pain recognition and treatment in farm animals · nmda antagonists α 2 agonists antispasmodics...
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Pain Recognition and Treatment in Farm Animals
R. Eddie Clutton Department of Veterinary Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom
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Pain & Treatment in Food Animals
definitions
R R R
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IASP (1986) An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
IASP (2011) The inability to communicate verbally does not negate the possibility that an individual is experiencing pain and is in need of appropriate pain-relieving treatment
• “stress” hyperalgesia
• biological purpose
• unreliable (!)
Pain & Treatment in Food Animals
what is pain ?
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• “sensitization”
• biological purpose ?
• explains • allodynia
• post-traumatic (surgical) pain
• neuropathic states, e.g., PLS
• informs logical treatment
Pain & Treatment in Food Animals
what is pain ?
peripheral sensitisation
central sensitisation
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Pain & Treatment in Food Animals
production w transport w slaughter
laboratory
castration disbudding
dystocia trauma
mastitis arthritis • pain recognition
• pain quantification • prophylaxis • treatment • legislation
well described
not
basis ?
* experimental surgery, eg…
welfare
publishable data
Field vs Laboratory trauma
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• ethical
• justice
• legal
• practical
• production
• medical
Why bother ?
Pain & Treatment in Food Animals
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hypothalamic – pituitary – adrenal
(cortical)
• cardiovascular hyperdynanism • oliguria • reduced appetite • -ve E and N2 balance • immunosuppresion • catabolism & cachexia • inadequate sleep • adverse memory • behavioural changes • retarded convalescence
Pain & Treatment in Food Animals
• ethical
• justice
• legal
• practical
• production
• medical
• scientific
• effective pain treatment mandatory
• requires recognition
Why bother ?
sympathoadrenal
renin – angiotensin – aldosterone
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Robertson et al. Flecknall et al.
Pain & Treatment in Food Animals
post-operative pain recognition: species effects
“fight-or-flight” (ergotropic) responses “conservation – withdrawal” (trophotropic) responses
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Pain & Treatment in Food Animals
post-operative pain recognition: species effects
• complicates pain assessment
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Pain & Treatment in Food Animals
post-operative pain recognition: food animals
• changes in normal, appearance, spontaneous & provoked behaviour
Canadian Council on Animal Care 1993 Flecknell & Waterman-Pearson 2000 Australian Government; National Health and Medical Research Council 2008
National Academy of Sciences; Institute for Laboratory Animal Research 2009
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spontaneous behaviour & appearance (sheep) ears: hanging close to head directed backwards eyes: bright, open, normal pupil size sunken, partially closed, mydriasis expression: normal grimacing, flemen mentation: BAR, food searching depressed, lethargic, stare,
wound inspection position: standing (head down for food)
sternal (head up, ruminating) sternal (head down, 0 activity) lateral recumbency (worst)
social behaviour: flock engagement self-imposed (corner) separation food arguments
appetite: eating, ruminating or searching uninterested vocalisation: normal (food-seeking) bleats bruxism, depressed bleats, groaning
Pain & Treatment in Food Animals
post-operative pain recognition
• promotes “pigeon-holing” • easily applied • inaccurate • insensitive
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changes in spontaneous behaviour & appearance (sheep) ears: hanging close to head directed backwards eyes: bright, open, normal pupil size sunken, partially closed, mydriasis expression: normal grimacing, flemen mentation: BAR, food searching depressed, lethargic, stare,
wound inspection position: standing (head down for food)
sternal (head up, ruminating) sternal (head down, 0 activity) lateral recumbency (worst)
social behaviour: flock engagement self-imposed (corner) separation food arguments
appetite: eating, ruminating or searching uninterested vocalisation: normal (food-seeking) bleats bruxism, “depressed” bleats, groaning
Pain & Treatment in Food Animals
post-operative pain recognition
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changes in provoked behaviour (sheep) “….start bleating, walk or run to the door and are looking at the person who is approaching the pen; even more active if the person has a feeding bucket or hay in his hand “ “….smell the hand, try to chew the fingers, looking for food in the hand”
“…….escape away from the door (not familiar with the person) “ “……..do not respond (remain recumbent)”
Pain & Treatment in Food Animals
post-operative pain recognition: sheep
Pain Recognition and Management in Small Ruminants Involved in Musculoskeletal Research AVA questionnaire study 2005
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Pain & Treatment in Food Animals
post-operative pain recognition
changes in provoked behaviour (sheep) • interaction assessment
• more sensitive
• more informative
• time consuming (2 – 4 weeks) interaction
• do-able in pigs
• beware
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Pain & Treatment in Food Animals
post-operative pain recognition
some breeds do not allow familiarization
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Pain & Treatment in Food Animals
post-operative pain recognition
Variation in the analgesic effects of xylazine in different breeds of sheep. Ley, S.; Waterman, A.; Livingston, A. Veterinary Record 1990 Vol. 126 No. 20 pp. 508 Welsh mountain > Swaledales > Cluns
some breeds do not show pain
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Pain & Treatment in Food Animals
post-operative pain recognition
pain behaviours change with age
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Pain & Treatment in Food Animals
post-operative pain recognition: food animals
• difficulty α-1 degree of familiarisation
• age-dependent
• breed – dependent
• “production pain” of little value
• does it matter?
