pain modulation prof. ashraf husain modulation pain modulation means pain perception variability...
TRANSCRIPT
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PAIN MODULATION
Prof. Ashraf Husain
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MODULATION
• Pain modulation means pain perception variability which is influenced by endogenous and exogenous mechanism
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Referral of pain from the internal organs
• Meninges Back of head and neck• Heart Central chest arms
(usually left), neck, occasionally abdomen.
• Trachea Behind sternum• Diaphragm Shoulder tip• Oesophagus Behind sternum
Cont…
Organ Site of reffered pain
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• Stomach, duodenum Upper abdomen, epigastrium
• Small bowel, pancreas Around umbilicus• Large bowel, bladder Lower abdomen
above pubic bone
Organ Site of reffered pain
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VISCERAL PAIN
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VISCERAL PAIN PATHWAY
Pain - Aδ and fibersTravel with autonomic afferent
Spinal cord(Dorsal Horn)
Lat. spinothalamic tract
Thalamus
Somatosensory Cortex
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• Poorly localized• Associated with nausea and autonomic disturbance• Often referred to another part of the body• Cutting, crushing are not painful when applied to viscera• Pain is caused by distension, ischemia and inflammation
CHARACTERSITICS OF VISCERAL PAIN
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MODULATION
• Pain modulation means pain perception variability which is influenced by endogenous and exogenous mechanism
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• Pain modulation can be discussed under following headings– Spinal modulation of pain input
• Gate theory of pain
– Supra spinal modulation• Role of periaqueductal grey (PAG) matter• Role of Nucleus Raphe Magnus (NRM)
– Pain modulation by use of Opioid neurotransmitters eg: endorphin, enkaphalin Dynorphin.
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A MODAL OF “GATING” OF PAIN
SPINAL MODULATION
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13DORSAL HORN GATING MECHANISM
SPINAL MODULATION
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ASCENDING AND DESCENDING PAIN PATHWAYS
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Descending AnalgesicPathway
SUPRASPINAL MODULATION
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SU
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Neurotransmitters in AnalgesicPathway
OPIOID RECEPTOR MODULATION
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MECHANISM OF OPIOID NEUROTRANSMITTER ACTION:•ENDORPHIN:
•Neurons using endorphin or enkaphalin are found in PAG where they inhibit GABAnergic interneurons that normally suppress the anti-nociceptor neurons
•ENKAPHALIN:•It is used by interneurons in lamina II responsible for inhibiting the lamina – I nocioceptor-specific spinothalamic neurons
•ENDOGENOUS MORPHIN:•It has been identified in terminals forming synapses with neuron having μ-opioid receptors in pain modulating pathways.
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Chronic Pain
• Chronic pain can be considered as bad
pain because it persist long after injury
and is often refractory to pain killers.
• Chronic pain caused by nerve injury is
called neuropathic pain.
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Neuropathic pain
• Caused by the damage to peripheral nerve ( adrenalin release by sympathetic discharge)
• The distal cut end develops a scar tissue forming rounded ball ( neuroma) which is sensitive to pressure.
• Repeated activation causes continuous pain.• Examples are like, post herpetic neuralgia
and diabetic neuropathy.
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Phantom pain
• Pain felt in an amputated part long after amputation was done.
• Many explanations are given to explain this phenomenon.
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Stress induced analgesia
• It’s a well known phenomenon seen when the soldier is wounded in battle field but feels no pain until the battle is over. The cause is not known may be it is similar to Gate control hypothesis.
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• Hyperalgesia: Excessive Pain• Allodynia: Pain caused by any other sensation
e.g. touch will cause pain.• Muscular Pain: Less blood flow in the muscles
(ischemia).• Stress analgesia: Mild degree of pain is not felt if
the other part of the body has excessive pain.• Causalgia: Burning pain.
TERMS FREQUENTLY USED
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Thalamic Syndrome.Obstruction of the thalmogeniculate branch of the posterior cerebral artery Affects posterior thalamic nuclei.. Prolonged severe pain.
TERMS FREQUENTLY USED
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TRIGEMINAL NEURALGIA•It is excruciating intermittent pain by stimulation of trigger area in the face as for eg. Washing of face, combing hair, blast of air on face.•It results from compression of trigeminal nerve root by blood vessels
TERMS FREQUENTLY USED
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SITES & MECHANISM OF PAIN RELIEF
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Trans Coetaneous Electrical Nerve Stimulation
(TENS)
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