Peptides 2010

Tales ofPeptides

Proceedings of the Thirty-First

European Peptide SymposiumSeptember 5-9, 2010, Copenhagen, Denmark

Edited by

Michal Lebl

Prompt Scientific Publishing, San Diego, CA, USA

michallebl@gmail. comMorten Meldal

Carlsberg Laboratory, Copenhagen, Denmarkmpm@crc.dkKnud J. Jensen

University ofCopenhagen, Faculty ofLife Sciences,Denmark

kjj@life.ku.dkThomas Heeg-JensenNovo Nordisk A/S, Maaloev, Denmark

tshj@novonordisk. com

European Peptide

Table of Contents

N-Pi Interactions in the Molecules of Life 2Amit Choadhary, Ronald T, Raines

Mimicry Effect ofthe Neo-Epitope [Asn641(Glc)]FAN(635-655) withCSF114(Glc) Detecting Autoantibodies in Multiple Sclerosis 4Shashank Pandey, Elisa Peroni, Maria Claudia Alcaro, Fabio Rizzolo, MarioChelli, Paolo Rovero, Francesco Lolli, Anna Maria PapiniCyclic Peptides with a Diversely Substituted Guanidine Bridge: Synthesis,Structural and Biological Evaluations of Model Peptides 6Youness Touati Jallabe, Engin Bojnik, Laurent Chiche, Abdullah Hamze,Andre Aumelas, Nga IV, Chung, Peter W. Schiller, Dorothee Berthomieu,Sandor Benyhe, Vincent Lisowski, Jean Martinez, Jean-Francois HernandezPhotolabile Protecting Groups Based on Novel Thiocoumarins andThioquinolones: Synthesis and Photorelease of a Model Amino Acid

Conjugate 8Andrea S.C. Fonseca, M. Sameiro T, Gongalves, Susana P.G. CostaAmino Acid Coupling Reactions in Aqueous Environment Using MicrowaveAssistance Heating 10Athanassios S. Galanis, Fernando AIbericio, Morten GrotliBis-Azobenzene Photoswitchable a-Amino Acids for NanomaterialsApplications 12Alessandro Moretto, Marco Crisma, Paola Fatas, Gema Ballano, Ana I.Jimenez, Carlos Cativiela, Claudio TonioloStabilization of B-Turn Conformation in Melanocortin Like Peptide by ClickSide Chain-to-Side Chain Cyclization 14Chiara Testa, Stefano Carganico, Francesco Nuti, Mario Scrima, AnnaMaria D'ursi, Marvin L. Dirain, Nadeje Lubin Germain, Carrie Haskell-Luevano, Michael Chorev, Paolo Rovero, Anna Maria PapiniImpact of Ionic Liquids on the Conformation of Peptides Studied by HR-MAS NMR Spectroscopy 16Annekathrin Richardt, Carmen Mrestani-Klaus, FrankBordusa

Next Generation Peptide Microarrays 18

F. RalfBischoff, Frank Breitling, Volker Stadler

Imide-Click Ligation and Click-Unclick Peptide-Based Prodrug Strategy 20Reda Mhidia, Nicolas Beziere, Nicole Pommery, AnnickBlanpain, OlegMelnykDesigned Hairpins Modulate the Amyloidogenesis of Alpha Synuclein:Inhibition and Diversion to Non-Amyloid Aggregates 22Niels H. Andersen, Kelly N. L. Muggins, Marco Bisaglio, Liugi BubaccoSelective Targeting of Extracellular Cyclophilins by Novel Cyclosporin ADerivatives

24Miroslav Malesevic, Jan Kiihling, Vikloria Kahlert, Frank Erdmann, Molly A.Balsley, Michael I, Bukrinsky, Stephanie L. Constant, Gunter Fischer

XXV

Design of Peptidyl-Inhibitors for Glutathione Transferase (GST) Useful in

Targeted Cancer Chemotherapy 26

Irine Axarli, Georgia A. Kotzia, Christos Petrou, Paul Cordopatis, Nikolaos

E. Labrou, Yannis D. Clonis

Exploring the HBV Envelope Protein for Liver-Specific Drug Targeting 28

Thomas Miiller, Alexa Schieck, Barbro Beijer, Anja Meier, Uwe Haberkorn,

Stephan Urban, Walter Mier

Biocompatible Triazole Ligations Via 1,3-Dipolar Cycloadditions of Peptidyl

Phosphoranes and Azido Peptides 30

Jorg Rademann, Ahsanullah

Peptide Fragmentomics 32

Alexander A. ZamyatninMolecular Knots As Templates for Protein Engineering: the Story of Lasso

Peptides 34

Kok-Phen Yan, Severine Zirah, Yanyan Li, Christophe Goulard, Remi

Ducasse, Alain Blond, Jean Peduzzi, Sylvie RebuffatCryptides: Receptors and Signaling Mechanisms for Novel Neutrophil-Activating Peptides Hidden in Mitochondrial Proteins 36

Hidehito Mukai, Tetsuo Seki, Yoshinori Hokari, Akiyoshi Fukamizu, Yoshiaki

Kiso

Mcd4-HS12: Closing and Locking Doors for HIV-1 Entry 38

F. Baleux, P. Clayette, F. Arenzana-Seisdedos, D. Bonnaffe, H. Lortat-Jacob

Use of Ester-Containing Peptides Toward Understanding the Functions of

Amyloid Beta Peptide and Human Insulin 40

Youhei Sohma, Stephen B. H. Kent, Yoshiaki Kiso

The Dynamic Ras Cycle 42

Christian Hedberg, Herbert Waldmann, Frank Dekker

Synthesis of Biaryl Cyclic Peptides Through Solid-Phase Borylation and

Cyclization by a Suzuki-Miyaura Cross-Coupling 44

AnaAfonso, Marta Planas, Lidia Feliu

Synthesis and Characterization of Flaib, a Completely RigidifiedBenzophenone Containing a-Amino Acid 46

Karen Wright, Antonio Blanco Alvarez, Marco Crisma, Alessandro Moretto,

Fernando Formaggio, Claudio Toniolo

Straightforward Syntheses of Deuterated Precursors to Be Used As Powerful

Tracers Under Fermentative Conditions 48

Florine Cavelier, Aurelie Roland, Alain Razungles, Remi Schneider

Tert-BuNH2 As An Efficient Reagent for the Deprotection of Fmoc Protected

Amino Acids 50

Armin Arabanian, SaeedBalalaie

Peptide Diketopiperazine Thioester Formation At the Cys-Pro-Cys Position 52

Tom Kawakami, Sakiko Shimizu, Saburo Aimoto

Fmoc Deprotection by Tert-Butylamine in Solution and in the Synthesis of

Cyclic Part of Oxytocin Like Peptides 54

Martin Flegel, Zuzana Flegelovd, Petr Malon, Sixtus Hynie, Vera Klenerovd

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Radical Scavenging Activity ofHydroxycinnamoylamides of Amino Acids -

Precursors of Biogennic Amines 56Maya G. Chochkova, Hristina G. Nikova, Galya I. Ivanovo, Lyubomir N.

Georgiev, Tsenka S. Milkova

Repetitive Cleavage ofAib-Peptides by Trifiuoroacetic Acid 58Hans Bruckner, Christoph Theis, Thomas Degenkolb, Renate Gessmann,Michael Kokkinidis

Antioxidant Potential of Phenolic Acid Amides ofAromatic Amines 60

Lyubomir N. Georgiev, Iskra Totseva, Katya Seizova.Emma Marinova, MayaG, Chochkova, Tsenka S. Milkova

Solid Phase Synthesis and Characterisation of a Platelet-Derived GrowthFactor Receptor (PDGFR) Specific Affibody Molecule 62Bard Indrevoll, Roger Bjerke, Dimitrios Mantzilas, ErlendHvattum, Astri

RogstadRacemization of Amino Acids on Heating with Sugars Or

(Hydroxyalkyl)Aldehydes Or -Ketones 64

Hans Briickner

Nicotianamine and Thermonicotianamine: Supported Synthesis and Chelation

Ability 66

Manuel Larrouy, Jean Martinez, Florine Cavelier

Tert-Butylation of Hydroxy 1 Group Using MTBE 68

Sorour Ramezanpour, Saeed Balalaie

Synthesis of New Polymer Matrices Including Amino Acids 70Dantcho L. Danalev, Jean-Marie Ringeard, Stephane Serfaty, Jean-Yves Le

Huerou, Emmanuel Caplain, Lyubov K. Yotova, Pascal Griesmar

Convenient Synthesis ofTfm-Dipeptides from Unprotected Enantiopure Alfa-Tfm-Proline and Alfa-Tfm-Alanine 72

Gregory Chaume, Nathalie Lensen, Caroline Caupene, Thierry BrigandConcise Access to (S)- and (R)-Alfa-Tfm Serine and Alfa-Tfm Aspartic Acidfrom Chiral Trifluoromethyloxazolidines (Fox) 74

Julien Simon, Thuan Nguyen, Gregory Chaume, Evelyne Chelain, NathalieLensen, Julien Pytkowicz, Thieny BrigaudCF3-Pseudoprolines: Synthesis and Conformational Stud}' ofHydrolyticallyStable Proline Surrogate Containing Dipeptides. 76

Olivier Barbeau, Caroline Caupene, Debby Feytens, Gregory Chaume,Philippe Lesot, Emeric Miclet, Thieny Brigaud

Solid Phase Synthesis Substituted Peptide Amides on Aryl Hydrazine Resin 78

WitoldA. Neugebauer, Anna Kwiatkowska, Xue Wen Yuan, Robert DaySolid-Phase Synthesis C-Terminus Chloromethyl Ketone Peptides 80