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TREAT post-operative pain J
surgeon control body position opioids NSAIDs local anaesthetics NMDA antagonists α2 agonists antispasmodics general anaesthetics new knowledge
SAIDs benzodiazepines anticonvulsants antidepressants
post-operative pain treatment: principles
Pain & Treatment in Food Animals
PREVENT post-operative pain J
familiarisation (2 - 4 weeks) feeding watering bedding grooming attention exercise Dr Green physiotherapy dressings & wound inspection monitoring pain behaviours reporting
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cm phospholipids â
phospholipase A2 â
arachidonic acid â â
LOX COX2 â â
LTB4 PGE2 TXA2 PGI2 TXB2
“sensitizing soup”
Pain & Treatment in Food Animals
1) Pre-emptive analgesia: peripheral
Giving analgesics before needed
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cm phospholipids â
phospholipase A2 â
arachidonic acid â â
LOX COX2 â â
LTB4 PGE2 TXA2 PGI2 TXB2
“sensitizing soup”
Pain & Treatment in Food Animals
NSAIDs
local anaesthetics
SAIDs
1) Pre-emptive analgesia: peripheral
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Pain & Treatment in Food Animals
axonal sprouting
δ gene expression
adrenoreceptor induction
NMDA activation
seconds minutes
hours days
“wind-up”
1) Pre-emptive analgesia: central
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Pain & Treatment in Food Animals
axonal sprouting
δ gene expression
adrenoreceptor induction
NMDA activation
seconds minutes
hours days
“wind-up”
1) Pre-emptive analgesia: central
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Pain & Treatment in Food Animals
axonal sprouting
δ gene expression
adrenoreceptor induction
NMDA activation
seconds minutes
hours days
“wind-up”
local anaesthetics
α2 agonists
some NSAIDs
opioids
local anaesthetics
NMDA antagonists
e.g. ketamine
1) Pre-emptive analgesia: central
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Pain & Treatment in Food Animals
2) Partial intravenous anaesthesia
general anaesthetics
no effect
no effect
opioids ketamine α2 agonists
• 2
• reduce vaporizer setting
• analgesic infusion
PAIN
block
block
◄► general anaesthetics
opioids ketamine α2 agonists
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Pain & Treatment in Food Animals
• pre-surgery
• pre-emptive analgesics
• 5 – 30 days NSAIDs
local anaesthetic
3) Prolonged postoperative analgesia
general anaesthesia
NSAIDs
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But…….
Pain & Treatment in Food Animals
• effective analgesia theoretically devisable
• analgesics cause behavioural changes
• e.g., δ appetite
• analgesics cause physiological effects
• e.g., ileus
• δ (or un-δ ) postoperative behaviours
• drugs w pain w both
• drugs may affect studied variables……..
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Na+ Na+ Na+
c
Aα
B
Pain & Treatment in Food Animals
4) Local anaesthetics
• profound prolonged analgesia
• (at low cost)
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Conclusion
Pain & Treatment in Food Animals
• analgesics
• pain behaviours
• pain scoring system
• encourage (?) familiarisation
• motivate staff
• adequate staff • adequate time
• veterinary (anaesthetist) on moderate – severe band procedures
• moratorium on food animal use for experimental surgery
limited information
non-existent
research
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Conclusion
Pain & Treatment in Food Animals
• traditional, not demonstrable “good models”
• medically – driven (inherent specism)
• inexpensive - widely available
• ostentatious pain behaviours
• < noble
• < cuddleble
• < politically contentious
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Conclusion
Pain & Treatment in Food Animals
“The question is not, can they reason ? Nor can they talk ?
But can they suffer ?”
………possibly more