inBiology Chemistry or related science with 1-3 yearsof experience in protein purification. FPLC experi-ence preferred but not required.

Quality AssuranceQuality Control Analysts (R3001-2) B.S./M.S. InBiological Sciences. Two highly motivated indi-viduals are needed, one with a background inmicrobiology, and the other in immunology.Experience with ELISAS, HPLC, or in a QC labis a plus.

Bio-OrganicChemistrySynthetic Organic Chemist (A1007-2) B.S./M.S. inOrganic Chemistry. The successful candidate willhave demonstrated skills in the synthesis of bio-organic molecules and/or polymers. Biologicalbackground is a plus.

Repligen Corporation offers a competitive salary,excellent benefits and equity participation. Pleasesubmit a cover letter, resume and references toBarbara Fleming, Recruiter, Repligen Corpora-tion, One Kendall Square, Bldg. 700, Cambridge,MA 02139. (Please refer to job code when applying).An Equal Opportunity Employer.

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jCellular

l ImmunologistM.D. or Ph.D. wanted to join immunolo-gy group studying human autoimmu-nity. Position is full time research atjunior staff level. Experience with cellsorting, B cell closing and B cellphenotyping required.

Molecular BiologistM.D. or Ph.D. wanted to establishmolecular genetics laboratory with im-munology group studying human au-toimmunity. Specific interest in thestudy of immunoglobin genes re-quired. Position is full time research atjunior staff level.For confidential consideration,please submit resume to:Vincent Agnello, M.D.Department of Laboratory MedicineLahey Clinic Medical Center41 Mall RoadBurlington, MA 01805

The Department of Drug Metabolism of Smith Kline & French Laborato-ries, located in suburban Phibdelphia, PA, is seeking qualified ai-cants to join a collborve and ex ding Bi n l ReseahGroup. The successful candidate will: operate and maintain a triplestage quadrupole mass spectrometer dedicated to thenmospray LC/MSanalysis of drug metabolites, interpret and report mass spectrl data,particpate in metabolite isolation and chracterization studies, and par-ticipate in basic research progams in drug development.Candidate qualifications will include:* B.S. or M.S. in Chemistry, Anablcal Chemistry or related area plus

1-3 years experience in analytical mass spectrometry.* Demonstrated experience with the daily operation and maintenance

of quadrupole mass spectrometers. Expenence with LC/MS and LC/Ms analysis of drug metabolites in biological fluids and interpretationof mass spectral data are preferred.

* Knowledge of chemical Pathways of biotransformation of xenobioticsand isolation of meabolites by HPLC methods desiable.

* Proven research abilt as evidenced by scientific publications pre-ferred.

* Excelent communication and interpersonal skills required.We offer an excelent compensation, benefits and relocation package aswel as opportunities for personal and professional growth. For confiden-tial consideration, please forward your resume and the names of threereferences to Ms. Angela Varrichio, Associate Employment Administra-tor, V0033, SK&F Laboratories, P.O. Box 1539, King of Prussia, PA19406-0939. We are an equal opportuni employer, M/F/H/V.

ORGANON TEKNIKA CORPORATION is a leader in bio-medical research and application. Our research and productdevelopment efforts pioneer new advances in the develop-ment of diagnostic and therapeutic products. Our continuedgrowth creates an immediate opportunity for a

PROJECT LEADERBLOOD BANKING/

IMMUNOHEM IILOGYYou will serve as scientific leader of research projectsleading to novel and state-of-the-art blood banking reagentsand technologies. You will plan, direct, and conduct alltechnical activities required to accomplished project goals.The successful candidate will have a Ph.D. in immunologyand at least five years experience conducting research inserology, including cell surface antigens. Experience inmedical diagnostics and blood banking technologies andreagents is preferred.ORGANON TEKNIKA CORPORATION offers a competitivecompensation package which includes dental insuranceand an attractive 401 (K) Savings Program. Qualifiedapplicants please send resume and salary history to:

Human Resources Department

ORGnnDn TEHNNIHA

P.O. Box 13867, Research Triangle Park, N.C. 27709An Equal Opportunity Employer P1/F/V/H (No Agency Referrals or Phone Calls Please)

BUILDING ANEW LAB?

LET THE SCIENCE FREE PRODUCTINFORMATION SERVICE PUT YOU INTOUCH WITH THE VENDORS WHOSEPRODUCTS YOU WILL NEED.

SIMPLY WRITE US A LETTER STATINGTHE SPECIFICS ABOUT YOUR PROPOSEDLAB AND WE WILL DO THE REST.

WRITE TO:

SCIENCE MAGAZINENEW LAB SERVICE DEPT.1I515 BROADWAYNEW YORK, N.Y. 10036

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Drug Delivery

The Department of Drug Delivery at Eastman Phar-maceuticals, a new division of Eastman Kodak Com-pany, is conducting research directed toward develop-ing parenteral polymeric drug delivery systems andorally active drugs including peptides. Several posi-tions are available for motivated and highly qualifiedscientists with the abilities to make significant con-tributions to the research efforts.

PARENTERAL DRUG DELIVERY,POLYMER-PROTEIN INTERACTIONSPositions involve: Quantifying and kineticallycharacterizing the adsorption of proteins ontopolymeric nanoparticulates; determining the confor-mational orientation of adsorbed proteins; identifyingpolymer surface characteristics responsible for adsor-bing proteins and developing polymers that do notadsorb proteins; and developing methods to covalent-ly link proteins to polymer surfaces.

SENIOR RESEARCH SCIENIlST - Requires a Ph.D.in Polymer Sciences or Protein Chemisty or equivalentwith 1-5 years postdoctoral experience in pro-tein/biomembrane/polymer interactions; experiencewith techniques for the isolation and identification ofproteins, spec copic techniques and their applicationfor studying membrane interactions and characteriza-tion of adsorption phenomena is essential; scientificpublications demonstrating innovative approaches to thestudy of surface interactions are requirec (When respon-ding to this advertisement refer to Position A.)

RESEARCH SCIENTIST - Requires a BS or MS inBiochemiry or equivalent with 3-5 years experience inthe isolation and identification of proteins, experiencewith chromatographic techniques is required; ex-perience with protein-polymer interaction studies, ad-sorption phenomena and photon correlation spec-btscopy is desirable. (hen responding to this advertise-ment refer to Position B)

PARENTERAL DRUG DELIVERY,IV ViTRO MODELINGPositions involve: Establishing and validating cellculture lines and utilizing them to evaluate theassociation or uptake of polymeric based drugdelivery systems; developing methods to study the invitro biodegradation/bioerosion of polymeric baseddrug delivery systems; and identifying targeting vec-tors that influence the cellular association ofpolymeric based drug delivery systems.

SENIOR RESEARCH SCIENTST - Requires a Ph.D.in Biochemity or Biology or equivalent with 1-5 yearspostdoctoral experience in in vitro cell modeling ofdisease states experience with isolation and studies withmacrophages and neutrophils, cell membrane ransportphenomena and biomembrane interactions is essential;experience characterizing the biodegradation/bioero-sion of polymeric microparticulates in vitro is desirable;scientific publications demonstrating innovative ap-proaches to studying the uptake of materials by cell arerequired. (When responding to this advertisement referto Position C.)

RESEARCH SCIENTIST - Requires a BS or MS inBiochemistry or equivalent with 3-5 years experiencein tissue and cell culture; experience with isolationand studies with macrophages and neutrophils, andbiomembrane-polymer interactions is desirable.(When responding to this advertisement refer to Posi-tion D.)

ORAL DELIVERY, IN VITRO MODELING

Positions involve: establishing and validating in vitromethods to study GI tract transepithelial transport,digestion and metabolism of drugs; characterizing theluminal and brush border enzyme systems limitingavailability of drugs; identifying optimum sites in theGI tract for delivery of drugs; and developing ap-proaches to enhance the bioavailability of peptides.

SENIOR RESEARCH SCIENTIST - Requires a Ph.D.in Physiology or Pharmaceutics or equivalent, with1-5 years post doctoral experience in the transport ofmolecules across isolated epithelial tissue; experiencein the isolation and identification of peptides, drugsand their metabolites, transport phenomena andmembrane structure and enzyme kinetics is essential;scientific publications that demonstrate innovative ap-proaches to studying the transport of materials acrossmembranes are required. (When responding to thisadvertisement refer to Position E.)The positions offer competitive salaries and a fullrange of benefits together with outstanding oppor-tunities for personal and professional growth. For con-fidential consideration please send your resume withsalary history/requirements and the names of threereferences to Personnel Relations, DepartmentPDDD, Eastman Pharmaceutials, 9 Great ValleyParkway, Great Valleyq PA 19355. We are an equalopportunity employer M/F/H/V.

Eastman PharmaceuticalsA Division of Eastman Kodak Company

POSITIONS OPEN

EDUIOR (CHEMISIRY/MATH)Chicag-based multi-national publishing company

seeks an expeienced editor to review, evaluate, an editarticls in te fields of chemistry and related sciences andmathematics. The successful candidate will have a collegedegree in chemistry, or in mathematics with a strongchemistry minor, and a minimum of 2 years of editinFecperience, preferable with reference or academiic publi-cations.We offer a compcensation and benefits

packge. Please forward your resume and salary historym confidence to: Box 96, SCIENCE.

ELBCTRON MICROSCOPISTSENIOR RESEARCH SPECIALISTHoward Hughes Medical Institute

Department of BiochemityUniversity of California Bereley (UCB)

A qualified electron microscopist is sought for a long-term senior research specialist position, available imeiately, to work in conjunction with our laboratory'sstudies on the molecular genetics of neuronal develop-ment in the embryo ofthe fiuit fly Drosophila melanogaster.Opportunity to use EM in collaboration with otherlaboratory members studying the mechanisms control-ling cell fate and cell reconiton durng neuronal deve-opment. Qualified candidates should have extensiveexperience with ultrastutural studies and be comfort-able in thercparation of serial section electron micro-graphs and/or mununo-EM. Salary based upon experi-ence. Send letter of interest, currculum vitae, and namesof three refcrences to: Professor Corey S. G nHHMI Invesigtor Department of BiolemityUniveity of California, Berl, CA 94720. HHMIand U.C.B. are Equal Opponunity/AJlmive Action Em-ployers.

BROWN UNIVERSITYEVOLETIONARY MORPHOLOGIST

The Division ofBiology and Medicine plans to make asenior appomtmcnt (associate professor or professor), totaiedfit for the 1989 to 1990 academic year. Theappointee is expected to assume leadership in teachinaanatomy to medical students in the Progam in Medi-cine, establish an cxternally supported research proamin vertebrate evolutionary morphology at the organismallevel, and serve as a member of the Graduate Progam inEcology and Evolutionary Biology. The appointee willalso lead the scarch to fil two junior faculty positions.Responsibilities indude organizing and tea thecourse in human anatomy, teaching a course in a special-ty area, and academic advising ofstudents. Opportunitiesexist for interaction with programs in biomechanics,applied mathematics, paleoecology, and a widc range ofbiological and dinical areas. Applicants should submit aresunm induding teaching and research expericnce, plansfor teachin* medical anatomy, future rsearch plans, a listof publications and representative reprints, and arrangeto have three letters ofrefcrence sent, all to be received by15 October 1988, to: Dean Frank G. Rotman Divi-sion of Biology and Medicine, Brown Unversity,Providence, RI 02912. An Equal Opportunity/AfirmativeAction Employer.

