our students do well! our programs are strong, particularly postgraduate residency and clinical...
TRANSCRIPT
Our students do well!
Our programs are strong, particularly Postgraduate Residency and Clinical Fellowship
We need to improve our Undergraduate Education performance
Surgery
University of Toronto
SummarySummarySummarySummary
Resident PresentationNir Lipsman, R4 Neurosurgery
2nd year PhD student through IMSSupervisor: Dr Andres Lozano
Surgeon Scientist ProgramClinician Investigator Program
CIHR Fellowship
Resident PresentationNir Lipsman, R4 Neurosurgery
2nd year PhD student through IMSSupervisor: Dr Andres Lozano
Surgeon Scientist ProgramClinician Investigator Program
CIHR Fellowship
Surgery
University of Toronto
Probing and modulating neural circuitry underlying reward and emotional processing
•Probing and modulating neural circuitry underlying reward and emotional processing
• Intraoperative single-unit recording (SUR)• Post-operative multi-unit recording (MUR)• Perioperative frequency analysis, interregional coherence and MUR
• Intraoperative single-unit recording (SUR)• Post-operative multi-unit recording (MUR)• Perioperative frequency analysis, interregional coherence and MUR
• Deep Brain Stimulation
Probing and modulating neural circuitry underlying reward and emotional processing
PhD Supervisor Dr. Andres M. Lozano
CollaboratorsUniversity of Toronto: Dr. Jonathan Dostrovsky (Physiology)
Dr. Bill Hutchison (Physiology)Dr. Peter Giacobbe (Psychiatry)Dr. Sidney Kennedy (Psychiatry)Dr. Blake Woodside (Psychiatry)Dr. Jeff Daskalakis (Psychiatry)Dr. Roger McIntyre (Psychiatry)
Dr. Adam Anderson (Psychology)
USC/McGill: Dr. Antoine Bechara (Neurology/Psychology)
University of Hong Kong: Dr. Savio Wong (Psychology)
University of Ottawa: Dr. Georg Northoff (Psychiatry/Psychology)Dr. Takashi Nakao (Psychology)
•Probing and modulating neural circuitry underlying reward and emotional processing
1) Acquire unique data to answer questions not previously subject to empirical testing (e.g. The nature of self and its relationship to reward)
2) Develop novel therapeutic options for patients with no treatment alternatives (e.g. Treatment resistant psychiatric disease)
Single-neuron activity during Self Task in Subgenual Cingulate Gyrus during Depression
DBS
Own Famous Neutral
Mean firing rate for Own is significantly higher in first second of stimulus presentation vs. Famous
vs. Neutral (p<0.05)
Own Famous Neutral
Mean firing rate for Own is significantly higher in first second of stimulus presentation vs. Famous vs.
Neutral (p<0.05)
Single-neuron activity during Self Task in Subgenual Cingulate Gyrus during Depression
DBS
FAMOUSNEUTRA
LOWN
Logarithmic representation of local field potential frequencies
Diminished power in
alpha band
‘Frequency of Self’
•Tasks now under development will look at decision-making under uncertainty, emotion recognition and reward anticipation
•From Neurophysiology to Clinical Research
– Depression– Bipolar Disorder– Obsessive-Compulsive Disorder– Anorexia Nervosa– Schizophrenia– Drug Addiction– Alcoholism
Disorders of self processing and primary
reward dysfunction
Implications
Depression Alzheimer’s Disease
DBS can modulate neural circuits underlying mood and memory
Mayberg et al 2005; Laxton et al 2010
Disorder Target Subjects Status
*Obsessive-Compulsive Disorder
Inferior Thalamic Peduncle 6 Operated on 1;
Now recruiting
*Bipolar Disorder type II
Subgenual cingulate gyrus (SCG) 6 REB Approved;
Now recruiting
**Anorexia nervosa, restricting subtype
SCG and Nucleus Accumbens (NAcc) 12 REB Approved;
Now recruiting
**SchizophreniaNAcc and Ventral Tegmental Area
(VTA)6 REB Approved;
Now recruiting
*Canadian First**Global First
Modulating Neural Circuitry
Surgery
University of Toronto
Saturday July 9th, 2011 149 Mossgrove TrailSaturday July 9th, 2011 149 Mossgrove Trail
Welcome Party for PGY1’s
Welcome Party for PGY1’sSaturday July 9th, 2011 149
Mossgrove TrailSaturday July 9th, 2011 149 Mossgrove Trail
Welcome Party for PGY1’s
Welcome Party for PGY1’s
Surgery
University of Toronto
Coming your way in 2011-12! Coming your way in 2011-12!
Dept WebmasterCommunications
Stephanie Neilson
Coming your way in 2011-12! Coming your way in 2011-12!
Surgery
University of Toronto
Also Coming Your Way!Also Coming Your Way!Strategic Planning Initiative 2011-12Strategic Planning Initiative 2011-12
Also Coming Your Way!Also Coming Your Way!
Surgery
University of Toronto
Also Coming Your Way!Also Coming Your Way!Strategic Planning Initiative 2011-12Strategic Planning Initiative 2011-12
• Co-Chairs Late fall, early winter• Tagline: TBD• Retreat: January 2012• Survey Monkey: Sept 2011• Stra: James Rutka and Bryce Taylor• Facilitator: Helena Axler• Timeline: tegic Foci: Education, Research, Faculty Development, Best Practices, Integration
Also Coming Your Way!Also Coming Your Way!
Surgery
University of Toronto
A New Department of Surgery Brand!A New Department of Surgery Brand!
Keep your eyes open for.....Keep your eyes open for.....
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New Dept Surgery Logo
Keep your eyes open for.....Keep your eyes open for.....
Surgery
University of Toronto
Thank you!Thank you!Thank you!Thank you!