Witold A. Neugebauer, Nabil G. Seidah, Delia Susan-Resiga, Xue Wen Yuan,Robert DayPhoto-Uncaging of Neurotransmitter Amino Acids from Fluorescent 5,6-Benzocoumarinyl Precursors 82

Maria Jose G. Fernandes, M. Sameiro T. Gonqalves, SusanaP.G. Costa

What Could Be the Role ofQuinacrine in Creutzfeldt-Jakob Disease

Treatment? 84

Zbigniew Zawada, Jaroslav Sebestik, Martin Safaflk, Anna Krejcifikova,Anna Bfezinovd, Jan Hlavdcek, Ivan Stibor, Karel Holada, Petr Bour

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Synthetic Antifreeze Glycopeptide Analogs 86

Lilly Nagel

Peptide Based Artificial Receptors for Carbohydrate Recognition 88

Predrag Cudic, Andreja Jakas, Nina Bionda, Mare Cudic

Synthesis of Glycopeptides Potential Inhibitors ofHuman Rhinovirus 3c

Prorease 90

Dantcho L. Danalev, Nadege Lubin-Germain, Jacques Uziel, Jacques AugeStereoselective Synthesis of Tetrahydro-B-Carbolines Via Pictet-SpenglerReaction 92

Saeed Balalaie, Vahid Dianati

Synthesis of Aza-B3-Homoserine, Incorporation of This New Aza-B3-Amino

Acid into 26rfa(20-26) and Microwave-Assisted Deprotection of Its Side

Chain 94

Olivier Tasseau, Patrick Bauchat, Cindy Neveu, Benjamin Lefranc, Jerome

Leprince, Michele Baudy-Floc 7?

Dimerization ofthe Immunosuppressory Decapeptide Ubiquitin Fragment 96

Marzena Cydzik, Monika Biernat, Alicja Kluczyk, Piotr Stefanowicz,Remigiusz Bqchor, Michal Zimecki, Zbigniew SzewczukThe Application ofthe New Tin(IV) Chloride Deprotection for the

Preparation ofGlycosylated Peptides 98

Orsolya Szolomdjer-Csikos, Kinga Rdkosi, Orsolya Hegyi, Ldszlo Kalmdr,Jdnos Kerekgydrto, Gdbor K. Toth

Efficient Microwave-Assisted Synthesis of Mitochondrial Signal PeptideUsing Cltr-Cl and Wang Resin 100

Maria-Eleni Androutsou, Panagiotis Plolas, George Agelis, John Matsoukas

Electrochemical Reduction ofBeta-Aryldehydroamino Acid Derivatives 102

Paida M. T, Ferreira, Luis S. Monteiro, EHsabete M.S. Castanheira, Goreti

Pereira, Carla LopesNew Building Blocks for Solid-Phase Synthesis ofPeptide Analogues: Nb-Fmoc-Nb-Methyl-Aza-B3-Amino Acides 104

Ksenija Kisselnova, Irene Nicolas, Patrick Bauchat, Jaak Jdrv, Michele

Baudy-Floc 'h

Synthesis and Biological Studies of Cyclolinopeptide A Analogs Modified

with 4-Substituted-Phenylalanine 106

K. Kierus, K. Ciupinska, M. Waskiewicz, M. Grabowska, KrzysztofJ.

Kaczmarek, J. Olejnik, MichalZimecki, S. Jankowski, Janusz Zabrocki

Synthesis and Folding of Kvl.3 Ion-Channel Blocking Peptides 108G. Dello-Iacono, T. Leedom, L. Wood, D. Tumelty, A. Bhat, G. Woodnutt, C.

Bradshcrw, P. Morton, R. Numann, J. Ozer, G. Anderson, G. Weber, M.

Schmidt, Z-L. Mo, K. Keys, B. Koci, M, Williams, J. Desharnais

Synthesis of(Glyco)Protein by the Ligation Methods 110

Hironobu Hojo, Hidekazu Katayama, Akiharu Ueki, Yuko Nakahara, Yoshiaki

Nakahara

S-Acyl Isopeptide Method: Preparation ofThioester-Containing Isopeptidesby Fmoc-Based SPPS with Aloe Group /12

Taku Yoshiya, Yuka Hasegawa, Wakana Kawamura, Hiroyuki Kawashima,Youhei Sohma, TooruKimura, Yoshiaki Kiso

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Computational Study on Helical Structure ofa,a-Disubstituted Oligopeptides 114

Containing Chiral a-Amino Acids

Masaaki Kurihara, Yosnke Demizu, Yukiko Sato, Nanako Yamagata,Haruhiro Okuda, Masanobu Nagano, Mitsitnobu Doi, Masakazu Tanaka,Hiroshi Suemune

En Route to Bicyclic Biaryl Peptides 116

Soledad Royo, Ernest Giralt

Chemical Synthesis and Evaluation of a Backbone-Cyclized Minimized 2-

HelixZ-Domain 118

Peter Jarver, Cecilia Mikaelsson, Amelie Eriksson KarlstromRacemization-Free Synthesis of Cyclic Peptides by Use ofthe O-AcylIsopeptide Method 120Hiroyuki Kawashima, Taku Yoshiya, Yuka Hasegawa, Kazuhiro Okamoto,Tooru Kimura, Youhei Sohma, Yoshiaki Kiso

Traceless Chiral Triazine Based Coupling Reagent, a New Concept for

Synthesis of Optically Peptides Products from Racemic Carboxylic Acids 122Katarzyna Frankowska-Kasperowicz, Beata Kolesinska, Zbigniew J.Kaminski

P-Triazinylphosphonium Sulphonates As Coupling Reagents for PeptideSynthesis in Solution 124

Beata Kolesinska, Olga Cieslak, Inga Relich, Zbigniew J. Kaminski

Triazine Condensing Agents for Synthesis ofPeptide Bond in Aqueous Media 126

KrzysztofJ. Zajac, Ireneusz Kaminski, Jastyna Fraczyk, Zbigniew J. Kaminski

Synthesis ofNovel Non-Proteinogenic Amino Acids: N-EthyldehydroaminoAdds 128

Luis S. Monteiro, Joanna Kolomanska, Ana C. Suarez

The Total Regioselective Control of Tartaric Acid 130Jan Spengler, Ana I. Femdndez-Llamazares, Javier Ruiz-Rodriguez, Klaus

Burger, Fernando Albericio

DTT Reacts with TFA to Form a Novel Bicyclic Dithioorthoester 132Jan Pawlas, Stefan Hansen, Anne H. Sorensen, Gannar Staerkaer, Anette

Moller, Neil Thompson, Thomas Pagano, Fangming Kong, Steve Koza, MarkPozzo, Jari Finneman, Patricia DroegeSolid Phase Synthesis of Structurally Diverse 1,2,5-Benzothizadiazepin-4-on-1,1-Dioxides'

'

134

Karel-Simon Slock, Jurgen Caroen, Johan Van Der EyckenEvaluation of Packing Materials Used for Preparative HPLC Purification of

Peptide Derivatives 136

Kiyoshi Nokihara, Takafumi Ohyama, Noriko Ono, Kazuhiro Kitaori,Tetsuyuki Saika

Structure-Activity Studies ofAngiotensin IV Analogues Containing the

Conformational!}- Constrained Aia Residue 138

Isabelle Van Den Eynde, Aneta Lukaszuk, Koen Buysse, HeidiDemaegdt,Philippe Karoyan, Georges Vauquelin, Attila Keresztes, Geza Toth, Antal

Peter, Dirk Tourwe

A Novel Method to Prepare Cyclic Peptides At Non-Cysteine Sites Using the

Auxiliary Group, 4,5-Diniethoxy-2-Mercaptobenzyl (Dmmb) 140

Jane Spetzler

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Synthesis and Oxidative Folding of Cyclic Cystine Knot Peptides: Towards

Backbone Engineering 142

Teshome Leta Aboye, Richard J. Clark, Robert Burman, David J. Craik, UlfGoransson

Synthesis and Structure Confirmation of the Cysteine Knotted PeptideGurmarin by Selective Disulphide Formation 144

Rasmus Eliasen, Thomas Lars Andresen, Kilian W. Conde-Frieboes

Mimicking ofDisulfide Bonds by Triazoles 146

Kai Holland-Nell, Morten Meldal

Identification of Sulphated Peptides Binding FGF1 Using a Micro Particle

Matrix (MPM) Encoded Librae 148

Manat Renil, Morten Meldal

Direct Synthesis ofMtraq® Reagent Labeled Peptides Using the 433A

Peptide Synthesizer 150

Stephan Rawer, Andrea Hartmann, Matthias Gluckmann

Synthetic Studies Toward the Mannopeptimycins 152

M, Morelle, K. Cariou, J. Thierry, R. H. Dodd

Design and Synthesis of B-Cyclodextrin/Gnrh-Analogue Conjugation for the

Treatment ofHormone Dependent Cancer 154

Despina Laimou, Gerasimos Tsivgoulis, Theodore Tselios

Novel Synthesis of Benzophenone Units for Photo-Affinity Labeling 156

ShirlyNaveh, Carni Lipson, Michal Breker, Yftah Tal-Gan, Maya Schuldiner,Michal Sharon, Chaim Gilon

The Chains of Insulin-Like Peptides Reveal Properties ofOxidoreductases 158

Kostas K. Barlos, Zoe Vasileiou, Vasso Chatziharalampous, Dimitrios Gatos,

Kleomenis Barlos

Solid Phase and Ligation Approaches to Dendrimeric Immunogen Synthesis 160

Wioleta Kowalczyk, Marta Monso, Beatriz G. De La Torre, DavidAndreu

Synthesis ofthe Thiolactone Derivative of Enterococcus Faecalis Gelatinase

Biosynthesis-Activating Pheromone Using the Gyra Mini-Intein 162

Koji Nagata, Yosuke Yamanaka, Shoichiro Horita, Hidekazu Katayama, Kou

Hayakawa, Akihiro Yamamura, Mami Sato, Kenzo Nishiguchi, KenjiSonomoto, Jiro Nakayama, Masaru Tanokura

