OUR PORTFOLIO COMPANIESOur portfolio companies share a common goal – a fearless approach to addressing medical needs through bold ideas

and transformative science. We discover, launch and build great companies based on bold ideas that meet at the intersection of science, strategy, business and medicine – where transformational science meets

operational reality – providing the best opportunity to dramatically impact the lives of patients.

P U B L I C C O M P A N I E S

AGIOS PHARMACEUTICALS

Agios Pharmaceuticals (NASDAQ: AGIO) is focused on discovering and developing novel investigational medicines to treat cancer and rare genetic metabolic disorders through scientific leadership in the field of cellular metabolism.

Focus: Cancer, Metabolic Disorders, Rare Genetic & Orphan Diseases, Personalized Medicine, Small MoleculesPhase of Development: Clinical Year Invested: 2008Location: Cambridge, Mass.

ALLENA PHARMACEUTICALS

Allena Pharmaceuticals (NASDAQ: ALNA) is dedicated to bringing first in class, specific, non-absorbed, oral protein therapeutics to patients with serious renal, urologic and orphan diseases.

Focus: Metabolic Disorders, Rare Genetic & Orphan Diseases, Renal, Biologics Phase of Development: CommercialYear Invested: 2011Location: Newton, Mass.

BLUEBIRD BIO

bluebird bio (NASDAQ: BLUE) has built an integrated product platform for severe genetic diseases and cancer through its lentiviral-based gene therapies, T cell immunotherapy expertise and genome editing capabilities.

Focus: Cancer, Rare Genetic & Orphan Diseases, Personalized Medicine, Gene Therapy Phase of Development: Clinical Year Invested: 2010Location: Cambridge, Mass.

BLUEPRINT MEDICINES

Blueprint Medicines (NASDAQ: BPMC) is developing a new generation of highly selective and potent kinase medicines to improve the lives of patients with genomically defined diseases.

Focus: Cancer, Personalized Medicine, Small MoleculesPhase of Development: ClinicalYear Invested: 2011Location: Cambridge, Mass.

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EDITAS MEDICINE

Editas Medicine (NASDAQ: EDIT) is a leading genome editing company dedicated to treating patients with genetically defined diseases by correcting their disease-causing genes.

Focus: Rare Genetic & Orphan Diseases, Personalized Medicine, Gene TherapyPhase of Development: Research & PreclinicalYear Invested: 2013Location: Cambridge, Mass.

ELEVEN BIOTHERAPEUTICS

Eleven Biotherapeutics, Inc. (NASDAQ: EBIO) is a late clinical-stage company advancing a pipeline of novel anti-cancer agents based on the company’s targeted protein therapeutics platform.

Focus: Cancer, Biologics, Small Molecules Phase of Development: Clinical Year Invested: 2010 Location: Cambridge, Mass.

FOUNDATION MEDICINE

Foundation Medicine (NASDAQ: FMI) is a molecular information company dedicated to a transformation in cancer care in which treatment is informed by a deep understanding of the genomic changes that contribute to each patient’s unique cancer.

Focus: Cancer, Diagnostic, Personalized Medicine Phase of Development: Commercial Year Invested: 2010Location: Cambridge, Mass.

CYTOMX

CytomX (NASDAQ: CTMX) is an oncology-focused biopharmaceutical company pioneering a novel class of investigational antibody therapeutics based on its Probody technology platform.

Focus: Cancer, BiologicsPhase of Development: Clinical Year Invested: 2010Location: South San Francisco, Calif.

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ABLEXIS

Ablexis created and commercializes the AlivaMab Mouse Technology, a unique next-generation transgenic mouse platform for human therapeutic antibody discovery.

Focus: Technology Platform, Biologics Phase of Development: Research & PreclinicalYear Invested: 2009 Location: San Francisco, Calif.

ALCRESTA THERAPEUTICS

Alcresta Therapeutics is dedicated to developing and commercializing novel enzyme-based products designed to address challenges faced by people living with gastrointestinal disorders and rare diseases.

Focus: Metabolic Disorders, Rare Genetic & Orphan Diseases, Biologics, Device/Therapeutic TechnologyPhase of Development: ClinicalYear Invested: 2011Location: Newton, Mass.

