Keynote speaker: Annette Majnemer, PhD, M.Sc. Professor of Physical and Occupational Therapy

Division of Neurology, Faculty of Medicine, McGill University

Program

PediatricPediatricResearch

DayDayResearch

Wednesday, May 17, 2017

8:30 am - 5:00 pmL1-490 Edmonton Clinical Health Academy

“Building bridges from knowledge toaction - it takes a crew”

Department of Pediatrics Research Day

Committee Judges

Lopaschuk Gary,Chair Geoff Ball

Lavallee Celeste Po-Yin Cheung

Persad Sujata Maria Castro Codesal

Rose Girgis

Shereen Hamza

Anne Hicks

Andrew Mackie

Joanna MacLean

Amanda Newton

Sujata Persad

This research event has been funded by:

and the generous support of the Stollery Children’s Hospital Foundation through

the Women and Children’s Health Research Institute

Wednesday, May 17th, 2017 PEDIATRIC RESEARCH DAY

Time Activity

7:30-8:30am Registration, Continental Breakfast, & Poster set up

8:30-8:45am

Welcome & Introductions - Gary Lopaschuk, Associate Chair Research, Pediatrics - Susan Gilmour, Chair, Pediatrics - Sandra Davidge, Director, WCHRI

8:45-10:00am

Oral Presentations Session #1, Chair: Dawn Davies David Eisenstat (Faculty) – “ Transcriptional regulation of the homeobox genes CRX and OTX2 - implications for medulloblastoma group 3” Majid Nabipoor (Postdoctoral Fellow) – “On adjusting P_values: Applications to association rules in medical data mining” Cary Ma (Non-academic staff) – “Handheld point-of-care lactate measurement predicts mortality in Ugandan children hospitalized with pneumonia” Carina Majaesic (Faculty) – “Prevalent use of gastrostomy tubes in children with tracheostomies” Paula Ospina (Junior Graduate Student) – “Physical therapy interventions for children and adolescents with cancer: linking patient needs, clinical expertise, and research evidence”

10:00-10:30am

Break & Poster Viewing

10:30-11:45am

Oral Presentations Session #2, Chair:David Eisenstat Elizabeth Garcia (Faculty) – “Study of the interaction of particulate matter with THP-1 cells: effect on the aryl hydrocarbon receptor (AHR)CYP1A1 pathway” Sonia Rawat (Junior Graduate Student) – “Cardiac hypertrophy suppresses glucose oxidation in newborns with congenital heart defects” Dawn Davies (Faculty) – “Medical Assistance in Dying: Canadian Paediatric Surveillance Program results for requests by mature minors and parents” Andrew Dixon (Faculty) – “A comparison of temporal artery and rectal thermometry in infants 90 days and younger presenting to a Pediatric Emergency Department” Florencia Ricci (Senior Graduate Student) – “Deterioration of functional abilities in children surviving the Fontan operation”

11:45-1:30pm

Lunch and Poster Viewing Caricature Artist

1:30-2:30pm

Keynote speaker – Annette Majnemer “Building bridges from knowledge to action – It takes a crew."

2:30-3:00pm

Break & Poster Viewing

3:00-4:15pm Oral Presentations Session #3, Chair: Anita Kozyrskyj Maria Castro-Codesal (Faculty) – “Longitudinal changes in the children receiving long-term non-invasive ventilation and their outcomes” Daniel Garros (Faculty) – “Outcomes of young infants having extracorporeal life-support within 48 hours of cardiac surgery” Lesley Prichard-Wiart (Faculty) – “Six Minute Walk Test (6MWT) in Children with Juvenile Idiopathic Arthritis (JIA)” Daliwe Ngwezi (Senior Graduate Student) – “Exploring the spatial variation of exposures to developmental toxicants and effects on congenital heart disease in urban and rural Alberta, Canada” Heather Armstrong (Postdoctoral Fellow) – “Using Immunoglobulin G as a marker to Sselectively identify pathobionts in paediatric inflammatory bowel diseases”