Solvent-Free Synthesis of Peptides in a Ball-Mill 164

Valerie Declerck, Pierrick Nun, Jean Martinez, Frederic LamatyA Study to Assess the Cross-Reactivity of Cellulose Membrane Bound

Peptides with Detection Systems: An Analysis At the Amino Acid Level 166

Carsten C. Mahrenholz, Victor Tapia, Rudolf Volkmer

The Microwave Revolution: Recent Advances in Microwave Assisted

Peptide Synthesis 168

Sandeep K. Singh, Alicia D. Douglas, Eric J. Williamson, Grace S. Vanier

Microwave-Assisted Solid-Phase Peptide Synthesis of the 60-110 Domain of

Human Pleiotrophin (Hptn) on CLTR-C1 Resin 170

Irene Friligou, Evangelia Papadimitriou, Dimitrios Gatos, Theodore Tselios

Solid-Phase Synthesis of the Lipopeptide Myr-Hbvpres/2-78, a Hepatitis BVirus Entry Inhibitor 172

Alexa Schieck, Thomas Midler, Uwe Haberkorn, Stephan Urban, Walter Mier

xxx

Automated Microwave-Assisted Peptide Synthesis with a Novel Robotic

Synthesizer: Synthesis of Difficult Sequences 173

Soren L. Pedersen, Amit Mehrotra, KnudJ. Jensen

The Oxime-Based Family of Coupling Reagents 176

Ramon Subiros-Funosas, Ayman El-Faham, Fernando Albericio

Engineering of Amyloid-B-Binding Affibody Molecules for ImprovedChemical Synthesis and Higher Binding Affinity 178

Joel Lindgren, Lars Abrahmsen, Sebastian Warml&nder, Amelie Eriksson

Karlstrom

Chemical Synthesis of Fluorescent-Labeled Affibody Molecules for Use in

Cancer Diagnostics 180

Anna Perols, Amelie Eriksson Karlstrdm

Oxyfold : A New Solid Supported Reagent for the Simple and Effective

Formation ofDisulfide Bond in Peptides 182

Luisa Ronga, P. Verdie, M. Cristau, M. Amblard, S. Cantel, C. Enjalbal, K.

Puget, G. Subra, Jean Martinez

An Efficient MW-Assisted Synthesis of Dicarba-Analogues 184

G. Cane, A. Di Cianni, M. Litmini, Anna Maria Papini, Mauro Ginanneschi

Microwave-Assisted Solid Phase Synthesis of [Asn641(Glc)]FAN(635-655):A New Case Study for Optimisation of Glycopeptide Synthesis 186Fabio Rizzolo, Francesco Nuti, Shashank Pandey, Mario Chelli, Paolo

Rovero, Anna Maria PapiniConventional and Microwave-Assisted SPPS Approach: A ComparativeStudy ofPthrp(l-34)NH2 Synthesis 188

Fabio Rizzolo, Chiara Testa, Michael Chorev, Mario Chelli, Paolo Rovero,Anna Maria PapiniMicrowave-Assisted Total Synthesis ofMacrocvclic Cystine Knot

Miniproteins 190

S. Park, S. Gunasekera, T. Aboye Teshome, UlfGoransson

Racemization in Automated Solid Phase Synthesis 192

KrzysztofDarlak, Miroslawa Darlak, Thomas E. HopkinsOctapeptide Ligands with Affinity for Recombinant Erythropoietin Derivedfrom the Screening of Combinatorial Libraries 194Maria C. Martinez-Ceron, Mariela M. Marani, Marta Tattles, Marina

Etcheverrigaray, Fernando Albericio, Osvaldo Cascone, Silvia A. CamperiPost-Synthesis Modification ofP-lodo-Phenylalanine-Containing Peptides on

Solid-Phase Via the Palladium-Catalyzed Sonogashira Reaction 196

Ngoc-Duc Doan, David Chatenet, Alain Fournier

Specific Substrates and Inhibitors of Human Furin 198

Adam Lesner, Magdalena Wysocka, Anna Lqgowska, KrzysztofRolkaNovel Peptide Conjugates: Heterocyclic Modifications of the

Immunomodulatory Ubiquitin Fragment 200

Alicja Kluczyk, Malgorzata Ratajska, Anna Staszev/ska, Marek Cebrat, Hubert

Bartosz-Bechowski, Piotr Stefanowicz, Michal Zimecki, Zbigniew SzewczukThe Characterization of Staphopains Enzyme Family from StaphylococcusAureus Using Combinatorial Chemistry Methods 202

Adam Lesner, Magdalena Wysocka, Marcelina Jams, Anna Lqgowska, KatarzynaGuzow, Grzegorz Dubin, Benedytkt Wladyka, Wieslaw Wiczk, Krzysztof'Rolka

xxxi

Convergent Syntheses ofHuprpl06-126 (Difficult Sequence) Using Native

Chemical Ligation and Desulfurization/ Deselenization 203

Jaroslav Sebestik, Martin SafaHk, Zbigniew Zawada, Jan Hlavdcek

Functionalized PNA Backbone Building Blocks Eligible for Diels Alder

Click Chemistry in Molecular Imaging 206

Rildiger Pipkorn, M. Wiefiler, Waldemar Waldeck, Mario Koch, Klaus Braun

Fmoc Solid Phase Synthesis ofPeptide Thioesters for Native Chemical

Ligations Employing a Tert-Butyl Thiol Linker 208

RichardRaz, Jorg Rademann

Assembly and Stimulatory Activity of Backbone to Side Chain Cyclic

Octapeptide-Ligands for the N-Terminal SH2-Domain ofthe Protein-

Tyrosine-Phosphatase SHP-1 210

MohammadS. Zoda, Martin Zacharias, Franziska Mussbach, Buerk

Schaefer, Siegmund Reissmann

Synthesis of Neuropeptide Y Analogues As PET Imaging Agents 212

Simon J. Mountford, Lei Zhang, Herbert Herzog, Bim Graham, Philip E.

Thompson

3ts : Thiazolidine-Triggered Thioester Synthesis 214

Julien Dheur, Nathalie Ollivier, Annick Blanpain, Oleg Melnyk

Convenient Synthesis ofC-Terminal Glycopeptide Conjugates Via Click

Chemistry 216

Jean-Philippe Ebran, Nabil Dendane, Oleg MelnykPreparation of Thioacid-Containing Amino Acids and Peptides and Their

Application in Ligation Reactions 218

Katja Rohmer, Odin Keiper, Jamsad Mannuthodikayil, Valentin Wittmann

Molecular Dynamics Calculation and NMR Conformational Studies of

Heterodetic Triazolyl Cyclo-Nonapeptides: A Comparative Study 220

Mario Scrima, Anna Maria Papini, Michael Chorev, Anna Maria D'ursi

Reverse Thioether Ligation Approach to Dendrimeric Peptide Platforms:

Solution and Solid Phase Studies 222

Marta Monsa, Beatriz G. De La Torre, WioletaKowalczyk, DavidAndreu

A Double Heteroatom Mitsunobu Coupling with Amino HydroxybenzoicAcids on Solid Phase: A Novel Application of the Mitsunobu Reaction to

Form Dendron Building Blocks 224

Tzachi Shalit, Amnon Albeck, Gary Gellerman

Peptidomimetic PKB/Akt Inhibitors As Anti-Cancer Drug Leads 226

Yftah Tal-Gan, Shoshana Klein, Alexander Levitzki, Chaim Gilon

Application of Fragment Based Drug Design for the Discovery of

Peptidomimetic As Inhibitors of Cyclophilins. 228

Lionel Colliandre, Abdelhakim Ahmed-Belkacem, Jean-Michel Pawlotsly,Jean-Franqois Guichou

SPOS Route to Novel 9-Anilinoacridine Derivatives: Biological Evaluation 230

Gary Gellerman, Tamara Brider, Arie Budovsky, Stella Aronov

Hepatitis C Virus NS3 Protease Inhibitors Based on a 2(lH)-Pyrazinone-Glycine Scaffold 232

Anna Karin Belfrage, Johan Gising, Pernilla Ortqvist, Aparna Vema, SofiaSvahn Gustafsson, Mats Larhed, U. Helena Danielson, Anja Sandstrom

xxxii

Peptide Nucleic Acids with Chiral Backbone - Synthesis and Properties 234

Tatyana A. Dzimbova, Tamara I. Pajpanova

A New Synthetic Strategy for Novel Antibacterial 236

/. Lapidot, G. Zats, Amnon Albeck, Gary Gellerman, S. Shatzmiller

Design and Synthesis of Protein-Protein Interaction Mimics As Plasmodium

Falciparum Cysteine Protease Falcipain-2 Inhibitors 238

Luca Rizzi, Srividhya Simdararaman, Katarina Cendic, Nadia Vaiana,

Reshma Korde, Dipto Sinha, AsifMohmmed, Pawan Malhotra, SergioRomeo

Structural Features of Antimicrobial Aza-B3-Peptides 240

Baptiste Legrand, Mathieu Laurencin, Celine Zatylny-Gaudin, Joel Henry,Arnaud Bondon, Michele Baudy Floc'h

