p4 transport trans membran

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     Transport Trans Membran Andhi Fahrurroji, M. Sc., Apt

    Program Studi Farmasi Fakultas kedokteran

    Universitas Tanjungpura

    2!"

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     Transport obat  Peristi#a perpindahhan dari satu tempat

    ketempat lain $ang disertai

    penembusan sel membran  Semakin kecil ukuran partikel obat maka

    semakain besar proses transport obat

     Semakin larut lipid suatu bhan maka

    peristi#a trans%er pada barier hidro%obik semakin besar

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    &omposisis Membran sel Membran sel  memisahkan

    kompartemen ekstraseluler dan

    intraseluler  protein globular lapisan hidro'lik

     Trigliserida  lapisan lipo'lik

     &olesterol dan lesitin  barier bimolekuler

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    PERJALANAN OBAT MELINTASI MEMBRAN SEL

     Passive Difusion – Fick’s Law o Difusion

     Facii!a!e" Difusion

     #a$$ie$%&e"ia!e" 'In!es!ina( !$ans)o$! – Ac!ive T$ans)o$!

    *esicua$ T$ans)o$!

     Po$e '#onvec!ive( T$ans)o$!

     Ion Pai$ Fo$&a!ion

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    PASI*E DIFF+SION  Passive !$ans)o$! &eans &ovin, 

    -ioc.e&icas an" a!o&ic o$

    &oecua$ su-s!ances ac$oss !.e ce &e&-$ane/

    +nike ac!ive !$ans)o$!0 !.is )$ocess "oes no! invove c.e&ica 

    ene$,1/  T.e ou$ &ain kin"s o )assive

    !$ans)o$! a$e "ifusion0 acii!a!e" "ifusion0 2!$a!ion an"

    os&osis/

    http://en.wikipedia.org/wiki/Motion_(physics) http://en.wikipedia.org/wiki/Biochemistry http://en.wikipedia.org/wiki/Cell_membrane http://en.wikipedia.org/wiki/Active_transport http://en.wikipedia.org/wiki/Chemistry http://en.wikipedia.org/wiki/Energy http://en.wikipedia.org/wiki/Diffusion http://en.wikipedia.org/wiki/Facilitated_diffusion http://en.wikipedia.org/wiki/Filtration http://en.wikipedia.org/wiki/Osmosis http://en.wikipedia.org/wiki/Osmosis http://en.wikipedia.org/wiki/Filtration http://en.wikipedia.org/wiki/Facilitated_diffusion http://en.wikipedia.org/wiki/Diffusion http://en.wikipedia.org/wiki/Energy http://en.wikipedia.org/wiki/Chemistry http://en.wikipedia.org/wiki/Active_transport http://en.wikipedia.org/wiki/Cell_membrane http://en.wikipedia.org/wiki/Biochemistry http://en.wikipedia.org/wiki/Motion_(physics)

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    &A(A&T)(*ST*& T(A+SP(T -*FUS* PAS*F

    AT )(/)(A0 searah gradien kadar obat

     Proses akan berhenti jika konsentrasi obat

    pada kedua kompartemen sama  &ecepatan di%usi tergantung pada p0

    medium

     Prosesn$a tergantung pada koe'sien partisi

     Tergantung pada p&a  &etebalan membran

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    Difusion

     

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    PASI*E DIFF+SION

    3uku& Fick’s 4 "M 5 "! 6 'D7S 5 .( '#s – #(

      "M 5 "! 6 J 6 Fu8

    D7 5 . 6 Pe$&ea-ii!1 'coe9cien!( 'P(

      #s – # 6 :# 6 #oncen!$a!ion

    ,$a"ien!

      S 6 Su$ace a$ea

      . 6 &e&-$ane !.ickness 7 6 Pa$!i!ion coe9cien!

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    S!okes%Eins!ein e;ua!ion<

     

    D 6 'k T( 5 '> ? @ a(

     

    D 6 Difusion coe9cien!

      k 6 Bo!&ann’s cons!an!

      T 6 Te&)e$a!u$e 'o7(

      @ 6 'kine&a!ic( viscosi!1

      a 6 &oecua$ sie

    Ba,ai&ana ki!a "a)a! &en,.i!un, P ')e$&ea-ii!1(0 D '"ifusion coe9cien!(0 "an 7 ')a$!i!ion coe9cien!( &oeku o-a! &ein!asi &e&-$an -ioo,is

     

    Maka ki!a .a$us &eakukan eks)e$i&en "en,an &en,,unakan &e&-$an in!es!ina5 sen!e!is &e&-$an "an ke&u"ian "ianaisis "a!a 1an, "i)e$oe./

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    Facilitated Difusion

    Diusi !e$asii!asi a"aa. )e$)in"a.an &oeku &ein!asi &e&-$an se via

    )$o!en !$ans)o$! !e$!en!u 1an, &ene&)e "ian!a$a se &e&-$an/ Ban1ak&oeku se)e$!i ,ukosa0 !i"ak a$u! "aa& e&ak "an !e$au -esa$ un!uk &ein!asi cea. an!a$a &e&-$an/ Sen1awa !e$se-u! akan -e$ika!an "en,an )e&-awa )$o!ein s)esi2k0 "an ko&)eks !e$se-u! akan -e$ika!an )a"a $ese)!o$ se.in,,a "a)a! -e$,e$ak &eaui &e&-$an se/"iusi !e$asii!as &e$u)akan )$oses )asi "an akan -e$,e$ak -e$"asa$kan ,$a"ien konsen!$asi/