FACULTY POSMIIONIN MICROBIOLOGY

The Institute ofMicrobiology, at the Hebrew Univer-sity Medical School, is currentiy recruiting individualswith teaching and research expertise in either ofthe twoareas:

(a) Medical Bacteriology(b) Microbial Physiology

Preference will be given to candidates with researchinterests directed toward basic molecular mechani-rus ir.their field of specialization.The positions are tenure-track appointments at any

rank.Interested individuals should send curriculum vitae

including a brief description of research experience andplans, and a list of three referees, before 1 DecemberT988, to: Ms. Ditza Gordon, Secretary of SearchCm ittee, Institute of Microbiology, the HebrewUniversity, Hadasah Medical School, P.O.B. 1172,Jeualm, 91010, IsraeL

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If you're ready to make a lasting con-tribution, build a career with ProgramResources, Inc. at the NationalCancer Institute's Frederick CancerResearch Center. Right now, wehave opportunities for researchersexperienced in molecular biologyand x-ray crystallography to supportc igoing studies on protein-DNAinteractions.Using chemically synthesized DNA,you will survey crystallization condi-tions; isolate repressor-operator ortranscription-activator DNA co-

crystals suitable for x-ray diffractionanalysis; and collect and analyzedata by crystallographic methods toobtain structure of protein-DNAcomplex at high resolution. By sitedirected mutagenesis will mutate arepressor or transcription-activatorand study their interactions with DNAusing computer graphics to elucidatefactors important in the sequencerecognition by proteins.You must have a PhD with workingexperience in molecular biology,biochemistry, or x-ray crystallo-graphy. These roles are one-yearappointments subject to renewal.PRI offers a salary commensuratewith credentials plus an attractivefringe benefits program includinginsurances, relocation allowance,and a 401 (k) savings plan. For con-sideration, please forward CV in con-fidence to:Barbara Norton-GillTechnical RecruiterProgram Resources, Inc.NCI-FCRFBldg. 244, P.O. Box BFrederick, MD 21701

PROGRAMRESOURCES,INC.An equal opportunity employer.

Division of Oncology, Dept. ResearchUniversity Hospital, Basle, Switzerland

POSTDOCTORAL POSITIONAvailable for a biochemist. Appli-cants with experience in molecularimmunology are invited to join aresearch group investigating the cel-lular interaction of macrophageswith tumor cells in vitro and ex vivo.The project is concerned with theisolation, structural and functionalanalysis of macrophage membraneglycoproteins.

The post is available as soon aspossible for a period of up to threeyears.

Applications including a curriculumvitae and publication list should besent to PD Dr. R. Obrist, Division ofOncology, Dept. of Internal Medi-cine, Kantonsspital, 4031 Basel,Switzerland.

Genelabs, a progressive biotechnologycompany in the San Francisco Bay Area,has the following opportunity:MANAGER PROTIN

BIOCHEMISTlRYA Ph.D. in biochemistry or a related scien-tific discipline with 5-8 years researchexperience, some in an industrial setting,plus 2-3 of those years managing orsupervising fellow scientists will qualifyyou to lead a group of biochemists/pro-tein chemists at Genelabs. You will alsointeract closely with scientists in phar-maceutical development.The ideal candidate will have hands-onexperience in protein or peptide purifica-tion and primary structural analysis andbe current with modern techniques inprotein biochemistry and analyticalmethods. Excellent oral and writtencommunication skills and experience inan entrepreneurial environment aredefinitely desirable.Our work environment is exceptional inour expanding facilities located in theSeaport Centre on the San FranciscoPeninsula. Please forward CV and namesof 3 references in confidence to:GENELABS INCORPORATED, 505Penobscot Dr., Redwood City CA 94063.Attn: Human Resources. EOE.

G E N E LA B SI N C 0 R P 0 R A T Ei D

SCIENTISTS

Senior Scienust I-__ * -.

Molecular BiologistGene Expression/Development

At The Upjohn Company, our research and developmenteffort has three goals: to maximize use of criticaltechnology resources; to increase continuity and speedof drug development; and to make the most effective useof our external resources. Upjohn's continued success inthe discovery, manufacturing and marketing of phar-maceuticals depends upon the scientific talent in ourlaboratories.An expanded research program in our HairgrowthResearch Group has created an immediate need for amolecular biologist to conceive and conduct research asa member of multidisciplinary team studying the regula-tion of gene expression during epithelial proliferation anddifferentiation and epithelial-mesenchymal interaction.The successful candidate will have a Ph.D. degree plusa minimum of two years of post-doctoral experience andhave a comprehensive knowledge of recombinant DNAtechnology. The candidate will define and carry out in-

dependent projects of their own design and will be ex-pected to publish and present data at national and inter-national meetings. Collaboration with other scientistswithin and outside the company is expected. Prior ex-posure to skin and hair biology and/or epithelial differen-tiation is desirable, however, candidates applyingmolecular techniques in the study of related developmen-tal systems are also encouraged to apply.We are located in Kalamazoo, a mid-sized community insouthwestern Michigan, midway between Chicago andDetroit. Upjohn offers advancement opportunities, an ex-cellent salary, comprehensive benefits and relocationassistance. For confidential consideration, please call fromoutside of Michigan toll free 1/800/253-8600, ext. 3-6767,(inside Michigan call collect 616/323-6767) to request anemployment application be sent. Please refer to adver-tisement number 21944-HA when calling. An EqualOpportunity Employer M/F.

Our Commitment to ScientificExcellence Continues ...

PESTICIDE CHEMIST ANDDATA MANAGERThe Geochemical and Environmental Research Group (GERG)in the Department of Oceanography at Texas A&M Universityhas two positions available. Both positions require a Ph.D.Competitive salanes commensurate with experience will beoffered. Active participation in research programs and strongpublication record are expected. GERG is a self-supportingresearch group specializing in environmental chemistry;petroleum geochemistry; organic geochemistry; and marinechemistry and biology. The GERG organization has more than50 personnel including twelve Ph.D.'s with annual fundingexceeding $4 million from a variety of governmental andprivate sources.

The Pesticide Chemist position requires experience with allphases of environmental pesticide analyses includingextraction, purification, quantitation (GC/ECD) and QA/QC.GERG's analytical laboratory includes 12 GC's, 4 GC/MS'sand 3 LC's. All analytical and laboratory managementsystems are computer based. Experience in a broad range ofenvironmental analyses is preferred as well as experiencewith EPA QAIQC procedures. GERG would prefer an applicantwith 2-4 years of contract and management experience pastthe Ph.D. Refer to job #8800487.The Data Management position requires management ofGERG's data bases, interaction with governmental contractorsand development of laboratory software and hardware.Although the person will act as GERG's Data Manager onlarge environmental projects, GERG would prefer a candidatethat would also panicipate scientifically in funded research.Experience with statistics and environmental experimentaldesign as well as a background in one of the basic sciencesis expected. GERG will try to fill this position with a Ph.D. incomputer science or statistics. However, applicants with aPh.D. in Oceanography or other applied sciences withcomputer and data management experience will beconsidered. Refer to job #8800486.Submit resume to: Employment Manager, Texas A&MUniversity, Personnel Department, YMCA Bldg.,College Station, TX 77843-1255.

ANAFFIRMATIVE ACTIONEOUAL OPPORTUNITY EMPLOYER

Sandoz Pharmaceuticals Corporation is a leader in immunotherapy products that im-prove the quality of life. Our developments are the result of research conducted byprofessionals who specialz in many different fields.

The Sandoz Research Institute is currently seeking an experienced immunologist toplay a vital role in research on therapeutic applcations of monoclonal antibodies.Our position offers a unique opportunity for an innovative, self-motivated, indepen-dent scientist to develop products for diverse areas like immunoregulation and infec-tious and tumor diseases. The successful candidate will work dosely within aninter-disciplinary research team of molecular biologists, immunologists, biochemistsand cei biologists.The requirements of the position indude:* Ph.D. or equivalent, and at least two years' post-doctoral experience, inimmunology or related discipline.

* Record of significt publications in major scientific journals.Pbsitions at Sandoz offer personal satisfaction, professional opportunity/challenge,competitive salaries and an excellent benefts package. Our campus-like facilitiesare conveniently located in northern New Jersey.For prompt consideration, please forward your resume with salary requirements inconfidence to: Director of Human Resources, SANDOZ RESEARCH INSTITUTE,SANDOZ PHARMACEUTICALS CORPORATION, East Hanover, New Jersey07936.

ASANDOZbringing resarch to life

An Equal Opportunity Employer M/F/H/V

POSITIONS OPEN

FISHERIES ASSISTANT PROFESSORSHIP,non-tenure-track, 3-year duration. Responsibilities:teaching one course in fishenes and wildlife managementand conducting research in fisheries ecology/manage-ment. Ph.D. in fisheries or related field at time ofappointment. Send statement of interest, resum6, tran-scripts, and three letters of reconmmndation to: IraAdelman, DeIpartent of Fisheries and Wildlife,1980 Fohweil Avenue, St. Paul, MN 55108, by 5 July1988.

The University of Minnesota is an Equal OpportunityEducator and Employer and specifically invites and encouragesapplicationsfrom women and minorities.

THE CENTER FOR BLOOD RESEARCHHARVARD MEDICAL SCHOOLFLOW CYTOMETRY OPERATOR

Position available to run a new core flow cytometryand sorting facility using the most up-to-date CoulterEpics, lasers and computer interfaces. Previous experi-ence desired. Competitive salary and generous benefits.Please send r6sumi to: Dr. Timothy Springer, TheCenter for Blood Research, 800 Huntington Avenue,Boston, MA 02115. Equal Opportunity Employer.

IMMUNOLOGIST with special interest in macro-phage function needed fur development of researchprogram in the subdivision of Hepatology at RhodeIsland Hospital, Providence, Rhode Island. Candidatemust have a Ph.D. in related area of cell biology andqualify for appointment as an assistant professor ofmedicine at Brown University. Candidate should haveexperience with immunologic, electrophoretic, cell cul-ture, and molecular biologic techniques. Experience withevaluation of macrophage function including monokineproduction is desirabl. The individual is expected todevelop an indepndent research program in an arearelated to the interaction between liver and tumor cells.Send letter ofapplication and curriculum vitae to: HenryBodenheimer, M.D., Dirmtor, Subdivision of Hepa-tology, Rhodc Island Hospital, 593 Eddy Steet,Providence, RI 02902. Letters are to be received nolater than 22 July 1988. The Rhode Island Hospital is an

Equal Opportunity/Afirmative Action Employer.

MOLECULAR PARASITOLOGISTThe Department of Microbiology, Immunology and

Parasitology, New York State College of VcterinaryMedicinc, secks candidates for a tenure-track position asassistant professor of parasitology. Appointment at ahigher level may be possible for an exceptional candidate.The successful applicant will be expected to develop anindependent, competitively funded research program fu-

cusing on an animal parasite system and to teach veteri-nary and graduate students. Applicants should have aPh.D., D.V.M./Ph.D. or equivalent. Experience in mo-lecular parasitology and training at the postdoctoral levelisrequired. This position is part of a major commitmentby the department to apply molecular approaches toinfectious disease research.

Applications including curriculum vitae and the namesand addresses of three referees should be sent to: Dr.Roger J. Avry, Chairman, Department ofMicrobiol-ogy, Immunology and Parasitology, NYS College ofVeterinary Medacine, 616 Veterinary Research Tow-er, Cornell Uniity, Ithaca, NY 14853-6401, by 5July 1988. Telephone inquiies will be welcomed 607-

253-3400.Comell University is an Equal Opportunity/Affirmative

Action Employer/Educator.

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POSITIONS OPEN

INDUSIIAL WASTE SPECIALIST

Sacramento County, California is now accepting appli-cations. The position provides technical and professionaladvice in the analysis and evaluation of industrial dis-charges to the Sacramento Regional Sanitation District.B.S. degree and/or experience required. Fiscal year 1987to 1988 monthly salary: $2777 to $3376. Applicationsand application supplements must be obtained from:The Sacramento County Employment Office, 710 'T'

Street, Sacramento, CA 98814. Completed applica-tions and application supplements must be received bythe Employment Office no later than 5:00 p.m., 5 July1988. Telephone: 916-440-5593. Affimative Action!Equal Opportunity Employer.

MEDICAL OFFICERSDHHS-PHS-FDA

NATIONAL CENTER FORTOXICOLOGICAL RESEARCHJEFFERSON, ARKANSAS 72079

NCIR is a nationally recognized research center andmajor operating component of the Departmcnt ofHealth and Human Services, Public Health Service,Food and Drug Administrtion. Its mission is to conductresearch in such basic disciplines as pharmacology, physi-ology, biochemistry, microbiology, toxicology and bio-logical modeling, to gain a more thorough understand-ing of the risks posed to human health by exposure totoxic chemicals. 'he incumbents will serve as medicalofficers in the Human Risk Assessment Division.The Human Risk Assessment Division has been estab-

lished to explore in detail the assumptions underlyingrisk assessment with special emphasis on the incorpo-ration ofhuman biology. Physicians with special interestin risk assessment in reproductive toxicology, inmuno-

toxicology, pulmonary toxicology, developmental toxi-

cology, carcnogenesis, or toxicit to other organs are

especially encouraged to apply.These positions are permanent career-conditional ap-

pointments made competitively through the U.S. Officeof Personnel Management; PHS Commissioned CorpsOfficers are also encouraged to apply. Salary ranges from$48,000 to $67,000, plus physican comparability allow-ances depending on qualifications. Excellent benefitspackage induded. Doctor ofMedicine degree from U.S.or Canada or foreign medical school (properly certifiedby ECEMG) is required.

