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29/11/2010 Προεδρείο: Κωνσταντινίδης Θ. ΟμιλίαΙατρική Στατιστική Ανάλυση Συνήθεις μέθοδοι (επιλογή‐εφαρμογή‐ αξιολόγηση)», Κοντακιώτης Θ. ΟμιλίαΜεταναλύσεις», Χάιδιτς Άννα Μπετίνα Βασικές γνώσεις για την σύνταξη ερευνητικών μελετών 1

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  • 29/11/2010 : . : (), .

    :,

    1

  • .

    29/11/2010910

    ( )

  • 9

  • SPSS,StatisticalPackagefortheSocialSciences,computersoftware

    ThecompanyannouncedJuly28,2009thatitwasbeingacquiredbyIBM forUS$1.2billion.AsofJanuary2010,itbecame"SPSS:AnIBMCompany".

    PASWStatistics18.0.2 April2010

  • Price:Freetotry$799.00tobuyOperatingsystem:WindowsXP/VistaDateadded:October08,2009TotalDownloads:144,213Downloadslastweek:1,055ProductRanking:#2inMathSoftwareSeefullspecifications

    Morepopular MathSoftwaredownloads1,683downloads 1.Matlab1,055downloads 2.PASWStatistics988downloads 3.SASSystem929downloads 4.FaceRecognitionSystem833downloads 5.Graph

    Predictive Analytics SoftwarePASW

    SPSS , ,

  • VariableType Theavailabledatatypesareasfollows: Numeric.Avariablewhosevaluesarenumbers.Valuesaredisplayedinstandardnumericformat.TheDataEditor

    acceptsnumericvaluesinstandardformatorinscientificnotation. Comma.Anumericvariablewhosevaluesaredisplayedwithcommasdelimitingeverythreeplacesanddisplayed

    withtheperiodasadecimaldelimiter.TheDataEditoracceptsnumericvaluesforcommavariableswithorwithoutcommasorinscientificnotation.Valuescannotcontaincommastotherightofthedecimalindicator.

    Dot.Anumericvariablewhosevaluesaredisplayedwithperiodsdelimitingeverythreeplacesandwiththecommaasadecimaldelimiter.TheDataEditoracceptsnumericvaluesfordotvariableswithorwithoutperiodsorinscientificnotation.Valuescannotcontainperiodstotherightofthedecimalindicator.

    Scientificnotation.Anumericvariablewhosevaluesaredisplayedwithanembedded Eandasignedpowerof10exponent.TheDataEditoracceptsnumericvaluesforsuchvariableswithorwithoutanexponent.TheexponentcanbeprecededbyEorDwithanoptionalsignorbythesignaloneforexample,123,1.23E2,1.23D2,1.23E+2,and1.23+2.

    Date.Anumericvariablewhosevaluesaredisplayedinoneofseveralcalendardateorclocktimeformats.Selectaformatfromthelist.Youcanenterdateswithslashes,hyphens,periods,commas,orblankspacesasdelimiters.ThecenturyrangefortwodigityearvaluesisdeterminedbyyourOptionssettings(fromtheEditmenu,chooseOptions,andthenclicktheDatatab).

    Dollar.Anumericvariabledisplayedwithaleadingdollarsign($),commasdelimitingeverythreeplaces,andaperiodasthedecimaldelimiter.Youcanenterdatavalueswithorwithouttheleadingdollarsign.

    Customcurrency.AnumericvariablewhosevaluesaredisplayedinoneofthecustomcurrencyformatsthatyouhavedefinedontheCurrencytaboftheOptionsdialogbox.DefinedcustomcurrencycharacterscannotbeusedindataentrybutaredisplayedintheDataEditor.

    String.Avariablewhosevaluesarenotnumericandthereforearenotusedincalculations.Thevaluescancontainanycharactersuptothedefinedlength.Uppercaseandlowercase lettersareconsidereddistinct.Thistypeisalsoknownasanalphanumericvariable.

  • Numeric: . . Data Editor .

    String. . . . .

  • SORTCASESBYgroup.SPLITFILELAYEREDBYgroup.DESCRIPTIVESVARIABLES=FEV1postFEV1,FEV16monts/STATISTICS=MEANSTDDEVMINMAX.

    C:\Users\TURBO_X\Desktop\\\Untitled1.sav

  • SORTCASESBYSEX.SPLITFILELAYEREDBYSEX.DESCRIPTIVESVARIABLES=FEV1postFEV1FEV16monts/STATISTICS=MEANSTDDEVMINMAX.

  • Instatisticalhypothesistesting,therearetwotypesoferrorsthatcanbemadeorincorrectconclusionsthatcanbedrawn.