CIBIEM

Cibiem is a medical device company leveraging its proprietary, minimally invasive, catheter-based approach focused on Carotid Body Modulation (CBM) for the treatment of sympathetic nervous system-mediated diseases such as hypertension, heart failure, diabetes and renal failure.

Focus: Cardiovascular Disease, Device/Therapeutic TechnologyPhase of Development: Clinical Year Invested: 2012Location: Los Altos, Calif.

CONSTELLATION PHARMACEUTICALS

Constellation Pharmaceuticals is a leader in epigenetics, leveraging insights from chromatin biology to discover and develop small molecule therapeutics for the treatment of cancer.

Focus: Cancer, Personalized Medicine, Small Molecules Phase of Development: Clinical Year Invested: 2008Location: Cambridge, Mass.

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ZAFGEN

Zafgen (NASDAQ: ZFGN) is dedicated to significantly improving the health and well-being of patients affected by obesity and complex metabolic disorders.

Focus: Metabolic Disorders, Rare Genetic & Orphan Diseases, Small Molecules Phase of Development: Clinical Year Invested: 2007Location: Cambridge, Mass.

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VOYAGER THERAPEUTICS

Voyager Therapeutics (NASDAQ: VYGR) is developing life-changing treatments for severe diseases of the central nervous system.

Focus: Rare Genetic & Orphan Diseases, Neurologic/Psychiatric Diseases, Personalized Medicine, Gene TherapyPhase of Development: ClinicalYear Invested: 2014Location: Cambridge, Mass.

SAGE THERAPEUTICS

Sage Therapeutics (NASDAQ: SAGE) is developing novel medicines to transform the lives of patients with life-altering central nervous system (CNS) disorders.

Focus: Neurologic/Psychiatric Diseases, Rare Genetic & Orphan Diseases, Small MoleculesPhase of Development: Clinical Year Invested: 2011Location: Cambridge, Mass.

MYOKARDIA

MyoKardia (NASDAQ: MYOK) is pioneering a precision medicine approach to discover, develop and commercialize targeted therapies for the treatment of serious and rare cardiovascular diseases, with an initial focus on the treatment of heritable cardiomyopathies.

Focus: Cardiovascular Disease, Rare Genetic & Orphan Diseases, Personalized Medicine, Small MoleculesPhase of Development: ClinicalYear Invested: 2012Location: South San Francisco, Calif.

JOUNCE THERAPEUTICS

Jounce Therapeutics (NASDAQ: JNCE) is discovering and developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients.

Focus: Cancer, BiologicsPhase of Development: ClinicalYear Invested: 2013Location: Cambridge, Mass.

KALA PHARMACEUTICALS

Kala Pharmaceuticals is advancing novel nanoparticle-based treatments for ocular diseases, leveraging its proprietary mucus-penetrating particle (MPP) technology .

Focus: Ophthalmology, Small Molecules Phase of Development: ClinicalYear Invested: 2009Location: Waltham, Mass.

RHYTHM

Rhythm is developing peptide therapeutics for the treatment of rare genetic deficiencies that result in life-threatening metabolic disorders.

Focus: Gastrointestinal, Metabolic Disorders, BiologicsPhase of Development: Clinical Year Invested: 2010 Location: Boston, Mass.

GLOBAL BLOOD THERAPEUTICS

Global Blood Therapeutics (NASDAQ: GBT) is dedicated to discovering, developing and commercializing novel therapeutics to transform the treatment of patients with grievous blood-based disorders, including sickle cell disease.

Focus: Rare Genetic & Orphan Diseases, Personalized Medicine, Small MoleculesPhase of Development: ClinicalYear Invested: 2012Location: South San Francisco, Calif.

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CORVIA MEDICAL

Corvia Medical is revolutionizing the treatement of heart failure with first-in-class structural heart devices.

Focus: Cardiovascular, Device/Therapeutic TechnologyPhase of Development: ClinicalYear Invested: 2009Location: Tewksbury, Mass.

DECIBEL THERAPEUTICS

Decibel Therapeutics is translating scientific advances in inner ear biology into novel therapies for people with hearing disorders.