Association with the University ofArkansas for Medi-cal Sciences is encouraged.Send curriculum vitae, resume of research and clinical

interests and list ofthree references to: Dick King, FDA/NCTR, Personnel Office, Jefferson, AR 72079. Fortelephone inquiries, call: Mr. King or Ms. Hutchinson,

AC 501-541-4475 or 541-4505. DHHS-PHS-FDA isan Equal Opportunity Employer.

TWO MOLECULAR BIOLOGISTS to join well-funded laboratory to study complement killin of tumorcells. One position requires strong backgound in molec-ular cloning. The other position requires experience withtissue culture and protein chemistry. Salary is competi-tive and depends on experience. For applicants with priorpostdoctoral experience, appointment as research assist-ant professor possible. Positions available immediately.Submit application to: Dr. Carl-Wilhelm Voel, De-

partment of Biochemistry, Gooretown Unversity

3900 Reservoir Road, NW, Washington, DC 20007.

Equal Opportunity/Affirmative Action Employer.

MOLECULAR GENETICIST/BIOLOGISr. Ad-vanced Genetic Sciences (AGS), a company exploring theapplication ofmodem biotechnology to agriculture, hasa postdoctoral or research scientist position open in theplant genetics department to further develop plant trans-posable elements as gene isolation tools. The successfulcandidate will be responsible for optimizing maize trans-poson systems in tobacco and applying them to isolateuseful genes from Arabidopsis. Applicants should be expc-riencedin recombinant DNA techniques. A workingknowkdge of bacterial plasmid manipulations and Agro-bacterium-mediated transformation is highly desirable.Salary and position title will depend on qualifications andexperience. Please send curriculum vitae and three lettersofreference to: Dr. Hugo Dooner, Advanced GeneticSciences, 6701 San Pablo Avenue, Oakland, CA94608.

POSITIONS OPEN

MOLECULAR VIROLOGIST. The Section ofComparative Medicine, Yale University School ofMedi-cine, invites applications for an assistant professorshiCandidates should be enthusiastic about pursuing the

biology of rodent viruses induding mechanisms control-ling duration and spread of infection. An interest in thedevelopment ofmolecular diagnostic reagents for animalviruses is highly desirable. Please send curriculum vitaeto: Dr. Abl L. Smith, Section of ComparativeMedicine, Yale Univity School of Medicine, 333Cedar Street, P.O. Box 3333, New Haven, CT 06510by 15 July 1988. Yale University is an Afinnative Action!Equal Opportunity Employer. Women and minorities are en-couraged to apply.

POSTDOCTORAL-Development of micron-sizedfiber optic sensors for remote measurement of biochemi-cal environments. Experience in thin film polymer chem-istry highly desirable, but not required. New technology,potential wide applications, work in interdisciplinaryresearch program. Full details at 307-766-5353. Twoyears. Salary: $24,000. Screening begins 15 July 1988.Curriculum vitae and three recommendations to: D.Buttry, University ofWyoming, Box 3838, Laramie,WY 82071-3838. Equal Opportunity/Afirnative ActionEmployer.

POSTDOCTORAL FELLOW. Position availableimmediately for a Ph.D. or M.D. with training in cellularimmunology to characterize immunologic alterationsinduced by thermal injury. Salary range: $22,000 to$27,000, based on experience. U.S. citizenship or perma-nent residence required. Send curriculum vitae andnames of three references to: Dr. Ann Bjornson, Direc-tor, Division ofImmunology, James N. Gamble Insti-tute of Medical R ch, 2141 Auburn Avenuc,Cincinnati, OH 45219. Affirmative Action/Equal Oppor-tunity Employer.

POSTDOCTORAL FELLOW/RESEARCH AS-SOCIATE POSMON in neuronal transplantation andregeneration studies involving the mammalian visualsystem with particular emphasis on photoreceptor cellrescue in dystrophic animal models. A 2-year positionwith an option for an additional year will be availableduring June to September 1988 for a candidate who hasextensive training in retinal research with particularemphasis in neuroanatomical and immunohistochemicaltechniques at the light and electron microscopic levels.Starting date and salary negotiable. Send curriculumvitae and names of three reterences to: Dr. James E.

Turner, Department of Anatomy, Bowman GraySchool of Medicine, Wake Forest University, 300South Hawthorne Road, Winston-Salem, NC27103. Affirmative Action/Equal Opportunity Employer.

POSTDOCTORALOPPORTUNITES

IN NEUROSCIENCEHoward Hughes Medical Institute, one of America's

leading medical research organizations, in conjunctionwith Johns Hopkins University School of Medicine, hastwo positions available to study the regulation of thenicotinic acetylcholine receptor ion channel by proteinphosphorylation.The two projects involve: (i) the study of the effect of

protein phosphorylation on the singie channel kinetics ofthe receptor by patch clamp recording from reconstitutedliposomes containing purified receptor as well as fromoocytes injected with normal and mutant roceptormRNAs. And (ii) the study of the regulation oftyrosinephosphorylation ofthe nicotinic acetylcholine receptor in

muscle ces in culture.Individuals are sought who have experience in electro-

physiology or biochemistry. Send curriculum vitae andthree letters of reference to:

Dr. Richard L. HuanrHoward Hughes Medical Institute

Department of NeuroscienceJohns Hopkins Univity School of Medicine725 North Wolfe Stret, Room 818 PCTB

Baltimore, MD 21205An Equal Opportunity/Afirmative Action Employer.

SCIENCE, VOL. 240

HISTOLOGISTThe American University of the Caribbean,

School ofMedicine (AUC), located in Montser-rat, British West Indies, soeks a histologist toprovide instruction to first year medical students.Excellent salary, benefits, and many recreationalopportunities. One year or permanent full-timeappointments available. Join AUC now for anadventure ofa lifetime. Send resume to: MedicalEducation Office(S), 2801 Ponce de LeonBoulevard, #800, Miami, FL 33134.

POSITIONS OPEN

POSTDOCTORAL FELLOW/RESEARCH AS-SOCIATE position available Scptember 1988 to study(i) novel genes controlling growth of hepatocytes, and(ii) mechanisms by which insulin and other growthfactors stimulate hepatic growth. Requires expeiencewith a varicty of molecular biologic techniques. Salaryguaranteed. Send curriculum vitae and names of threereferences to: Dr. Rebecca A. Taub, Department ofHuman Genetics, Universty of Pennsyvhnia SchoolofModicine, Philadelphia, PA 19104-6072.

POSTDOCTORAL FELLOWSHIP to study theproduction of singlet oxygen in biological systems by

near-infrared emission spectoscopy and to studysingit oxygen production in biological systems exposedtoght and photosensitizers. Applicant should have aPh.D.in biocheniistry, biophysics or dosely related arca.Send curriculum vitac and ist ofrefeences to: Jef ReKanofky, M.D., Ph.D. S nctio of Hematology/On-cology Loyola University Stritch School of M

vue, Maywood, IL 60153.

POSDOICTORAL FELLOWSHIP/RESEARCHASSOCIATE. Several funded positions are available ina study of molecular mechanisms ofhost defense systemswith appointments at the postdoctoral or asso-ciate leve. Research areas include (i) doning, sucture-function studies and biological Properties of a newlyrecogized up of cndotoxin binding proteins, (ii)reguation ofTNF genc cxpression and (ii) the role ofTNF and other cytokines in inflammation. Expertse inmolecular biology, protein cheit or lycolipid/lipidchemistry is desirab. Send carrculum vitae and namesof three references to: Richard J. Ukevitch, Ph.D. orPeter S. Tobias, Ph.D., Research Institute of ScrippsClinic, IMM 12,10666 North Torrey Pines lRoad,aJolla, CA 92037.

POSTDOCTORAL POSMONCHEMISTRY/BIOLOGY

Los Alamos National Laboratory is seeking postdoc-toral candidates to participate in a project to design andsynthesize novel fluorescent probes and apply theseprobes to problems in cellular and molecular biology.The successful canddate should have cxperience or inter-est in several of the folowing areas: (i) oanic and/orbiochemical synthesis of fluorescent molecules; (ii) hor-monal regulation of cell function; (iii) chromosome andnudeic acid labeling; (iv) biophysical measurements in-duding flow cytometry and sorting, cell imaging, andfluorescence microscopy. The candidate should havereceived a Ph.D. in chemistry, biochemistry, cell biology,molecular biology or related fidd within the past 3 years.For more information on the research project, contactonc of the principal investigators: Babetta Marrone,505-667-3279; Clifford Unkcfer, 505-665-2560;Thomas Whaley, 505-667-2765.

This poesition ofirs the opportunity to intcract with amultidisciplinary team of scientists and utilized state-of-the-art facilities in chemistry and biology. The Biosci-cnces Program at Los Alamos National Laboratory in-dudes the National Flow Cytometry Resource, the Hu-man Gcnome Program, and the Stable Isotopes Re-sourcc.

Postdoctoral appointmcnts arc for 1 year, renewablefor a second year, and salaries range from $32,820 to$34,580 per year. Appointecs receivc employec benefits,induding incoming travel and moving expenses.To formally apply, plcase send r6sum,employment

application, three letters of reference, and praduatc andundergraduate transcripts to: Carol MA Rich, HumanR rces Development Division PD-88-027, LosAlamos National Laboratoy, Los Alamos, NM87545. Los Alamos National Laboratory is an AfirmativeAction/Equal Opportunity Employer.

GLYCOPROTEIN/CARBOHYDRATEBIOCHEMIST

Postdoctoral position available immediately, for aPh.D. trained in glycoprotein and/or carbohydrate bio-chemistry to study the role of glycoprotein oligosaccha-rides in membrane assembly. Must have expcnence inHPLC and column chromatography ofproteins/pcptidesand carbohydrates. Salary range negotiable. Scnd curric-ulum vitae and names of dtree refirences to: Dr. StevenFliesler, Bethesda Eye Institute, St. Louis UniversitySchool of Medicne, 3655 Visa Avenue, St Louis,MO 63110.

ONE DISCOVERYDESERVES ANOTHER

Boehrlnger Mannheim is a leader in Medical Diagnostics, Biochemicals,and Medical Research This leadership has been attained through

emphasis on quality and team effort. We are continuing our expansionand growth throughout 1988, and are seeking those talented individuals

looking for a dynamic, progressive orgamiation which offers thepotential to turn aspirations into reality.

*CHEMISTRYrClinical Biochemistry Organic

Polymer Protein Analytical

*BIOLOGICAL SCIENCES*Cell Molecular-Probe Technology Micro

* TESTDEVELOPMENT§

*ENGINEERING*

Mechanical Software ElectricalElectro Optical Chemical

*APPLIED MATHEMATICS*

*MARKETRESEARCH*

At Boehringer Mannheim, we offer an exciting and challengingenvironment as well as an excellent compensation and benefit program.

We invite you to send your resume with salary history, for confidentialconsideration to. Dept SCI, Human Resources, BOEHRINGER

MANNHEIM, P0. Box 50100, 9115 Hague Road, Indianapois, IN 4 0.

We are an equal opportunity employer.

BOEHRINGERMANNHEIM

PERSONNEL PLACEMENT 1565

;..;.;..U..

IO JUNE I988

POST-DOCTORALFELLOWSHHIP

Merck Sharp & Dohme Research Laboratories is offer-ing a Post-Doctoral Fellowship position to study themolecular biology of the components Involved in theblood coagulation cascade. Specifically, the studieswill focus on the molecular aspects of factor VIl/tissuefactor interactions. The use of site specific muta-genesis and all aspects of molecular biology, includingDNA library construction, screening and characteriza-tion as well as heterologous expression in mammalianand bacterial cells is required.You will find a stimulating and challenging scientificenvironment within our labs as well as an excellent op-portunity to carry out meaningful research and publish.Excellent salary and benefit programs accompany thisposition at our modern research facilities located 25miles northwest of Philadelphia.