    Ifanullhypothesis isincorrectlyrejectedwhenitisinfacttrue,thisiscalledaTypeIerror (alsoknownasafalsepositive).ATypeIIerror (alsoknownasafalsenegative)occurswhenanullhypothesisisnotrejecteddespitebeingfalse.

    TheGreekletter isusedtodenotetheprobabilityoftypeIerror,andtheletter isusedtodenotetheprobabilityoftypeIIerror.

  • H ,

    , .

    , : (0) (1).

    (). ( 0).

    ( 0).

    14

  • Statisticalsignificantdifferencep
  • Pairedttest

    Mean= SD = SEM =

    95%CI 95%

    8

    independentsamplesttest,

    pairedttest,

    where isthestandarddeviationoftheoriginaldistributionandNisthe

    samplesize

    SEM

  • Adatasetwithameanof50(showninblue)andastandarddeviation()of20.

    Aplotofanormaldistribution (orbellcurve).Eachcoloredbandhasawidthofonestandarddeviation.

    Exampleoftwosamplepopulationswiththesamemeananddifferentstandarddeviations.Redpopulationhasmean100andSD10;bluepopulationhasmean100andSD50.

  • where isthestandarddeviationoftheoriginaldistributionandNisthe

    samplesize

    SEM

  • Between Groups 4.024 2 2.012 15.267 .000

    Within Groups 1.713 13 .132

    Total 5.738 15Between Groups 9.816 2 4.908 15.717 .000

    Within Groups 4.684 15 .312

    postFEV1

    Total 14.500 17Between Groups 10.128 2 5.064 15.429 .000

    Within Groups 5.251 16 .328

    f

    FEV16monts

    Total 15.379 18Between Groups 7.116 4 1.779 3.173 .024

    Within Groups 20.745 37 .561

    Total 27.861 41Between Groups 6.484 4 1.621 2.099 .101

    Within Groups 28.574 37 .772

    postFEV1

    Total 35.058 41Between Groups 4.622 4 1.155 2.634 .049

    Within Groups 17.110 39 .439

    males

    FEV16monts

    Total 21.732 43

    ANOVA 4

  • Repeatedmeasurementsanalysis

  • TheGenerallinearmodelprocedureprovidesanalysisofvariancewhenthesamemeasurementismadeseveraltimesoneachsubjectorcase.Ifbetweensubjectsfactorsarespecified,theydividethepopulationintogroups.Usingthisgenerallinearmodelprocedure,youcantestnullhypothesesabouttheeffectsofboththebetweensubjectsfactorsandthewithinsubjectsfactors.Youcaninvestigateinteractionsbetweenfactorsaswellastheeffectsofindividualfactors.Inaddition,theeffectsofconstantcovariatesandcovariateinteractionswiththebetweensubjectsfactorscanbeincluded .

    ,

    betweensubjectsfactors withinsubjectsfactors

  • ;

    . . ANOVA (RMF)., ANOVA Mauchly p

  • p
  • whereparameter isthemean(locationofthepeak)and2isthevariance(themeasureofthewidthofthedistribution).Thedistributionwith =0and2=1iscalledthestandardnormal.

    Bonferonni correction0.05/4=0.01250.05/6=0.0083

  • test1. (splitfile)2. ( ) FEV1

    test 1. FEV1VSPostFEV12.

    Friedmantest

    Wilcoxon signedRankstest

  • FEV1VSPostFEV1

    FEV1VSPostFEV1VSFEV16months

    Friedmantest

    Wilcoxon signedRankstest

  • pairedttest,Wilcoxon ttest

    indepented ttest,MannWhitneytest

    onewayANOVA,Kruskall Wallistest,Bonferonnis correction

    anova fortwowaycrossoverdesign(twoerrors)

    % XS2test,oddsratio

  • multiplemeasurementsanalysis Friedmantest

    splitfile

    TheWilcoxon signedranktest isanonparametric statisticalhypothesistest

    forthecaseoftworelatedsamples orrepeatedmeasurementsonasinglesample.ItcanbeusedasanalternativetothepairedStudent'sttest whenthepopulationcannotbeassumedtobenormallydistributed.

  • 4:

    : . 2080.( )

    II: . . 100200 .( )

    III: , . .( )

    IV: .

  • Doubleblindcontrolledstudyrandomizecontrolledtrial

    FEV1,FEV1post,FEV16months FEV1,19,2 (),Placebo (),controlgroup

  • 9

  • ()randomizecontrolledtrial doubleblind

    9 Variable TypeH Statistical significant difference p