periset oral solution (ondansetron) ppt
TRANSCRIPT
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Cause of Nausea & Vomiting
Radiotherapy & ChemotherapyDuring Pregnancy (Hyperemesis Gravidarum)SurgeryDuring Journey Severe Diarrhea (Acute Gastroenteritis)After Accident
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Existing Product Information
Brand Name : PERISET Composition : Ondansetron Hydrochloride USP
8 mg tablet and 4 ml injection (2 mg/ml)
Therapeutic group : Anti-emetic Product group : B & G Pack Size : 3 X 10’s tablets (8 mg tablet)
1 X 5’s ampoules (4 ml injection)
Unit Price (proposed) : 10.00 tk (8 mg tablet) 30.00 tk (4 ml injection)
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NEW Product Information
Brand Name : PERISET Composition : Ondansetron Hydrochloride USP
Therapeutic group : Anti-emetic Product group : B & G Pack Size : 1 X 1’s Phial 50 ml Oral Solution (4 mg/ 5 ml) in PET
bottle Unit Price (proposed) : 40.00 tk (50 ml Oral Solution
)
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Indications
The management of nausea and vomiting
◙ induced by cytotoxic chemotherapy,
◙ for the prevention and treatment of post-operative nausea and vomiting (PONV)
◙ for the prevention of nausea and vomiting associated with radiotherapy, either total body irradiation or single high dose fraction to the abdomen.
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Serotonin release from Small intestine
Vomiting center(medulla)
Serotonin binds with central 5-HT3 receptor inChemoreceptor Trigger zone
Radio & Chemotherapy
Serotonin binds with Serotonin binds with peripheral 5-HT3 receptorperipheral 5-HT3 receptor in GI Tract in GI Tract
VOM reflex
VOM reflex
P
E
R
I
S
E
T
X
X
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Mechanism of Action
Ondansetron is a selective Serotonin 5-HT3 receptor antagonist.
Its effects are thought to be on both peripherial and central Vagus nerves. Peripherharal ► reduce the activity of the peripheral vagus nerve, which activates the vomiting center in the medulla oblongata.
Central ► The other is a blockage of serotonin receptors in the chemoreceptor tigger zone.
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Dosage And Administration
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Age Category Oral Solution
Adults/ Geriatric / Child of 12 years or over
Highly emetogenic cancer chemotherapy: 30 ml (24 mg) Periset Oral Solution administered 30 minutes before start of emetogenic chemotherapy.
Moderate emetogenic cancer chemotherapy: 10 ml (8 mg) Periset Oral Solution administered 30 minutes before start of emetogenic chemotherapy. A further 10 ml (8 mg) dose should be administered after 8 hours of the first dose. One 10 ml (8 mg) dose should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy.
Pediatric (4-11 years) 5 ml (4 mg) Periset Oral Solution should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 5 ml (4 mg) oral solution should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy.
Chemotherapy Induced Nausea and Vomiting
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Age Category Oral Solution
Adults/ Geriatric / Child of 12 years or over
The recommended oral dosage is 10 ml (8 mg) Periset Oral Solution 3 times daily. For total body irradiation, 10 ml (8 mg) Periset Oral Solution should be administered 1-2 hours before each fraction of radiotherapy administered each day. For single high-dose fraction radiotherapy to the abdomen, one 10 ml (8 mg) Periset Oral Solution should be administered 1-2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1-2 days after completion of radiotherapy. For daily fractionated radiotherapy to the abdomen, 10 ml (8 mg) Periset Oral Solution should be administered 1-2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.
Radiotherapy induced nausea and Vomiting
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Age Category Oral Solution
Adults/ Geriatric / Child of 12 years or over
20 ml (16 mg) Periset Oral Solution 1 hour before induction of anesthesia.
Postoperative Nausea and Vomiting
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Pregnancy category B.
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Use In Children
This drug Ondansetron IM/IV injection is recommended for child (from 1 month).
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Target Doctors
Oncology Surgery practitioners Hospital practitioners General practitioners Gyane practitioners PC doctors Child specialist
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Market Information (Generic)
The market size of Ondansetron is 22.38 crore (app.) with Growth 33.08%.
Ref: 2nd Q, 2012
Brand Company Sales value(crore) yearly
Emistat Healthcare 9.90
Zofra SK+F 3.31
Anset Opsonin 3.24
Onaseron Incepta 2.29
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Market Information (Oral Solution)
The market size of Ondansetron is 4.34 crore (app.).
Ref: 2nd Q, 2012
Brand Company Sales value(crore) yearly
Zofra SK+F 1.70
Anset Opsonin 1.08
Onaseron Incepta 0.52
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Highlighting Points
PERISET…◙ Relives nausea and vomiting effectively & safely in adults and children
◙ Ensures effective control of vomiting in acute gastroenteritis
◙ Is an effective first-line antiemetic for patients undergoing chemotherapy, radiotherapy and surgery
◙ Safe & effective in hyperemesis gravidarum
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NVP Don-A Periset
Nausea and vomiting during
pregnancy
Prevention and relief of acute nausea & vomiting, nausea associated with
migraine
Control nausea & vomiting in various condition (Radiotherapy, Chemotherapy, PONV, Acute gateroenterititis,
Hyperemesis gravidarum)
Stomach mortility Safe for child (IM/IV from 1 month and Tablet, Oral solution from 4 years)
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PERISET(Ondansetron Hydrochloride USP)
Presented by
Mohammed Moshiur Rahaman
Brand Executive
Brand Management Department
The ACME Laboratories Ltd.