Please send resume with salary requirements to:

Manager, Research PersonnelW42-2

Merck Sharp & DohmeResearch Laboratories

West Point, PA 19486EEOIAA/VH/Employer )

* BIQENGINEER

* PROCESSDEVELOPMENT

SCIENTISTApplled bioTechnology Is a growing

company speclallzing in:*genetically engineered vaccines for the

veterinary and human markets*novel products for cancer diagnostics andtherapeutics based on oncogene technologyWe are currently developing a pilot plant operation

and have opportunities available In the establishmentof our Fermentation and Separations capabilities.Key responsibilities will include Scale-up, ProcessDevelopment, Optimization, and Production of

clinical lots.We are seeking individuals with a BS/MS/PhD in

Biological Engineering or Sciences, with at least 3 yrs.of relevant experience. Demonstrated expertise in

mammalian cell culture preferred.Please submityourresume or curriculum vitae to:

Applied bioTechnology, Inc.80 Rogers Street

Cambridge, MA 02142An equal opportunitv employer rn/f

Syntex, an intemational leader in the pharmaceuticaland health care industry, has an opportunity in ourInstitute of Biological Sciences, Department of Endo-crine Physiology for a:

Staff ResearcherBased in our research headquarters on the SanFrancisco Peninsula, you will characterize novelsomatonstatin analogs in vivo and in vitro. Respon-sibilities include studying receptor interactions at themolecular level and the development of a variety ofanimal models, particularly in the area of diabetes andtumor biology.

To qualify, you must have a PhD in endocrinology or

related field. Coursework in molecular biology and/ordiabetes would be helpful. Other requirements include1-3 years' postdoctoral work and experience in one or

more of the following: radioimmunoassays, HPLC,cell culture and DNA/RNA assays.

Syntex offers a competitive compensation and relocationpackage in campus-like surroundings.For immediate consideration, pleasesend your resume, to: Syntex, Profes-

sional Staffing, Dept. KH/SR, 3401Hillview Ave., Palo Alto, CA 94304.Syntex is an equal opportunityemployer.

UNIVERSITY OF COPENHAGENFACULTY OF NATURAL SCIENCES

Applications are invited for a Chair (Professorship) in GENERAL/MOLECULARPHYSIOLOGY at the Zoophysiological Laboratory B, the August Krogh Institute,from 1 July, 1989.The professor will be appointed as a Civil Servant underthe Ministry of Educationand Research. The annual salary amounts to approximately 360,000 Danishkroner.Candidates are being sought with research interests in the area of ion transportacross biological membranes. The physiology and biochemistry of the cellmembrane is being given high priority in the planning of the direction of futureresearch at the August Krogh Institute. Current research in this field ranges frombiophysical and biochemical characterization of membrane transport systems,and studies of the cellular regulation of membrane transport, to studies ofintegrated transport systems in heterocellular epithelia.In the evaluation of the applicaits, a background in general physiology andbiophysics will be given importance, as will expertise in experimental techniquesin the above mentioned research area. The selected candidate will be expected tointeract with the existing research groups at the August Krogh Institute.

Further information about research planning, facilities, and staff can be obtainedfrom the Chairman of the Zoophysiological Laboratory B, or from the Chairmanof the August Krogh Institute (13 Universitetsparken, DK-2100 Copenhagen 0,Denmark).The Professor will participate in the Department's teaching at all levels. Thelanguage of instruction is Danish, but English will be accepted for the first twoyears of the appointment.Applications should include a current curriculum vitae, a complete list ofpublications, copies of the scientific publications and further documentationwhich the applicant wishes to be considered, and a brief outline of proposedresearch. Information conceming the applicant's teaching experience, which willbe evaluated by the Study Board, should also be enclosed. All material should besubmitted in triplicate together with a complete list of the enclosed material.

After evaluation of the applicants' qualifications by a Search Committee, thereport will be sent to all applicants in complete form.

Applications are to be addressed to Her Mjesty the iOnof Denmark and sentto the Faulty el Naural Sciences, Penum Inltutte, Blegdamse 3, DK-2200Copenhiaen N, Denmark.

The closing date for receipt of applications is 1 September 1988.

1

-

L.

t

byne Sbt Unversity

DEANSchool of Medicine

Wayne State University invites applications andnominations for the position of Dean, School ofMedicine. The School of Medicine has been operatingand granting degrees as a college of medicine since1868. The School is the largest single campus medicalschool in the country. It is closely affiliated with TheDetroit Medical Center (DMC), a comprehensive healthcare delivery system with a high technology focus onwhose main campus the school is situated. The DMCconsists of six acute care hospitals and onerehabilitation hospital comprising 2,200 beds and anextensive network of ambulatory care centers and otherservices. The primary mission of the School ofMedicine is to improve the health of the communitythrough its combined educational, research and serviceprograms.

Responsibilities: The dean, as principaladministrative officer, reports to the Provost. Inconsultation with the School's faculty, the Dean leadsin the formulation of academic and administrativematters, the allocation of resources, in faculty/staffpersonnel matters and in all relationships with theaffiliated institutions that comprise the Detroit MedicalCenter and the local Veterans Administration hospital.The Dean plays a major role in the DMC as a seniorcorporate officer and serves as the Chairman of theDMC Medical Board. This is the senior DMC medicalpolicv administrative post reporting directly to thePresident/CEO of the DMC and works directly on thedevelopment of DMC clinical programs.

Qualifications: Candidates must possess the M.D.degree and have compiled a record of clinical andscholarly achievement and teaching commensuratewith appointment to the rank of professor with tenure.The candidate should be a proven leader with adistinguished record of administrative excellence, andwith a commitment to affirmative action. Thecandidate should be skilled at interpersonal relations,and be able to work effectively with a large and talentedfaculty and with outside medical and health caregroups. The applicant should have a proven record ofobtaining and managing substantial budgets and grantactivities. Salary and benefits are negotiable.

Application: Interviews with potential candidates will beconducted during the Summer/Fall, 1988. Applicationletters should include a vita, names and addresses ofthree references and supporting materials.Nominations and applications should be submitted to:

Charles Whitten, M.D.Chairman, School of Medicine

Dean Search CommitteeOffice of the Dean1270 Scott Hall

Wayne State UniversityDetroit, Ml 48202

For best consideration, applications should bereceived by July 16, 1988.

Wayne State University is an EqualOpportunity/Affirmative Action employer.

IO JUNE I988

PROTEIN ENGINEERING LABS

We are offering a unique and excitingopportunity to join us at an early stage of

development, on the frontiers of proteinengineering technology. Protein Engineering labsemploys state-of-the-art techniques in peptide/protein synthesis, computer modeling, molecularbioloa, organic chemistry, and semi-syntheticanalog chemistry to develop novel human thera-peutics. You can work with leading scientists fromindustryandresearch institutionsand can contrib-ute to the building of a company which is on theforefrontofcreatingnewtherapeutic approaches toanti-virals, anti-cancer agents, and immunemodulators.We are seking outstanding scientistsand technical personnel with the followingexpertise:

ProteiniPeptide andSemi-Synthetic ChemistryPhD in Chemistry or Biochemistry with back-ground and experience in protein and peptidechemistry, purification techniques, and derivationand modification of proteins and peptides, to par-ticipate in collaborative and independent projects.

MolecularBiologyPhD in Molecular Biology with background andexperience in construction, expression and ma-

nipulation ofDNA including site-directed and cas-sette mutagenesis, to participate in collaborativeand independent projects.

MolecularModelingPhD in Biophysics or related discpline with back-ground and experience in computer-aided-molecular modeling and rational drug design toparticipate in collabrative and independentprojects.

Inmmunology

MD/PhD or PhD with experience in basic cellularand molecular immunology and the design ofnoveland dynamic assays and screening systems.

PROTEIN ENGINEERINGLABS provides a chal-lenging and creative work environment in closeprmitytoseveralmajoracademicresearchinsti-tutions.Weoffercompetitive salaryand benefits aswell as an incentive option program.

Please send curriculum vitae and a list ofpublica-tions and/or resume to:

PROTEINENGINEERING LABS60 Town Center Drive, Suite 810

Costa Mesa, CA926Attn: Hnman Resources Department IiI

POSITIONS OPEN

POSTDOCTORAL POSMONMOLECULAR AND CELLULAR BIOLOGYJEWISH HOSPITAL AT WASHINGTON

UNIVERSITY MEDICAL CENTERPosition available for quality person to study the gene

expression of tissue inhibitor of metalloproteinases(TIMP) in fibroblasts and during the diffcrentiation ofhuman mononudear phagocytes. Studies will involve themechanisms ofTIMP regulation in fibroblasts and U937cells utilizing state-of-the-art molecular and cell biologicapproaches. The position allows for collaborative re-search with other faculty mcmbers studying the biologyof extracellular matrix. Applicants should send theircurriculum vitae and names of references to:

Dr. Howard G. WelgusDivision of Dermatology

Jewish Hospital at WashingtonUniversity Medical Center

St. Louis, MO 63110

POSTDOCTORAL POSMONHARVARD MEDICAL SCHOOL

Opportunity available immediately for Ph.D. to studymolecular andcellular biology of muscarinic receptorsand G-proteins in cardiac cells. Experience in moleculardoning techniques desirable. First year salary guaran-teed. Send curriculum vitae to: J. B. Galper, M.D.,Ph.D., Cardiovascular Division, Brigham & WomensHospital, 75 Francis Street, Boston, MA 02115.Telephone 617-732-5679.

POSTDOCTORAL POSMON available in theareas of molecular biology and immunology to pursueresearch on equine viral diseases and immunobiology.Send curriculum vitae and names of three references to:Drs. George Allen and Ernest Bail ent ofVeterinary Science, Glucks E§quine Reeac Center,University of Kentuck, Ion , KY, 40546-0099. An Equal Opportunity/Ajirmative Action Employer.

POSTDOCTORAL POSMON available to studygene expression and molecular genetics ofthe surfactant-associated proteins [Floros etal.JBC: 261, 9029 (1986);Jacobs et al.JBC: 262 9808, (1987)]. Molecular biology/biochemistry background is preferable. Please send cur-riculum vitae and names of three references to: JoannaFloros, Ph.D., Harvard Medical School, 221 Long-wood Avenue, Ridson-Fuller Building, Boston,MA 02135. Telephone: 617-732-4154.

An Equal Opportunity Employer

POSTDOCTORAL POSMONPLANT TISSUE CULTURE

Position available starting after 1 September 1988, fora postdoctoral associate to work with an internationalteam of molecular biologists to transform and regeneratccassava plants to improve agronomic characteristics. Theposition will run for 2 to 3 years in the U.S. withpossibility of permanency at a European location to bedetermined. Experience in cell culture and plant regener-ation required, cytogenetics or in situ techniques desir-able. Send curriculum vitae and three letters of referenceto: Dr. R. N. Bcachy, Departmcnt of Biology, Box1137, Washington University, St. Louis, MO 63130.Washington University is an Afimnnative Action/Equal Oppor-tunity Employer.

UNIVERSITY OF CONNECTICUTHEALTH CENTER

RESEARCH ASSOCIATE/POSTDOCTORAL FELLOW

This position involves the development of acousticaland electrical measurements to be used for evaluation ofthe functional state of the peripheral and central compo-nents of the auditory system. The research will beconducted in both laboratory and clinical settings. Thcposition provides an excellent opportunity for strength-ening skils in computer applications and knowledge ofthe auditory system. Qualifications: Doctoral degree.Applicants should send curriculum vitae and letters ofrecommendation to: Dr. D. 0. Kim, Director of Re-search, Division of Otolarynglogy, University ofConneticuat Health Center, Fam n, CT 06032.Telephonc: 203-679-3690. An AJfirmative Action/EqualOpportunity Employer M/W/H.

i568

Integrated Genetics utilizes recombinant DNA methods to produceproteins for therapeutic use and, since its inception in 1981, has pi-oneered the use of mammalian cells as the expression system ofchoice. Continuing growth at the company has lead to the crea-tion of this challenging new position.