Synthesis of Peptidomimetics by the Pictet-Spengler Reaction 242

Marta Slupska, Karolina Pulka, Malgorzata Przygodzka, Aleksandra Misicka

From Peptides to Non Peptide Mimetics: the Examples of Angiotensin II and

Myelin 244

Amelia Resvani, George Agelis, Maria-Eleni Androutsou, Dimitra

Kalavrizioti, Konstantinos Kelaidonis, Maria Katsara, George Deraos, Irene

Friligou, Panagiotis Plotas, Vasso Apostolopoalou, John Matsoukas

Efficient Synthesis and Biological Evaluation ofImidazole ATI Ang II

Receptor Antagonists Based on 4(5)-Butylimidazole 246

George Agelis, A. Resvani, T. Tiimovd, Jifina Slaninovd, John Matsoukas

Synthesis and Biological Evaluation of 1-Biphenylmethyl Substituted

Imidazole ATI ANG II Receptor Antagonists 248

K. Kelaidonis, George Agelis, Dimitra Kalavrizioti, Amalia Resvani, John

Mih'oyiannidis, Panagiotis Plotas, Dimitrios Vlahakos, John Matsoukas

Three Disulfide Bridged u.-Conopeptoids and Their Minimized Disulfide-

Depleted Selenopeptide Derivatives 250

Aleksandra Walewska, Tiffany S. Han, Min-Min Zhang, Doju Yoshikami,

Baldomero M. Olivera, Grzegorz Bulaj, KrzysztofRolkaConformational Analysis of Aliskiren, a Potent Renin Inhibitor, in Solution

Using Nuclear Magnetic Resonance (NMR) and Molecular Dynamics (MD) 252

Minos - Timotheos Matsoukas, Panagiotis Zoumpoulakis, Theodore Tselios

Development ofa Protease-Resistant Bicyclic Peptide Targeting HumanPlasma Kallikrein 254

Elise Bernard, DavidLoakes, Gregory Winter

Structure-Activity Relationship Study ofAn Interleukin-1 Receptor NegativeModulator by a-Amino G-Lactam Scanning 256

Luisa Ronga, Kim Beauregard, Andrew G. Jamieson, Daniel St-Cyr,Christiane Quiniou, Sylvain Chemtob, William D. Lubell

The Synthesis of Peptide Dualag 258

Zhiguo Liu, Shengwu Wang, Qian Qiu, Shawn Lee, Xiaohe TongStructure - Activity Relationship Studies for Cystapep 1 and Its Analogues 260

A. Pogorzelska, S. Rodziewicz-Motowidlo, M. Smuzyhska, Z. Freiburghaus,A. Grubb, F. Kasprzykowski

Anticancer Activity of Short Cationic Beta-Peptidomimetics 262

Veronika Torfoss, D. Ausbacher, T, Hansen, M. Havelkova, Morten B, Strom

xxxiii

Bactericidal Activity of Small Beta-Peptidomimetics 264

Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strom

Synthesis ofPeptidomimetics Mimicking the Hormone Binding Domain of

the Estrogen Receptor 266

Rosa Romeralo Tapia, Frederique Backaert, Jan Goeman, Johan Van Der

EyckenPyrrolo[3,2-E][l,4]Diazepin-2-One G-Turn Mimic Synthesis on TAP Soluble

Support. 268

Nicolas Boittard, Julien Dufour-Gallant, William D. Lubell

Cellular Binding and Internalization by Water-Soluble Aromatic Amide

Foldamers 270

Jone Mondo-Alberdi, Katta Laxmi-Reddy, Aissa Bouguerne, Cathy Staedel,

Ivan Hue

Detection of the Apo-B,E-Binding Site of Low Density Lipoprotein Receptor 272

Irina V. Shutova, Vladimir P. Golubovich

Silver Nanoparticle - Peptidoglycan Cell Wall Interaction 274

Fateme Mirzajani, Alireza Ghassempour, Atousa Aliahmad, Mohammad Ali

Esmaeili

Peptidomic Analysis of Human Blood Serum for Specific Disease Markers 276

Rustam H. Ziganshin, Georgii P. Arapidi, Igor V. Azarkin, Vadim M.

Govorun, Vadim T. Ivanov

The Top-Down Analysis of Chemical Modification of Ubiquitin by ECD

Method 278

Piotr Stefanowicz, Karolina Kowalewska, Monika Kijewska, Alicja Kluczyk,

Marek Cebrat, Zbigniew SzewczukEffect of Point Mutation in the Hinge Region on a Structure ofAn

Atnyloidogenic Protein - Human Cystatin C 280

Marta Orlikowska, Elzbieta Jankowska, Dominika Borek, Robert

Kolodziejczyk, Zbyszek Otwinowski, Mariusz Jaskolski, Aneta Szymanska

Crystal Structure of L68V Mutant ofHuman Cystatin C, An AmyloidogenicProtein 282

Marta Orlikowska, Elzbieta Jankowska, Dominika Borek, ZbyszekOtwinowski, Aneta SzymanskaMutants of An Amyloidogenic Human Cystatin C in Pressure-Induced

Denaturation Studies Using Hydrogen Exchange Mass Spectrometry 284

Elzbieta Jankowska, Marta Orlikowska, Marta Sosnowska, Aneta

Szymanska, Piotr Stefanowicz, Karolina Kowalewska, Zbigniew Szewczuk

Characteristics of a Human Cystatin C - Antibody Complex 286

Anna Sladewska, Aneta Szymanska, Aleksandra Kolodziejczyk, Anders

Grubb, Paulina CzaplewskaCharacterization of Human Cystatin C - Serum Amyloid A Complex 288

Marta Spodzieja, Aneta Szymanska, Anna Sladewska, Piotr Stefanowicz,Zbigniew Szewczuk, Zbigniew Grzonka, Claudia Cozma, Michael Przybylski,

Aleksandra Kolodziejczyk, Paulina CzaplewskaRecognition ofCytoskeletal Proteins Monoclonal Iggs by CSF114(Glc), the

Synthetic Probe of Multiple Sclerosis 290

ShashankPandey, Duccio Lambardi, Feliciana Real-Fernandez, Maria

Claudia Alcaro, Elisa Peroni, M. Chelli, A. M. Papini, F. Lolli, Paolo Rovero

xxxiv

Role of Triple Hyp-Pro Substitution on Conformation and Bioactivity ofIntegramide A 292Marta De Zotti, Wim De Borggraeve, Bernard Kaptein, Quirinus B.

Broxterman, Sheo B. Singh, Peter J, Felock, Daria J. Hazuda, Fernando

Formaggio, Claudia Toniolo

Angiotensin 1 Converting (ACE) Inhibitor)' Peptides - A Bioinformatic-Assisted Idea of Research 294

Anna Iwaniak

A Method for Screening Peptides Bound to EGFR by Using MultipleFluorescent Amino Acids As Fluorescent Tags 296

Mizuki Kitamatsu, Takahiro Yamamoto, Masahiko Sisido

Improving Peptide Therapeutics for HIV and Other Viral Diseases 298Antonello Pessi, Matteo Porotto, Christine Yokoyama, Laura M. Palermo,Aparna Talekar, Ilaria Devito, Barry Rockx, Heinz Feldmann, Riccardo

Cortese, Anne Moscona

De Novo Designed Cyclic Decapeptides with Anticancer Activity 300Lidia Feliu, Gloria Oliveras, Anna D. Cirac, Cristina Roses,Ramon Colomer, EduardBardajl, Marta Planus, Teresa PuigSynthesis of Tacrine Analogues Comprising Peptide Moiety 302

Dantcho L. Danalev, Lyubomir T. Vezenkov, Nikola}' Vassilev

Inhibition of Amyloid Formation in Model Peptides 304

Enrico Brandenburg, Hans V. Berlepsch, Beate Koksch

Synthesis and in Vitro Characterization of New, Potent and Selective

Oxytocin Receptor Agonists 306

Kazimierz Wisniewski, Robert Galyean, Claudia D. Schteingart, Hiroe

Tariga, Glenn Croston, Sudarkodi Alagarsamy, Pierre J.-M. RiviereAmidine Neighbouring-Group Effect on the Stability of B9870, a HighlyPotent Anti-Cancer Bradykinin B1/B2 Antagonist Peptide Dimer 308

Lajos Gera, Richard Duke, Daniel C. Chan, Paul A. Bann, Robert S. Hodges,John M. Stewart, James BlodgettSynthesis and Biological Evaluation of Cytotoxic Peptide ConjugatesContaining 5-Fluorouracil 310

Sergey V. Burov, Tatyana V. Yablokova, Maria V. Leko, Anton Yu. Alenko,Marina Yu. Dorosh

Immunopepdb a Novel Immunomodulatory Peptides Database 312Osmar N. Silva, William F. Porto, Diego G. Gomes, Simoni S. Dias, OctavioL. Franco

Delta-Sleep Inducing Peptide (DSIP) and Its Analogues: Studies on Their

Therapeutic Potency 314/. /. Mikhaleva, J, A. Prudchenko, E. S. Efremov, L. V. Onoprienko, L. D,

Chikin, R. I. Yakubovskaya, E. P. Nemtsova, O. A. Bezborodova

Dual M-/D-Opioid Antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph: Potential

Candidate for Management of Obesity, Diabetes and Osteoporosis 316

Lawrence H. Lazarus, Gianfranco Balboni, Severn Salvadori, Ewa D. Marczak

Molecular Modeling of the Interactions Between M-Conotoxin Smiiia and the

Pore ofVoltage-Gated Sodium Channel Subtypes Navl.2 andNavl.4 318Pawel Gruszczynski, Doju Yoshikami, Rajmund Kazmierkiewicz, Min-Min

