personalised treatment of breast cancer/media/confederation/files...breast cancer study • april...
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Personalised Treatment of Breast Cancer
From the Bench to Bedside
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Observation
• Cancers of the same type vary:– Natural history & presentation– Response to treatment– Individual survivability
• What underpins this variation?– Cancer genetics
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Breast Cancer Study
• April 2012 – Prof Carlos Caldas (Cambridge)– Vancouver Breast cancer Agency scientists
• 2000 breast cancer samples– Genetics of tumour cells– Gene mutations
• switched on• switched off
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Breast Cancer Study
• Changes in cells when they became cancerous grouped into 10 categories
• Each ‘category’ behaved differently– Prognosis– Response to treatment
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Breast Cancer Study
• Implications– Tailored or personalised therapy based on tumour genetics
• Less toxic therapy for ‘better prognosis’ tumours• More intensive therapy up front for poorer prognostic groups
• Sequence full genome of all breast cancers over 5 years (n= ~2000)– Use this information to personalise treatment for each patient