We seek a preeminent scientist to take overall responsibility for alarge group of professionals involved in several aspects of MolecularBiology at IG. Reporting to the Vice-President of Science, this posi-tion will require expertise in at least one central area of molecularbiology, such as cloning, expression, and/or characterization of raremRNAs and their genes. Additional background in cell biologywould be highly desirable.In addition to graduate and postdoctoral research in molecularbiology, the successful candidate will have at least five years' ex-perience running their own laboratory, though not necessarily inan Industrial setting. An exceptional record of published research,innovation, drive, and the ability to interact with and lead othersis essential.Integrced Genefics Is locaed In an attractive suburban area25 mies west of Boston. We offer an excellent compensatIon andbenefits package Including equity prtIcipation. For Immediateconsideration, please send your resume toc Manager of HumanReources, Dept. S610, Integrated Genetics, Inc, 31 New YorkAvenue, Framingham, MA 00.An equal opportunity employer

U INTEGRATED_ GENETIC

AQUATIC TOXICOLOGIST$42,180-$59,040

Comprehensive BenefitsSan Francisco Bay Area

East Bay Municipal Utility District, the West's largest independently operated waterand wastewater utility is pleased to announce this new position in our LaboratoryServices Division.

Responsibilities include establishing and managing key District programs in theareas of:* Water Quality-based Toxicity Control* Development and implementation of Toxicity Reduction Evaluations (TREs)for wastewater treatment plant

* Evaluation of health risk assessment standards as related to water andwastewater treatment

* Assessment ofwastewater treatment plant volatle emissions and organic com-pounds in drinking water

Requires 6 years' experience and strong academic background; PhD preferred.Knowledge of regulatory requirements for water and wastewater industry is highlydesirable. Starting salary commensurate with educational and work experience.

Requests for special applications will be accepted starting May 31, 1988 and theposition will be open until filled.I~~~~~~~~ ,/: '-~~~~~~~ * £ *

l~~~~~~~3 g,..

The Division of Trauma in theDepartment of Surgery at theState University of New Yorkat Stony Brook is recruiting foran individual to develop andorganize its research programin trauma, burns, shock, sep-sis and intensive care. A Ph.D.in Physiology, Cell Biology,Biochemistry or Bioengineer-ing or intensive care is re-quired. Please send CV to:

David J. Kreis, Jr., MD, FACSChief, Division of TraumaHealth Sciences Center(HSC) 19, 060SUNY at Stony BrookStony Brook, NY 11794

SUNY at Stony Brook is anEqual/Opportun ity/Affirmative

Action Employer

RESARH SCIENTISTS/RESE ASSOCIATESPROTEIN STRUCThRE

Amgen, a recognized leader in the production of human pharmaceutical, animal healthcare and specialty chemical products through applied biotechnology, has immediateopportunities for Research Scientists and Research Associates in our Protein Develop-ment Group. RESEARCH SCIENTISTS

Dept. #317Candidates for these positions must have a Ph.D. and extensive experience in proteinsequencing as well as a complete knowledge of protein chemistry.Responsibilities will include support of products currently under development andcharacterization of new proteins and factors as part of our ongoing exploratoryresearch efforts.

RESEARCH ASSOCIATESDept. #318

Qualified candidates for these positions must have a BS or MS in Biochemistry,Chemistry or a related discipline and have hands-on experience with HPLC. Anunderstanding of computer-based data acquisition is highly desirable.

Responsibilities for these positions will include the characterization of proteins byHPLC, amino acid composition and sequence analysis.

Amgen is a dynamic and fast paced organization providing an exciting and innovativeresearch environment as well as an attractive location northwest of Los Angeles. Amgenalso offers an excellent compensation and benefits package.If you have the necessary qualifications and are interested in the career opportunties thatonly a company like Amgen can provide, please send a c.v. or resume, including a list ofreferences, in confidence, to:Recruitment, (Specify Dept. #)AMGEN1900 Oak Terrace LaneThousand OaksCA 91320Equal Opportunity Employer

PostdoctoralFellowJoin our Tissue Culture Develop-ment research team where weoffer scientific professionals anopportunity to develop their exper-tise while significantly advancingour research efforts.Position requires PhD in Cell Biol-ogy/Biochemistry. Must have astrong background in cell physiol-ogy and very good understandingof molecular biology. Knowledgeof modern analytical techniquesand an ability to plan and executeresearch projects independentlyare necessary. (TM87-32)We offer a competitive salaryand benefits package. Pleaseforward resume indicating job #to:Mr. M. Urdanick, Schering-PloughCorporation, 1011 Morris Avenue,Union, NJ 07083. We are an equalopportunity employer.

q3 Schering-Plough

-.I-. -1.1-

-U- -~~~~~~~~Postdoctoral FellowshipApplicants are invited for a postdoctoral fellowshipimmediately available at the Biotechnology Depart-ment of Ciba-Geigy in Basel, Switzerland.

Postd t Visiting Scientists positions The research will involve the identification of thementatDuPnt'shin thenMedicalProductsrDpart- eukaryotic receptor for a bacterial toxin and the

sylvania. The successful candidate willb invoved in susequent cloning of the receptor gene. A combina-the cloning, expression and/or characterization of tion of DNA technologies and immunological screen-novel proteins involved in immunoregulation, with a ing methods will be applied.particular emphasis on lymphokine receptors. Can-didates shou[d possess a Ph.D. with experience in Qualified candidates with a strong background in themolecular biolog or receptor purification and relevant technologies will be given preference.characterization. e appointment will be for twoyears. The successful applicant will be able to work in an

interesting and exciting environment in which cooper-At the world renowned Du Pont Corn- ation is strongly encouraged.pany, you'll find a highly stimulating scientific en-vironment in addition to an excellent salary. To be con- Applications including curriculum vitae, a descriptionsidered, please send resume, bibliography and of research, the names and addresses of three refer-references by August 10, 1988 to: Dr. Richard Robb,Glenolden Laboratory E. I. du Pont de Nemours and ences from whom we may request letters of evalua-

Company, 500 S. Ridgeway Avenue, Glenolden, PA tion should be sent under ref. "SC 477" to Dr. M. Graf,19036. CIBA-GEIGY Ltd., Personnel Department, Posffach,

4002 Basel, Switzerland.

";,~~~~~U Cft WIn or fiJ[IU

liRESEARCH ASSOCIATE RESEARCH ASSOCIATEPURIFICATION PROCESS lEast-West Center

The East-West Center, established in 1960 by the United States Congress which

DE VELOPMENT provides principal funding, is a public, nonprofit educational institution, with an

intemational board of govemors. Support also comes from Asian and Pacific governments,Amgen is a recognized leader in the development of human intemational organizations, and private institutions.

health care, animal health care and specialty chemical Applications are being accepted for a three-year limited Research Associateproductsthrough applied biotechnology. As a result of our

position. The Research Associate will be responsible for planning, developing, andproducts through applied biotechnology. As a result of our coordinating the programs, jointly based in the Environment and Policy Institute and the

continuing growth we have an opportunity for a Research Population Institute, dealing with urban environmental issues and the range of problemsAssociate with skills in analytical biochemistry to assist in our associated with the dynamics of human settlements evolution in Asia and the Pacific.

Purification Process Development Group. Among the issues to be defined and dealt with are the changing nature of urban-ruralrelationships, the structures and functions of urban and settlement hierarchies, theResponsibilites for this position include the isolation and environmental planning implications of such changes, the movement of jobs and people

within the spatial systems that are evolving particularly in Asian countries, thepurification of recombinantly produced proteins at both the environmental consequences of rural industrialization and multi-nodel metro-politaniza-

laboratory and pilot scale. tion, the changing character of environmental perceptions as between rural and urbanareas, and the maintenance and enhancement of environmental quality within variously

Qualified candidates must have a BS or MS in Biochemistry sized settlements ranging from village to metropolis. Responsibilities will include basicor a related discipline, and several years' experience in the research on any and all of these issues; organizing research-related conferences;

purification and characterization of proteins. Experience withpromoting interaction among scientists and govemmental officials from developingcountres within the realm; seeking sources of extemal financial support; advising EWC

HPLC, column chromatography, SDS-PAGE and IEF is student grantees; and maintaining liaison with centers of research in the Asia-Pacifichighly desirable. realm concemed with urban environmental problems.

Amgen offers a stimulating and challenging research environ- REQUIRED QUALIFICAIONS: Ph.D. (or equivalent) in sociology, geography, planning,

ment as well as an excellent compensation and benefits l } | | ydemography, or one of the cognate environmental or social sciences, plus least twobenefitsyears' research or professional experience and a strong publications record in research on

package. Our location (about an hour northwest of Los urbanization and environmental problems. Familiarty with the Asia/Pacific realm andAngeles) offers the best in Southern California living. first-hand knowledge of at least one country in the region as shown by publications.

Qualified candidates should send a c.v. or resume, including PREFERRED QUALIFICATIONS: Experence in planning, organizing, and managinga list of references, in confidence to: research projects involving individuals from various countries in Asia and the Pacific.

SALURY RANE: $27,716 to $46,679 per year, depending on qualifications, plusRecruitment, Dept. #319 cost-of-living allowance currently at 22.5% (subject to change).AMGEN SpG Submit resume with cover letter which includes title of position you are applying for,1900 Oak Terrace Lane ! a narrative description detailing relevance of your qualifications and background to the

Thou d O k responsibilities position, three professionalThousand OaksS A * o, Applications must be postmarked by July 15, 1988. Send to: Rebecca Dixon, Personnel

CA 91320 l| Ofice, Dept. 19, East-Wed Center, 1777 East-West Road, Honolulu, Hawaii 96848.

Equal Opportunity Employer An Equal Employment Opportunity/Affirmative Action EmployerAliINI

Opportunities in Cystic Fibrosis Research

NIDDKINIHCystic Fibrosis Foundation

FELLOWSHIP PROGRAMat the

NATIONAL INSTIlTUTES OF HEAITHBethesda, Maryland

The National Institute of Diabetes andDigestive and Kidney Diseases (NIDDK) ofthe National Institutes of Health and theCystic Fibrosis Foundation announce theavailability of postdoctoral trainingopportunities at the NIH. This fellowshipprogram will offer advanced researchtraining with NIH intramural staff andsabbatical support for M.D.'s and/or Ph.D.'sin fields relevant to the rapidly developingcystic fibrosis research areas.

Subjetandpreptors idcu.:

* CELI BIOLOGY OF SECRETIONH.B. Pollard,J.D. Gardner, R. Ornberg,A.L. Bums, R. Crystal

* ION- CHANNEISE. Rojas, P. Skolnick, K. Spring, B. Baum

* MOLECULAR BIOLOGYD. Camerini-Otero, L. Henighausen,G. Felsenfeld

* MOLECULAR EMBRYOLOGYJ. Dean, F. DePablo

* GLYCOPROTEINS AND GLYCOLIDPSB. Weintraub, V. Ginsburg, A. Minton,D. Roberts

* MICROBIOLOGYJ. Foulds

Consideration will be given to supportingprogrms with other preceptors and/orlaboratories at the NIH.

Forfitther infomation contact eih.

Harvey B. Pollard, M.D, Ph.D. ORDirctorNIDDK.Cystc FbrsisFoundation Fellowshp ProgramBuilding 8 Room 401National Instiutes of HealthBethesda, Maylnd 20892

RolertJ. Beall, Ph.D.Executve Vice Presidentfor Medical AffairsCystic Fibrosis Foundation6931 Arlington RoadBethesda, Mayland 20814

Request ForResearch GrantApplications

ONINFECTION, IMAND INFLAMTIONIN CYSTIC FIBROSIS

The Cystic Fibrosis Foundation invitesinvestigator-initiated research grant applica-tions in the areas ofhost responses to chronicpseudomonas lung infection, and the role ofinfection and host inflammatory reactions inlung damage in cystic fibrosis (CF).

This special request is intended to encourageinnovative, meritorious studies focusing onareas including, but not limited to:

* Host and bacterial factors that predisposeto pseudomonas colonization and immun-ologic approaches to limit this process.

* Defects in phagocytic defense of theCF lung.

* Roles of immunologic and pro-inflam-matory mediators in lung destruction.

* Role of host and bacterial proteases inCF lung disease.

* Use of immunomodulators, anti-inflam-matory drugs or protease inhibitors.

Applications must demonstrate potentialrelevance to CF.

Awards will be made as grants-in-aid. Ap-plicants may request up to $100,000 in totalannual costs (direct and indirect) for up totwo years.