4:15-4:45pm

Closing Remarks and Prize Announcements - Gary Lopaschuk, Associate Chair, Research, Pediatrics

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

Poster No. Presenter Name Co-Investigators/Co-Authors Abstract Title 01 Cathy Sheppard Ari R Joffe MD, Jessica Hogan RN, Gerda Tawfik BSc Pharm,

Jonathan Duff MD, Gonzalo Garcia Guerra MD. Chloral Hydrate enteral infusion fOr SEdation in veNtilated children: the CHOSEN pilot study

02 Eric Wong Loretta Fiorillo Congenital hemangioma in the setting of transient thrombocytopenia in a 1 week old infant

03 Jessica Hodson Christiana Garros, Jodie Pugh RN, Jonathan Duff MD, Gonzalo Garcia Guerra MD, Ari R Joffe MD

Parental feelings about, and understanding of different methods of obtaining consent to observational research in PICU

06 Elizabeth Rosolowsky Maryna Yaskina, Robert Couch Pediatric Type 1 Diabetes (T1D) Patients’ and Caregivers’ Perceptions of Glycemic Control

07 Yarden Yanishevsky Adil Adatia, MD, Moshe Ben-Shoshan, MD, MSc, Ann E. Clarke, MD, MSc, Edmond S. Chan MD, Greg Shand MSc, Scott Delaney, MD

Rate and Management of Anaphylaxis in Adult Patients at a Tertiary Care Centre Emergency Department

08 Kim Ho Cory Wagg, Liyan Zhang, John R. Ussher, and Gary D. Lopaschuk

The contribution of fatty acid and ketone body oxidation to energy production increases in the failing heart and is associated with a decrease in cardiac efficiency

09 Maryam Kebbe Kebbe, M., Byrne, JLS., Damanhoury, S., Ball, GDC. How Can Families Set Priorities in Pediatric Weight Management?

10 Amanda Liu Justine Turner, Farid Mahmud, Peggy Marcon, Esther Assor & Diana Mager

Dietary intake and adherence to micronutrient supplementation in youth with CD with or without Type 1 Diabetes

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

11 Noureen Ali Geetha Venkateswaran, Elizabeth Garcia, Sujata Persad Can Active Beta Catenin serve as a prognostic marker for Osteosarcoma progression?

13 Jocelyn Shulhan Bodil Larsen, Manoj Kumar, Allyson Jones, Kassi Shave, Lisa Hartling

A scoping review of enteral nutrition and necrotizing enterocolitis and a systematic review of hydrolyzed formulas

14 Liane Kang Petya T Koleva, Catherine J Field, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Anita L Kozyrskyj and CHILD Study Investigators

Maternal pre and postnatal depressive symptoms are associated with reduced fecal immunoglobulin A levels in Canadian infants

15 Prabhjot Bedi

Kristie Dehaan, Maria Castro-Codesal, Joanna E. MacLean Infants represent a distinct group with respect to long-term non-invasive ventilation in children

16 Usha Rai Usha Rai *1, Theodore Konya 2, David S. Guttman3, Allan B Becker4, Piushkumar J Mandhane1, Stuart E Turvey5, Padmaja Subbarao6, Malcolm R Sears7, James A Scott2, Andrea M. Haqq1, Radha Chari8, Anita L Kozyrskyj1 and the CHILD study investigators.

