THE ROLE OF THE ROLE OF PEGYLATED PEGYLATED

INTERFERONS IN THE INTERFERONS IN THE MANAGEMENT OF HCV MANAGEMENT OF HCV

INFECTIONINFECTION Dr Nasir Khokhar MD FACP FACGDr Nasir Khokhar MD FACP FACG

Professor of Medicine and Professor of Medicine and Director, Division of Director, Division of

GastroenterologyGastroenterologyShifa International Hospital, Shifa International Hospital,

IslamabadIslamabad

16-Wk vs 24-Wk Therapy 16-Wk vs 24-Wk Therapy for Genotypes 2/3for Genotypes 2/3

Peginterferon alfa-2a (180 g/wk) + Ribavirin

800-1200 mg/day

Untreated ptswith HCV

genotype 2 or 3 (N = 153)

16-wktreatment(n = 71)

24-wktreatment(n = 69)

24-wktreatment(n = 13)

HCV RNA (+)

EOT SVR

94% 79%

85% 75%

71% 29%

Randomized, multicenter study [1]

1. von Wagner M, et al. AASLD 2004. Abstract LB-02.2. Dalgard O, et al. AASLD 2004. Abstract 197.

Wk 4 HCV RNA (-)

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