Interested individuals are encouragedto contact the Foundation to discuss thepotential relevance of their work. Thedeadline for submission of applications isSeptember 1, 1988. Application materialsare available from:

CyHFlbrosI s

_iFoundafon6931 Arlington Road

Bethesda, Maryland 20814(301) 951-4422

l

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POSITIONS OPEN

POSTDOCTORAL POSMONS are available inthe Department of Anesthesia Rcsearch Laboratories,Harvard Medical School/Brigham and Women's Hospi-tal. Applicants should have a doctoral degree either inmolecular biology or in electrophysiology. A candidatewith cDNA cloning experience will participate in thestudy on the expression of voltage-gated Na channels incells, initially at the mRNA level. Another candidate withvoltage-clamp experience will participate in single chan-nels studies on the pharmacological properties of Nachannels. Please send a description of research interests,curriculum vitae, and the names of three references to:Dr. Ging Kuo Wang, Dqertment of Anesthesia,Brigham and Women's Hospital, 75 Francis Street,Boston, MA 02115.POSTDOCTORAL POSMONS: Available in the

Departments of Plant Pathology and Agronomy to workon: (i) Cloning, sequencing, and expression of plant andfungal virus genes; and (ii) Inheritance and stability offoreign genes in transgenic plants. Excellent environmentfor strong interdepartmental programs in molecular vi-rology and gene transfer technology. Applicants shouldhave Ph.D. with strong background in recombinantDNA technology. Send curriculum vitae and thrce lettersof reference to: S. A. Ghabrial, Department of PlantPathology, University of Kentucky, Lxiton, KY40546-0091. An Equal Opportunity Employer.

RESEARCH ASSISTANTParmly Hearing Institute at Loyola University has an

opening for a research assistant. Primary responsibilitieswill be supervising the anatomy laboratory and preparingvertebrate neural tissue for viewing under the lightmicroscope. B.S. in biological science and experience inbasic histological techniques are required. M.S. degreeand experience in neurobiology and SEM techniques aredesirable. Submit resume by 24 June 1988, to:

Stan HewitsonDirector ofHuman ResourcesLoyola University of Chicago6525 North Sheridan Road

Chicago, IL 60626Equal Opportunity Employer MIF

POSTDOCTORAL POSMTIONS (two) Available 1December 1988 to study molecular aspects of naturaltoxin/receptor interaction in excitable membranes. Adetailed background in synthetic micro-organic chemis-try or an extensive working knowledge of receptorpharmacology and toxinology at the molecular level isrequired. Send curriculum vitae and three letters ofreference by 1 August 1988 to: Dr. Daniel G. Baden,Rosenstiel School of Marinc and Atmospheric Sci-ence, 4600 Rickenbr Causeway, Miami, FL33149. The University of Miami is an Afinnative Action!Equal Opportunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATE.Position available immediately for Ph.D. with strongbackground in mamma cell biology/membrane bio-chemistry to join a research project investigating mam-mary epithelial cell differentiation, under the direction ofDr. =ren Thompson. Emphasis will be placed ondetermining if stage-specific markers for norm;il mamma-rysepithelial cell development can be defined.Send curriculum vitae with complete reference infor-

mation to: Children's Hospital Oakland-ResearchInstitute, Human Resources Department 1455, 74752nd Stroet, Oakland, CA 94609. Equal OpportunityEmployer.

RESEARCH ASSOCIATE, to conduct research ona potential neurotoxin detected in the CSF of patients ofAlxheimer's disease. Duties indude conducting experi-ment focused on chemical structure of this compoundand mechanism of its effect in the brain. Develop strate-gies for solving research projects; supervise two assistantsand present findings at scientific conferences. Require-ments indude Ph.D. in physiology or pharmacology aswell as strong barcground in techiques required tostudy effect of substances on the brain, induding deter-mination of biogenic amines by HPLC- administrationof drugs by push-pull cannula; brain tissue superfusion;and brain perfusion. Salary $21,375 per year, 40 hoursper week. Respond with resumE orly to: Job Order#8651, Division of Emplment Security, Govern.ment Center, Boston, MA 02114. No experiencerequired.

Postdoctoral PositonsNew England Biolabs, a pioneer and leader inbiotechnology located twenty miles north of Boston,is seeking applicants for:Gene Cloning in Streptomyces-Candidate shouldhave a strong background in Streptomyces molecularbiology to work on projects involving cloning, over-production and mutagenesis of restriction-modifica-tion systems in Streptomyces.

Molecular Genetics-Candidate should have strongbackground in molecular biology or bacterial geneticsto study the interaction between restriction-modifica-tion systems and the host cell.In addition to competitive salary, New EnglandBiolabs offers a very generous fringe benefitspackage. Attendance at meetings, publication ofresearch results and open communication with othersare encouraged.Candidates please submit curriculum vitae with threereferences to:New England Biolabs, Inc.Human Resources32 Tozer RoadBeverly, MA 01915-5510

NEW ENGLAND

HARVARD UNIVERSITY AND BOSTONUNIVERSITY MBEDICAL CENTER

Position open for a RESEARCH ASSOCIATE toexamine the role of cytoplasmic calcium and pH changesin steroid secretion at the single cell level. Techniquesemployed include whole-cell calcium digital imaging aswell as cell population and single cell aldosterone secre-tion measurement. This position is part of an interdisci-plinary program investigating the endocrinological as-pects of hypertension.

Requirements: U.S. citizenship or permanent residen-cy; Ph.D. or equivalent; cell electrophysiology cxperi-ence preferable.

Please send curriculum vitac and brief letter of intentto: Douglas Tillotson, Ph.D., BUMC, Physiology,R406, 80 East Concord Street, Boston, MA 02118.Affinnative Action/Equal Opportunity Employer.

RESEARCH ASSOCIATE/POSTDOCTORALposition in neuropharmacology available immediately tostudy synaptic mechanisms responsible for cthanol in-toxication, tolerance and physical dependence. Currentemphasis includes biochemical, physiological, and elec-trophysiological models to cvaluate changes in GABAAreceptor-chforidc ion channel transducer efficacy. Experi-ence in neurochemistry and cell culture helpful. Sendcurriculum vitae, names of three references, and state-ment of interests to: G. D. Frye, Department ofMedical Pharmacology, Texas A M- University,College Station, TX 77843.

An Equal Opportunity Affirnative Action Employer.

Beecham Laboratories, a leading manufacturer of vet-erinary biologicals, has oepnings for innovative RE-SEARCH MICROBIOLOGISTS in the fields of vi-rology and bacteriology. Experience in vaccine develop-ment preferred. To apply send r6sumi to: HansDraayer, Manager, Biological Research and Develop-ment, Beecham Laboratories, East Lincoln Road,White Hall, IL 62092. An Equal Opportunity/AfirmativeAcion Employer.

CHIMERA BIOTECH, INC.TRANSGENIC ANIMAL RESEARCH

Chimera Blotech, Inc. Is a dynamlc and excitingblotechnology company located In San Diego,California.We area rapidlygrowingcompanywiththe god ofbecoming the technology and marketleader In the productlon and use of transgenlcanlrnals.

DIRECTOR OF RESEARCHThe successful candidate will have a Ph.D. In Mo-lecular Bliogy or a related dIcipline with exper-ence In state-of-the-art techniques In transgenicanimal productlon,such as mlcro-InJection,embry-onal stem cel culture, mammalian gene expres-slon and animal physiology.The above candidate must also possess strongcommwunicatlon skills and a proven ability anddesire to design and direct research programs.

Chimera Blotech offers an excellent salary andbenefits package Including substantial equlty.Please send resumes to:

Mr. Lawrence Bock650 Town Center Drive, Sulte 810

Costa Mesa, CA 92626

'Ar-

POSITIONS OPENPOSITIONS OPEN

BIOTECHAT BESTIntegrated Genetics, Inc., a recognized leaderin biotechnology, develops therapeutic anddiagnostic products for the health care indus-try. Our continuing success leads to these newopportunities:

Applied ExpressionTake a leading role in our research effort in thearea of gene expression, particularly in the ap-plication of expression vectors in mammaliancells. Requires a Ph.D. in molecular biology,2 yrs' postdoctoral training, and 2-5 yrs. of researchexperience in industry. we seek a highly moti-vated, accomplished scientist with a goo publi-cation record and experience with one or moreeucaryotic expression systems.

II

PharmacologyCoordinate and perform testing of new thera-peutic drugs including toxicology studies forFDA approval. Requires a Ph.D. in Pharmacolo-gy, Biopharmaceutics, or Pharmacokinetics andat least 2 yrs! experience in pharmacokineticsof peptide/protein molecules, coagulationand or thrombosis animal model systems, andtoxicology studies for human clinical trials.

Applied ExpressionCarry out research in the area of the expressionof foreign genes in eucaryotic cell hosts. Re-quires a Ph.D. in molecular biology and at least2 years of relevant postdoctoral experience.Familiarity with eucaryotic expression systemsis essential.

Molecular BiologyA Ph.D. with a broad base of molecular biologyskills, particularly in the areas of cDNA synthe-sis and library constructions in both phage andplasmid vectors is needed to work on variousresearch projects. Experience with procaryoticand/or eucaryotic expression systems wouldbe helpful.

Cell BiologyCell biologists are needed to study the utilityof growth factors for therapeutic use and theinf[uence of cell type on protein production bymammalian cells. Requires a Ph.D. and at least21yrs postdoctoral experience in one or more

e following: cell surface receptor-ligand in-teractions; intracellular mechanisms ofgrowthfactor or transforming protein action; effects ofgrowth factors and/or extracellular matrix on thebiosynthetic capacity of cells.

DiscoveryJoin a team investigating and evaluating newproduct opportunities. Lequires close interac-tion with scientific staff, research and evaluationof publications, and attendance at scientificmeetings with follow-up on contacts. Requiresa Ph.D./M.D. in science, superior communicationand interpersonal skills, and a broad understand-ing of the science and business of biotechnology.

Protein ChemistryEnhance our structural characterization of naturaland recombinant proteins by developing noveltechniques to study post-translational modifi-cations. A Ph.D. in Biochemistry and experiencein peptide mapping, purification, sequencingand amino acid analysis, or chemical modifica-tion of proteins is required. Postdoctoral and/orindustrial experience in a protein sequencingfacility a plus.

Integrated Genetics is located in an attractive suburban area 25 miles west of Boston. We offeran excellent compensation and benefits package, including three weeks' vacation and equityparticipation. For immediate consideration, please send your resume, referencing the positionof interest, to:David Nikka, Dept. S610Integrated Genetics, Inc.31 New York Avenue, Framingham, MA 01701.An equal opportunity employer.

1

INTEGRATED

-_ GENETICS

I1iiliiiliii III

1111'1

m

a ....

Research Assodates|ZymoGenetics, Inc. is a recombinant DNA companyengaged in developing human plasma proteins, growthfactors, immunoglobulins, and other commercially valuableproducts. We currently have positions available in ourMammalian Cell Expression and Protein Chemistrydepartments.Both positions require a BS/MS degree. For MammalianCell Expression we require experience in several of thefollowing: DNA and RNA isolation; cloning DNA intoplasmid vectors; tissue culture; isolation and purification ofproteins; and assay of proteins.For Protein Chemistry, experience in a number of thefollowing is needed: isolation and purification of proteinsand peptides; ELISAs; SDS electrophoresis; assay ofproteins; and monoclonal antibody preparation.ZymoGenetics, Inc. offers a research-oriented atmosphere,intellectual challenge and modern facilities. Seattle's beau-tiful surroundings, reasonable cost of living, and lively cul-tural activities are further incentives to relocate. Salary iscommensurate with experience and ZymoGenetics offersfull benefits including a tuition reimbursement program inour compensation package. Please send a detailed resumeof your work experience and academic background, as wellas the names and addresses of three references to: LauraCastelano, ZymoGenetcs, Inc. 4225 RooseveltWayNE, Seatle,WA 98105, (206) 547-8080. Equal Oppor-tunity Employer.

i$ m ss

Postdoctoral position available tostudy the regulation of blood celldifferentiation at the cellular andmolecular levels with emphasison monocyte/macrophages andmegakaryocytes. Opportunity tostudy the effects of HIV onmonocyte development and func-tions. Experience with contem-porary techniques in molecularand cellular biology required.Send curriculum vitae andreferences to Dr. Allan Mufson,American Red Cross, HollandLaboratory, 15601 Crabbs BranchWay, Rockville, MD 20855.An Equal Opportunity/Affirmative ActionEmployer M/F/HN

¢| ¢ American Red Cross

GROUP LEADER TOXICOLOGYThe Colgate-Palmolive Company's Medical Depart-ment currently seeks an experienced professional tojoin its Pharmacology/Toxicology staff as a GROUPLEADER.Major responsibilities include leading a team ofprofessionals to provide data support for the safety ofColgate-Palmolive products, and for systems on datastorage, analysis, and retrieval.To qualify, an individual must have a Ph.D. in one of thefollowing: Pharmacology, Toxicology, Biochemistry, orPhysiology. Five years experience in toxicology-riskassessment in a regulatory environment, computersystems, and excellent verbal and written communi-cation skills.The Corporate Technology Center is located on an80-acre campus in suburban Central New Jersey,near Rutgers and Princeton Universities, and onehour from Manhattan.For immediate consideration, please forward resumewith salary history, in confidence to: Mr. Ron Thomas,Human Resources Dept. MS/SM-24, 909 River Road,Piscataway, NJ 08854.