DURATION OF LABOUR: Influence on the Infant Gut Microbiota

17 Shelly Jun

Amy C Plint, Sarah Curtis, Amanda S Newton (Supervisor) Screening, brief intervention, and referral to treatment (SBIRT) for adolescent alcohol use in emergency departments: A national survey of pediatric emergency physicians

18 Victor Do Tina Ojala, Timothy Colen, Silvia Goncalvez-Alvarez, Sandra Davidge, Jesus Serrano-Lomelin, Lisa Hornberger

Fetal Programming: Cardiovascular Health of Offspring of Diabetic Mothers from the Fetus Through Late Infancy Stages

19 Dora Gyenes Jesus Serrano-Lomelin, Venu Jain, C. Monique Bohun, Winnie Savard, Angela McBrien, and Lisa K. Hornberger

EXPLORING DOPPLER-BASED PREDICTORS OF MATERNAL DIABETES-INDUCED PATHOLOGY THROUGH FIRST TRIMESTER FETAL ECHOCARDIOGRAPHY

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

20 Chantal Allan Simon Urschel, Ingrid Larsen, Sunita Mathur, Lori West Let's get physical: Aerobic capacity, muscle strength, and muscle endurance in pediatric heart transplant recipients

21 Brittany Matenchuk B. A. Matenchuk, T. Konya, D.S. Guttman, A.B. Becker, P.J. Mandhane, S.E. Turvey, P. Subbarao, M.R. Sears, J.A. Scott, A.L. Kozyrskyj and the CHILD Study Investigators.

Is the Infant Gut Microbiota Shaped by Sleep Duration

22 Anne Halpin M. Sosniuk, S. Urschel, P. Campbell, I. Larsen, L. West Old Dogs with New Tricks: A Standardized Flow Cytometry Panel Measuring Donor-Recipient Allo-Reactivity

23 Adekunle Jamal Alabi Faqi Wang, Shijun Deng, Dawei Zhang Membrane Type 1 Matrix Metalloproteinase-Induced cleavage of the Low Density Lipoprotein Receptor

24 Michelle Pollock Michelle Pollock, Ian Sinha, Lisa Hartling, Brian H Rowe, Sanja Schreiber, Ricardo M Fernandes

Inhaled short-acting bronchodilators for managing emergency childhood asthma: an overview of reviews

25 Sarah Raza Lori R. Sacrey, Lonnie Zwaigenbaum, Susan Bryson, Jessica Brian, Isabel M. Smith, Wendy Roberts, Peter Szatmari, Tracy Vaillancourt, Caroline Roncadin, & Nancy Garon

The Infant-Toddler Social and Emotional Assessment (ITSEA) for Early Risk Detection of Autism Spectrum Disorder: A Prospective High-Risk Cohort Study

27 Mon Tun Mon H.Tun, Hein M. Tun, T. Konya, David S. Guttman, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Malcolm R. Sears,Jeffrey R Brook, Tim K Takarao, James A. Scott, Anita L. Kozyrskyj, and the CHILD Study Investigators

High-efficiency Particulate Air (HEPA) filter vacuum cleaning changes infant gut microbiota and wheezing risk at 1 year

28 Maha Alsaif Maha Alsaif, Michelle L Mackenzie, Carla M Prado and Andrea M Haqq

Fasting and postprandial glucose, insulin and GLP-1 levels in children with Prader-Willi Syndrome

29 Ashley Bahry Edward A Armstrong and Jerome Y Yager Alterations in Neuronal Morphology in a Model of Placental Insufficiency Induced Intrauterine Growth Restriction and the Effects of Broccoli Sprout Supplementation

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

30 Amarjot Padda Darren Nichols, Mel Lewis, and Karen Forbes Learning resources and study methods in a Longitudinal Integrated Clerkship

31 Saba Rehman R.Todd Alexander MUTATIONS IN CLAUDIN-14 ASSOCIATED WITH HYPERCALCIURIA AND KIDNEY STONES

32 Deenaz Zaidi Hien Q. Huynh, Matthew W. Carroll Shairaz Baksh, Eytan Wine

Dysregulation of TNFAIP3 (A20) is associated with inflammation in pediatric Crohn Disease.