Focus: OtolaryngologyPhase of Development: Research & PreclinicalYear Invested: 2015Location: Cambridge, Mass.

EDIMER PHARMACEUTICALS

Edimer Pharmaceuticals was engaged in the research and development of treatments for rare dermatological diseases, including X-linked Hypohidrotic Ectodermal Dysplasia (XLHED). The company wound down operations in late 2016.

Focus: Rare Genetic & Orphan Diseases, Personalized Medicine, BiologicsYear Invested: 2009

ELEMENT SCIENCE

Element Science is developing a cost-effective wearable therapeutic device that aims to re-define the treatment for temporary periods of elevated sudden cardiac death risk.

Focus: Cardiovascular Disease, Device/Therapeutic TechnologyPhase of Development: Research & PreclinicalYear Invested: 2013Location: San Francisco, Calif.

FULCRUM THERAPEUTICS

Fulcrum Therapeutics is a biotechnology company developing new medicines to deliver a new future to patients and their families by transforming gene regulation in disease.

Focus: Rare Genetic & Orphan Disease, Personalized Medicine, Small Molecules Phase of Development: Research & Preclinical Year Invested: 2016 Location: Cambridge, Mass.

GOLDFINCH BIO

Goldfinch Bio is a biotechnology company that is singularly focused on discovering and developing precision therapies for patients with kidney disease.

Focus: Renal, Personalized Medicine Phase of Development: Research & Preclinical Year Invested: 2016 Location: Cambridge, Mass.

IGENICA BIOTHERAPEUTICS

Igenica Biotherapeutics is focused on the discovery of innovative antibody-based therapies for the treatment of cancer .

Focus: Cancer, BiologicsPhase of Development: ClinicalYear Invested: 2012Location: Burlingame, Calif.

MAGENTA THERAPEUTICS

Magenta Therapeutics is harnessing the power of stem cell science to revolutionize stem cell transplantation for patients with immune- and blood-based diseases.

Focus: Metabolic Disorders, Personalized Medicine Phase of Development: Research & PreclinicalYear Invested: 2016Location: Cambridge, Mass.

NEON THERAPEUTICS

Neon Therapeutics is focused on developing novel therapeutics leveraging neoantigen biology to treat cancer.

Focus: Cancer, Personalized Medicine, Technology Platforms, Small MoleculesPhase of Development: Research & PreclinicalYear Invested: 2015 Location: Cambridge, Mass.

NINEPOINT MEDICAL

NinePoint Medical is a medical device company that designs, manufactures and sells an Optical Coherence Tomography (OCT) platform for clinical use for the evaluation of human tissue microstructure.

Focus: Cancer, Diagnostic Phase of Development: Commercial Year Invested: 2009 Location: Cambridge, Mass.

NURIX

Nurix, Inc. is a leader in the discovery of small molecules that modulate the ubiquitin proteasome system (UPS) to address significant, unmet medical needs.

Focus: Cancer, Small MoleculesPhase of Development: Research & Preclinical Year Invested: 2013Location: San Francisco, Calif.

PANOPTICA

PanOptica is focused on licensing and developing a portfolio of exciting and innovative therapeutics for major ophthalmic diseases.

Focus: Ophthalmology, Small MoleculesPhase of Development: Clinical Year Invested: 2010Location: Bernardsville, NJ

PLIANT THERAPEUTICS

Pliant Therapeutics is harnessing the therapeutic capabilities of integrin biology and TGF-β signaling to develop breakthrough treatments for fibrotic diseases.

Focus: Rare Genetic & Orphan Diseases, Respiratory, Small Molecules, Technology PlatformPhase of Development: Research & PreclinicalYear Invested: 2016Location: Redwood, Calif.

RELAY THERAPEUTICS

Relay Therapeutics is committed making a transformative difference for patients by building the first dedicated drug discovery pipeline centered on protein motion.

Focus: Protein Motion, Cancer, Small Molecules, Personalized MedicinePhase of Development: Research & PreclinicalYear Invested: 2016Location: Cambridge, Mass.

REVOLUTION MEDICINES

REVOLUTION Medicines is developing new therapies through an innovative approach that harnesses the complex chemicals of life by reconfiguring natural substances into best-in-class medicines.

