oxitec overview march 2008 v3 (pdf) [modo de compatibilidade]
TRANSCRIPT
HEALTHY PEOPLE HEALTHY ENVIRONMENT
September 2006 Oxitec confidential
71 Milton Park, Abingdon, Oxford, OX14 4RX, UKTelephone +44 1235 832393 www.oxitec.com in Latin America: [email protected] +55 21 9961 1960
Market Opportunity: Dengue Fever
� Global pandemic� More than 100 million cases
annually (WHO, CDC)� Asia and Latin America � Globalisation and global
warming drive spread
� Severity increasing� Increase in Dengue
Haemorraghic fever, a lethal complication
� No specific medication or vaccine
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Dengue Fever
� Transmitted by Aedes aegypti mosquitoes
� Urban dwellers
� Also spreads yellow fever and chikungunya
The Dengue mosquito Aedes aegypti
� Over $1.0 billion worldwide spent on controls – largely ineffective� Insecticides� Breeding site sanitation
� New tools required
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Thermal insecticide fogging
Breeding site sanitation
Oxitec
� Environment-friendly technology to control insect pests:
� Public health – disease vectors
� Agriculture
� Global leaders in a new field Asian tiger mosquito� Global leaders in a new field
� Molecular biology and insect genetics
� Intellectual property
� Regulatory affairs
� Relationship management
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Asian tiger mosquito
Injecting DNA into mosquitoeggs
Oxitec
� Founded in 2002
� Building on innovative research by Dr. Luke Alphey at the University of Oxford
of Oxford
� 30 employees
� HQ in Oxford, UK
� Privately held with UK and US financing
Oxitec’s RIDL® Technology Solution
� Genetic enhancement of Sterile Insect Technique (SIT)
� SIT
� Rear millions of insects
� Sterilise with irradiation
New world screwworm eradicated from USA and Central America with SIT
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� Sterilise with irradiation
� Release over wide area
� Sterile males mate with wild females: progeny don’t survive
� Pest population declines
� Clean technology : Species-specific
� Used for over 50 years� But constrained by existing technology
Mediterranean Fruit Fly (USDA photo)
RIDL® Benefits
� RIDL insects are sterile in the absence of a diet supplement
� Available in lab and rearing facility
� Not available in nature
� Sterilization – no more irradiation
� Fitter, more competitive sterile insects improve cost-effectiveness
� Applicable to insects where irradiation is too damaging
� Fail-safe bio-containment
� Enhanced biosafety; reared insects are sterile outside the facility
� Sexing - release only males
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Irradiators at a mass-rearing facility
Mating Mediterranean Fruit Flies
Benefits: Improved monitoring
� Population monitoring essential for insect control
� Oxitec strains contain heritable, fluorescent markers� Improvement over fluorescent � Improvement over fluorescent
dusts and food dyes
� Field monitoring devices in development
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Pink Bollworm Pupae with red and green markers
Mediterranean Fruit Fly showing fluorescence at all life stages
Dengue: A Genetic Solution
� Bill and Melinda Gates Grand Challenges for Global Health award
� US/Mexico focused consortium
� Large scale field cages being constructed in Mexico
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constructed in Mexico
� Oxitec has RIDL strains of Aedes aegypti validated by external labs
� Product development in Malaysia
� Rolling out model worldwide
� Brazil, India, Other
Dengue fever mosquito, Aedes aegypti
Dengue product: Oxitec progress in Malaysia
� Agreement with Ministry of Health, Institute for Medical Research
� Excellent trial results from purpose built quarantine field-house
� Island identified for open field release and baseline data collection
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release and baseline data collection
� Regulators reviewing permit application for open release trial
� Negotiating production and distribution venture with local company
Purpose built quarantine field-house
Trial planning meeting on the island
Agriculture Opportunity: Insect Control
� Increasing global demand for pest-free, pesticide-free fresh produce
� Fruits, nuts and vegetables
� Quarantine and trade restrictions
� $1.0 billion accessible new market Cotton Pink Bollworm� $1.0 billion accessible new market
� $2.5 billion insecticide market in fresh produce crops - 40% accessible
� Replacement Sterile Insect Technique (SIT) market of $0.2 billion� Growth and profitability constrained by
existing technology
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Cotton Pink Bollworm
Codling moth in apple
Agricultural Progress: Pink Bollworm
� Cotton pest in USA
� SIT program since 1970s
� Oxitec ProgressCollaboration with USDA since � Collaboration with USDA since 2002
� Two years open field release
� Pilot in CA planned 2008
� Program conversion planned 2009
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Cage trials Arizona
DsRed marker in dead adult
Mediterranean Fruit Fly
� Pest of global economic importance� Quarantine pest prevents exports
� SIT used worldwide ~20 programs
� Oxitec Progress� RIDL strains tested by IAEA/FAO for
mass-rearing parametersMediterranean fruit fly
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mass-rearing parameters
� RIDL strains in testing with USDA in Guatemala
� Collaboration with USDA� Federal Business Opportunities
announcement of sole source contract
� Drive regulatory framework
Mediterranean fruit fly
USDA El Pino rearing facility Guatemala – rears 2 billion flies per week for US, Mexico, Guatemala
Regulatory and Public Acceptance
� Regulatory Framework
� The USDA is conducting an Environmental Impact Statement (EIS) on the use of autocidal technology in fruit flies and PBW
� North American Plant Protection Organization (NAPPO) standards issued in 2007
� Confined trials in Malaysia, USA, Guatemala, UK and Austria
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� Two years of open field testing in USA
� Public Acceptance
� PR strategy to focus on public health benefits
� Press attention positive so far
� Consultation with Gates and other ethics groups
Summary
� Oxitec has developed RIDL ® technology that can provide environmentally-friendly control of insect pests
� Oxitec’s technology will provide control of the mosquito that spreads dengue fever, an increasing global menace
Oxitec Limited
that spreads dengue fever, an increasing global menace
� Oxitec has established collaborations with the governments of USA and Malaysia
� Oxitec seeks institutional and commercial partners to develop and commercialise its technology worldwide