pantheon - ukcab · pantheon • an nihr programme grant for applied research: a comprehensive...
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PANTHEON
• AnNIHRprogrammegrantforAppliedResearch:
Acomprehensiveassessmentofcost-
effec?venessofHIVpreven?onandtes?ngstrategies,includingHIV-self-tes?ng,amongmenwhohavesexwithmen(MSM)intheUK.
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Collaborators
• RoyalFree,UCL:AlisonRogers,AndrewPhilips• MRCCTU,UCL:SheenaMcCormack,DavidDunn
• LSHTM:PeterWeatherburn,CharlieWitzel• PHE:ValerieDelpech,TonyNardone
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Programme
• Workstream1:– Feasibilitystudy– Processevalua?on
• Workstream2:SELPHItrial• Workstream3:Costeffec?venessanalysis
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SELPHI
• Anevalua?onofHIVself-tes?nginEngland&Wales
• Recruitmentviasocialmediaandapps• Internetbaseddatabase– Par?cipantinforma?onandconsent– Selfreporteddata– Distribu?onofkits
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RATIONALE
• PreviousandongoingstudiesofHIVself-tes?nghavegenerallybeensmallandqualita?ve.SELPHIisalarge,randomisedtrialwhoseprimaryaimistomeasuretheimpactofself-tes?ngonnewconfirmedHIVdiagnoseslinkedtoclinicalcare.
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PrimaryObjec?ves
1. Istheonlinepromo?onandpostaldeliveryoffreeHIVself-testkits(withtes?ngreminders)feasibleandacceptable?
2. Willtheofferofasinglefreeself-testatenrolmentleadtotheconfirmeddiagnosisofprevalentHIVinfec?onsandentrytostandardHIVclinicalcare?
3. Amongsero-nega?vemenathighriskofacquiringHIVInfec?on,willtheofferofregularfreeself‑testswithtes?ngremindersresultinmorerapidconfirmeddiagnosisofanincidentHIVinfec?onandentryintostandardHIVclinicalcare?
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SecondaryObjec?ves• ComparisonofthefollowingbetweenthosewhoreceivedfreeHIVself-
testandthosewhodidnot;– frequencyofHIVtes?ng– howindividualsaccesstes?ngop?ons(e.g.attes?ngwitha
healthcareprofessional,self-samplingorself-tes?ng)– frequencyofSTIscreening.
• ReportedusageofHIVself-tes?ngkits.• AcceptabilityofHIVself-tes?ng.• Assesspost-testlinkagewithcounsellingandtreatmentservicesincluding
a^endanceforconfirmatoryHIVtest• Assesstheextenttowhichdemographic,socio-economic,health-related
factors,sexualriskbehavioursusepredicttes?ngbehaviours• ExamineiftheofferofHIVself-testsinfluencesthefrequencyof
condomlesssex(eitherself‑reportorasreflectedinnewSTIdiagnoses).• Providedatatoinformkeyparametersforcost-effec?venessmodels.
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Randomisa0onAschema
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Randomisa0onAschema
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Randomisa0onBschema
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Randomisa0onBschema
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BioSureHIVself-testkit• TheonlyCEMarkedSelfTestavailable,BioSureHIVSelf
Test(some?mesknownasaHIVhometest)isover99.7%accurateandallowsyoutodiscreetlydetermineyourHIVstatusata?meandaplacethatisconvenientforyou.
• TherapidHIVtestisextremelyeasytoperform,requiresonlya?nydropofblood,andgivesaclearandsimpletoreadresultinjust15minutes.
• ThepriceofasingleHIVSelfTestKitis£29.95(freeStandardUKdelivery)
h^p://hivseleest.co.uk/
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PPI
• PPIlead:SimonCollins• CAB– Representa?vesfromUKCAB(12-17)– Representa?vesfromPROUD(2-3)
• Protocol&surveyreview– UKCAB– SELPHICAB
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Timelines
• Ethicssubmission:October2016• Soerelease:early2017• Hardrelease:med2017• Followup:3years