32 Megan Beggs Intestinal calcium absorption pathways are altered at weaning

33 Istahil Abdullahi Kevin Dietrich, LG Mitchell Hemostatic factors genes are expressed in Neuroblastoma and Wilms' tumor: A novel potential mechanism for tumor metastasis

34 Kassi Shave Robin M. Featherstone; Allison Gates; Shannon D. Scott; Lisa Hartling

Using Social Media to Promote Cochrane Evidence in Pediatric Emergency Medicine: Assessment of a Knowledge Dissemination Strategy

35 Risha Dutt Cary Brown Providing the Best Bedroom Sleep Environment for Children with Cerebral Palsy

36 Catherine Stewart Sarah Curtis, Marcella St. Louis, Melanie Rock, Sylvia Checkley, Manasi Rajagopal

Dog Related Injury in the Stollery’s Emergency Department

37 Michael Schlegelmilch Sunita Vohra, Hsing Jou, Dawn Hartfield, Maria Mayan, Arto Ohinmaa, Bev Wilson, Maria Spavor, Paul Grundy

Pediatric integrative medicine clinical trial for relief of common symptoms in hospitalized children

38 Anmol Sidhu Kandice Mah, Michiko Maruyama, Nee Khoo, Timothy Colen Tricuspid Valve Adaptation in Hypoplastic Left Heart Syndrome

39 Christiana Garros Jessica Hodson, Jodie Pugh RN, Jonathan Duff MD, Gonzalo Garcia Guerra MD, Ari R Joffe MD

Parental opinions about types of consent acceptable for observational research in a PICU before and after background information.

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

40 Nichole Marks Tamizan Kherani "Cystic Fibrosis Status Positive Indeterminate Diagnosis: A Quality Improvement Project to improve Follow-Up and Medical Care"

41 Mohammadmehdi Houshmandi

"Mohammadmehdi Houshmandi Luke Eckersley, Winnie Savard, Deborah S. Fruitman , Lindsay Mills, Lisa K. Hornberger

Prenatal Diagnosis Improves the Perioperative Condition of Neonates Requiring Surgical Intervention for Coarctation But is Associated with Longer Preoperative Stay

42 Beata Mickiewicz Graham C. Thompson, Jaime Blackwood, Craig N. Jenne, Brent W. Winston, Hans J. Vogel, Ari R. Joffe

Biomarker Phenotyping for Triage of Sepsis to the Pediatric Intensive Care Unit

43 Atsushi Kawaguchi Steven Drews, Bonita Lee, Daniel Garros The Impact of Viral Respiratory Infections On Respiratory Distress in Critically Ill Children

44 Lori Sacrey Lonnie Zwaigenbaum MD, Susan Bryson PhD, Jessica Brian PhD, Isabel M. Smith PhD, Wendy Roberts MD, Peter Szatmari MD, Tracy Vaillancourt PhD, Caroline Roncadin PhD, and Nancy Garon PhD

Parent and clinician agreement in early behavioural signs in 12-month-old infants at-risk of Autism Spectrum Disorder: A high-risk sibling cohort

45 Hein Min Tun S.L. Bridgman, R. Chari, C.J. Field, D.S. Guttman; A.B. Becker; P.J. Mandhane, S.E. Turvey, P. Subbarao, M.R. Sears, J.A. Scott, A.L. Kozyrskyj and the CHILD Study Investigators.

Birth mode and infant gut microbiota sequentially mediate the association of maternal overweight with childhood overweight

46 Luke Eckersley Lisa Howley, Tim Colen, Nee Khoo, Paul Brooks, Lisa K Hornberger

Reduced Left Ventricular Global Strain in Fetal Ebstein Anomaly and Tricuspid Valve Dysplasia Compared to Pulmonary Atresia with Intact Ventricular Septum Secondary to Septal Dyssynchrony

48 Alexandra Rydz Fangfang Fu, Mark Drew, Dax Rumsey, Yan Yuan, Mercedes Chan

Quality of Referral Letters to Pediatric Rheumatology and Its Impact on Access to Care

