AWaktu (hr)Cp (mg/ml)ln cpln cpt=ln cpo-k.t1724.27672.2796t 1/2 (jam)ln cpt+k.t=ln cpo2513.93180.3040Kcl=k*vd3333.49655.1240vd (L)AUC=Cpo/K4202.99574.5807Ln cpo0.693*Vd/Cl=t1/2 elim6142.639197.5794cpo (mg/ml)Vd=Div/Cpo892.19721.5577Cl 1041.38632.2796t1/2 el320.9848AUC

Bt(jam)Cp(mcg/mL)Ln Cp111.432.436227.131.964334.381.477042.640.970861.060.0583100.16-1.8326120.06-2.8134Obat Y dosis 500mg (IV bolus)k0.4750t1/21.4589Ln Cpo2.9112Cpo (mcg/ml)18.3796Vd27.2041Cl12.9219t1/2elim1.4589AUC38.6939

Ct(jam)Cp(mcg/mL)Ln Cp14.821.572824.261.449333.421.229642.680.985861.840.6098100.81-0.2107120.53-0.6349Obat Z dosis 300mg (IV bolus)k0.2030t1/23.4138Ln Cpo1.7758Cpo (mcg/ml)5.9048Vd50.8057Cl10.3136t1/2elim3.4138AUC29.0879

Dwaktu (hari)Cp (mg/L)Ln CpLn C'C'C ResLn C res000.00000.61701.85341.85340.6170Ke0.28600.250.901-0.10430.54551.72550.8245-0.1930Ka3.65900.51.3090.26930.47401.60640.2974-1.2127t1/2 el2.42310.751.5260.42260.40251.4956-0.0304AUC7.289411.5770.45550.33101.3924-0.1846Vd43.17041.51.4290.35700.18801.2068-0.2222Cl12.346730.964-0.0367-0.24100.7858-0.178260.384-0.9571-1.09900.3332-0.0508120.062-2.7806-2.81500.0599-0.0021180.01-4.6052-4.53100.01080.0008240.002-6.2146-6.24700.0019-0.0001\

EDosis Obat 20mg peroralWaktu (hour)Cp (mg/L)Ln CpLn C'C'C resLn C resKe0.1690000-0.62200.53690.5369-0.622Ka3.09200.250.264-1.3318-0.66430.51470.2507-1.3836603231t1/2 el4.10060.50.379-0.9702-0.70650.49340.1144-2.1683342481AUC2.95530.750.406-0.9014-0.74880.47300.0670-2.7036989796Vd36.040610.414-0.8819-0.79100.45340.0394Cl6.09091.50.395-0.9289-0.87550.41670.021730.309-1.1744-1.12900.32340.014460.189-1.6660-1.63600.19480.0058120.069-2.6736-2.65000.07070.0017180.026-3.6497-3.66400.0256-0.0004240.009-4.7105-4.67800.00930.0003

fObat V dosis 100 mg (PO)Time (hr)Cp (mg/L)ln Cpln C ekstrapolasiC ekstrapolasiC Resln C Res0002.73115.348227575915.34822757592.7310.257.5142.01676794722.656514.24633954956.73233954951.90692271320.510.2962.33175547032.58213.22355884792.92755884791.0741689180.7511.0392.4014344572.507512.27420615621.23520615620.2112378843111.0982.40676491192.43311.39300989240.2950098924-1.22074638981.59.9572.29827582142.2849.815865449-0.141134551ERROR:#NUM!36.4471.86361490631.8376.2776769524-0.1693230476ERROR:#NUM!62.6330.96812388050.9432.567672894-0.065327106ERROR:#NUM!120.43-0.8439700703-0.8450.4295573582-0.0004426418ERROR:#NUM!180.071-2.6450754019-2.6330.07186255090.0008625509-7.0556164183240.012-4.4228486292-4.4210.01202220410.0000222041-10.7152350629ke0.298ka3.356t1/2 eliminasi2.3255AUC50.7273Vd5.9537Cl 1.7742

