pages 349-353. when blood is given intraveneously usually donated blood transfusions are given...
TRANSCRIPT
Pages 349-353
When blood is given intraveneously Usually donated blood
Transfusions are given for: Blood loss due to injury Surgery To supplement your own blood
Transfusions must be given to compatible recipients Those individuals with the same antigens
Blood cells have their own antigens Genetically determined proteins Allows us to determine “self”
Antibodies bind to the (foreign) antigens on the donor RBC Antibodies are proteins specialized to recognize
foreign substances and provide immunity against them
Incompatible transfusions cause agglutination – clumping of the foreign RBCs
RBCs burst open (hemolysis) releases hemoglobin into bloodstream
Hemoglobin can block kidney tubules Can cause kidney failure and death
The ABO Blood groups: Type A (Both A antigens) Type B (Both B antigens) Type AB (Both A and B antigens) Type O (neither antigen is present; recessive)
Rh (rhesus) factor ( + or - ): Positive or negative for presence on the surface of
the RBC Pregnant women risk destruction of baby’s RBCs
Differences in Rh factor between baby and mother Most of the time, the first baby is fine Antibodies are built up after first baby
Second pregnancy, RBCs of baby can be destroyed
This causes Hemolytic disease of the newborn
Jaundice Anemia Enlarged liver/spleen
RBC mfr is here until fetus is around 7 months
Incompatible mothers are given an immune serum called RhoGAM to prevent immune response