perception and memory in the medial temporal lobe: insights from anatomy and physiology
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Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology. Wendy A. Suzuki Center for Neural Science New York University. MDRS Chapel Hill, NC 9/25/09. Talk Outline. Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments. - PowerPoint PPT PresentationTRANSCRIPT
Perception and Memory in the Medial temporal Lobe: Insights from Anatomy
and Physiology
MDRS Chapel Hill, NC9/25/09
Wendy A. SuzukiCenter for Neural Science
New York University
Talk Outline
• Neuroanatomy of the PRC and area TE
• Physiology of the PRC and area TE
• Future experiments
Ventral View of Macaque Monkey Brain
rs
PR
ER
PHTE
24/25/32Pi
Ia
Id
Ig
Frontal Lobe Temporal Lobe InsularCortex
CingulateGyrus
ParietalLobe
V4
23/29/30
7a/LIP
STSd STG
TE
STSv
TEO
11/1246
13
DG
SubHPC
30-60%18-29%5-17%<5%
Entorhinal
ParahippocampalPerirhinal
Suzuki and Amaral, 1994
TE/TEO 63%
TF/TH 25%STSd 6%
Insula 2%Frontal lobe 2%
Cingulate/Retrosplenial <1% V4 2%
PerirhinalCortex
Cortical Inputs to the Perirhinal Cortex
Dorsal area TE
TFOrbital areas 11 and 13
V4/TEO
Area TE
Frontal area 8 and 45
Cortical Inputs to Area TE
PerirhinalParietal (LIPd)
24/25/32Pi
Ia
Id
Ig
Frontal Lobe Temporal Lobe InsularCortex
CingulateGyrus
ParietalLobe
V4
23/29/30
7a/LIP
STSd STG
TE
STSv
TEO
11/1246
13
DG
SubHPC
30-60%18-29%5-17%<5%
Entorhinal
ParahippocampalPerirhinal
Suzuki and Amaral, 1994
What about the cytoarchitectonic features of these areas?
24/25/32Pi
Ia
Id
Ig
Frontal Lobe Temporal Lobe InsularCortex
CingulateGyrus
ParietalLobe
V4
23/29/30
7a/LIP
STSd STG
TE
STSv
TEO
11/1246
13
DG
SubHPC
30-60%18-29%5-17%<5%
Entorhinal
ParahippocampalPerirhinal
Suzuki and Amaral, 1994
Talk Outline
• Neuroanatomy of the PRC and area TE
• Physiology of the PRC and area TE
• Future experiments
Pair Coding response
Naya et al., 2003
Individual cell responses in area 36
Pro
babi
lity
Cor
rect
0 10 20 30 40 500
0.2
0.4
0.6
0.8
1
Behavioral Learning Curve and Delay Activity Over Time to Scene 653
Response (S
pikes/Sec
)
-10
0
10
20
30
40
50
Baseline Activity
Trials C110600.4 Wirth et al., 2003
Early
Late Early
Late+
+ +
+
Object 1 Object 2
Place 1
Place 2
Object-Place Association Task
Wirth et al, 2009
Fixation500ms
Cue500ms
Delay700ms
Early500ms
Late500ms
Reward ITI2000ms
++ ++ ++ ++ ++
Bar Release Period
Fixation500ms
Cue500ms
Delay700ms
Early500ms
Late500ms
Reward ITI2000ms
++ ++ ++ ++ ++
Bar Release Period
Conclusions:
Pair coding neurons are built in the perirhinal cortex from the sensory input
from area TE.
Talk Outline
• Neuroanatomy of the PRC and area TE
• Physiology of the PRC and area TE
• Future experiments
Experiments?