Zhang, Baldomero M. Olivera, Grzegorz Bulaj, Thomas E. Cheatham

xxxv

Bradykinin Analogues Acylated on Their N-Terminus 320

Malgorzata Sleszynska, Darinsz Sobolewski, Tomasz H. Wierzba, Jifina

Slaninovd, Adam Prahl

Synthesis and Biological Activity of Quercetin Derivatives of Endogenous

Opioid Peptides Leu- and Met-Enkephalin 322

Andreja Jakas, Nina Bjelis, Ivo Piantanida, Marijeta Krai]

Cryptophycins - Synthesis of Potent Functionalized New Antitumor Agents 324

Benedikt Sammet, Norbert Sewald

Efficient Synthesis of Fertirelin Acetate As a Reproductive Control Drug: A

Gnrh Hormone Analogue 326

VahidDianati, Annin Arabanian

Synthesis, Characterization and Activity of Antamanide and Its Analogues As

Inhibitors ofthe Mitochondrial Permeability Transition Pore 328

Andrea Calderan, Nicola Antolini, Luca Azzolin, Paolo Bernardi, Andrea

Rasola, Paolo Rnzza, Stefano Mammi

Clicktophycin-52: A Bioactive Cryptophycin-52 Triazole Analogue 330

Tobias Bogner, Markus Nahrwold, Norbert Sewald

CD and Fluorescence Screening of A-Synuclein-Peptide Interactions 332

Anna Marchiani, Giada Massalongo, Stefano Mammi, Isabella Tessari, Luigi

Bubacco, Andrea Calderan, Paolo Ruzza

Antidepressive Action of Short Human Urocortin III Fragments and

Analogues 334

Kinga Rdkosi, Masaru Tanaka, Gyula Telegdy, Gdbor K. Toth

Design, Synthesis and Rnase Activity ofNovel Peptidomimetics AgainstInfluenza Viruses 336

Lyudmila S. Koroleva, O. V. Morozova, E.I. Isaeva, L.M. Rustamova, V.M.

Sabynin, N.P. Schmeleva, N.V. Gribkova, VladimirN. Silnikov

Solid Phase Synthesis and in Depth Analysis ofthe Tumour Targeting

Peptide DOTATOC for Clinical Applications 338

Susanne Kramer, Carl Von Gall, William Edmund Hull, Michael Eisenhut,

Uwe Haberkorn, Walter Mier

Solid-Phase Synthesis and Analytical Characterization of Myrcludex B, a

Potent New Entry Inhibitor for the Treatment of HBV Infections 340

Alexa Schieck, Thomas Mutter, Uwe Haberkorn, Stephan Urban, Walter Mier

Binding ofHemopressin Peptide with Cannabinoid CB1 Receptor: A

Structural Study 342

Mario Scrima, SaraDi Marino, Manuela Grimaldi, Ettore Novellino,

Maurizio Bifulco, Anna Maria D'ursi

Synthesis of a PEG Conjugated HIV Gp41 MPER Fragment: A New Gp41Helix Bundle Mimic 344

Manuela Grimaldi, Antonia Mastrogiacomo, Daniela Eletto, Mario Scrima,

Simone Giannecchini, Fabio Rizzolo, Paolo Rovero, Anna Maria D'ursi

Investigation on the Inhibition ofthe Two Active Sites ofAngiotensin I

Converting (ACE) Enzyme by Modified Prolyl Peptides 346

B. K. Yakimova, B. Pandova, S. G. Yanev, B. B. Tchorbanov, I. B. Stoineva

Protection Against Heat Stress Injury 348

Guan Wang, Pengfei Li, Shuwen Guan, Changrun Guo, Limin Zhu,

Hongkuan Fan, Liping Wang

xxxv i

Mechanism in Inhibition of Histone Deacetylase by Cyclic Tetrapeptides withVarious Functional Groups 350Md. Shahidid Islam, Md. Nurul Islam, Nsiama Tienabe, Naoto Oishi, TamakiKato, Norikazu Nishino, Akihiro Ito, Minoru Yoshida

Anti-Plasmodium Effects ofAngiotensin II Analogues 352

VaniX. Oliveira, Mayra Chamlian, Ceres Maciel, MargarethL. Capurro,Antonio Miranda

Targeted Platinum Peptide Complexes Holding Diamino and DicarboxylicCoordination Modes 354

Agnieszka M. Glowinska, Anna Lesniak, Marzena Lazarczyk, Ewa Matyja,Andrzej W. Lipkowski, Aleksandra Misicka

Preclinical Pharmacokinetics ofMyrcludex B, a Novel Entry Inhibitor for theTreatment of HBV Infections 356

Alexa Schieck, Anja Meier, Thomas Midler, Uwe Haberkorn, Walter Mier

Chemical Modification ofNatural Immunomodulators Tuftsin and MuramylDipeptide Significantly Influence Their Biological Activity 358Anna Wardowska, Kiystyna Dzierzbicka, Malgorzata Rogalska, PiotrTrzonkowski

Synthesis and Antimicrobial Evaluation of Temporin L AnaloguesContaining D-Amino Acids 360

Alfonso Carotenuto, Maria Luisa Mangoni, Ludovica Marcellini Hercolani

Gaddi, Maria Rosaria Saviello, Salvatore Di Maro, Pietro Campiglia, IsabelMonterrey-Gomez, Luigia Auriemma, Ettore Novellino, Paolo Grieco

Conjugates of Tuftsin and Muramyl Dipeptide As Stimulators of Monocyte-Derived Dendritic Cells 362Anna Wardowska, Krystyna Dzierzbicka, Agnieszka Menderska, Piotr

Trzonkowski

Synthesis of Peptide Analogs of the A2 Subunit (Sequence 558-565) ofthe

Factor Fviiia of Blood Coagulation 364

Charts Anastasopoulos, Yiannis Sarigiannis, George StavropoulosPeptides Versus Nonpeptides As Therapeutics: An Exciting Challenge for

Big Pharma 366

Maurice Manning, Stoytcho Stoev, KrzysztofBankowskiFluctuations and the Rate-Limiting Step of Peptide-Induced Membrane

Leakage 368

C. Mazzuca, B. Orioni, M. Coletta, F. Formaggio, C. Toniolo, G. Maulucci,M. De Spirito, B. Pispisa, M. Venanzi, L. Stella

Effect of Helix Kink on the Activity and Selectivity of An Antimicrobial

Peptide'

370Sara Bobone, Gianfranco Bocchinfuso, Antonio Palleschi, Jin Y. Kim,Yoonkyung Park, Kyung-Soo Hahm, Lorenzo Stella

Membrane Insertion of Para-Cyanophenylalanine Labeled Alamethicin

Analogues. Correlation of Fluorescence and Infrared Absorption Data 372

S. Bobone, M. De Zotti, A. Bortolotti, G. Ballano, F. Formaggio, C. Toniolo, L. Stella

Cell-Penetrating Peptides As Adenovirus Vector Carrier 374

K. Kawasaki, S. Kida, Y. Eto, Y. Yoshioka, S. Nakagawa, K. Hojo, M. Maeda

Jelleine-I Analogues with Improved Antibacterial Activity 376

Paul R. Hansen

xxxvii

Antimicrobial Activity ofSmall 3-(2-Naphthyl)-L-Alanine Containing

Peptides"

378

Paul R. Hansen, Niels-Frimodt Moller

Antimicrobial Peptides Containing D-Amino Acids with in Vivo Activity

Against Plant Pathogenic Bacteria 380

Imma Giiell, Esther Badasa, Montse Talleda, RafaelFerre, Jordi Cabrefiga,Emili Montesinos, Eduard Bardaji, Lidia Felia, Marta Fionas

Synthesis and Preliminary Conformational Analysis ofTOAC Spin-LabelledAnalogues of the Medium-Length Peptaibiotic Tylopeptin B 382

Marina Gobbo, Barbara Biondi, Marta De Zotti, Fernando Formaggio,

Claudia Toniolo

Porphyrin-Antimicrobial Peptide Conjugates: Synthesis, Conformational

Studies and Preliminary Light Activated Biocidal Activity 384

Cristiano Tampieri, Barbara Biondi, Sandro Campestrini, Ryan Dosselli,

Elena Reddi, Marina Gobbo

Sequences ofthe Polypeptide Antibiotics (Peptaibiotics) Acretocins 386

Hans Bruckner, Jochen Kirschbaum

Conformational Studies of Toac-Analogues from New Cytolytic PeptideIsolated from Hypsiboas Albopunctatus 388

Eduardo F. Vicente, Graziely F. Cespedes, Edson Crusca, Mariana S. Castro,

MariaJose S. Mendes-Giannini, Lids Guilherme M. Basso, Antonio J. Costa-

Filho, Reinaldo Marchetto, Eduardo M. Cilli

Increasing Amphiphilicity in Peptaibiotics: Gly to Lys Replacements in

Trichogin GAIV 390

Marta De Zotti, Barbara Biondi, Cristina Peggion, Fernando Formaggio,Yoonkyung Park, Kyung-Soo Hahm, Claudia Toniolo

Synthesis, Preferred Conformation, and Membrane Activity of Heptaibin, a

Medium-Length Peptaibiotic 392

Marta De Zotti, Barbara Biondi, Cristina Peggion, Marco Crisma, Fernando

Formaggio, Claudio Toniolo

Synthesis, Characterization and Cytostatic Effect of New Pemetrexed-

Peptide Conjugates 394

Erika Orbdn, Zsanett Mikldn, Zoltdn Banoczi, Ferenc Hudecz

Towards Lasso Peptide Engineering: Insights into the Maturation Mechanism

ofMicrocin J25 396

Kok-Phen Yan, S. Zirah, Yanyan Li, C. Goulard, S. RebuffatEnterocins L50A and L50B from Enterococcus Durans A5-11:

Conformational and Antibacterial Studies 398

Severine Zirah, Christophe Goulard, Remi Ducasse, Michele Dalgalarrondo,Jean Peduzzi, Jean-Marc Chobert, Thomas Haertle, Sylvie Rebuffat

