14 | FEB | 2017

08:30-09:00 Greetings H.E. Francesco Maria Talo', Ambassador of Italy to Israel Prof. Yitshak Kreiss, Director, CEO Sheba-Tel-Hashomer Prof. Iris Barshack, Head Medical School Tel Aviv University Prof. Asher Barzilai, Director, Edmond and Lily Safra Children’s Hospital Session 1: Gene-therapy and Immuno-therapies Chairs: Amos Etzioni and Jerry Stein09:00 - 09:25 Stem Cell Gene Therapy for Inborn Errors: from Clinical Studies to Approved Drug Alessandro Aiuti09:25 - 09:50 Primary Immunodeficiencies – from Bed to Bench and Back Raz Somech09:50 - 11:05 Mini Symposium: Cure of Childhood Malignancies Through Immunotherapy: Reality or Dream? Andrea Biondi, Franco Locatelli, Amos Toren11:05 - 11:35 Coffee BreakSession 2: Inflammation and Autoimmunity Chairs: Batia Weiss and Shimon Reif11:35 - 12:00 What is Common Between Asthma, Atopic Dermatitis, Arthritis and Childhood Leukemia? – Therapeutic Opportunities and Challenges Shai Izraeli12:00 - 12:25 The Future of Celiac Disease Riccardo Troncone12:25 - 12:50 Can Celiac Disease be Prevented? Raanan Shamir12:50 -13:10 Molecular and Microbial Advances in Pediatric IBD – Vision of Personalized Therapies? Yael Haberman13:10 -14:10 Lunch BreakSession 3: Stem Cells and Regenerative Medicine Chairs: Sara Ferber and Shoshana Greenberger14:10 - 14:35 Towards Lung Healing by Committed Lung Progenitors: the Lung Niche and Other Analogies to Bone Marrow Transplantation Yair Reisner14:35 - 15:00 Regenerative Medicine and Tissue/ Organ Regeneration: the New Approach of Stem Cell-Derived Extracellular Vesicles Benedetta Bussolati15:00 - 15:25 Stem Cell and Gene Therapies for Inherited Skin Diseases Michele De Luca15:25 -15:50 Life in 3D: Boosting Kidney Spheroid Function for Kidney Regeneration Benjamin Dekel

THE SHEBA MEDICAL CENTER THE TEL AVIV UNIVERSITY INSTITUTE FOR PEDIATRIC RESEARCHEDMOND AND LILY SAFRA CHILDREN'S HOSPITAL, TEL-HASHOMER

ARE DELIGHTED TO INVITE YOU TO THE:

PEDIATRIC MEDICINE INTO THE FUTURE: BREAKTHROUGH THERAPEUTIC APPROACHES – MANIPULATING GENES, IMMUNITY AND STEM CELLS

AN ITALIAN ISRAELI SYMPOSIUM

לרישום ניתן לפנות למחלקת השיווק: marketing@sheba.health.gov.il ניתן לשלוח מייל לדוא"ל: https://www.sheba.co.il/57328/98/114 :או להרשם בקישוראו להתקשר למס' 03-5305000 שלוחה 0 ואז 2, בין השעות 08:00-16:00

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15 | FEB | 2017

08:30-09:00 Gathering and Greetings Session 4: Neurometabolic Disorders – New Therapeutic Opportunities Chairs: Ronen Spiegel and Yair Anikster 09:00-09:25 Novel Insight in Neurometabolic Disorders of Cellular Trafficking Carlo Dionisi-Vici09:25-09:50 "Solving the Unsolved" - Genomics in Neurodevelopmental and Neurodegenerative Disease Research Marco Tartaglia09:50-10:15 Repurposing Phenylbutyrate for Therapy of Maple Syrup Urine Disease and Pyruvate Dehydrogenase Deficiency Nicola Brunetti-Pierri10:15-10:40 The Role of Urea Cycle Enzymes in Central Nervous System Functions Ayelet Erez10:40-11:10 Coffee BreakSession 5: Progress in Pathogenesis and Treatment of Neurological Disorders Chairs: Doron Lancet and Bruria Ben Zeev 11:10-11:35 Understanding Rett Syndrome and MeCP2 Deficiency Molecular Consequences Through Novel Transgenic Mice Nicolleta Landsberger11:35-11:55 Ataxia Telangiectasia - Past, Present and Future Andreea Nissenkorn11:55-12:20 Inhibitors of the mTOR Cascade: a Potential New Systemic Treatment for Tuberous Sclerosis Complex Paolo Curatolo 12:20-12:40 From the Single Patient to a Novel Potentially Treatable Neurometabolic Disease Gali Heimer12:40-13:40 Lunch BreakSession 6: Breakthroughs in Neurodegenerative and Neuropsychiatric Disorders Chairs: Abraham Weizman and Annick Raas-Rothschild 13:40-14:05 The Cholinergic Tradeoff of Stress Micromanagement Hermona Soreq14:05-14:30 22q11 Deletion Syndrome and Schizophrenia Marco Armando14:30-14:55 Neuro-Inflammation in Pediatric Psychiatric Disorders: 22q11.2 Deletion Syndrome as a Model Doron Gothelf14:55-15:20 RNA Modifications in Neurodegenerative Diseases Gidi Rechavi

THE SHEBA MEDICAL CENTER THE TEL AVIV UNIVERSITY INSTITUTE FOR PEDIATRIC RESEARCHEDMOND AND LILY SAFRA CHILDREN'S HOSPITAL, TEL-HASHOMER

ARE DELIGHTED TO INVITE YOU TO THE:

PEDIATRIC MEDICINE INTO THE FUTURE: FRONTIERS IN GENETICS OF NEURO-METABOLIC AND BRAIN DISORDERS

AN ITALIAN ISRAELI SYMPOSIUM

לרישום ניתן לפנות למחלקת השיווק: marketing@sheba.health.gov.il ניתן לשלוח מייל לדוא"ל: https://www.sheba.co.il/57328/98/114 :או להרשם בקישוראו להתקשר למס' 03-5305000 שלוחה 0 ואז 2, בין השעות 08:00-16:00

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