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Research Buildings 2006

Rensselaer Center for Biotechnology and

Interdisciplinary Studies

Robert E. Palazzo, PhD, DirectorBoston, May 2006

Tradeline Inc.

Rensselaer CBIS

Rensselaer CBIS

Project Timelineand

Team

Project Timeline and Cost

April 2001 Programming startJune 2001 Design startMay 2002 Construction startNov 2004 Completion Total design time: 16 mos.Total construction time: 21 mos.

Construction Cost: $70,000,000 $321 / Sq. Ft.

Project TeamOwner – Rensselaer Polytechnic InstituteArchitect – Burt Hill Kosar Rittelmann Assoc.Assoc. Architect – Bohlin Cywinski JacksonLab Programmer – Research Facilities DesignMEP Engineering – Burt Hill Kosar Rittelmann, Assoc.Structural Engineering – Ryan Biggs AssociatesLandscape Architects – Burt Hill Kosar Rittelmann, Assoc.Site Civil – Claugh Harbour

Construction Manager – McCarthy Casework Installation Company- Northeast Interior SystemsFume Hood and Metal Casework Company- Jamestown Metal ProductsFlexible and Adaptable Casework and Overhear Service Carrier – Case

SystemsMechanical Contractor – TougherElectrical Contractor - LaCort

The Constellation Concept

• Biotechnology AND Interdisciplinary Research– The research is organized by focus areas or

Centers of Excellence and specifically NOT by discipline.

– Some Constellations have as many as 6 disciplines working together.

– The Center was intended to bring Rensselaer’s already prodigious reputation in Science, Engineering, Computer Science and Biomedical Engineering research to the Biotechnology arena

The Tertiary Lab Concept

•General Research Labs•Support Labs•Core Labs


• General Research Labs– Very open, very flexible, easily rearranged

by the research staff.– Overhead service modules to allow

freedom of work surfaces below. Much work is done with equipment that is not benchtop apparatus.

– Indirect lighting allows researchers to work anywhere in the lab without creating shadows.

– Little need for partitioning.


• The Support Lab– Houses those functions that are either

equipment or process specific.– Allows the sharing of more expensive or

seldom used apparatus by the entire Constellation.

– Contains those activities and equipment that would likely be an impediment to flexibility if they occurred within the General Research Labs.


• The Core Labs– Labs which support the entire Center.– Contains the most expensive equipment.– Contains equipment that require

specialized skills to operate not usually held by most researchers. (NMR, X-ray Crystallography etc.).

– Includes central services such as; Vivarium, Glass wash, autoclaves, fermenters, etc.

Lab Management

• The Constellation Concept and the Tertiary Lab Concept require a substantially different lab management approach than the traditional individual PI Grant management methods.– A strong lab manager and staff are needed– Support Lab and Core Lab equipment is not

“owned” by a PI. It is owned by the Institute and furnished to many PI’s on a “Fee-for-Service” basis.

– Cleaning, calibration, maintenance, ordering accessories etc. is done by the lab manager.

– The PI’s must have confidence in the lab management staff’s competence to provide high quality support.

Lab Management

• The Constellation Concept and the Tertiary Lab Concept require a substantially different lab management approach than the traditional individual PI Grant management methods.– Research grant writing is trending away from

the individual PI toward a “Center of Excellence” or research team effort. Hence the Constellation structure. This is partially in response to the research funding policy trends of major funding sources such as NSF and NIH.

Constellations

• Functional Tissue Engineering• Integrative Systems Biology• Computational Biology and

Bioinformatics• Biocatalysis and Metabolic

Engineering

Research Laboratory Focus Areas:

Biocatalysis and Metabolic Engineering Biocomputation and BioinformaticsIntegrative Systems BiologyFunctional Tissue Engineering and

Regenerative MedicineBiology and BiochemistryBiochemistry and Biophysics NanobiotechnologyBiochips and MicrosystemsBioimaging and Bioinstrumentation

CBIS Personnel

• Staff – 5• Core directors – 3• Faculty – 27 (assistant professors – 13)• Grad students/research personnel – 191 • Undergrads – 46• Total – 237

– Average personnel per faculty – 8.78– Average personnel per assoc/full professor – 9.43– Average personnel per assistant professor – 8.08

• Total building capacity – 460

Lab Areas

Gross Building (without mech. equip. penthouse) 202,025 sqft

Net (Assignable) Building 126,754 sqft

Net/Gross Ratio 0.63

Laboratory and Laboratory Support 73,787 sqft

Laboratory and Laboratory Support/Gross Building 0.37

Laboratory Support 24,104 sqft

Laboratory Support/ Laboratory & Laboratory Support 0.33

Laboratory Planning Module 10'-8" x 29'-5"

Lab AreasOpen Research Labs31,240 sqftSupport Labs 13,009 sqftCore 27,350 sqftSeminar 5,831 sqftOffices 33,124 sqftAuditorium 5,027 sqftNet Assignable 115,581

sqft

Note that the total support labs plus core labs are 129% of the general research labs. This ratio continues to increase.