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

49 Angela Han Sandy Whitehouse, Steve Tsai, Sandy Hwang, Sally Thorne Perceptions of the family physician from adolescents and their caregivers preparing to transition to adult care

50 Brenda Law Po-Yin Cheung, Sylvia van Os, Bin Zheng, Georg Schmölzer Eye of the Beholder – Analysis of Neonatal Resuscitation from the View of the Resuscitator Using Eye-Tracking – A Pilot Study

51 Jayani Abeysekera Dora Gyenes, Charlene M.T. Robertson, Gwen Bond, Irina Dinu, Dianne Creighton, Joseph Atallah, Ivan M. Rebeyka and Lisa K. Hornberger.

Umbilical Arterial Blood Flow in the Third Trimester and Its Association With Clinical and Neurodevelopmental Outcomes in Children With Critical Neonatal Congenital Heart Disease

52 Telford Yeung Israel Amirav Evaluating Caregiver Management of Asthma Exacerbations at Home

53 Gabriela Kuraim D. Garros, A. Joffe, F Moradi, L. Ryerson, Garcia Guerra G, I. Dinu, G. Bond, C. Robertson

Prediction of need for extracorporeal life support within 48 hours of cardiac surgery in infants up to 6 weeks of age

54 Silvia Alvarez Paul Brooks, Nee Khoo, Timothy Colen, Lisa K Hornberger The Incremental Benefit of Color Tissue Doppler Imaging in Fetal Rhythm Assessment

55 Tariq Altamimi Jennifer Kwong, Arata Fukushima, Jeffery D. Molkentin, Gary D. Lopaschuk

Impaired Mitochondrial Calcium Uptake in the Heart Does Not Compromise Cardiac Energetics or Function Due to a Preferential Increase in Fatty Acid Oxidation During Increased Cardiac Work

56 Kathy Tang Michael R. Doschak, R. Todd Alexander

Forkhead Box O 3 Transcription Factor (FoxO3a) is essential for Osteoblast Differentiation and Matrix Calcification

57 Charlene Nielsen Alvaro Osornio-Vargas (Pediatrics), Carl Amrhein (Earth and Atmospheric Sciences), Jesus Serrano Lomelin (School of Public Health) and Osmar Zaiane (Computing Sciences)

SPATIAL-TEMPORAL HOT SPOTS – HOW DO THE PATTERNS COMPARE FOR SUBNORMAL BIRTHWEIGHT AND OUTDOOR POLLUTANTS?

Poster presenters must be present at their posters for judging during the following times: 10:00am – 10:30am, 12:30pm – 1:30pm, 2:30pm – 3:00pm

58 Osnat Wine K. Kovacs Burns; M. van Manen; J. Spiers; A. Osornio- Vargas, and on behalf of the DoMiNO team

How to Develop Knowledge Translation Plans for Innovative Environmental Health Research?

59 Jesus Serrano-Lomelin Charlene Nielsen, Khalid Aziz, Manoj Kumar, Sue Chandra, Nancy Aelicks

IDENTIFICATION OF KEY MATERNAL RISK FACTORS AND THE ROLE OF SOCIOECONOMIC STATUS IN AREAS WITH HIGH PREVALENCE OF ADVERSE BIRTH OUTCOMES IN ALBERTA

61 Ibrahim Adam Bruce Motyka, Kesheng Tao, Jean Pearcey, and Lori J West CD4 T CELLS AND CO-ENGAGEMENT WITH FORIGEN PROTEIN ARE REQUIRED IN ANTIBODY RESPONSE TO BLOOD GROUP A-ANTIGEN

62 Arnaldo Perez Predictors of treatment enrollment in multidisciplinary clinical care for pediatric weight management in Alberta

63 Samah Damanhoury Geoff DC Ball, Amanda S Newton Gaining Expert Consensus on Defining Metabolically Healthy Obesity (MHO) in Pediatrics: A Delphi Study