New Patents v

4552872

PENETRATING TOPICAL PHARMACEUTICAL

COMPOSITIONS CONTAINING CORTICOSTEROIDS

Eugene R Cooper, Maurice E Loomans, Mahdi Fawzi assigned to The Procter & Gamble Com- pany

Topical pharmaceutical compositions con- taining a corticosteroid component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C3- C4 diol and a cell-envelope disordering com- pound The vehicle provides marked transepidermal and percutaneous delivery of corticosteroids. A method of treating certain rheumatic and inflammatory conditions, sys- temically or locally, is also disclosed.

4552877

NB-QUATERNARY DERIVATIVES OF SANDWICINE AND

ISOSANDWICINE METHODS AND INTERMEDIATE PRODUCTS IN THE MANUFACTURE OF THEIR DERIVATIVES AND METHODS

OF USING SAME AND PHARMACEUTICAL

COMPOSITIONS THEREOF

Wolfgang Kehrbach, Joachim Wegener, Ulrich Kuehl, Renke Budden, Gerd Buschmann, Hanover, Federal Republic Of Germany as- signed to Kali-Chemie Pharma GmbH

B r ~ ~ _ _ . . _ . _ ~ A~

L,,7" L~\ j~,,,,, CH3 ~ C2H5

0)

4552876

BISBENZOXAZINES AND PHARMACEUTICAL USE

Howard Jones, Ernest Magnien, John H Mus- ser, Mujahid L Shaikh assigned to USV Pharma- ceutical Corp

RI RI

¥ , I --Ib- (x),,--I-- U /Y \N~ ~'N I I R R

Compounds of the formula: See Patent for Chemical Structure wherein, R is H, alkyl, cyclo- alkyl, aryl, or heteroaryl; R1 is H, alkyl, cyclo- alkyl, aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aryl, halo, OR2, SR2, NR2, CF3, NO2, CN, COOR2, CHO, SO3H or SO2NH2, wherein R2 is H, methyl, ethyl or propyl; Y is See Patent for Chemical Structure See Patent for Tabular Presentation Z is O, S, NH or CH2; X is -CH2-, See Patent for Chemical Structure See Patent for Tabular Presentation See Patent for Tabular Presentation or (CH2)nCHOH(CH2)n-; wherein R2 is H, methyl, ethyl or propyl; n is 1-10, and pharma- ceutically acceptable salts thereof have anti- allergy and antiinflammatory activity.

--(CH2)n--~H--(Ctl2)m-- x

Y

(I1)

New Nb-quaternary 10-bromosandwicine and 10-bromoisosandwicine derivatives are dis- closed which exhibit antiarrhythmic properties and adrenolytic properties and which have the formula I See Patent for Chemical Structure I wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A negative earth represents an acid anion, as well as pharmaceutical formulations thereof and pro- cesses and intermediates for their preparation.

4552879

BENZOHETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL

COMPOSITION THEREOF

Hiroshi Ishikawa, Testuyuki Uno, Masanobu Kano, Kazuyuki Nakagawa, Tokushima, Japan assigned to Otsuka Pharmaceutical Co Ltd

O R2 II

R~"- T N

(CH2),~ L-.RI

ll')