Constellation Areas (Lab, Lab Support and Offices)

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Offices

Office Areas

Typical Office Area 160 Sqft

Total number of Offices 147 offices

Total Office Area 33,124 sqft

Office Space allocation:Principle Investigator – 160 sqft – (1 PI per office)Post Doctorate – 80 sqft per person – (2 Post Doc per office)Graduate Student – 60 sqft per person – (4 GA’s per office)

Office Areas

• The mix of PI’s, post-doc’s, graduate assistants within the Constellation can change substantially. To accommodate this changing mix, ONE office module size of 160 S.F. was selected. It can house; one PI, two post-docs, or four GA’s.

• Traditional methods of office planning that use some hierarchical method of assigning office space based on rank or title are antithetical to efficient flexibility.

Office

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Floor Plans

Second Floor Plan

Fourth Floor Plan

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General Research

Labs

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Flexible Lab Bench space• Biocatalysis and Metabolic

Engineering • Biocomputation and Bioinformatics• Integrative Systems Biology• Functional Tissue Engineering and

Regenerative Medicine

Adjustable tables

Flexible Research Lab

General Research Labs

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Support Lab

Support Lab Spaces

Tissue CultureEquipment RoomsCold and Warm roomsFly KitchenInstrumentation RoomsMicroscope roomsSpectroscopy rooms

Support Lab

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Core Labs

Shared Core Research Facilities:

Analytical BiochemistryHistology CoreZebra fish FacilityMicrobiologyMicroscopy and Imaging SuiteMolecular Biology Tissue Engineering and Cell Culture FacilityBiocomputationProteomics SuiteGlass wash and AutoclavesHigh-Throughput Screening Facility800 MHz NMR facility ( Space exists for a 900 MHz

magnet)Various Spectroscopy techniques.X-ray CrystallographyVivarium

Molecular Biology Core

Zebra Fish Room

Glasswash and Autoclave

Laboratory Systems

• Central Natural Gas• Central Compressed Air• Central Nitrogen• Central DI/RO• Floor Localized Vacuum

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Interactive Spaces

Interactive Spaces

The Center has a very carefully developed hierarchy of interactive or collaboration spaces.– Atrium– Auditorium– Conference center– Oxbridge Rooms– Conference Rooms– Outdoor Forum– Lobby Gathering Spaces– Breakout Areas

Interactive Spaces

• Interactive spaces are arguably the most important spaces in a lab building. They must be planned and programmed.

• Labs are the spaces where ideas or discoveries may occur.

• Interactive spaces are where discoveries are;– Discussed– Challenged– Added-to– Matured– Combined– Defended

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Atrium4600 Sq. Ft.

Atrium West Entrance

Atrium South Entrance

Atrium Interior

Auditorium

Auditorium

• Auditorium and Gallery Area: 5028 sqft

• Auditorium capacity 153 seats• Full audio visual and network

capabilities.

Auditorium

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Exterior Forum5050 Sq. Ft.

Exterior Forum

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Conference Center

2150 Sq. Ft.

Conference Center

Lobby Views

Conference Center

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Conference Rooms

1,800 sqft located over 4 floors

Conference Room

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Oxbridge Rooms 1,860 sqft located on three

floors

Oxbridge Room

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Lobby Gathering space

700 Sq. Ft. on each floor

Lobby Gathering Space

Lobby Gathering space

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Open Breakout Areas

Distributed throughout the building

Open Breakout Space

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Overhead Service Carrier

Data

Power (110v and 220 single and three phase)

Up-lighting fixtures

Lab Gas (natural gas)

Nitrogen (N2)

Lab Air

Future Gasses


Overhead Service CarrierRensselaer Polytechnic InstituteBiotechnology and Interdiciplinary Studies BuildingNumber Size Cost (schedule of value) L&M2 10'-0" 20 Lin ft54 14'-0" 756 Lin ft2 18'-0" 36 Lin ft

Total 812 Lin ft $519,600.00Cost per lineal Foot $639.90


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Operable Benches

Operable Benches

Adjustable table

Adjustable Height Table

Operable Benches

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Research Equipment Programming

Research Equipment Programming

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