Revealing the Lytic Mechanism ofthe Antimicrobial Peptide Gomesin by OpticalMicroscopy ofGiant UnilamellarVesicles and Isothermal Titration Calorimetry 400

TatianaM. Domingues, Joachim Seelig, KarinA. Riske, Antonio Miranda

Study ofa New Maurocalcine CPP Analogue Devoid ofPharmacological Activity 402

Cathy Poillot, Michel De Waard

Comparison ofthe Mechanism of Action of Antimicrobial Peptides on Giant

Unilamellar Vesicles Via Optical Microscopy 404

MartaN.C. Martins, TatianaM. Domingues, KarinA. Riske, A. Miranda

xxxviii

Lasiocepsin: Novel Antimicrobial Peptide from the Venom of Eusocial Bee

Lasioglossum Laticeps 406Lenka Monincovd, Jirina Slaninova, Vladimir Fucik, Oldfich Hovorka,Zdenek Voburka, Lucie Bedndrovd, Petr Malon, Vaclav CefovskySelective Membrane Interactions ofNucleolar-Targeting Peptides 408Margarida Rodrigues, Gandhi Radis-Baptista, Beatriz G. De La Torre,Miguel Castanho, David Andreu, Nuno C. SantosInteractions of Cell-Penetrating Peptides in the Model of Giant PlasmaMembrane Vesicles 410

Pille Saalik, Aira Niinep, Mats Hansen, Ulo Langel, Margus PoogaAntimicrobial Oligopeptides and Rapid Alkalinization Factors in Chilean

Grape 412

Alexander A. Zamyatnin, OlgaL. Voronina

Glycine and Histidine-Rich Antifungal Peptides: on the Way to the Mode ofAction of Shepherin I 414Cesar Remuzgo, Thiago R. S. Lopes, Thais S. Oewel, GldnciaM. Machado-Santelli, Sirlei Daffre, M. Teresa Machini Miranda

Targeting the Nuclear Pore Complex with Proteomimetic Cell PenetratingPeptides 416

Sarah Jones, John Howl

Antimicrobial Protein Analyzer (AMPA): A Computational Tool to ScreenAntimicrobial Domains in Proteins and Peptides 418

Marc Torrent, DavidAndreu

Analogs of Contulakin-G, An Analgetically Active Glycopeptide from Conus

Geographus 420

Samson Afewerki, Ola Blixt, Henrik Clausen, Thomas NorbergActive Peptidomimetic Insect Kinin Analogs with Type VI Turn Motif 4-

Aminopyroglutamate Lack Native Peptide Bonds 422KrzysztofJ. Kaczmarek, Geoffrey M. Coast, Janusz Zabrocki, Ronald J.

Nachman

Synthesis and Bioactivity Studies on the C-Terminally ExpressedHeptapeptide Orthologues of Various Proenkephalin A Sequences 424

Fruzsina Babos, Engin Bojnik, Sandor Benyhe, Anna MagyarSubstitution ofVarious P-N-Alkylcarboxamidophenylalanine Analogues for

Tyrl in T1PP Opioid Peptides."

426

Irena Berezowska, Carole Lemieux, Nga N. Chung, Peter W. Schiller

NMR Studies of Vasopressin Analogues Modified with Indoline-2-

Carboxylic Acid in Position 2 in Dodecylphosphocholine Micelle 428

Emilia Lubecka, Emilia Sikorska, Anna Kwiatkowska, Jerzy Ciarkowski

Synthesis of New Lgnrh-III Analogues and Studies on Prostate Cancer Cell

Proliferation 430

Paul Cordopatis, Eleni V. Pappa, Aikaterini A. Zompra, Zinovia Spyranti, Zoi

Diamantopoulou, Fotini N. Lamari, Panagiotis Katsoris, Georgios A.

SpyrouliasNew Analogues of Arginine Vasopressin and Its Selected Agonists ModifiedAt Position 2 with (S)-2-(l-Adamantyl)Glycine 432BernardLammek, Anna Kwiatkowska, Dariusz Sobolewski, Lenka

Borovickovd, Jirina Slaninova, Adam Prahl

xxxix

Interaction of Curcumin with A-Synuclein and Its Relationship to Curcumin's

Ability to Inhibit Fibril Deposit 434

Anna Marchiani, Stefano Mammi, Isabella Tessari, Luigi Bubacco, Sandra

Monti, Francesco Manoli, Paolo Ruzza

Synthesis, Antiproliferative Activity on Prostate Cancer Cells, Enzymatic

Stability and Conformational Studies of New Gnrh Analogues 436

FotiniN. Lamari, Eleni V. Pappa, Zinovia Spyranti, Aikaterini A. Zompra,Zoi Diamantopoulou, Panagiotis Katsoris, George Liapakis, Ceorgios A.

Spyroulias, Paul CordopatisAnalogues of Neurohypophyseal Hormones, Oxytocin and Arginine

Vasopressin, Conformationally Restricted and Acylated in the N-Terminal

Part ofthe Molecule 438

Dariusz Sobolewski, Anna Kwiatkowska, Lenka Borovickovd, Jifina

Slaninovd, Adam Prahl

Side-Chain to Side-Chain Cyclization ofOpioid Peptides Enhances

Proteolytic Stability of Their Exocyclic Peptide Bonds 440

Marek Cebrat, Piotr Stefanowicz, Alicja Kluczyk, Zbigniew Szev/czuk,Katarzyna Filip, Malgorzata Ciszewska, Janlzdebski

VCD Spectroscopic Analysis ofMu-Opioid Peptides 442

Attila Borics, Geza Toth, Sdndor Lovas

Synthesis, Evaluation and Conformational Solution Studies ofCysteine-Based A4bl Integrin Ligands 444

George K. Daletos, Margarita Lamprou, Panagiotis Zoumpoulakis, Maria

Zervou, Nikos L. Assimomytis, Athina Geronikaki, Evangelia Papadimitriou,Vassiliki Magafa, Paul CordopatisSynthesis and Biological Evaluation ofNew Linear and Cyclic Analogues of

Neurotensin 446

R. Exarchakou, V. Magafa, E. Manessi-Zoupa, N. L. Assimomytis, M.

Georgiadou, M. Venihaki, G. Varvonnis, G. Liapakis, P. CordopatisInfluence ofNon Natural Amino Acids At Position 3 of [Mpal, D-Tyr(Et)2]Or [Mpal, D-1-Nal2] Oxytocin on Their Pharmacological Properties 448

Vassiliki Magafa, N. L. Assimomytis, George Pairas, Revekka Exarchakou,George K, Daletos, Lenka Borovickovd, Jifina Slaninovd, Paid CordopatisConformational Behaviour of Vasopressin-Like Peptides in the Membrane-

Mimetic Environment 450

Emilia Sikorska, Anna Kwiatkowska

Ml 154 - A Novel Galanin Ligand to Delineate the Galaninergic System 452

Johan Runesson, Indrek Saar, Rannar Sillard, Ulo LangelDesign, Synthesis and Biological Evaluation ofNovel Endomorphins with

Multiple Structural Modifications 454

Geza Toth, Jayapal Reddy Mallareddy, A. Borics, K. E. Kdver, A. Keresztes

A Neuropeptidomics Study ofthe Bovine Hypothalamus Reveals Novel

Endogenous Peptides and Processing Pathways 456

Michelle L. Colgrave, LiXi, SigridLehnert, Traute Flatscher-Bader, Henrik

Wadensten, Anna Nilsson, Per E, Andren, Gene WijffelsSynthesis, Conformational Analysis, and Biological Activity of [Aza-3-Indoylgly4] GHRP-6 as an Aza-Tryptophan Analog of Growth Hormone

Releasing Peptide-6 458

C. Proulx, DavidSabatino, Petra Pohankova, Huy Ong, William D. Lube11

xl

N-Linked Homodimers of the Kinin Bl Receptor Antagonist R-715 460WitoldA. Neugebauer, Martin Savard, Klaus Klarskov, Fernand GobeilIdentification of a New Citrullinated Epitope on Filaggrin for the EarlyDiagnosis of Rheumatoid Arthritis 462Fruzsina Babos, Eszter Szarka, Adam Bartos, Gydrgy Nagy, GabriellaSdnnay, Anna Magyar, Ferenc Hudecz

4-Methylpseudoproline Analogues of Cyclolinopeptide A: Synthesis,Conformation and Biology 464

J. Katarzynska, S, Jankowski, K. Hubert, Michal Zimecki, Jamisz ZabrockiDesign, Synthesis and Stability Studies of Potent Inhibitors ofPro-ProteinConvertases (Pes) 466A. Kwiatkowska, N. Chevalier, R. Desjardins, F, Couture, F. D 'anjou, S.Routhier, C. Levesque, Y. Dory, W. A. Neugebauer, R. DayA New Class ofSomatostatin Analogues with Antiproliferative Activity inHuman Cancer Cells 468Yuko Tsuda, Anna Miyazaki, Emiko Okuno, Isoko Kuriyama, YoshiyukiMizushina, Hiromi Yoshida

Analogues of Trypsin Inhibitor SFTI-1 Modified in Absolutely Conserved PI'Position by Synthetic Or Non-Proteinogenic Amino Acids 469Rafal Lukajtis, Anna Lqgowska, Dawid Debowski, Magdalena Wysocka,Adam Lesner, KrzysztofRolkathe Influence of Disulfide Bridge of Trypsin Inhibitor SFTI-1 for Enzyme -