GObat W dosis 30 mg (per oral)Time (hr)Cp (mg/L)ln Cpln C ekstrapolasiC ekstrapolasiC Resln C Res000-0.1280.87990.8799-0.12800.250.453-0.7918631535-0.159750.85240.3994-0.91790.50.651-0.4292456368-0.19150.82570.1747-1.74460.750.705-0.3495574762-0.223250.79990.0949-2.354810.759-0.2757535016-0.2550.77490.0159-4.14041.50.725-0.3215836241-0.31850.72720.0022-6.101730.616-0.4845083154-0.5090.6011-0.0149ERROR:#NUM!60.411-0.8891620645-0.890.4107-0.0003ERROR:#NUM!120.19-1.6607312068-1.6520.19170.0017-6.3972180.088-2.4304184645-2.4140.08950.0015-6.5315240.041-3.1941832123-3.1760.04180.0008-7.1923ke0.127ka3.002t1/2 eliminasi5.4567AUC6.4884Vd32.7661Cl4.1613

Hobat A dosis 100 mg (p.o)misal BA=90%time (hr)Cp (mg/L)Ln CpLn C expolC expolC resLn C res0001.2593.5223.5221.2590.251.0980.09351.24153.4612.3630.8600.51.7860.58001.2243.4011.6150.4790.752.240.80651.20653.3421.1020.09712.5290.92781.1893.2840.755-0.2811.52.8631.05191.1543.1710.308-1.17832.9551.08351.0492.855-0.10062.3790.86670.8392.314-0.065121.5280.42400.4191.520-0.008180.991-0.0090-0.0010.9990.008240.66-0.4155-0.4210.656-0.004K (/jam)0.07Ka (/jam)1.5374t 1/2 el (jam)9.9AUC (mg.jam/L)39.540625Vd (L)32.516Vd=F*Dev/(K*AUC)Cl (L/jam)2.276Cl=F*Dev/AUC

Iobat B dosis 25 mg (p.o)time (hr)Cp (mg/L)Ln CpLn C expolC expolC resln C res0000.2741.3151.3150.2740.250.76-0.2740.2381.2680.508-0.6770.51.0250.0250.2021.2230.198-1.6180.751.1230.1160.1661.1800.05711.1180.1120.1291.1380.0201.51.0660.0640.0571.059-0.00730.847-0.166-0.1590.8530.00660.552-0.594-0.5930.5530.001120.232-1.461-1.4590.2320.000180.098-2.323-2.3250.098-0.000240.041-3.194-3.1920.0410.000K (/jam)0.1444Ka (/jam)3.7830t 1/2 el (jam)4.799AUC (mg.jam/L)8.705Vd (L)17.900Cl (L/jam)2.585

Jobat C dosis 200mg (PO)time (hr)Cp (mg/L)Ln Cpln C expolC expolC resLn C res0003.50233.18533.1853.5020.2511.8582.4733.43831.11319.2552.9580.517.632.8703.37329.17011.5402.4460.7520.8143.0363.30927.3496.5351.877121.2983.0593.24425.6414.3431.521.0713.0483.11522.5391.468314.8722.6992.72815.3080.43666.881.9291.9557.0620.182121.5010.4060.4071.5030.002180.321-1.136-1.1400.320-0.001240.068-2.688-2.6880.0680.000K (jam)0.2579Ka (/jam)2.1547t 1/2 el (jam)2.687AUC117.191Vd5.956Cl1.536

Kobat D dosis 10 mg (PO)time (hr)Cp (mg/L)ln CpLn C expolC expolC resln C res000-1.1840.3060.306-1.1840.250.079-2.538-1.2630.2830.204-1.5900.50.122-2.104-1.3420.2610.139-1.9710.750.144-1.938-1.4220.2410.097-2.32910.157-1.852-1.5010.2230.0661.50.153-1.877-1.6590.1900.03730.109-2.216-2.1350.1180.00960.045-3.101-3.0870.0460.001120.007-4.962-4.9900.007-0.000180.001-6.908-6.8930.0010.0002400K (/jam)0.3172Ka (/jam)1.5273t 1/2 el (jam)2.185AUC0.794Vd35.740Cl11.337