>COLGATE-PALOLIVE COMPANYAn Equal Opportunity Employer M/F

Immunology ResearchPfizer Central Research is inviting applications from immu-nologists to take part in the development of a new researchprogram. Working with a strong multidisciplinary projectteam, you will apply your basic research skills to concep-tualizing new strategies for the discovery of immunemodulating agents for animal health applications.You must possess a PJhD and at least two years of postdoc-toral experience in Microbial Immunology. While specificexperience with assays for cytokines and immune cell func-tions will be considered an asset, educational training, in-tellectual capabilities and leadership traits are mostimportant. Prior experience in drug discovery or evaluationis not required.This position offers an excellent opportunity for professionalrecognition and growth. We also offer excellent salary,benefit and relocation package plus an attractivesoutheastern Connecticut shore location. Qualified appli-cants should submit their resume, a brief description ofresearch accomplishments, and the names, addresses andphone numbers of three professional references to: Mr.Donald R. Nelson, Manager of Employee Relations, PfizerCentral Research, Eastern Point Road, Groton, CT 06340.

An equal opportunity employer

II

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As the t985joint venture between Corning Glass Worksand Ciba Geigy Ltd., Ciba Corning Diagnostics Corp. isrecognized as a world leader in the medical diagnosticsand biomedical research fields.

* PROJECT MANAGER -

CONTROLS RESEARCH &DWELOPMENTWe are looking for a person who can manage R&Dprojects in our controls business in Irvine, CA facility. Thesuccessful candidate should have good skills in projectplanning and tracking, as well as the ability to plan andmanage meetings. Also, this person should have excellentpeople skills and be assertive, in addition to being able towork relatives unsuperised toward a goal oftransferringa completed R&D project into manufacturing.Experience in the Clinical Chemistry Controls or Reagentbusiness is essential for success in this position.Excellent starting salaries and benefits. Reply wIthresume, In confldence, to the Human ResourcesDept., CIba Corning Diagnostics Corp., 63 NorthStreet, Medfleld, MA 02052.Ciba Corning Diagnostics Corp. is an equal opportunityemployer, m/f/h/v.

CIBACORNING

MERRELL DOWRESEARCH INSTITUTE

STRASBOURG CENTERhas an openingfor a

Molecular VirologistWe are seeking an independent scientist (PhD. +3 years postdoctorate) with a demonstrated expertise in the molecular biology ofretroviruses. The successful candidate will be expected to initiate a basicresearch program that will investigate viral-encoded proteins as targetsfor antiviral drug design. Integrating within a multisciplinary team ofscientistsfocusing on signal transduction, the virologist will haveabundant opportunitiesfor scientific collaborations with molecularbiologists, immunologists, protein and medicinal chemists, andpharmacologists. The scientist selectedfor this opening will immediatelyoccupy an important role in the development of the biological sciencesprogram at MDRI, Strasbourg. Knowledge ofFrench is desirable, but nota requirementfor this position.

Applicants should send a curriculum vita, and three letters of referencesto: Mrs MJ. Bildstein Director ofPersonnel ServicesMerrell Dow Research Institute 16, rue dAnkaraF-67084 STRASBOURG Cedex - France.

EXPANDING OPPORTUNITIES INENVIRONMENTAL/HEALTH SCIENCES

Since 1936 IITRI has been a leading independent, nt-for-profit contractresearch organization. Weseek unique indiMduals rthebifitng positios:

SENIOR VICE PRESIDENT,APPUED SCIENCES

Reporting direcly to the President, the Senior Vice President will be respon-sible for direcing chemistry, chemical engineering, ervironmental siences,petroleum, energy research, life sciences, exploin/hazards analysis, andmanufacturing technology activities. Ph.D. in physical/biolgical sciencesor engineering required; 10.15 years' expenence in a research environmentof which 5-10 years were in mid- or upperlevel management resulting in aproven track record in technical management and organiztion. Excepionalcommunication skills, demontatd leadership in meeting financial goalsand mdivational abilities comnplte the desired prfile.

DIRECTOR, CHEMISTRY &CHEMICAL ENGINEERING

The Director, reporting to the Senior Vice President, will manage and leadtechnical staff involved in analytical chemistry, polymer and organicresearch, pild plantstudies, and environmental sciencs. Ph.D. in chemistryor chemical engineerng required; plus 8-10 years' epience in a rsearchenvironment. Experience will include management responsibilities resultingin a progressive growth record in organization and management of hightechnology activities.Both of these positions require U.S. citizenship.Receipt of your credentials will indicate interest in these positions. Sub-mit to: Ms. L. Amft, Sr. Peomnnel Representative, Dept. EHSILA, IITReseuch InstItu, 10 est 35th Ste, ChiWc , Illinoes 60616. EqualOpportunity/Affirmative Action Employer.

PROTEIN CHEMISTThe Worcester Foundation is seeking an experi-

enced protein chemist to be the primary operator of aProtein Chemistry Facility now being established. Thiscore facility will be equipped to provide protein se-quencing, peptide synthesis, amino acid analysis andpeptide mapping services to our faculty. The positionoffers the opportunity to contribute to a diverse set ofprojects studying protein structure and function, in-cluding cytoskeletal proteins, receptors, signal trans-duction proteins, mammalian pheromones and severalenzyme systems and proteins found in the nervous andmale reproductive systems. Applicants should haveextensive protein chemistry experience and some famil-iarity with a gas-phase sequencer and peptide synthe-sizer. Salary and level of appointment of this non-faculty position will be commensurate with experience.The Worcester Foundation is a non-profit, basic re-search institute located on a 100 acre wooded campus40 miles west of Boston. Send curriculum vitae, astatement of career objective and three letters ofreference to Protein Chemist, do Personnel Office,Worcester Foundation for Experimental Biology,222 Maple Avenue, Shrewsbury, MA 01545 USA.

AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTIONEMPLOYER M/F/H

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POSITIONS OPEN

STANFORD UNIVERSITYSCHOOL OF MEDICINE

PROFESSOR OR ASSOCIATEPROFESSOR OF BIOSTATISTICS

Stanford University's School of Medicine seeks appli-cations or nomination ofcandidates for a tenure positionin the Division of Biostatistics in the Department ofHealth Research and Policy. Appointment will be at thelevel of professor or associate professor, depending onthe ,ualification of the appointee. The long-standingDivision of Biostatistics now resides in the new Depart-ment of Health Research and Policy, which is currentlyrecruiting not only for this position in the Division ofBiostatistics but also for additional faculty in its twoother divisions, Epidemiology and Health Services Re-search.

Applicants should be strongly *rounded in theoreticalstatistics and experienced in applications to biology andmedicine. A strong record of scholarship is essential.Duties will include (i) teaching medical students, resi-dents and fellows (ii) consultin with both clinical andlaboratory investigators, (iii) idependent and collabora-tive research in biostatistical methods and their applica-tions to substantive investigations. Previous administra-tive experience would be desirable but is not required.

Stanford University's School of Medicine is committed toincreasing representation of women and members of minoritygroups among its faculty. We encourage the application andnomination of such candidates.

Applcations and nominations, induding curricula vi-tac, should bc sent to:

Professor Lincoln E. MosesStanford University School of Medicine

Department of Health Research and PolicyDivision of Biostatistics

HRP Suite 114Stanford, CA 94305-5092

University ofMinnesota Department ofRadiology hasa temporary, non-regular, position available for a RA-DIOCBMIST at the rank of assistant professor begin-ning 1 July 1988. Minimum requirements include aPh.D. in synthetic organic chemistry with documentedresearch expericnce in the synthesis and radiolabeling ofanalogs of MPTP. The candidatc must be experiencedwith the safe handling of neurotoxins. In addition, thecandidate should have experience in the synthesis of non-classical nucleotides as potential antiviral agents. Experi-ence in animal handling to determine the biodistributionof these compounds and potential adverse effects is alsorequired. The candidate must be able to perform autora-diographic analysis of animal specimens, and should becomfortable with quantum mechanical modeling to de-termine structure activity relationships of potential radio-pharmaceuticals. An interest in the application of super-computer based al&orithms to this modeling is desirable.Responsibilities will also include graduate and under-graduate instruction in radichemistry and medicinalchemistry. Salary is negotiable and competitive, and isdependent upon past scholarly activity and post-Ph.D.expericnce. Applications for this position will be accept-ed through 30 June 1988. Send letters to: Dr. RobertBoudrcau, Director of Nuclear Mdicine, Dcpart-ment of Radiology, University of Minnesota MedicalSchool, Box 382 UMHC, 420 Dclaware Street S.E.,Minneapolis, MN 55455. The University ofMinnesota isan Equal Opportunity and Affirnative Action Educator andEmployer and specifically encourages applications from womenand minorities.

o _ - Agricultural United StatesResearch Department ofService Agriculture

U.S. Department of Agriculture, Agricultural Re-search Service. RESEARCHMOLECULAR BIOLO-GIST/BIOCHEMIST, Plant Molecular Genctics Labo-ratory, Beltsville, Maryland. ARS has two positionsavailable to identify and characterize genes involved inthe resistance response of crop plants to pathogen inva-sion. Must be U.S. citizen. Salary is commensurate withexperience; $32,567 to $38,727 per annum. Send appli-cations (SF171) and transcripts to: Rose Cunninham,USDA, ARS, Personnel Operations Branch, Building003, Room 415, BARC-W, Bcltsvile, MD 20705 ortclephonc: 301-344-3954. Applications in response tothis advertisement should bc marked 8E014 and rc-ceived by 1 July 1988. An Equal Employment OpportunityEmployer.

1576

MOLECULAR BIOLOGY-The Human Genome project at the Los Alamos National Labora-tory is seeking a Molecular Biologist to work as a team member ontheoretical problems of mapping and sequencing the humangenome. Will analyze strategies for ordering DNA fragments toobtain physical maps of human chromosomes and develop andapply computer programs for ordering sets of partially character-ized fragments. Must work closely with experimental molecularbiologists responsible for physical mapping. Expected to conducttheoretical research independently and/or with others on genomeproblems such as automatic organization and annotation of geneticdata bases and pattern recognition in sequences.The successful applicant will be expected to have a Ph.D. inMolecular Biology or equivalent combination of training andexperience. Ph.D. in Physical or Computer Science together withdetailed knowledge of molecular biology considered. Researchexperience with publications in molecular biology, experience inprogramming for scientific computation, and good oral and writtencommunication skills desired.To formally apply send resume, employment application, threeletters of reference and graduate/undergraduate transcripts toRichard Garcia (MS P280) Personnel Services Division 80113-AC,Los Alamos National Laboratory, Los Alamos, New Mexico 87545.For additional information contact Karl Sirotkin, T-1 0, MS K71 0,(505) 665-0839.Affirmative Action/Equal Opportunity Employer

University of California

-Lo$ /0FL]©

DIAGNOSTICS RESEARCHBURROUGHS WELLCOME CO., a leader in the research, development and manufactureof pharmaceuticals, has openings for a Trials Coordinator and a Research Scientist in theDiagnostics Research Section at their Research Triangle Park, North Carolina facility.

Scientific Evaluation Trials Coordinator-DiagnosticsThis individual will be responsible for designing and monitoring clinical trials for in vitrodiagnostics products. Requirements include a Ph.D. in microbiology or related field with aminimum ofone year's experience in commerical development of in vitro diagnostic productsor Master's degree with five years' experience in product development and the managementof diagnostics trials or equivalence in training and experience. Familiarity with hepatitis andretrovirus diagnostic or screening tests is essential. Also, experience with immunoassaymethodologies involving enzyme immunoassay and latex agglutination is highly desirable.Knowledge of study design, statistics and device regulations is useful.

