ottimizzazione delle forme molecolari e cristalline di ... · advanced methods of crystal...
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Ottimizzazione delle forme molecolari e cristalline di farmaci, fitofarmaci, pesticidi in relazione ad
attività, biodisponibilità, aspetti brevettuali, e alla produzione di polimorfi, solvati e co-cristalli con
metodi a basso impatto ambientale
I protagonisti
Davide Capucci Aleksandar CvetkovskiDavide PrestiSaverio Nanna
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Advantages of Crystal Design
Collaborations with
SPINNER network
-Improved properties (solubility,
stability, bioavailability etc.)
- Patent Protecting (issuing new
patents, market-extended product lifecycle)
-Resolution of optically active
crystal forms (drugs, pesticides, etc.)
- Bottom-up synthesis (green
chemistry, environmentally friendly)
Università di Ferrara
Dipartimento di Chimica e
Centro di Strutturistica Diffrattometrica
Aleksandar Cvetkovski
Expertise and Know-How
of the Lab (since 1989)
Physical Chemistry and
Crystallography of
Intermolecular Interactions
► Hydrogen Bond
► Charge-Transfer Interactions
Applications to the Design
of Multicomponent Crystals
► New Molecular Materials
► Pharmaceutical Cocrystals
►Methods of crystal preparation
► Advanced carachterization
Research Facilities
- Crystallization
- Diffraction
- Databases
- Modeling
Case Study: Cocrystals of model
drug “Met” with carboxylic acids
“Met” / Succinic acid “Met” / Maleic acid
“Met” / Fumaric acid “Met” / Salicylic acid
www.ggilli.comThe Dual Hydrogen Bond