Focus: Infectious Diseases, BiologicsPhase of Development: Research & Preclinical Year Invested: 2015Location: Redwood, Calif.

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SEVENTH SENSE BIOSYSTEMS

Seventh Sense Biosystems aims to create a new standard for blood collection that increases patient compliance with testing orders, leading to faster diagnoses and better outcomes.

Focus: Diagnostic Phase of Development: CommercialYear Invested: 2008Location: Cambridge, Mass.

TOPICA PHARMACEUTICALS

Topica Pharmaceuticals, Inc. was focused on developing luliconazole for the treatment of onychomycosis, or fungal infections of the nail. The company wound down operations in 2016.

Focus: Infectious Diseases, Small MoleculesYear Invested: 2011

TANGO THERAPEUTICS

Tango Therapeutics is a biotechnology company developing novel medicines for patients by discovering and drugging context-dependent vulnerabilities in cancers.

Focus: Cancer, Personalized MedicinePhase of Development: Research & PreclinicalYear Invested: 2017Location: Cambridge, Mass.

WARP DRIVE BIO

Warp Drive Bio is exploiting the molecules and mechanisms of nature to create transformative medicines .

Focus: Small Molecules Phase of Development: Research & PreclinicalYear Invested: 2011Location: Cambridge, Mass.

THIRD ROCK PARTNERS LOCATIONS

Alexis Borisy Abbie Celniker, Ph.D.Neil ExterKevin GillisCharles Homcy, M.D.Sarah Larson

Mark Levin Craig MuirCary Pfeffer, M.D.Kevin StarrRobert Tepper, M.D.

BOSTON29 Newbury Street3rd FloorBoston, MA 02116P (617) 585-2000 F (617) 859-2891

For more information about Third Rock, visit our website ThirdRockVentures.com or check us out on LinkedIn.

To learn more about career opportunities within the firm and our portfolio companies, please visit ThirdRockVentures.com/Careers-Overview or email us at trvtalent@thirdrockventures.com.

SAN FRANCISCO455 Mission Bay Blvd. SouthSuite 575San Francisco, CA 94158P (415) 766-3600F (415) 766-3699

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M E R G E R S & A C Q U I S I T I O N S

LOTUS TISSUE REPAIR (ACQUIRED BY SHIRE PLC IN 2013)

Lotus Tissue Repair developed first-in-class protein replacement therapy for the rare, genetic disorder DEB.

Focus: Rare Genetic & Orphan Diseases, Personalized Medicine, Biologics Year Invested: 2011

MOTUS (ACQUIRED BY ALLERGAN IN 2016)

Motus is a biopharmaceutical company developing peptide therapeutics for the treatment of gastrointestinal (GI) diseases. Motus spun out of Rhythm Health in 2016.

Focus: Gastrointestinal, Metabolic Disorders Year Invested: 2010

TARIS BIOMEDICAL (ACQUIRED BY ALLERGAN IN 2014)

TARIS Biomedical is developing a pipeline of innovative treatments for bladder diseases.

Focus: Urology, Device/Therapeutic Technology Year Invested: 2011

AFFERENT PHARMACEUTICALS (ACQUIRED BY MERCK IN 2016)

Afferent Pharmaceuticals developed first-in-class, proprietary, small molecule compounds that target P2X3 receptors for the treatment of chronic pain, respiratory and urology conditions.

Focus: Respiratory, Urology, Small MoleculesYear Invested: 2009

ALNARA PHARMACEUTICALS (ACQUIRED BY ELI LILLY AND COMPANY IN 2010)

Alnara designed innovative non-systemic protein therapeutics to make a difference for cystic fibrosis patients.

Focus: Metabolic Disorders, Rare Genetic & Orphan Diseases, Biologics Year Invested: 2008

EMBER THERAPEUTICS (MERGED WITH MARIEL THERAPEUTICS IN 2016)

The combined company, known as Ember Therapeutics, Inc., is focused on developing regenerative medicines for disease modification of osteoarthritis, reversal of insulin resistance and the inhibition and reversal of organ fibrosis in diseases such as chronic kidney disease and Alport Syndrome.

Focus: Respiratory, Urology, Small MoleculesYear Invested: 2011

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