Diagnostics Research ScientistThe primary responsibility in this position will be to develop in vitro diagnostic enzyme-immunoassays to retroviruses. The successful candidate will have a Ph.D. or equivalentexperience/training in virology, microbiology, or related field or a Master's degree with aminimum of five years' experience as above. Experience with retroviruses and recombinantDNA technology are highly desirable.

BURROUGHS WELLCOME CO. offers some of the best benefits in the industry, salariescommensurate with ability, and a stimulating work environment. Qualified minority, female,veteran and handicapped individuals are encouraged to apply. To apply, submit curriculumvitae, specifying position, to: Employment Supervisor, Burroughs Wellcome Co.,3030 Cornwallis Rd., Research Triangle Park, NC 27709.

5 BURROUGHS WELLCOME CO.Welcome

VacancyAnnouncement

National Instituteof Neurological

and CommunicativeDisorders and Stroke

National Institutes of HealthPublic Health ServiceDepartment of Healthand Human Services

The National Institute of Neurological andCommunicative Disorders and Stroke(NINCDS), National Institutes of Health(NIH), Public Health Service (PHS), invitesnominations and applications for theposition of Chief, Neuroepidemiology nSBranch. This is a Senior Executive Serviceposition with a salary range of $64,700 to$73,400 per annum. The individualselected may be eligible for a Physician'sComparability Allowance ranging from$5,000 up to $20,000. The position is Schenng t andlocated in Bethesda, Maryland. evaluatio ies for

professi ourThe Chief, Neuroepidemiology Branch efforts. If t

provides technical and administrative researchdirection and leadership to the Institute's these paepidemiological program and service asthe focal point within the Federal sector, Seniorthe scientific community, and the public forthese activities. contribut he

Candidates must meet minimum evaluatiof kevelop-educational requirement for MedicalmetotOfficer, GS-602 (or equivalent combination Senio

of experience and training), as defined by You will ntrol ofthe U.S. Office of Personnel Management oncogen riptionalHandbok X-118, Qualificaion Standards nfor Positions under the General Schedule. lvl.AltoThis information is available in Federal experien,Personnel Offices and Federal Job SnoInformation Centers. Further information Y15 as _about qualifications can be obtained by You'll ascontacting Mr. Clifford Schein on (301) interventi. _ hD and496-6334. Information regarding theposition can be obtained by contacting Dr. oncogenl| Im sMark Hallett on (301) 496-1561. An appli-Ascation for Federal Employment (Form SF-171), accompanied by a current curriculum A

vitae and bibliography should be submitted Srntto Mr. Clifford Schein, NINCDS Personnel and/ort esOffice, National Institutes of Health, Thesep ntributeBuilding 31, Room 8A23, 9000 Rockville to researPike, Bethesda, MD. 20892.

Applicatons Must Be Postmarked you nee ingNo Later Than July 1, 1988. resource n attrac-

tive salar lilalaAll qualified candidates will receive consider r. Louis

consideration without regard to race, De M art Id, NJreligion, color, sex, age, national origin, 003lawful political affiliation, marital status,union membership, or any nondisqualifyingphysical or mental handicap.l

- IAIS>_-0 ;::x_ ~ ~ ~ ~ ~ ~ ~ ~ ~

U.S. citizenship required.NIH is an equal opportunity employer.

POSITIONS OPEN

RESEARCH ANIMAL GENETICISTThe U.S. Dcpartment of Agriculture, Agricultural

Research Service, Regional Poultry Research Labora-tory, East Lansing, Michigan, invites applications fromanimal geneticists with experience in virology and molec-ular biology. The incumbent is expected to takc the leadin a team effort to further develop methods for produc-ing transgenic chickens using avian retroviral vectors,and develop a long range research program aimed at thetransfer of genes controlling immune response and dis-ease resistance in poultry. This is a career, permanentposition. U.S. citizenship, research experience, Ph.D. orequivalent, and knowledge of animal genetics requlred.Beginning salary: $33,218 to $39,501 (GS-12/13), de-pending on qualifications. For information on the posi-tion, contact: Dr. R L. Witter, USDA/ARS/RPRL,3606 East Mt. Hope Road, East Lansing, MI 48823.Telephonc: 517-337-6828. For information on appli-cation procedures contact: Barbara Lamm, USDA/ARS Personnel Operations Branch, Northern Sec-tion, Building 419, BARC-East, Beltsville, MD20705. Telephone: 301-344-1542. Applicationsshould be marked 8N025, sent to: Barbara Lamm, andmust be received by 19 July 1988. Equal OpportunityEmployer.

RESEARCH ASSOCIATEPosition available for a biochemist in the Department

of Ophthalmology at Harvard Medical School to doresearch in the general area of lens metabolism. Appli-cants should have a Ph.D. and at least 2 years ofpostdoctoral experience. Familiarity with enzymology,HPLC, electrophoresis, tissue culture, and immunologi-cal techniques would be helpful. Salary and rank com-mensurate with experience. send curriculum vitae and abrief statement of research interests to: Dr. John KWolfe, Howe Laboratory of Ophthalmology, Massa-chusetts Eye & Ear Inirmary, Boston, An 02114.An Equal Opportunity/Afimnative Action Employer.

RESEARCH ASSOCIATE/Pharmnacology-bio-chemistry positions available immediately for investiga-tion ofenzymes encapsulated into carrier erythrocytes ordrug antagonism studies. Experience with enzyme purifi-cation essential. No experience in drug carner systemsnecessary. Send curriculum vitae and three references to:Dr. J. L. Way, Department of Pharmacology, TexasA &M University Medical Sciences Building, CollegeStation, TX 77843. Equal Opportunity/Afirmative Action.

RESEARCH POSMIION-Environmental microbi-ology, 2-year contract position to conduct research onthe physiology and use of autotrophic (i.e., hydrogenoxidizing), denitrifying bacteria for removing nitratefrom contaminated groundwater. Applicants should havea Ph.D. or M.S. degree in environmental microbiologyor a closely related discipline and extensive experiencewith denitrifying bacteria. Research will focus on theisolation, physiological characterization, and activity ofautotrophic denitrifying bacteria in experimental bior-eactors. Starting date ror position is I Au t 1988.Salary: $29,172 per year plus complete beneft package.Submit curriculum vitae and three letters of recommen-dation by 1 July 1988 to: Personncl Department,Orangc County Water District, P.O. Box 8300,Fountain Vallcy, CA 92728-8300.

SCIENTIFIC DIRECTORRETROVIRUS RESEARCH CENTER

The Baltimore VA Medical Center and University ofMaryland at Baltimore are seeking an academic leader toserve as the Scientific Director of the Retrovirus Re-search Center (RRC). This federally funded center hasprograms in viral pathogenesis, immunology, and anti-viral pharmacology. Candidates should have a Ph.D.with a strong background in animal or human molecularretrovirology and should be appointable at the associateor full professor level. Laboratory space and start-upsupport will be provided through the RRC programs. Acompetitive salary based upon qualifications and experi-ence is offered.Send curriculum vitae and name and address of three

references to: Paul M. Hoffman, M.D., AssociateChief of Staff for Research and Development (151),VA Medical Center, 3900 Loch Raven Boulevard,Baltimore, MD 21218. The Veterans Administration andUniversity ofMaryland are Equal Opportunity Employers.

SCIENCE WRITER with capability to translatebiological, psychological, and social scientific materialsinto forms useful to service providers, policymakers, andthe general public. Must demonstrate successful experi-ence in grant writing and ability to bring professionalsfrom different backgrounds together to prepare grantsubmissions. Salary in mid-30's; competitive benefitpackage. Submit resume with relevant supporting docu-mentation to: P.O. Box 897, Buffalo, NY 14209.Alfirmative Acion/Equal Opportunity Employer.

ICIITISTAFF SCIENTIST

The Chemical Industry Institute of Toxicology(CIIT), an innovative leader in toxicology research, isseeking a scientist with an interest in chemical injury tothe lung. The successful candidate will establish anindependent research program to elucidate the cellularand molecular mechanisms involved in chemical induc-tion of respiratory injury and/or neoplasms. Multidis-ciplinary couaborative support is available in the areas ofpathology, inhalation exposure, cell culture, and molecu-lar biology.Applicants shaould have a Ph.D. in biochemistry, cell

biology, molecular biology, or related discipline andseveral years of postdoctoral research experience. Pleasesend complete resume to: Employment Office, CUT,P.O. Box 12137, Research Truangle Park, NC 27709.An Equal Opportunity/Afinative Action Employer.

JPL/NASA VISITINGSENIOR SCIENTIST

OFFICE OF EXPLORATIONSCIENCE ADVISER

The Jet Propulsion Laboratory is seeking candidateswith outstanding professional attainment in one of thefollowing fields of space seience: planetary seience, astro-physics, space physics, or space e seiences. The Officeof Exploration (OEXP) at NASA Headquarters has beenformed to develop strategies and implementation plansfor human space exploration missions, consistent withthe goal of extending human activities beyond Earthorbit, as expressed in the recently issued national spacepolicy. The visiting senior scientnst would have a majorrole in the development of the science content ofhumanexploration missions. The duties will include advising theAssistant Administrator for the OEXP on science oppor-tunities and issues in the exploration program; providingthe principal interface between OEXP and NASAs Of-fice of Space Science and Applications; and representingthe OEM' science potential and programs to the scien-tific community. Tenured faculty members are the pre-ferred choice although qualified individuals from non-profit research institutions may also be considered. Thisposition is open for immediate filling. Normal assign-ment in the Visiting Senior Scientist Program does notexceed 2 years. Appointees must be U.S. Citizens orPermanent Residents, and are expected to retum to theirhome institution followin the NASA assignment. Pleaseprovide curriculum vitae, bibliography and the names offour references to:

Dr. Harry Ashkenas 180-900Department U67

Jet Propulsion Laboratory4800 Oak Grove DrivePasadena, CA 91109

Telephone: 818-354-8251An Equal Opportunity Employer

FELLOWSHIPS

POSTDOCTORAL FELLOWSHIP (Microbiolo-gy) in the Ocular Microbiology Laboratory, Departmentof Ophthalmology, Baylor College of Medicine, Hous-ton. Opportunity for motivated individual with Ph.D. inmicrobiology or infectious disease, to be involved inNIH and privately funded studies of the biology andpharmacology of Acanthamoeba. Please send curnculumvitae and names ofthree references to: K R. Wilhelmus,M.D., Cullen Eye Institute, Onc Baylor Plaza, Hous-ton, TX 77030.

SYMPOSIUM ONTHE MAILLARD REACTION

IN AGING, DIABETES,AND NUTRIMON

22 to 23 September 1988NATIONAL INSTITUTES OF HEALTH

BETHESDA, MARYLANDProgram includes more than twenty internationally

recognized scholars conducting research on the chemis-try and biochemistry of the Maillard reaction, role ofglycation, post-glycation and browning reactions in theaging of protein and DNA, interplay between glycationand sorbitol pathways in the development of pathologyin diabetes, and effects ofMaillard reactions on nutrition-al value of foods. Contributed posters welcome. Forregistration and information, contact: Dr. VimcentMonnier, Department of Pathology, Case-WesternReserve University, Cleveland, OHI 44106. Tele-phone: 216-368-6613.

FELLOWSHIPS

LA TROBE UNIVERSITYAUSTRALIA

La Trobe University RESEARCH FELLOWSHIPSThe University is offering postdoctoral research fellow-ships in any discipline of the University and applicationsare invited from persons who have gained doctoral orequlvalent qualifications within the last 5 years. A personwho currently holds a permanent appointment is noteligible to apply.The proposed research project must be in collabora-

tion with a current Umversity researcher and mustcomplement the existing research work.

Fellowships, which will be awarded for a period of 24months, are intended to advance the research activities ofthe University by bringing to or retaining in Australiapromising scholars.

Salary offered is within the range of $24,848 to$28,342 per annum.

-Appicatl must be made on the University's formwhich will be sent on request together with furtherinformation about the Fellowship.

Enquirers should briefly indicate the research disci-pline of interest to them. The closing date for applica-tions is 30 September 1988. For further information,write to: The Staff Officer, La Trobe University,Bundoora, Victoria, 3083, Australia.

Equal Opportunity is University Policy.

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