Inhibitor Interaction 472Anna Lggowska, DaM>id Debowski, Magdalena Wysocka, Adam Lesner,KrzysztofRolkaB-Cell Epitope Mapping of Immunodominant Proteins in PemphigusVulgaris: Prediction, Synthesis, and Immunoserological Evaluation 474Hajnalka Szabados, Szilvia Bosze, Antal Blazsek, Pdlma Sillo, SaroltaKdrpdti, Ferenc Hudecz, Ratalin UrayT-Cell Epitopes in Autoimmune Bullous Skin Disorders 476Katalin Uray, Mdrta Marschalko, Hajnalka Szabados, Antal Blazsek, FerencHudecz, Sarolta Kdrpdti, Szilvia Bosze

The Transcriptional Activator Phob; Chemical Synthesis of Epitopes andFunctional Studies

478Markus Ritzefeld, Katrin Wollschldger, Andre Komig, Michael Birlo, RobertRos, Dario Anselmetti, Norbert Sewald

Assay of Histone Methyltransferases Using Ac-Peptidyl-MCA As Substrates 480Norikazu Nishino, Tienabe K, Nsiama, Hongfang Chi, Yasushi Takemoto,Akihiro /to, Minoru Yoshida

Molecular Modeling, Design and Structural Studies of a New Class of PeptideInhibitors of Bacterial Topoisomerases 482Luiz Carlos B. Barbosa, S. S. Garrido, D. B, Delfino, A. Garcia, R. MarchettoStructural Aspects and Biological Evaluation ofNew Mannose Derived

Immunomodulating Admantyltripeptides 484Rosana Ribic, Lidija Habjanec, Branka Vranesic, Ruza Frkanec, SrdankaTomic-Pisarovic

N/OFQ(l-13)NH2 Analogues with Aminophosphonate Moiety: Synthesisand Analgesic Activity 486

E. D. Naydenova, P. T. Todorov, N. D. Pavlov, E B. Dzhambazova, A. I Bocheva

xli

Fluorescent and Luminescent Fusion Proteins for Detection of Amyloid Beta

Peptide Localization and Aggregation 488

Kenji Usui,Masayasu Mie, Takeshi Andou, Naoki Sugimoto, Hisakazu

Mihara, Eiry Kobatake

Phakellistatins: Are They True Active Natural Products? 490

Marta Pelay-Gimeno, Judlt Tidla-Puche, Andres M. Francesch, Carmen

Cuevas, Fernando Albericio

Celiac Disease: Synthesis of Overlapping Linear Peptide Epitopes of Ttg[Aa(l-230)] 492

Margherita Di Pisa, Giuseppina Sabatino, Mario Chelli, Paolo Rovero,Claudia Tiberti, Anna Maria PapiniCeliac Disease: Characterization ofAmino Acids and Short Peptides FingerPrint for a Fast I.V.D. 494

Margherita Di Pisa, Giuseppina Sabatino, Mario Chelli, Paolo Rovero,Claudio Tiberti, Anna Maria Papini

Search for Inhibitors Or Activators ofHuman Proteasome 496

R. Rostankowski, Elzbieta Jankowska, M. Gaczynska, P.A. Osmulski, S,

Madabhushi, Franciszek KasprzykowskiCharacterisation of the Minimal Epitope Detecting Autoantibodies in

Multiple Sclerosis by Surface Plasmon Resonance 498

Feliciana Real-Fernandez, Irene Passalacqua, Elisa Peroni, Francesco Lolli,Paolo Rovero, Anna Maria PapiniAntigenic Probes for Autoantibody Detection in Multiple Sclerosis: SyntheticPeptides Versus Recombinant Proteins 500Francesco Gori, Barbara Mulinacci, Lara Massai, Francesco Lolli, Anna

Maria Papini, Paolo Rovero

The Metabolisation of Different lodinated Peptide Species 502

Bart De Spiegeleer, Sylvia Van Dorpe, EwaldPauwels

Rational Design and Optimization ofthe Newly Designed GlycopeptideSequence to Develop the Diagnostic/Prognostic Assay for Multiple Sclerosis 504

Shashank Pandey, Elisa Peroni, Paolo Rovero, Francesco Lolli, Anna Maria

PapiniStructure-Function Relationships of a Hexapeptide Fragment ofthe

Carcinoembryonic Antigen 506

Sdndor Lovas, Nicholas Y. Palermo, Peter Thomas, Richard F. MurphyTying Up Loose Ends: Beta Capping Units As Non-Covalent Staples for

Loops and As Dynamics Probes 508

Brandon L. Kier, Irene Shu, Jackson Kellock, Niels H. Andersen

Two Short Peptides That Arise in Inflammation Demonstrated StrongNeuroprotective Effects in Vitro 510

Vsevolod G. Pinelis, Tatyana N. Storozhevykh, Kristina V. Glebova, TatyanaN. Danyukova, Yana E. Senilova, Stanislav I. Schramm, N. F. MyasoedovNeuroprotective Effect of Short Collagen-Related Peptides and Their Abilityto Interact with ACE Reveal Structure-Activity Similarity 512Stanislav I. Schramm, Tatyana N. Danyukova, Kristina V. Glebova, Igor Yu.

Nagayev, Ludmila A. Andreeva, Nikolay F. MyasoedovDesign and Synthesis of Guanidinium-Rich Molecular Transporters for DrugDeliver}' 514

Tatyana A. Dzimbova, Kaloyan Georgiev, Tamaral. Pajpanova

xlii

Synthesis and Biological Evaluation of Daunorubicin-Gnrh-III Prodrug 516

Rdzsa Hegediis, Erika Orban, lldiko Szabo, Marilena Mama, Gdbor MezoThe [Tc(N)PNP] Metal Fragment Labeled Peptide for MCI ReceptorsImaging: Preliminary Studies 518Barbara Biondi, Cristina Bolzati, Davide Carta, Nicola Salvarese, FiorenzoRefosco, Andrea Calderan, Paolo Ruzza

Kinetic Studies on Cellular Uptake of Polyarginine Peptide Using FRET 520Akihiro Ambo, Yasuyuki Suzuki, Motoko Minamizawa, Yusuke Sasaki

Synthesis and in Vitro Antitumor Activity of New Daunomycin ContainingGnrh-11 Derivatives

522lldiko Szabo, Erika Orbdn, Szilvia Bosze, Gdbor Mezo

Anthracycline-Gonadotropin Releasing Hormone-III Bioconjugates:Synthesis, Antitumor Activity and in Vitro Drug Release 524Gdbor Mezo, Ulrike Lenrs, Pascal Schlage, Erika Orbdn, lldiko Szabo,Szilvia Bosze, Marilena Manea

Design and Synthesis of Polyfunctional Spacers Based on BiodegradablePeptides 526LyubovA. Yarinich, Lyudmila S. Koroleva, Tatyana S. Godovikova, VladimirN, Silnikov

Amino Acids Esters ofAcyclovir-Synthesis and Antiviral Activity 528Ivanka G. Stankova, Stoyan Shishkov, Kalina Koslova, Daniel Todorov,Luchia Mukova, Angel Galabov

Homobivalent a-MSH Derivatives for Melanoma Imaging: 99mtc(CO)3-Labeling and Biological Evaluation 530M. Morals, P. D. Raposinho, M. C. Oliveira, JoaoD.G. Correia, I. SantosDevelopment of Drug Delivery Systems for Targeted Cancer ChemotherapyBased on Gnrh Antagonist and Agonist Peptides 532Bence Kapuvdri, Borbdla Vincze, Marilena Manea, Miguel Tejeda, AkosSchulcz, JozsefTovdri, Dezso Gadl, Erika Orbdn, lldiko Szabo, Gdbor Mezo

Miniprotein Engineering ofthe Knottin-Like Scaffold Min-23 - Solid-PhaseSynthesis and Oxidative Folding Strategies 534

Frederic Zoller, Christain Hauer, A. Markert, Uwe Haberkorn, Walter Mier

Synthesis and Characterization ofNovel Dipeptide Ester ofAcyclovir 536

Ivanka G. Stankova, Ivanka B. Stoineva, Michaela SchmidtkeNew Socsl-Kir Mimetic Peptides Through the Screening of Focused

Si mplified Combinatorial Libraries 538

Daniela Marasco, Nunzianna Doti, Pasqualina L. Scognamiglio, StefaniaMadonna, Menotti Ruvo, Carlo Redone, Cristina Albanesi

Utilization of Enzymes from the Red King Crab Hepatopancreas forObtainment ofCow Milk Protein Hydrolyzate 540

V.A. Mukhin, Yu. E. Trukhacheva, V. Yu. Novikov

Isovaline Containing Peptides: Configurational Assignment Using 2d-Nmr

Spectroscopy 542Marta De Zotti, Elisabetta Schievano, Stefano Mammi, Bernard Kaptein,Quirinus B. Broxterman, Sheo B. Singh, Hans Briickner, Claudio TonioloCyclic PDZ-Binding Peptides As Neuroprotective Agents AgainstExcitotoxic Brain Damage 544

Brian MAusten, Kate Duberley, Paul Turner, Ruth Empson

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Cellular Expression of the Human Angiotensin II Type 1 Receptor Containingthe Non-Canonical Photolabelling Amino Acid Bpa 546

Jason Arsenault, Julie Lehoux, Brian J. Holleran, Marilou Lefrangois,Gaetan Guillemette, Richard Leduc, Emanuel Escher

The Synthesis of Some Peptides Intended to Be Inhibitors of the RNA-

Polymerase of Influenza A Virus. 548

Oleg V. Matusevich, OlegI. Kiselev

The Adjuvant Activity of Glucosaminyl Muramyl Dipeptide (GMDP) Is

Linked to the Beta-Anomer Configuration and N-Acetylglucosamine(Glcnac) Uptake System. 550

Elena A. Meshcheryakova, Elena P. Dobrashkina, Tatyana M. Andronova,

Vadim T. Ivanov

Peptide Inhibitors of the Intrinsic Pathway of Apoptosis Targeting CARD-CARD Interactions 552

Yadira Palacios-Rodrigiiez, Guillermo Garcia-Lainez, Mar Orzdez, EnriquePerez-PaydSecondary Structure Modifications of Serine Protease Inhibitor Upain-1 to

Improve Binding Affinity 554

Renee Roodbeen, Peter A. Andreasen, Knud J. Jensen

Structural and Biophysical Studies of Ribose-5-Phosphate Isomerase A from

Francisella Tularensis 556

R, Rostankowski, Marta Orlikowska, Dominika Borek, C. Brautigam, T.