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    Fi!$a!ion

     Fi!$asi &e$u)akan )e$,e$akan ai$ "an &oeku !e$a$u! &ein!asi &e&-$an se aki-a! "a$i tekanan hidrostatik oleh sistem kardiovaskular / Pe$is!iwa ini !e$,an!un, )a"a uku$an cea. &e&-$an0 .an1a sen1awa !e$a$u! "an uku$an !e$!en!u 1an, "a)a! &eewa!in1a/

     E/, cea. &e&-$an Bow&anCs ca)sue )a"a ,ina san,a! keci "an .an1a a-u&in '&e$u)akan saa. sa!u )$o!ein !e$keci( 1an, "a)a! &ein!asi 2!!e$ !e$se-u!/ #on!o. ain0 cea. &e&-$an se ive$ 1an, san,a! -esa$ se.in,,a -an1ak sen1awa 1an, "a)a! &eewa!i "an &en,aa&i &e!a-ois&e/

    http://en.wikipedia.org/wiki/Bowman's_capsule http://en.wikipedia.org/wiki/Bowman's_capsule http://en.wikipedia.org/wiki/Liver http://en.wikipedia.org/wiki/Liver http://en.wikipedia.org/wiki/Bowman's_capsule http://en.wikipedia.org/wiki/Bowman's_capsule

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    Os&osis

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      eek os&osis )a"a se "a$a. )a"a -e$-a,ai kon"isi a$u!an/

    Os&osis &e$u)akan )e$is!iwa "ifusion  &oeku ai$&ein!asi &e&-$an seek!i )e$&ea-e/ Pe$,e$akan &oeku ai$ &eaui se-a,ian &e&-$an )e$&ea-e "a$i a$u!an "en,an )o!ensi ai$ -esa$ &enuu )o!ensi ai$ keci/

     Se "en,an )o!ensi ai$ keci akan &en1e$a) ai$

    !e!a)i !e$,an!un, ke)a"a ak!o$ ain/ E/ , )o!ensi a! !e$a$u! '!ekanan "aa& se e/,/ sou!e &oecues( "an )o!ensi !ekanan '!ekanan ua$ e/,/ ce wa(

    http://en.wikipedia.org/wiki/Diffusion http://en.wikipedia.org/wiki/Diffusion

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    Ac!ive !$ans)o$!

     Ac!ive !$ans)o$! &e$u)akan )$oses 1an, "i)e$an!a$ai oe. ene$,i ki&ia

    a"enosine !$i).os).a!e 'ATP(0 ATP u,a &e$u)akan !$ans)$o! ak!i u!a&a"aa& !u-u./  !ransport akti% kedua $ang terlibat adalah adan$a gradien elektrokimia/

     T$ans)o$! ak!i &e&-u!u.kan ene$,i "an !i"ak sa&a se)e$!i !$as)o$! )asi/

     Proses transort akti% akan mengalami kejenuhan apabila jumlah molekul obat lebih ban$ak daripada jumlah pemba#a

    http://en.wikipedia.org/wiki/Adenosine_triphosphate http://en.wikipedia.org/wiki/Adenosine_triphosphate http://en.wikipedia.org/wiki/Secondary_active_transport http://en.wikipedia.org/wiki/Secondary_active_transport http://en.wikipedia.org/wiki/Adenosine_triphosphate http://en.wikipedia.org/wiki/Adenosine_triphosphate

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    *esicua$ T$ans)o$!

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     En"osi!osis &e$u)akan se a-so$)si &oeku 'E/, )$o!ein( "a$i sisi ua$ se

    "en,an ca$a H&enean &oeku !e$se-u!ke "aa& &e&-$an se/ Pe$is!iwa ini "i,unakan oe. seu$u. se !u-u. ka$ena -an1ak -a.an 1an, )en!in, -e$-en!uk )a$!ike )oa$ a!au -esa$ se.in,,a !i"ak "a)a! &eaui &e&-$an .1"$o).o-ic  )as&a a!au &e&-$an se/

    P$oses se-aikn1a "a$i en"osi!osis a"aa. eksosi!osis

    http://en.wikipedia.org/wiki/Hydrophobic http://en.wikipedia.org/wiki/Plasma_membrane http://en.wikipedia.org/wiki/Plasma_membrane http://en.wikipedia.org/wiki/Hydrophobic

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    Po$e '#onvec!ive( T$ans)o$!

     Sc.e&a!ic "ia,$a& o an ion c.anne/

     % c.anne "o&ains '!1)ica1 ou$ )e$ c.anne(0  % ou!e$ ves!i-ue0

    K % seec!ivi!1 2!e$0

     % "ia&e!e$ o seec!ivi!1 2!e$0

     % ).os).o$1a!ion si!e0

    > % ce &e&-$ane/

    http://en.wikipedia.org/wiki/Protein_domain http://en.wikipedia.org/wiki/Potassium_channel http://en.wikipedia.org/wiki/Phosphorylation http://en.wikipedia.org/wiki/Cell_membrane http://en.wikipedia.org/wiki/Cell_membrane http://en.wikipedia.org/wiki/Phosphorylation http://en.wikipedia.org/wiki/Potassium_channel http://en.wikipedia.org/wiki/Protein_domain

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