Scheuermann, Zbyszek Otwinowski

Simplified T-Defensins: Search for New Antivirals 558

Piotr Ruchala, Sylvia Cho, Amy L. Cole, Chun-Ling Jung, Hai T. Luong, EwaD. Micewicz, Alan J. Waring, Alexander M. Cole, Betsy C. Herold, Robert I.

Lehrer

Venomics: Targeted Drug Discovery and Lead Optimisation Using Animal

Venoms 560

Reto Stdcklin, Estelle Bianchi, Daniel Biass, Cecile Cros, Dominique Koua,Frederic Ferret, Aude Violette, Philippe Favreau

Application of Conjugated Glutamic Acid Peptide (GAP) to a Novel 4-

Anilinoquinoline EGFR Inhibitor for Tumor-Targeted Imaging 562

Chumpol Theeraladanon, Nobukazu Takahashi, Masaaki Shiina, Keisuke

Hamada, Yuuki Takada, Hisashi Endo, Ukihide Tateishi, Takashi Oka,Kazuhiro Ogata, David J. Yang, Tomio lnoue

Quantifying Molecular Partition of Charged Molecules by Zeta-Potential

Measurements 564Joao Miguel Freire, Marco M. Domingues, Joana Matos, Manuel N. Melo,

Ana Salome Veiga, Nuno C. Santos, Miguel Castanho

Ccdb Toxin Peptides Derivatives and Its Interactions with an Analogue of

Bacterial Ccda Antitoxin 566

Saulo S. Garrido, CamilaAp. Cotrim, DaviB. Delfino, Anderson Garcia,Luiz Carlos B. Barbosa, Reinaldo Marchetto

A Regulator}' Role for the Muramyl Peptide (GMDP) in a Murine Model of

Allergic Asthma 568

Svetlana V. Guryanova, M. A. Shevchenko, I. G. Kozlov, T. M. Andronova

Molecular Dynamics ofAmylin Amyloid Single and Multiple Beta Sheets 570

D, Lapidus, Salvador Ventura, Cezary Czaplewski, Adam Liwo, Inta Liepina

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Molecular Modeling of Single and Multiple Beta-Sheets of Amyloid BetaProtein 25 - 35

572Vita Duka, Isabella Bestel, Cezary Czaplewski, Adam Liwo, Inta LiepinaNew Hybrid and Mutant PIA and Mil Toxins with Greater Affinty andSelectivity for the A6* Subtype 574R Longhi, L. Pucci, L. Rizzi, G. Grazioso, C. Dallanoce, F. Clementi, C. GottiMolecular Modeling of Novel Gnrh Analogues Using NMR Spectroscopyand Relation with Their Anti-Cancer Activities 576F. Tahoori, M. Erfani Moghaddam, Armin Arabanian, Saeed BalalaieSynthesis ofNovel Peptides Containing Unusual G-Amino Acids andInvestigation of Their Nanostructures 57 8B. Talaei, Armin Arabanian, Saeed Balalaie

Structural Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences 580

Y. Demizu, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara

Optical Spectroscopy and Conformational Analysis of Peptide Aggregates,the Role of Aromatic Interactions and Conformational Flexibility 582M. Caruso, E. Placidi, E. Gatto, L. Stella, A. Palleschi, G. Bocchinfuso, F.

Formaggio, C. Toniolo, M. Venanzi

Mapping Charge Derealization in a Peptide Chain Triggered by Oxidationof a Terminal Ferrocene Moiety 584V. Marcuzzo, A. Donoli, R. Cardena, A. Moretto, C. Toniolo, S. Santi

Paterno-Yang Photocyclization Reaction in Bpa/Met 3-10-Helical Peptides:Role of Spacer Length 586

Anna Cupani, Alessandro Moretto, Fernando Formaggio, Claudio TonioloExperimental and Theoretical Spectroscopy Study of 3-10-Helical PeptidesUsing lsotopic Labeling 588AhmedLakhani, Anjan Roy, Marcelo Nakaema, Matteo De Poli, FernandoFormaggio, Claudio Toniolo, Timothy A, KeiderlingOostatic Peptides Containing D-Amino Acids: Degradation, Accumulation inOvaries and NMR Study 590Jan Hlavdcek, B. Bennettova, B. Cerny, V. Vlasdkovd, J. Holik, M.

Budeslnsky, Jifina Slaninovd, R. TykvaDendrimeric Peptides with Affinity to Opioid Receptors - ComplexationStudies

592Marta Sowinska, Anna Lesniak, A. W. Lipkowski, Z. Urbanczyk-LipkowskaNMR-Based Conformational Studies of the C-Terminal

Heptadecapeptide(101-117) of Human Cystatin C 594

Martyna Maszota, P. Czaplewska, A. Sladewska, M. Spodzieja, J. Ciarkowski

Beta-Aspartic Acid Impairs the Ability to Bind Metal Ions by Immunosup-presory Fragment of Ubiquitin and Other Peptides As Studied by ESI-MS/MS 596

Marek Cebrat, Marlena Zajaczkowska, Piotr Stefanowicz, Zbigniew SzewczukEnsemble Fit of Conformational Equilibria ofRestrained Peptides to NMRData. Dependence on Force Fields: Amber8 Vs ECEPP/3 598

Jerzy Ciarkowski, S. Luczak, M. Oleszczuk, J. WojcikUnderstanding and Modulation ofthe Folding of a Helix-Loop-HelixDimerization Domain 600Michael Beisswenger, Sara Pellegrino, Roberto Fanelli, Nicola Ferri, MariaL. Gelmi, Chiara Cabrele

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2D IR Spectroscopy of Oligopeptides Conformationally Restrained by Ca,a-

Di alkylated Glycyl Residues 602

Hiroaki Maekawa, Matteo De Poll, Gema Ballano, Fernando Formaggio,Claudio Toniolo, Nien-Hui Ge

In Vitro Antiviral Properties ofAlloferon, Any-GS and Their AnaloguesAgainst Human Herpes Virus and Coxsackie B2 Virus 604

M. Kuczer, A. Midak-Siewirska, R. Zahorska, M. Luczak, D. Konopinska

Novel Calpain Inhibitors 606

Zoltdn Banoczi, Levente E. Ddkus, Agnes Tantos, Attila Farkas, Peter Tompa,Peter Friedrich, Ferenc Hudecz

PNA-Peptide Conjugates for Regulation ofDNA and RNA G-QuadruplexStructures Depending on a Particular Protease Concentration 608

Kenji Usui, Keita Kobctyashi, Naoki Sugimoto

Structure ofa New Stable Cu(III)/Cyclopeptide Complex by Cu K-Edge XAS

Study 610

Alessandro Pratesi, Gabriele Giuli, Maria Rita Cicconi, Tsu-Chien Weng,Giovanni Pratesi, Mauro Ginanneschi

Stability of CLIPS Peptides in Human Serum 612

Wim Schaaper, Peter Van Dijken, Peter Timmerman

Tryptophan Interactions That Stabilize Folding Motifs: A Guide to

Placement, Dynamics Applications, and Optimizing Fold Stabilization 614

Irene Shu, Michele Scian, Brandon L. Kier, D. V, Williams, Niels H. Andersen

Au25 Nanoclusters Capped by Photoactive Aib-Based Azopeptides 616

Ivan Guryanov, Sabrina Antonello, Mahdi Hesari, M. Zamuner, F. Maran

Photocurrent Generation Through Mono- and Bicomponent Peptide Self-

Assembled Monolayers: Antenna and Junction Effects 618

Alessandro Porchetta, Emanuela Gatto, Mario Caruso, Marco Crisma,

Fernando Formaggio, Claudio Toniolo, Mariano Venanzi

Vibrational Energy Transport in a Peptide Capping Layer Over Gold

Nanoparticles 620

Marco Schade, Paul M. Donaldson, Peter Hamm, A. Moretto, C. Toniolo

Cyclic Amino Acid-Containing a-Helical Peptide-Catalyzed Enantioselective

Epoxidation Reaction 622

Masakazn Tanaka, Masanobu Nagano, M. Doi, M. Kurihara, H. Suemune

Design and Synthesis of Bipyridyl-Containing Peptide Dendrimers As Iron

Protein Models 624

P. Geotti-Bianchini, Nicolas A. Uhlich, Tamis Darbre, Jean-Louis ReymondSynthesis of Self-Assembled Glycolipopeptide and Its Activation of

Peritoneal Macrophages 626

Ayumi Suzuki, Yasushi Suzuki, Naoya Kojima, Toshiyuki Inazu

Computational Studies ofthe Stability and Chirality of Self-Assembled

Complexes of a Novel Iron(II)-Binding Insulin Derivative 628

N. J. Christensen, H. K. Munch, S. T. Heide, T. Hoeg-Jensen, P. Waaben

Thulstrup, K. J. Jensen

Tubomicelle of Gene Transfection Agent 1,4-Dihydropyridine Lipid and Its

Binding with DNA 630

Inta Liepina, Ainars Zemitis, Gunars Duburs, Cezary Czaplewski, Adam Liwo

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